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David Sumpton
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Journal Articles

Nutrient-Sensitising Drug Repurposing Screen Identifies Lomerizine As a Mitochondrial Metabolism Inhibitor in Chronic Myeloid Leukaemia

Ahmed Khalaf, Lucie de Beauchamp, Eric Kalkman, Kevin Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary Scott, Karen Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 862.
https://doi.org/10.1182/blood-2023-186405
Published: 2023
Journal Articles

Novel Role of Mitochondrial Folate Metabolism in Cell Fate Decisions and Leukaemogenesis

Martha M. Zarou, Kevin Rattigan, Daniele Sarnello, Amy Dawson, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 1369.
https://doi.org/10.1182/blood-2023-185915
Published: 2023
Journal Articles

Inhibition of Folate Metabolism Drives Autophagy-Dependent Differentiation and Reduces Survival of Therapy-Resistant Leukaemic Stem Cells

Martha M. Zarou, Kevin Rattigan, Zuzana Brabcova, Amy Dawson, David Sumpton, Alexei Vazquez, Vignir Helgason
Journal: Blood
Blood (2021) 138 (Supplement 1): 2543.
https://doi.org/10.1182/blood-2021-149664
Published: 2021