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Journal Articles

Prolonged Persistence and Functional Activity of Anti-BCMA CAR-T Durcabtagene Autoleucel (PHE885) Manufactured Using the T-Charge™ Platform

Shuntaro Ikegawa, Adam S. Sperling, Sarah Nikiforow, Andrew Ghazi, Anthony Christidis, David Quinn, Dexiu Bu, Jennifer Mataraza, David Pearson, Allison Charles, Marc Credi, Nina Orwitz, Madisyn Strange, Rakuyo Tamada, Kevin M. Panaro, Casey Gervais, Michela Ansuinelli, Yohei Arihara, Rao Prabhala, Carol G. Reynolds, Robert Gentleman, Serena De Vita, Nikhil C. Munshi, Jerome Ritz
Journal: Blood
Blood (2024) 144 (Supplement 1): 149.
https://doi.org/10.1182/blood-2024-199890
Published: 2024
Journal Articles

Loss of GABARAP mediates resistance to immunogenic chemotherapy in multiple myeloma

Annamaria Gulla, Eugenio Morelli, Megan Johnstone, Marcello Turi, Mehmet K. Samur, Cirino Botta, Selma Cifric, Pietro Folino, Delaney Vinaixa, Francesca Barello, Cole Clericuzio, Vanessa Katia Favasuli, Domenico Maisano, Srikanth Talluri, Rao Prabhala, Giada Bianchi, Mariateresa Fulciniti, Kenneth Wen, Keiji Kurata, Jiye Liu, Johany Penailillo, Alberto Bragoni, Anna Sapino, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2024) 143 (25): 2612–2626.
https://doi.org/10.1182/blood.2023022777
Published: 2024
Includes: Supplemental data
Journal Articles

T-Charge™ Manufacturing of the Anti-BCMA CAR-T, Durcabtagene Autoleucel (PHE885), Promotes Expansion and Persistence of CAR-T Cells with High TCR Repertoire Diversity

Shuntaro Ikegawa, Adam S. Sperling, Michela Ansuinelli, Sarah Nikiforow, David Quinn, Dexiu Bu, Jennifer Mataraza, David Pearson, Lawrence Rispoli, Marc A Credi, Nina Orwitz, Yohei Arihara, Rao Prabhala, Lakshmi Bhavani Potluri, Carol Reynolds, Serena De Vita, Nikhil C Munshi, Jerome Ritz
Journal: Blood
Blood (2023) 142 (Supplement 1): 3469.
https://doi.org/10.1182/blood-2023-177721
Published: 2023
Journal Articles

Venetoclax Resistance Results in Broad Resistance to Majority of Anti-MM Agents Due to the Suppression of Apoptosis but Can be Overcome By BCMA-Targeted Immunotherapy

Mariateresa Fulciniti, Shuhui Deng, Sanika Dereibal, Vera Joy Weiler, Madhumouli Chatterjee, Jessica Ng Fong, Chandraditya Chakraborty, Rao Prabhala, Masood A. Shammas, Anil Aktas-Samur, Mehmet K. Samur, Annamaria Gulla, Kenneth C. Anderson, Nikhil C Munshi
Journal: Blood
Blood (2023) 142 (Supplement 1): 3311.
https://doi.org/10.1182/blood-2023-187374
Published: 2023
Journal Articles

Targeting Autophagy to Overcome Resistance to Immunogenic Chemotherapy in High-Risk Multiple Myeloma

Annamaria Gulla, Eugenio Morelli, Mehmet K. Samur, Megan Johnstone, Cirino Botta, Delaney Vinaixa, Marcello Turi, Mariateresa Fulciniti, Kenneth Wen, Selma Cifric, Srikanth Talluri, Giada Bianchi, Rao Prabhala, Paul G. Richardson, Dharminder Chauhan, Ruben D. Carrasco, Teru Hideshima, Nikhil C Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2022) 140 (Supplement 1): 7114–7115.
https://doi.org/10.1182/blood-2022-162653
Published: 2022
Journal Articles

Gabarap Loss Mediates Immune Escape in High Risk Multiple Myeloma

Annamaria Gulla, Eugenio Morelli, Mehmet K. Samur, Cirino Botta, Megan Johnstone, Giada Bianchi, Mariateresa Fulciniti, Leona Yamamoto, Rao Prabhala, Kenneth Wen, Paul G. Richardson, Yu-Tzu Tai, Dharminder Chauhan, Teru Hideshima, Nikhil C. Munshi, Kenneth C. Anderson
Journal: Blood
Blood (2021) 138 (Supplement 1): 891.
https://doi.org/10.1182/blood-2021-148621
Published: 2021
Journal Articles

Phase I Study of PHE885, a Fully Human BCMA-Directed CAR-T Cell Therapy for Relapsed/Refractory Multiple Myeloma Manufactured in <2 Days Using the T-Charge TM Platform

Adam S. Sperling, Sarah Nikiforow, Omar Nadeem, Clifton C Mo, Jacob P. Laubach, Kenneth C. Anderson, Alejandro Alonso, Shuntaro Ikegawa, Rao Prabhala, Diego Hernandez Rodriguez, Heather Daley, Kit L. Shaw, Yohei Arihara, Soudeh Ansari, David S Quinn, David Pearson, Anniesha Hack, Louise M Treanor, Dexiu Bu, Jennifer Mataraza, Lawrence Rispoli, Marc Credi, Jerome Ritz, Serena De Vita, Nikhil C. Munshi
Journal: Blood
Blood (2021) 138 (Supplement 1): 3864.
https://doi.org/10.1182/blood-2021-146646
Published: 2021
Journal Articles

Dysfunctional HDAC8 Impacts Genomic Integrity and Is a Novel Therapeutic Target in Multiple Myeloma

Zuzana Chyra, Srikanth Talluri, Rao Prabhala, Mehmet K. Samur, Anil Aktas-Samur, Yan Xu, Aaron B. Beeler, Roman Hajek, Mariateresa Fulciniti, Masood A. Shammas, Nikhil C. Munshi
Journal: Blood
Blood (2021) 138 (Supplement 1): 1610.
https://doi.org/10.1182/blood-2021-153382
Published: 2021
Journal Articles

Base Excision Repair and Homologous Recombination Pathway Intermediates Drive Genomic Instability and Evolution in Myeloma

Chengcheng Liao, PhD MD, Srikanth Talluri, PhD, Subodh Kumar, PhD, Leutz Buon, Jiangning Zhao, PhD MD, Lakshmi B. Potluri, MBBS, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 27–28.
https://doi.org/10.1182/blood-2020-141042
Published: 2020
Journal Articles

ABL1 Kinase Plays an Important Role in Spontaneous and Melphalan-Induced Genomic Instability in Multiple Myeloma: Potential Therapeutic Application

Subodh Kumar, PhD, Srikanth Talluri, PhD, Jiangning Zhao, PhD MD, Chengcheng Liao, PhD MD, Lakshmi B. Potluri, MBBS, Leutz Buon, Shidai Mu, Jialan Shi, MDPhD, Mychell Neptune-Buon, Chandraditya Chakraborty, PhD, Yu-Tzu Tai, PhD, Mehmet K. Samur, PhD, Mariateresa Fulciniti, PhD, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 51.
https://doi.org/10.1182/blood-2020-142793
Published: 2020
Journal Articles

Atpase Family AAA Domain-Containing Protein 2 (ATAD2) As a Novel Target in Multiple Myeloma

Lakshmi B. Potluri, MBBS, Srikanth Talluri, PhD, Leutz Buon, Mehmet K. Samur, PhD, Anil Aktas-Samur, PhD, Jialan Shi, MDPhD, Chandraditya Chakraborty, PhD, Subodh Kumar, PhD, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 50.
https://doi.org/10.1182/blood-2020-140466
Published: 2020
Journal Articles

Bortezomib Induces Anti-Multiple Myeloma Immune Response Mediated By Cgas/Sting Pathway Activation, Type I Interferon Secretion, and Immunogenic Cell Death: Clinical Application

Annamaria Gulla, MD, Eugenio Morelli, MD, Mehmet Kemal Samur, PhD, Cirino Botta, MDPhD, Teru Hideshima, MD PhD, Giada Bianchi, MD, Mariateresa Fulciniti, PhD, Stefano Malvestiti, MD, Rao Prabhala, Srikanth Talluri, PhD, Yu-Tzu Tai, PhD, Kenneth Wen, Paul G. Richardson, MD, Ruben D. Carrasco, MD PhD, Dharminder Chauhan, PhD, Nikhil C. Munshi, MD, Kenneth Anderson, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-140356
Published: 2020
Journal Articles

Enhancing the Immune Surveillance in Multiple Myeloma Via CDK4/6 Inhibition

Yan Xu, MD, Yao Yao, Woojun Daniel Park, Sanika Derebail, MS, Chandraditya Chakraborty, PhD, Shidai Mu, Rafael Alonso Fernández, Srikanth Talluri, PhD, Zuzana Chyra, PhD, Kenneth Wen, Qingsheng Yan, Osasenaga Idahor, Selene Cipri, Rao Prabhala, Kenneth Anderson, MD, Mehmet K. Samur, PhD, Mariateresa Fulciniti, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 33–34.
https://doi.org/10.1182/blood-2020-143327
Published: 2020
Journal Articles

Favorable Progression-Free Survival Associated with Immune Bio-Markers Modulated By Pomalidomide in Relapsed/Refractory Multiple Myeloma: An Analysis of Phase III Study

Rao Prabhala, PhD, Mehmet Kemal Samur, PhD, Srikanth Talluri, PhD, Megan Stekla, BS, Chaitanya Yenumula, MD, Michael A Lopez, Sanika Derebail, Lakshmi B. Potluri, Angela Wang, Aishwarya Katiki, Sahan D. Vangala, Eric Haas, Michael J Buonopane, BS, Alexander T Heubeck, BS, Mariateresa Fulciniti, PhD, Raphael Szalat, MD, Suzan Lazo-Kallanian, BS, Kevin Hong, Teresa Peluso, John Daley, PhD, Tsvetan Biyukov, MD, Albert Oriol, William E. Pierceall, Paul G. Richardson, MD, Kenneth C. Anderson, MD, Anjan Thakurta, Hervé Avet-Loiseau, MD PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1784.
https://doi.org/10.1182/blood-2019-131257
Published: 2019
Journal Articles

Loss-of-Function of Gabarap Impairs Bortezomib-Induced Anti-Tumor Immunity in Multiple Myeloma: Clinical Application

Annamaria Gulla, MD, Eugenio Morelli, MD, Mehmet Kemal Samur, PhD, Teru Hideshima, MD PhD, Giada Bianchi, MD, Mariateresa Fulciniti, PhD, Rao Prabhala, Srikanth Talluri, PhD, Yu-Tzu Tai, PhD, Dharminder Chauhan, PhD, Ruben D. Carrasco, MD PhD, Nikhil C. Munshi, MD, Kenneth C. Anderson, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 134.
https://doi.org/10.1182/blood-2019-127845
Published: 2019
Journal Articles

Integrated Genomics and Functional Validation Identifies a Global Kinase Gene Signature Impacting Genome Stability in Myeloma

Subodh Kumar, PhD, Leutz Buon, Srikanth Talluri, PhD, Chengcheng Liao, MD PhD, Jialan Shi, MD PhD, Mychell Neptune, Chandraditya Chakraborty, PhD, Mehmet Kemal Samur, PhD, Rao Prabhala, Masood A. Shammas, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 363.
https://doi.org/10.1182/blood-2019-129069
Published: 2019
Journal Articles

Restoring Innate and Adaptive Immune Repertoire in Multiple Myeloma for Therapeutic Application

Rafael Alonso Fernández, MD, Laetitia Pierre-Louis, Rao Prabhala, Yan Xu, MD, Joaquin Martinez-Lopez, MD PhD, Takahiro Miyazaki, Mehmet Kemal Samur, PhD, Loui Madakamutil, Mariateresa Fulciniti, PhD, Nikhil C. Munshi, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4398.
https://doi.org/10.1182/blood-2019-128767
Published: 2019
Journal Articles

Interleukin-6 Adversely Impacts Genomic Stability Via Targeting Multiple Pathways in Multiple Myeloma

Chaitanya Yenumula, MD, Srikanth Talluri, PhD, Tommaso Perini, MD, Subodh Kumar, PhD, Jialan Shi, MD PhD, Rao Prabhala, PhD, Masood A. Shammas, PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4467.
https://doi.org/10.1182/blood-2018-99-119346
Published: 2018
Journal Articles

Critical Role for Apobec and Its Interacting Partners in Mediating Mutations and Cell Growth in Multiple Myeloma (MM)

Srikanth Talluri, PhD, Mehmet Kemal Samur, PhD, Jialan Shi, MD PhD, Rao Prabhala, PhD, Hervé Avet-Loiseau, MD PhD, Masood A. Shammas, PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4462.
https://doi.org/10.1182/blood-2018-99-118441
Published: 2018
Journal Articles

Chromatin Accessibility Profiling Reveals Cis-Regulatory Heterogeneity and Novel Transcription Factor Dependencies in Multiple Myeloma

Christopher J. Ott, PhD, Raphael Szalat, MD, Matthew Lawlor, Mehmet Kemal Samur, PhD, Yan Xu, MD, Charles B Epstein, Charles Y Lin, PhD, Rao Prabhala, PhD, Nina Farrell, Lauren D Walter, Logan Schwartz, Kenneth Wen, BS, Yu-Tzu Tai, PhD, Mariateresa Fulciniti, PhD, Jinhua Wang, PhD, Nathanael Gray, PhD, Kenneth Anderson, MD, Richard A. Young, PhD, Nikhil Munshi, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1313.
https://doi.org/10.1182/blood-2018-99-119941
Published: 2018