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Journal Articles

IHP-102 reduces pain and modulates complement activation in a sickle cell mouse model

Kennedy Goldsborough, Srija Ponna, Ronake Desai, Ashwin Patel, John Paderi, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 4710.

https://doi.org/10.1182/blood-2025-4710

Published: 2025

Journal Articles

Higher baseline whole blood viscosity is associated with chronic SCD complications

Akshay Patwardhan, Ashwin Patel, Jedrzej Konarkowski, Jonathan Wade, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 7855.

https://doi.org/10.1182/blood-2025-7855

Published: 2025

Journal Articles

High-accuracy, transfusion-aware machine learning pipeline for hemoglobin genotype classification with shap-based interpretability

Jonathan Wade, Jedrzej Konarkowski, Varsha Bhat, Ugochukwu Agbakwuru, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 4743.

https://doi.org/10.1182/blood-2025-4743

Published: 2025

Journal Articles

Formalized transition interventions in adolescents and young adults with sickle cell disease: A study of a transition clinic

Chiamaka Nwachukwu, Melody Benton, Maissaa Janbain, Madison Blackstone, Justin Farge, Yue Ming, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 7891.

https://doi.org/10.1182/blood-2025-7891

Published: 2025

Journal Articles

Trans-auricular vagal nerve stimulation as an innovative approach to pain treatment in sickle cell disease patients hospitalized with acute pain.

Kennedy Goldsborough, Vipin Bansal, Abdul Yousaf, Benoit Niclou, Anna Woodbury, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 6539.

https://doi.org/10.1182/blood-2025-6539

Published: 2025

Journal Articles

Multiplex base editing enhances fetal hemoglobin production in sickle cell disease erythroid cells

Kun Jia, Xinyi Zhang, Roshani Sinha, Eric Soupene, Benjamin Lesch, Alexander Pendergast, Rachel Choi, Elisabetta Foppiani, Zachary Kostamo, Marco Cordero, Tippi MacKenzie, Vivien Sheehan, Kyle Cromer

Blood (2025) 146 (Supplement 1): 2531.

https://doi.org/10.1182/blood-2025-2531

Published: 2025

Journal Articles

Cerebral hemodynamic response to chronic transfusion is associated with cerebral vasculopathy in sickle cell anemia

Tara Urner, Rowan Brothers, Jada Oriahi, Seung Yup Lee, Katherine Turrentine, Ayesha Quadri, Eashani Sathialingam, Kyle Cowdrick, Vivien Sheehan, Kirshma Khemani, Shasha Bai, Bryan Philbrook, Adam Goldman-Yassen, Clinton Joiner, Clark Brown, Beatrice Gee, Erin Buckley

Blood (2025) 146 (Supplement 1): 531.

https://doi.org/10.1182/blood-2025-531

Published: 2025

Journal Articles

Development of whole blood viscosity measurements under hypoxia for use in sickle cell disease

Mary Aliche, Ashwin Patel, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 6120.

https://doi.org/10.1182/blood-2025-6120

Published: 2025

Journal Articles

EMU-116: An oral CXCR4 antagonist as mobilizer of stem and immune cells in normal, neutropenic and sickle cell mice.

Lawrence Wilson, Priscilla Davidson, Petra Foster, Hayden Kissick, John Petros, Eric Miller, Yesim Tahirovic, Leon Jacobs, Justin Yoo, Vivien Sheehan, Ezhilarasi Chendamarai, Michael Rettig, John DiPersio, Dennis Liotta

Blood (2025) 146 (Supplement 1): 4323.

https://doi.org/10.1182/blood-2025-4323

Published: 2025

Journal Articles

In vitro and In Vivo FOXO3 dependent induction of fetal hemoglobin

Anupama Priyadarshini, Justin Yoo, Jonathan Wade, Alex Pendergast, Zachary Kostamo, Ashwin Patel, Kennedy Goldsborough, Britney Hernandez, Srija Ponna, Mary Aliche, Kathleen Romero, Rachel Choi, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 2927.

https://doi.org/10.1182/blood-2025-2927

Published: 2025

Journal Articles

A phase 2 open-label study of epeleuton in patients with sickle cell disease

Biree Andemariam, Vivien Sheehan, Fuad El Rassi, Moayed Hamza, Kirsty Kelly, John Climax

Blood (2025) 146 (Supplement 1): 4754.

https://doi.org/10.1182/blood-2025-4754

Published: 2025

Journal Articles

Use of red cell deformability measurements to assess the impact of pyruvate kinase activators on combined drug and transfusion therapies

Abhinav Pasupuleti, Akshay Patwardhan, Ashwin Patel, Solomon Oshabaheebwa, Christopher Deliandes, Zoe Sekyonda, Erica Evans, Lindsey Abel, Michael Suster, Pedram Mohseni, Umut Gurkan, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 6136.

https://doi.org/10.1182/blood-2025-6136

Published: 2025

Journal Articles

Sickle cell disease is associated with early-onset clonal hematopoiesis involving DNA damage response pathway mutations

Blood (2025) 146 (Supplement 1): 8.

https://doi.org/10.1182/blood-2025-8

Published: 2025

Journal Articles

Sight: Sickle cell identification from general hematological testing, a machine learning approach for rapid screening in emergency medicine

Jedrzej Konarkowski, Jonathan Wade, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 1177.

https://doi.org/10.1182/blood-2025-1177

Published: 2025

Journal Articles

Red cell rheology predicts acute chest syndrome and vaso-occlusive events in sickle cell disease

Ashwin Patel, Ugochukwu Agbakwuru, Akshay Patwardhan, Jonathan Wade, Jedrzej Konarkowski, Monica Rivera, Justin Yoo, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 1152.

https://doi.org/10.1182/blood-2025-1152

Published: 2025

Journal Articles

Optimization of stem cell fitness and mobilization using moderate transfusion and an oral anti-sickling agent in the sickle mouse model.

Justin Yoo, Jonathan Wade, Ashwin Patel, Kennedy Goldsborough, Britney Hernandez, Mary Aliche, Lawrence Wilson, Dennis Liotta, Kevin Bunting, Vivien Sheehan

Blood (2025) 146 (Supplement 1): 1150.

https://doi.org/10.1182/blood-2025-1150

Published: 2025

Journal Articles

IHP-102 Reduces Hypoxia-Induced Pain Behaviors in Townes SCD Mice

Kennedy N Goldsborough, Israel Almeida, Ashwin P. Patel, John Paderi, Vivien Sheehan

Blood (2024) 144 (Supplement 1): 1106.

https://doi.org/10.1182/blood-2024-210418

Published: 2024

Journal Articles

Impact of BEAM-101 Treatment on Red Blood Cell Hemoglobin Expression, Rheology and Sickling Properties: Initial Data from the BEACON Phase 1/2 Study of Autologous CD34 + Base Edited Hematopoietic Stem Cells in Sickle Cell Disease

Priya S. Chockalingam, Ling Lin, Guo Chen, Alex C. Minella, Yinzhong Chen, Vivien Sheehan, Nan Zhang, Myriam Armant, Aliya U. Zaidi, Robert Goodrich, Patrick C. Hines, Sunita Goyal, Amy Simon

Blood (2024) 144 (Supplement 1): 4957.

https://doi.org/10.1182/blood-2024-200875

Published: 2024

Journal Articles

Rheological Comparison of Red Cells from Individuals with SCD Treated with Gene Therapy, Haploidentical Transplantation or Hydroxyurea

Britney Hernandez, Ashwin P. Patel, Erica N Evans, Jordan Zgodny, Stephen Gottschalk, Brandon M Triplett, Serena De Vita, Kirby Wallace, David C Shyr, Elizabeth O Stenger, Suhag Parikh, Akshay Sharma, Vivien Sheehan

Blood (2024) 144 (Supplement 1): 4956.

https://doi.org/10.1182/blood-2024-210578

Published: 2024

Journal Articles

Methods to Assess the Impact of Combined Pharmacologic and Transfusion Therapies on Red Cell Deformability

Abhinav K Pasupuleti, Akshay A Patwardhan, Ashwin P. Patel, Solomon Oshabaheebwa, Christopher A. Delianides, Zoe Sekyonda, Erica N Evans, Lindsey Abel, Michael A. Suster, Pedram Mohseni, Umut Gurkan, Vivien Sheehan

Blood (2024) 144 (Supplement 1): 7510.

https://doi.org/10.1182/blood-2024-207680

Published: 2024

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IHP-102 reduces pain and modulates complement activation in a sickle cell mouse model

Higher baseline whole blood viscosity is associated with chronic SCD complications

High-accuracy, transfusion-aware machine learning pipeline for hemoglobin genotype classification with shap-based interpretability

Formalized transition interventions in adolescents and young adults with sickle cell disease: A study of a transition clinic

Trans-auricular vagal nerve stimulation as an innovative approach to pain treatment in sickle cell disease patients hospitalized with acute pain.

Multiplex base editing enhances fetal hemoglobin production in sickle cell disease erythroid cells

Cerebral hemodynamic response to chronic transfusion is associated with cerebral vasculopathy in sickle cell anemia

Development of whole blood viscosity measurements under hypoxia for use in sickle cell disease

EMU-116: An oral CXCR4 antagonist as mobilizer of stem and immune cells in normal, neutropenic and sickle cell mice.

In vitro and In Vivo FOXO3 dependent induction of fetal hemoglobin

A phase 2 open-label study of epeleuton in patients with sickle cell disease

Use of red cell deformability measurements to assess the impact of pyruvate kinase activators on combined drug and transfusion therapies

Sickle cell disease is associated with early-onset clonal hematopoiesis involving DNA damage response pathway mutations

Sight: Sickle cell identification from general hematological testing, a machine learning approach for rapid screening in emergency medicine

Red cell rheology predicts acute chest syndrome and vaso-occlusive events in sickle cell disease

Optimization of stem cell fitness and mobilization using moderate transfusion and an oral anti-sickling agent in the sickle mouse model.

IHP-102 Reduces Hypoxia-Induced Pain Behaviors in Townes SCD Mice

Impact of BEAM-101 Treatment on Red Blood Cell Hemoglobin Expression, Rheology and Sickling Properties: Initial Data from the BEACON Phase 1/2 Study of Autologous CD34 + Base Edited Hematopoietic Stem Cells in Sickle Cell Disease

Rheological Comparison of Red Cells from Individuals with SCD Treated with Gene Therapy, Haploidentical Transplantation or Hydroxyurea

Methods to Assess the Impact of Combined Pharmacologic and Transfusion Therapies on Red Cell Deformability

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American Society of Hematology

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