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Journal Articles

Ivosidenib leads to durable responses in IDH1 mutated clonal cytopenias of undetermined significance: A phase II decentralized clinical trial

Blood (2025) 146 (Supplement 1): 635.

https://doi.org/10.1182/blood-2025-635

Published: 2025

Journal Articles

Haploidentical hematopoietic stem cell transplantation using low-dose alemtuzumab is effective for standard-risk hematological malignancies

Blood (2025) 146 (Supplement 1): 5995.

https://doi.org/10.1182/blood-2025-5995

Published: 2025

Journal Articles

The somatic DDX41 hot spot mutation (p.R525H) causes skewed differentiation into plasmacytoid dendritic cells in human iPSC and leukemia models

Junichiro Kida, Maggie Fricker, Emily Stepanchick, Yael Kusne, Talha Badar, Terra Lasho, Mrinal Patnaik, Timothy Chlon

Blood (2025) 146 (Supplement 1): 678.

https://doi.org/10.1182/blood-2025-678

Published: 2025

Journal Articles

Insights into clonal and CBC changes at disease evolution among ccus patients

Yazan Jabban, Rong He, Kurt Bessonen, Patricia Greipp, Dragan Jevremovic, David Viswanatha, James Foran, Talha Badar, Cecilia Arana Yi, Yael Kusne, Antoine Saliba, Mehrdad Hefazi Torghabeh, Aasiya Matin, William Hogan, Abhishek Mangaonkar, Mithun Shah, Hassan Alkhateeb, Mrinal Patnaik, Aref Al-Kali

Blood (2025) 146 (Supplement 1): 5621.

https://doi.org/10.1182/blood-2025-5621

Published: 2025

Journal Articles

Reduced overall survival in TP53-mutated ccus is driven by prior cytotoxic exposure and cytopenia rather than leukemic progression

Blood (2025) 146 (Supplement 1): 5643.

https://doi.org/10.1182/blood-2025-5643

Published: 2025

Journal Articles

IDH1/2-mutant clonal hematopoiesis: A novel driver of autoinflammatory disease

Blood (2025) 146 (Supplement 1): 3169.

https://doi.org/10.1182/blood-2025-3169

Published: 2025

Journal Articles

Unique NK-like T cell population identified in UBA1mt cells in vexas associated with IL-8 mediated activity and cytotoxic response pathways

Terra Lasho, Jenna Fernandez, Pankaj Pradeep, Christy Finke, Abhishek Mangaonkar, Nickolas Steinauer, Bhavisha Patel, Neal Young, David Beck, Kenneth Warrington, Matthew J Koster, Yael Kusne, Fernanda Guitterez-Rodrigues, Mrinal Patnaik

Blood (2025) 146 (Supplement 1): 1428.

https://doi.org/10.1182/blood-2025-1428

Published: 2025

Journal Articles

Phenotypic landscape and clinical outcomes associated with promotor TERT mutations in patients with telomere biology disorders

Madeline Franke, Terra Lasho, Abhishek Mangaonkar, Christy Finke, Yael Kusne, Rachel Reither, Alejandro Ferrer, Mrinal Patnaik

Blood (2025) 146 (Supplement 1): 4995.

https://doi.org/10.1182/blood-2025-4995

Published: 2025

Journal Articles

The somatic hotspot mutation of DDX41 (p.R525H) elicits dominant-negative effects upon non-truncating germline variants, explaining similar disease risk as truncating variants.

Julianna Fisher, Emily Stepanchick, Andrew Wilson, Junichiro Kida, Talha Badar, Terra Lasho, Yael Kusne, Mrinal Patnaik, Timothy Chlon

Blood (2025) 146 (Supplement 1): 3221.

https://doi.org/10.1182/blood-2025-3221

Published: 2025

Journal Articles

Rapid hematologic germline testing using hair follicle-derived DNA for germline predisposition and inherited marrow failure states

Emma St. Martin, Abhishek Mangaonkar, Ann Moyer, Juliana Perez Botero, Alejandro Ferrer, Ross Rowsey, Benjamin Kipp, Dong Chen, Talha Badar, Jenna Fernandez, Yael Kusne, Christy Finke, Jodi Rindflesch, Terra Lasho, Mrinal Patnaik

Blood (2025) 146 (Supplement 1): 3211.

https://doi.org/10.1182/blood-2025-3211

Published: 2025

Journal Articles

Causes of death in DDX41-mutated myeloid neoplasms: A retrospective study

Blood (2025) 146 (Supplement 1): 7370.

https://doi.org/10.1182/blood-2025-7370

Published: 2025

Journal Articles

Fetal hemoglobin dysregulation in inherited and acquired bone marrow failure syndromes

Blood (2025) 146 (Supplement 1): 6750.

https://doi.org/10.1182/blood-2025-6750

Published: 2025

Journal Articles

Lutetium-177 dotatate PRRT in GEP-NETs: Hematologic toxicity trends, recovery profiles, and discontinuation rates

Rana Megawer, Natasha Sheheryar, Mohamad Sonbol, Timothy Hobday, Patrick McGarrah, Rachel Eiring, Yael Kusne, Mrinal Patnaik, Jason Starr, Thorvardur Halfdanarson

Blood (2025) 146 (Supplement 1): 6698.

https://doi.org/10.1182/blood-2025-6698

Published: 2025

Journal Articles

Decoding DDX41: Clinical impact of germline and somatic mutations in 77 high-risk myeloid neoplasm patients

Talha Badar, Mahesh Kumar, Yael Kusne, Terra Lasho, James Foran, Hemant Murthy, Mohamed Kharfan-Dabaja, Timothy Chlon, Naseema Gangat, Hassan Alkhateeb, Abhishek Mangaonkar, Rong He, David Viswanatha, Jennifer Jiang, Yao-Shan Fan, Alejandro Ferrer, Mark Litzow, Aref Al-Kali, Mrinal Patnaik

Blood (2025) 146 (Supplement 1): 1442.

https://doi.org/10.1182/blood-2025-1442

Published: 2025

Journal Articles

Interplay between mutant DNMT3A and UBA1 worsens survival through altered inflammatory and metabolic pathways

Blood (2025) 146 (Supplement 1): 3191.

https://doi.org/10.1182/blood-2025-3191

Published: 2025

Journal Articles

Upfront therapy with allogeneic hematopoietic stem cell transplantation versus DNA methyltransferase inhibitors in patients with vexas syndrome: A comparative matched cohort efficacy analysis of 39 patients

Blood (2025) 146 (Supplement 1): 981.

https://doi.org/10.1182/blood-2025-981

Published: 2025

Journal Articles

PPM1D Somatic Mutations in Myeloid Neoplasms: Clinical Profile, Clonal Characteristics and Impact of Concurrent Somatic TP53 Mutations

Blood (2024) 144 (Supplement 1): 3218.

https://doi.org/10.1182/blood-2024-202688

Published: 2024

Journal Articles

Clinical Characteristics of Myeloproliferative Neoplasms in Patients with DDX41 MT Germline Predisposition Syndrome

Yael Kusne, Talha Badar, Terra L. Lasho, Ludovica Marando, Abhishek A. Mangaonkar, Christy Finke, James M. Foran, Aref Al-Kali, Hassan B Alkhateeb, Naseema Gangat, Jeanne Palmer, David Viswanatha, Mark R. Litzow, Animesh D. Pardanani, Ayalew Tefferi, Timothy Chlon, Alejandro Ferrer, Mrinal M. Patnaik

Blood (2024) 144 (Supplement 1): 3183.

https://doi.org/10.1182/blood-2024-202406

Published: 2024

Journal Articles

Prevalence and Clinical Features of Non-Myeloid Neoplasms in Patients with DDX41 Mutant Germline Predisposition Syndrome

Blood (2024) 144 (Supplement 1): 440.

https://doi.org/10.1182/blood-2024-203879

Published: 2024

Journal Articles

Preclinical Evaluation of Stx-0712, a CCR2 Cytotoxicity Targeting Chimera (CCR2-CyTAC) for the Treatment of Chronic Myelomonocytic Leukemia

Brandon Turunen, Craig Leach, Matthew Smith, Terra L. Lasho, Christy Finke, Abhishek A. Mangaonkar, Aref Al-Kali, Yael Kusne, Talha Badar, James M. Foran, Aisha Margaert, Michelle Baptista, Stephanie Wiltzius, Mrinal M. Patnaik

Blood (2024) 144 (Supplement 1): 2771.

https://doi.org/10.1182/blood-2024-209024

Published: 2024

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Ivosidenib leads to durable responses in IDH1 mutated clonal cytopenias of undetermined significance: A phase II decentralized clinical trial

Haploidentical hematopoietic stem cell transplantation using low-dose alemtuzumab is effective for standard-risk hematological malignancies

The somatic DDX41 hot spot mutation (p.R525H) causes skewed differentiation into plasmacytoid dendritic cells in human iPSC and leukemia models

Insights into clonal and CBC changes at disease evolution among ccus patients

Reduced overall survival in TP53-mutated ccus is driven by prior cytotoxic exposure and cytopenia rather than leukemic progression

IDH1/2-mutant clonal hematopoiesis: A novel driver of autoinflammatory disease

Unique NK-like T cell population identified in UBA1mt cells in vexas associated with IL-8 mediated activity and cytotoxic response pathways

Phenotypic landscape and clinical outcomes associated with promotor TERT mutations in patients with telomere biology disorders

The somatic hotspot mutation of DDX41 (p.R525H) elicits dominant-negative effects upon non-truncating germline variants, explaining similar disease risk as truncating variants.

Rapid hematologic germline testing using hair follicle-derived DNA for germline predisposition and inherited marrow failure states

Causes of death in DDX41-mutated myeloid neoplasms: A retrospective study

Fetal hemoglobin dysregulation in inherited and acquired bone marrow failure syndromes

Lutetium-177 dotatate PRRT in GEP-NETs: Hematologic toxicity trends, recovery profiles, and discontinuation rates

Decoding DDX41: Clinical impact of germline and somatic mutations in 77 high-risk myeloid neoplasm patients

Interplay between mutant DNMT3A and UBA1 worsens survival through altered inflammatory and metabolic pathways

Upfront therapy with allogeneic hematopoietic stem cell transplantation versus DNA methyltransferase inhibitors in patients with vexas syndrome: A comparative matched cohort efficacy analysis of 39 patients

PPM1D Somatic Mutations in Myeloid Neoplasms: Clinical Profile, Clonal Characteristics and Impact of Concurrent Somatic TP53 Mutations

Clinical Characteristics of Myeloproliferative Neoplasms in Patients with DDX41 MT Germline Predisposition Syndrome

Prevalence and Clinical Features of Non-Myeloid Neoplasms in Patients with DDX41 Mutant Germline Predisposition Syndrome

Preclinical Evaluation of Stx-0712, a CCR2 Cytotoxicity Targeting Chimera (CCR2-CyTAC) for the Treatment of Chronic Myelomonocytic Leukemia

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