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Serena De Vita
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Journal Articles

Prolonged Persistence and Functional Activity of Anti-BCMA CAR-T Durcabtagene Autoleucel (PHE885) Manufactured Using the T-Charge™ Platform

Shuntaro Ikegawa, Adam S. Sperling, Sarah Nikiforow, Andrew Ghazi, Anthony Christidis, David Quinn, Dexiu Bu, Jennifer Mataraza, David Pearson, Allison Charles, Marc Credi, Nina Orwitz, Madisyn Strange, Rakuyo Tamada, Kevin M. Panaro, Casey Gervais, Michela Ansuinelli, Yohei Arihara, Rao Prabhala, Carol G. Reynolds, Robert Gentleman, Serena De Vita, Nikhil C. Munshi, Jerome Ritz
Journal: Blood
Blood (2024) 144 (Supplement 1): 149.
https://doi.org/10.1182/blood-2024-199890
Published: 2024
Journal Articles

Rheological Comparison of Red Cells from Individuals with SCD Treated with Gene Therapy, Haploidentical Transplantation or Hydroxyurea

Britney Hernandez, Ashwin P. Patel, Erica N Evans, Jordan Zgodny, Stephen Gottschalk, Brandon M Triplett, Serena De Vita, Kirby Wallace, David C Shyr, Elizabeth O Stenger, Suhag Parikh, Akshay Sharma, Vivien Sheehan
Journal: Blood
Blood (2024) 144 (Supplement 1): 4956.
https://doi.org/10.1182/blood-2024-210578
Published: 2024
Journal Articles

T-Charge™ Manufacturing of the Anti-BCMA CAR-T, Durcabtagene Autoleucel (PHE885), Promotes Expansion and Persistence of CAR-T Cells with High TCR Repertoire Diversity

Shuntaro Ikegawa, Adam S. Sperling, Michela Ansuinelli, Sarah Nikiforow, David Quinn, Dexiu Bu, Jennifer Mataraza, David Pearson, Lawrence Rispoli, Marc A Credi, Nina Orwitz, Yohei Arihara, Rao Prabhala, Lakshmi Bhavani Potluri, Carol Reynolds, Serena De Vita, Nikhil C Munshi, Jerome Ritz
Journal: Blood
Blood (2023) 142 (Supplement 1): 3469.
https://doi.org/10.1182/blood-2023-177721
Published: 2023
Journal Articles

Treatment of Individuals with Severe Sickle Cell Disease with OTQ923, an Autologous, Ex Vivo , CRISPR/Cas9-Edited, CD34+ Hematopoietic Stem and Progenitor Cell Product, Leads to Durable Engraftment and Fetal Hemoglobin Induction

Akshay Sharma, Jaap Jan Boelens, Maria I. Cancio, Jane Hankins, Prafulla A Bhad, Andrew Lewandowski, Xiaojun Zhao, Shripad Chitnis, Radhika Peddinti, Yan Zheng, Neena Kapoor, Fabio Ciceri, Jianping Yuan, Vionnie W. Yu, Susan C. Stevenson, Serena De Vita, James LaBelle
Journal: Blood
Blood (2022) 140 (Supplement 1): 1906–1908.
https://doi.org/10.1182/blood-2022-166254
Published: 2022
Journal Articles

Phase I Study of PHE885, a Fully Human BCMA-Directed CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Manufactured in <2 Days Using the T-Charge TM Platform

Adam S. Sperling, Sarah Nikiforow, Omar Nadeem, Clifton C Mo, Jacob P. Laubach, Kenneth C. Anderson, Alejandro Alonso, Shuntaro Ikegawa, Rao Prabhala, Diego Hernandez Rodriguez, Heather Daley, Kit L. Shaw, Yohei Arihara, Soudeh Ansari, David S Quinn, David Pearson, Anniesha Hack, Louise M Treanor, Dexiu Bu, Jennifer Mataraza, Lawrence Rispoli, Marc Credi, Jerome Ritz, Serena De Vita, Nikhil C. Munshi
Journal: Blood
Blood (2021) 138 (Supplement 1): 3864.
https://doi.org/10.1182/blood-2021-146646
Published: 2021
Journal Articles

Small Molecule Inhibition of PDE6D-RAS Interaction Suppresses the Growth of Acute Lymphoblastic Leukemia Cell Lines

Sara Canovas Nunes, Haiming Xu, Serena De Vita, Andrew Anighoro, Francois Autelitano, Edward Beaumont, Pamela Klingbeil, Meaghan McGuinness, Beatrice Duvert, Chad E. Harris, Lu Yang, Sheela Pangeni Pokharel, Chun-Wei David Chen, Monika Ermann, David A. Williams
Journal: Blood
Blood (2021) 138 (Supplement 1): 1199.
https://doi.org/10.1182/blood-2021-147009
Published: 2021
Journal Articles

Vav1, a Rho GTPase Guanine Exchange Factor (GEF) Is Required to Integrate gp130 Cytokine Signaling for Successful Engraftment of Murine Hematopoietic Stem Cells Following Irradiation

Serena De Vita, MD PhD, Yanhua Li, MD PhD, Chad Everett Harris, MS, Meaghan McGuinness, BS, David A. Williams, MD
Journal: Blood
Blood (2016) 128 (22): 2149.
https://doi.org/10.1182/blood.V128.22.2149.2149
Published: 2016
Journal Articles

The Rac GTPase effector p21-activated kinase is essential for hematopoietic stem/progenitor cell migration and engraftment

Adrienne M. Dorrance, Serena De Vita, Maria Radu, Pavankumar N. G. Reddy, Meaghan K. McGuinness, Chad E. Harris, Ronald Mathieu, Steven W. Lane, Rachelle Kosoff, Michael D. Milsom, Jonathan Chernoff, David A. Williams
Journal: Blood
Blood (2013) 121 (13): 2474–2482.
https://doi.org/10.1182/blood-2012-10-460709
Published: 2013
Includes: Multimedia, Supplemental data
Journal Articles

Vav1 Deficiency Differentially Affects Engraftment of Fetal Hematopoietic Organs During Development Compared with Adult Marrow After Transplantation

Serena De Vita, MD, PhD, Chad E Harris, Raffaele Renella, MD, PhD, Ronald Mathieu, Meaghan McGuinness, David A. Williams, MD
Journal: Blood
Blood (2012) 120 (21): 1212.
https://doi.org/10.1182/blood.V120.21.1212.1212
Published: 2012
Journal Articles

Rac signaling in osteoblastic cells is required for normal bone development but is dispensable for hematopoietic development

Steven W. Lane, Serena De Vita, Kylie A. Alexander, Ruchan Karaman, Michael D. Milsom, Adrienne M. Dorrance, Amy Purdon, Leeann Louis, Mary L. Bouxsein, David A. Williams
Journal: Blood
Blood (2012) 119 (3): 736–744.
https://doi.org/10.1182/blood-2011-07-368753
Published: 2012
Includes: Supplemental data
Journal Articles

Pak A Proteins Are Essential for Hematopoietic Stem/Progenitor Cell (HSC/P) Engraftment Through Regulation of Signaling Pathways Controlling HSC/P Proliferation, Survival, Migration, and the Actin Cytoskeleton

Adrienne M. Dorrance, PhD, Rachelle Kosoff, Meaghan McGuinness, Chad Harris, Serena De Vita, MD, PhD, Ronald Mathieu, Steven W. Lane, MD, Michael D. Milsom, PhD, Jonathan Chernoff, MD, PhD, David A. Williams, MD
Journal: Blood
Blood (2011) 118 (21): 917.
https://doi.org/10.1182/blood.V118.21.917.917
Published: 2011
Journal Articles

Group A Pak Proteins Are Essential for HSC/P Engraftment.

Adrienne M. Dorrance, PhD, Abel Sanchez-Aguilera, PhD, Serena De Vita, MD, PhD, Michael D. Milsom, PhD, Jonathan Chernoff, MD, PhD, David A. Williams, MD
Journal: Blood
Blood (2010) 116 (21): 2624.
https://doi.org/10.1182/blood.V116.21.2624.2624
Published: 2010
Journal Articles

Peg-Filgrastim after High Dose Chemotherapy and Autologous Peripheral Blood Stem Cell Transplantation for Hematological Malignancies: A Matched-Pair Analysis.

Simona Sica, Nicola Piccirillo, Silvia De Matteis, Luca Laurenti, Patrizia Chiusolo, Serena De Vita, Federica Sorà, Rossana Putzulu, Giovanni Reddiconto, Giuliana Farina, Giuseppe d’Onofrio, Giuseppe Leone
Journal: Blood
Blood (2004) 104 (11): 5035.
https://doi.org/10.1182/blood.V104.11.5035.5035
Published: 2004