1-20 of 27
David Chen
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Mitochondrial RNA Methylation By METTL17 Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication in AML

Xueer Wang, Honghai Zhang, Lei Dong, Xiaoxu Zhang, Meilin Xue, Lili Ren, Hongjie Bi, Lucy Y. Ghoda, Mark Wunderlich, James C. Mulloy, Chun-Wei David Chen, Ling Li, Lin Xu, Bin Zhang, Guido Marcucci, Steven T. Rosen, Nora Heisterkamp, Marcin Kortylewski, Jianjun Chen, Rui Su
Journal: Blood
Blood (2024) 144 (Supplement 1): 625.
https://doi.org/10.1182/blood-2024-201916
Published: 2024
Journal Articles

ATLAS-AML: An Automated Bioinformatics Pipeline for Drug Target Characterization in Acute Myeloid Leukemia

Suraj Bansal, David Chen, Amanda Mitchell, Andy G.X. Zeng, John E. Dick
Journal: Blood
Blood (2024) 144 (Supplement 1): 2924.
https://doi.org/10.1182/blood-2024-211344
Published: 2024
Journal Articles

Synergistic Efficacy of Dual Menin and PRMT5 Targeting Against NPM1 mutated and KMT2A- rearranged Leukemia

Nadezda Dolgikh, Johanna Rausch, Marlene Steiner, Jonas Schönfeld, Catharina Lahrmann, Nina Hilke, Maria Alejandra Vila Molerio, Simon Weisemann, Maria Saura-Pañella, Aarón Gallego-Crespo, Matthias Theobald, Daniel Sasca, Chun-Wei David Chen, Michael W.M. Kühn
Journal: Blood
Blood (2024) 144 (Supplement 1): 206.
https://doi.org/10.1182/blood-2024-202460
Published: 2024
Journal Articles

Isomarker: An Explainable Machine Learning Framework for Identification of Cell State Markers in Acute Myeloid Leukemia

David Chen, Suraj Bansal, Amanda Mitchell, Anne Maria Tierens, Andy G.X. Zeng, John E. Dick
Journal: Blood
Blood (2024) 144 (Supplement 1): 1542.
https://doi.org/10.1182/blood-2024-210986
Published: 2024
Journal Articles

An Essential Role for the N-Terminus of GATA1 in Metabolic Regulation during Erythropoiesis

Te Ling, Lavanya Bezavada, Rashid Mehmood, Kevin Zhang, Jeremy Chase Crawford, Yan Ju, Chun-Wei David Chen, Yichao Li, Yong Cheng, John D. Crispino
Journal: Blood
Blood (2024) 144 (Supplement 1): 940.
https://doi.org/10.1182/blood-2024-210865
Published: 2024
Journal Articles

A Novel Form of AEBP2-Containing PRC2.2 Is a Genetic Dependency in Germinal Centre B-Cell Lymphoma and Its Targeting Can Overcome Acquired Resistance to EZH2 Inhibition

James Nolan, Daniel Angelov, Darragh Nimmo, Gráinne Holland, Molly Davies, Eugene Dillon, David Reck, Craig Monger, Chun-Wei David Chen, Gerard L Brien, Elisabeth Vandenberghe, Eric Conway, Adrian Bracken
Journal: Blood
Blood (2024) 144 (Supplement 1): 4121.
https://doi.org/10.1182/blood-2024-205382
Published: 2024
Journal Articles

COX4I1 Controls Mitochondrial Electron Transport Chain Complex IV Assembly and Leukemia Progression in Acute Myeloid Leukemia

Leisi Zhang, Mingli Li, Anthony KN Chan, Qiao Liu, Hyunjun Kang, Sheela Pangeni Pokharel, Nicole Mattson, Priyanka Singh, Lu Yang, Chun-Wei David Chen
Journal: Blood
Blood (2023) 142 (Supplement 1): 581.
https://doi.org/10.1182/blood-2023-188526
Published: 2023
Journal Articles

TP63 Fusions Drive Enhancer Rewiring, Lymphomagenesis, and Dependence on EZH2

Gongwei Wu, Noriaki Yoshida, Jihe Liu, Xiaoyang Zhang, Tayla B. Heavican-Foral, Huiyun Liu, Geoffrey M. Nelson, Lu Yang, Renee Chen, Marcus Kenneth Jones, Ran Xu, Ajit Johnson Nirmal, Salvia Jain, Catharine Leahy, Kristen Lynn Jones, Kristen E. Stevenson, Wenchao Wu, Abner Louissaint, Jr., Lydie Debaize, Wing C. Chan, Shannan Ho Sui, Samuel Ng, Andrew L. Feldman, Matthew Meyerson, Karen Adelman, chun-Wei David Chen, Myles Brown, David M. Weinstock
Journal: Blood
Blood (2022) 140 (Supplement 1): 1696–1697.
https://doi.org/10.1182/blood-2022-163368
Published: 2022
Journal Articles

Mutant NPM1 Is Recruited to MLL Target Genes Via Its Acidic Stretch and Nuclear Export Factor CRM1 and Regulates Oncogenic Transcription in Acute Myeloid Leukemia

Hannah J Uckelmann, Elena L Haarer, Reina Takeda, Eric Wong, Christian Marinaccio, Charles Hatton, Yanhe Wen, Florian Perner, Masooma Rajput, Noa J.C. Antonissen, Chun-Wei David Chen, Lorenzo Brunetti, Scott A. Armstrong
Journal: Blood
Blood (2022) 140 (Supplement 1): 5835–5836.
https://doi.org/10.1182/blood-2022-166630
Published: 2022
Journal Articles

The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax

Johanna Rausch, Margarita M. Dzama, Nadezda Dolgikh, Hanna Stiller, Stephan Bohl, Catharina Lahrmann, Kerstin Kunz, Linda Kessler, Hakim Echchannaoui, Chun-Wei David Chen, Thomas Kindler, Francis Burrows, Matthias Theobald, Daniel Sasca, Scott A. Armstrong, Michael Kuehn
Journal: Blood
Blood (2022) 140 (Supplement 1): 6226–6227.
https://doi.org/10.1182/blood-2022-167566
Published: 2022
Journal Articles

Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines

Sara Canovas Nunes, Haiming Xu, Serena De Vita, Andrew Anighoro, Francois Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad E. Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei David Chen, Monika Ermann, David A. Williams
Journal: Blood
Blood (2021) 138 (Supplement 1): 1199.
https://doi.org/10.1182/blood-2021-147009
Published: 2021
Journal Articles

Tudor Domain-Focused CRISPR Dropout Screen Identifies SGF29 As a Novel Essential Gene in MLL -Rearranged Leukemias

Anthony K. N. Chan, PhD, Christopher D. Delaney, Lu Yang, PhD, Wen-Han Chang, PhD, Kazuya Miyashita, PhD, Qiao Liu, MD, Sheela Pangeni Pokharel, MSc, Scott A. Armstrong, MD PhD, Chun-Wei David Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 530.
https://doi.org/10.1182/blood-2019-131467
Published: 2019
Journal Articles

HDAC8 Promotes MLL-Rearranged Acute Myeloid Leukemia By Inhibiting p53 Acetylation

Dijiong Wu, MD, Man Li, PhD, Lianjun Zhang, PhD, Jing Qi, PhD, Chun-Wei David Chen, PhD, Xin He, PhD, Yinghui Zhu, PhD, Haojie Dong, PhD, Jie Sun, PhD, Ling Li, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 642.
https://doi.org/10.1182/blood-2019-124134
Published: 2019
Journal Articles

Identification of ZNF217 As an Essential Oncogenic Gene in B-Cell Acute Lymphoblastic Leukemia By CRISPR/Cas9-Based Library Screening

Xi Qin, Rui Su, PhD, Lu Yang, PhD, Anthony K. N. Chan, PhD, Xiaolan Deng, Ying Qing, Lars Klemm, MS, Markus Müschen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1465.
https://doi.org/10.1182/blood-2019-129849
Published: 2019
Journal Articles

Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL -Rearranged AML with Mutated FLT3

Margarita M. Dzama, MSc, Martha C. Taubert, MSc, Kerstin Kunz, Johanna Rausch, MD, Chun-Wei David Chen, PhD, Annalisa Mupo, PhD, Patricia Hähnel, PhD, Matthias Theobald, MD PhD, Thomas Kindler, MD, Richard P. Koche, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Scott A. Armstrong, MD PhD, Michael W.M. Kühn, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1441.
https://doi.org/10.1182/blood-2019-122847
Published: 2019
Journal Articles

Ifitm3 Is Essential for PI(3,4,5)P3-Dependent B-Cell Activation and Leukemogenesis

Jaewoong Lee, PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Huimin Geng, PhD, Ning Ma, PhD, Lai N Chan, PhD, Kohei Kume, PhD, Matthew Nix, PhD, Zhengshan Chen, MD PhD, Chun-Wei David Chen, PhD, Jianjun Chen, PhD, Vishal Khairnar, PhD, Arun P. Wiita, MD PhD, Andrei Thomas-Tikhonenko, PhD, Michael Farzan, MD PhD, Michael S. Diamond, PhD, Jae U Jung, PhD, Nagarajan Vaidehi, PhD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2782.
https://doi.org/10.1182/blood-2019-127615
Published: 2019
Journal Articles

Leukemia Cell of Origin Influences p53 Activity and Therapeutic Sensitivity Via an Evi1-Dependent Mechanism

Sheng F Cai, MD PhD, S Haihua Chu, PhD, Aaron D Goldberg, MD PhD, Salma Parvin, PhD, Richard Koche, PhD, Jacob L Glass, MD PhD, Eytan M. Stein, MD, Martin S. Tallman, MD, Filiz Sen, MD, Christopher Famulare, MS, Monica Cusan, MD, Chun-Hao Huang, PhD, Chun-Wei David Chen, PhD, Lihua Zou, PhD, Keith B Cordner, BS, Vidushi Durani, MS, Mitali Kini, BS, Madison Rex, Johannes Zuber, Timour Baslan, PhD, Scott W. Lowe, PhD, Hugh Young Rienhoff, Jr., MD, Ross L. Levine, MD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 109.
https://doi.org/10.1182/blood-2019-122483
Published: 2019
Journal Articles

Dynamic Assembly of a Feedback Complex to Regulate Oncogenic B-Cell Receptor-Signaling

Jaewoong Lee, PhD, Kohei Kume, PhD, Zhengshan Chen, MD PhD, Gang Xiao, PhD, Kadriye Nehir Nehir Cosgun, PhD, Liting Chen, PhD, Lai N Chan, PhD, Lars Klemm, MS, Chun-Wei David Chen, PhD, Ning Ma, PhD, Wing C. Chan, MD, Stephen J Forman, MD, Francesca Zammarchi, PhD, Patrick Van Berkel, PhD, Ari Melnick, MD, Vu N Ngo, PhD, Huimin Geng, PhD, Selina M. Luger, MD FRCPC, Mark Litzow, MD, Michael T McManus, PhD, Nagarajan Vaidehi, PhD, Elisabeth M. Paietta, PhD, Eric Meffre, PhD, David M. Weinstock, MD, Markus Müschen, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 393.
https://doi.org/10.1182/blood-2019-131270
Published: 2019
Journal Articles

Characterization of Monoclonal Gammopathy of Undetermined Significance Progression to Multiple Myeloma through Meta-Analysis of GEO Data

Jihad Aljabban, MMSc, BA, David Chen, BS, Francesca Cottini, MD, Saad Syed, BS, Nabeal Aljabban, BS, Sharjeel Syed, BS, Tiffany Hughes, PhD, David Feldman, BS, Dexter Hadley, MD PhD, Don M. Benson, Jr., MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4395.
https://doi.org/10.1182/blood-2019-129699
Published: 2019
Journal Articles

Direct Detection of Expressed Mutations in AML Cells Using Single Cell RNA-Sequencing, and Its Impact on Defining Sources of Expression Heterogeneity

Allegra A Petti, PhD, Stephen R Williams, PhD, Christopher A Miller, PhD, Ian T Fiddes, PhD, David Chen, MD PhD, Sridhar Nonavinkere Srivatsan, MS, Catrina Fronick, BS, Robert Fulton, MS, Deanna M Church, PhD, Timothy J Ley, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1314.
https://doi.org/10.1182/blood-2018-99-119075
Published: 2018