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Journal Articles

Rapcabtagene autoleucel (YTB323) for patients with first line high-risk large B-cell lymphoma: Phase II interim results

Free
Jason Westin, Julio Chavez, Stephen J. Schuster, Vladan Vucinic, Patricia A. Young, Patrick Connor Johnson, Stefania Bramanti, Alessandro Rambaldi, Javier Briones Meijide, Koji Kato, Juan-Manuel Sancho, Mi Kwon, Carlos Solano, Shaun Fleming, Saurabh Dahiya, Alejandro Martin Garcia-Sancho, Pedro Marques Ramos, David Pearson, Salif Diallo, Aiesha Zia, Eduardo Segura, Aisha Masood, Pere Barba
Journal: Blood
Blood (2025) 146 (Supplement 1): 670.
https://doi.org/10.1182/blood-2025-670
Published: 2025
Journal Articles

Functional fitness of CAR-T cells in the bone marrow following anti-BCMA durcabtagene autoleucel (PHE885) therapy correlate with prolonged PFS in RRMM

Free
Rao Prabhala, Lakshmi Bhavani Potluri, Srikanth Talluri, Hannah Seah, Vaishnavi Bade, Sahan Vangala, Mehmet Samur, Sarah Nikiforow, Alejandro Alonso, Shuntaro Ikegawa, Sinead Dolan, David Pearson, Pedro Milanez-Almeida, Jennifer Mataraza, Jerome Ritz, Dexiu BU, Marc Credi, Adam Sperling, Nikhil Munshi
Journal: Blood
Blood (2025) 146 (Supplement 1): 5713.
https://doi.org/10.1182/blood-2025-5713
Published: 2025
Journal Articles

Phase 1 evaluation of the safety and efficacy of rapcabtagene autoleucel (YTB323) in adult patients with Relapsed/Refractory B-cell acute lymphoblastic leukemia (r/r B-ALL)

Free
Pere Barba, Alessandro Rambaldi, Nicolas Boissel, Noriko Doki, Didier Blaise, Fabio Ciceri, Javier Briones Meijide, Mi Kwon, Shaun Fleming, Cristina Blázquez Goñi, Takanori Teshima, Koji Kato, Marie Balsat, Ulrich Jaeger, Leyla Shune, Pedro Marques Ramos, David Pearson, James Corcoran, Aiesha Zia, Matthew Foster, Aisha Masood, Michael Dickinson
Journal: Blood
Blood (2025) 146 (Supplement 1): 811.
https://doi.org/10.1182/blood-2025-811
Published: 2025
Journal Articles

Rapcabtagene Autoleucel (YTB323) in Patients (Pts) with Relapsed/Refractory Diffuse Large B-Cell Lymphoma (R/R DLBCL): Phase II Trial Clinical Update

Free
Peter A. Riedell, Mi Kwon, Ian W. Flinn, Michael J. Dickinson, Carlos Solano, Ulrich Jaeger, Javier Briones, Koji Kato, Shaun Fleming, Emmanuel Bachy, Alessandro Rambaldi, Leyla O. Shune, Nirav N. Shah, Didier Blaise, Matthew J. Frigault, Aravind Ramakrishnan, Anne Yang, David Pearson, Aiesha Zia, Eduardo Segura, Aisha Masood, Pere Barba
Journal: Blood
Blood (2024) 144 (Supplement 1): 67.
https://doi.org/10.1182/blood-2024-204264
Published: 2024
Journal Articles

Prolonged Persistence and Functional Activity of Anti-BCMA CAR-T Durcabtagene Autoleucel (PHE885) Manufactured Using the T-Charge™ Platform

Free
Shuntaro Ikegawa, Adam S. Sperling, Sarah Nikiforow, Andrew Ghazi, Anthony Christidis, David Quinn, Dexiu Bu, Jennifer Mataraza, David Pearson, Allison Charles, Marc Credi, Nina Orwitz, Madisyn Strange, Rakuyo Tamada, Kevin M. Panaro, Casey Gervais, Michela Ansuinelli, Yohei Arihara, Rao Prabhala, Carol G. Reynolds, Robert Gentleman, Serena De Vita, Nikhil C. Munshi, Jerome Ritz
Journal: Blood
Blood (2024) 144 (Supplement 1): 149.
https://doi.org/10.1182/blood-2024-199890
Published: 2024
Journal Articles

T-Charge™ Manufacturing of the Anti-BCMA CAR-T, Durcabtagene Autoleucel (PHE885), Promotes Expansion and Persistence of CAR-T Cells with High TCR Repertoire Diversity

Free
Shuntaro Ikegawa, Adam S. Sperling, Michela Ansuinelli, Sarah Nikiforow, David Quinn, Dexiu Bu, Jennifer Mataraza, David Pearson, Lawrence Rispoli, Marc A Credi, Nina Orwitz, Yohei Arihara, Rao Prabhala, Lakshmi Bhavani Potluri, Carol Reynolds, Serena De Vita, Nikhil C Munshi, Jerome Ritz
Journal: Blood
Blood (2023) 142 (Supplement 1): 3469.
https://doi.org/10.1182/blood-2023-177721
Published: 2023
Journal Articles

YTB323 (Rapcabtagene Autoleucel) Demonstrates Durable Efficacy and a Manageable Safety Profile in Patients with Relapsed/Refractory Diffuse Large B-Cell Lymphoma: Phase I Study Update

Free
Pere Barba, Mi Kwon, Javier Briones, Ulrich Jaeger, Emmanuel Bachy, Didier Blaise, Nicolas Boissel, Koji Kato, Nirav N. Shah, Matthew Frigault, Peter A. Riedell, Leyla O. Shune, Takanori Teshima, Fabio Ciceri, David Pearson, Elena J Orlando, Lan Yi, Jaclyn Davis, Aisha Masood, Ian W. Flinn, Michael Dickinson
Journal: Blood
Blood (2022) 140 (Supplement 1): 1056–1059.
https://doi.org/10.1182/blood-2022-162520
Published: 2022
Journal Articles

Phase I Study of PHE885, a Fully Human BCMA-Directed CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Manufactured in <2 Days Using the T-Charge TM Platform

Free
Adam S. Sperling, Sarah Nikiforow, Omar Nadeem, Clifton C Mo, Jacob P. Laubach, Kenneth C. Anderson, Alejandro Alonso, Shuntaro Ikegawa, Rao Prabhala, Diego Hernandez Rodriguez, Heather Daley, Kit L. Shaw, Yohei Arihara, Soudeh Ansari, David S Quinn, David Pearson, Anniesha Hack, Louise M Treanor, Dexiu Bu, Jennifer Mataraza, Lawrence Rispoli, Marc Credi, Jerome Ritz, Serena De Vita, Nikhil C. Munshi
Journal: Blood
Blood (2021) 138 (Supplement 1): 3864.
https://doi.org/10.1182/blood-2021-146646
Published: 2021
Journal Articles

The CD22 Epitope, Dose, Dosing Interval, and Timing All Effect Efficacy of Anti-CD22 mAb-Based Therapy of NHL.

Free
Robert O’Donnell, MD, David Pearson, PhD, Hayes McKnight, Thomas Tedder, PhD, Joseph M. Tuscano, MD
Journal: Blood
Blood (2007) 110 (11): 2355.
https://doi.org/10.1182/blood.V110.11.2355.2355
Published: 2007
Journal Articles

Sodium Orthovanadate (NaV) Effects CD22 Expression, Intracellular Signaling, and Lymphomacidal Activity of the HB22.7 Anti-CD22 Monoclonal Antibody.

Free
Robert T. O’Donnell, MD, PhD, David Pearson, PhD, Hayes McKnight, Thomas F. Tedder, PhD, Joseph M. Tuscano, MD
Journal: Blood
Blood (2005) 106 (11): 1487.
https://doi.org/10.1182/blood.V106.11.1487.1487
Published: 2005