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Journal Articles

Novel Role of Mitochondrial Folate Metabolism in Cell Fate Decisions and Leukaemogenesis

Martha M. Zarou, Kevin Rattigan, Daniele Sarnello, Amy Dawson, Karen Dunn, Mhairi Copland, David Sumpton, Alexei Vazquez, G. Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 1369.
https://doi.org/10.1182/blood-2023-185915
Published: 2023
Journal Articles

Nutrient-Sensitising Drug Repurposing Screen Identifies Lomerizine As a Mitochondrial Metabolism Inhibitor in Chronic Myeloid Leukaemia

Ahmed Khalaf, Lucie de Beauchamp, Eric Kalkman, Kevin Rattigan, Ekaterini Himonas, Joe Jones, Daniel James, Engy Shokry Abd Shokry, Mary Scott, Karen Dunn, Saverio Tardito, Mhairi Copland, David Sumpton, Emma Shanks, Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 862.
https://doi.org/10.1182/blood-2023-186405
Published: 2023
Journal Articles

Leukaemia Exposure Alters the Transcriptional Profile and Function of Macrophages in the Bone Marrow Niche

Martha M. Zarou, Amy Dawson, Bodhayan Prasad, Joana Bittencourt-Silvestre, Désirée Zerbst, Giovanny Rodriguez Blanco, Mary Scott, Karen Dunn, Vaidehi Krishnan, Mhairi Copland, David Vetrie, Ravi Bhatia, Seth Coffelt, S.Tiong Ong, Helen Wheadon, Sara Zanivan, Kristina Kirschner, G. Vignir Helgason
Journal: Blood
Blood (2023) 142 (Supplement 1): 2704.
https://doi.org/10.1182/blood-2023-181630
Published: 2023
Journal Articles

Metabolism in stem cell–driven leukemia: parallels between hematopoiesis and immunity

Kevin M. Rattigan, Martha M. Zarou, G. Vignir Helgason
Journal: Blood
Blood (2023) 141 (21): 2553–2565.
https://doi.org/10.1182/blood.2022018258
Published: 2023
Journal Articles

Metabolic profiling of myeloproliferative neoplasms reveals subtype specific metabolic traits

Kristina Kirschner, Kevin Rattigan, Vignir Helgason, Fei Yan
Journal: Blood
Blood (2022) 140 (Supplement 1): 12180.
https://doi.org/10.1182/blood-2022-166992
Published: 2022
Journal Articles

Inhibition of Folate Metabolism Drives Autophagy-Dependent Differentiation and Reduces Survival of Therapy-Resistant Leukaemic Stem Cells

Martha M. Zarou, Kevin Rattigan, Zuzana Brabcova, Amy Dawson, David Sumpton, Alexei Vazquez, Vignir Helgason
Journal: Blood
Blood (2021) 138 (Supplement 1): 2543.
https://doi.org/10.1182/blood-2021-149664
Published: 2021
Journal Articles

hsa-mir183/EGR1 –mediated regulation of E2F1 is required for CML stem/progenitor cell survival

Francesca Pellicano, Laura Park, Lisa E. M. Hopcroft, Mansi M. Shah, Lorna Jackson, Mary T. Scott, Cassie J. Clarke, Amy Sinclair, Sheela A. Abraham, Alan Hair, G. Vignir Helgason, Mark Aspinall-O’Dea, Ravi Bhatia, Gustavo Leone, Kamil R. Kranc, Anthony D. Whetton, Tessa L. Holyoake
Journal: Blood
Blood (2018) 131 (14): 1532–1544.
https://doi.org/10.1182/blood-2017-05-783845
Published: 2018
Includes: Supplemental data
Journal Articles

Therapy Resistant CML Stem Cells Are Dependent on Mitochondrial Oxidative Metabolism for Their Survival

Elodie Marie Kuntz, Pablo Baquero, PhD, Tessa L. Holyoake, MD PhD FRCP, FRCPath, Eyal Gottlieb, PhD, G. Vignir Helgason, PhD
Journal: Blood
Blood (2016) 128 (22): 932.
https://doi.org/10.1182/blood.V128.22.932.932
Published: 2016
Journal Articles

Chronic myeloid leukemia stem cells are not dependent on Bcr-Abl kinase activity for their survival

Ashley Hamilton, G. Vignir Helgason, Mirle Schemionek, Bin Zhang, Svetlana Myssina, Elaine K. Allan, Franck E. Nicolini, Carsten Müller-Tidow, Ravi Bhatia, Valerie G. Brunton, Steffen Koschmieder, Tessa L. Holyoake
Journal: Blood
Blood (2012) 119 (6): 1501–1510.
https://doi.org/10.1182/blood-2010-12-326843
Published: 2012
Includes: Supplemental data
Journal Articles

Kill one bird with two stones: potential efficacy of BCR-ABL and autophagy inhibition in CML

G. Vignir Helgason, Maria Karvela, Tessa L. Holyoake
Journal: Blood
Blood (2011) 118 (8): 2035–2043.
https://doi.org/10.1182/blood-2011-01-330621
Published: 2011