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Journal Articles

Multidimensional Analysis of Relapsed Bone Marrow Reveals Cold Immune Microenvironment Post-TMLI in Acute Leukemia Transplant Patients

Srideshikan Sargur Madabushi, Ji Eun Lim, Yu-Lin SU, Paresh Vishwasrao, Dongyun Yang, James F. Sanchez, Sally Mokhtari, Amandeep Salhotra, Xiwei Wu, Haiqing Lee, Savita Dandapani, Ryotaro Nakamura, Raju Pillai, Marcin Kortylewski, Jeffrey Wong, MHD Monzr M. Al Malki, Anthony S. Stein, Susanta Hui

Blood (2024) 144 (Supplement 1): 775.

https://doi.org/10.1182/blood-2024-211180

Published: 2024

Journal Articles

Mitochondrial RNA Methylation By METTL17 Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication in AML

Blood (2024) 144 (Supplement 1): 625.

https://doi.org/10.1182/blood-2024-201916

Published: 2024

Journal Articles

Pharmacology of a CpG-Linked Anti-Mir-126 Oligonucleotide Targeting Acute Myeloid Leukemia (AML) in Rats and Non-Human Primates (NHP)

Lucy Ghoda, Kokilah Muthaiyah, Bin Amber Zhang, Marcin Kortylewski, James Simpson, Le Xuan Truong Nguyen, Marjorie Robbins, Guido Marcucci, Tim Synold

Blood (2023) 142 (Supplement 1): 5754.

https://doi.org/10.1182/blood-2023-191202

Published: 2023

Journal Articles

Acquired microRNA-142 Deficit Drives Escape Mechanisms of Anti-Leukemic Surveillance during Blast Crisis Transformation of Chronic Myeloid Leukemia (CML)

Blood (2023) 142 (Supplement 1): 3152.

https://doi.org/10.1182/blood-2023-182587

Published: 2023

Journal Articles

Targeting Leukemic Stem Cells in Acute Myeloid Leukemia Using a CpG-Linked Anti-Mir-126 Oligonucleotide

Lucy Y Ghoda, Ebtesam Nafie, Elizabeth Bloom-Saldana, Patrick T. Fueger, Timothy Synold, James Simpson, Piotr Swiderski, Kokilah Muthaiyah, Bin Zhang, Marcin Kortylewski, Steven Vonderfecht, Le Xuan Truong Nguyen, Jianying Zhang, Joycelynne Palmer, Guido Marcucci

Blood (2022) 140 (Supplement 1): 10673–10674.

https://doi.org/10.1182/blood-2022-171147

Published: 2022

Journal Articles

Revisiting TLR9 as a target for CLL therapy

Marcin Kortylewski

Blood (2021) 137 (22): 3006–3008.

https://doi.org/10.1182/blood.2020010618

Published: 2021

Journal Articles

Myeloid cell–targeted miR-146a mimic inhibits NF-κB–driven inflammation and leukemia progression in vivo

Yu-Lin Su, Xiuli Wang, Mati Mann, Tomasz P. Adamus, Dongfang Wang, Dayson F. Moreira, Zhuoran Zhang, Ching Ouyang, Xin He, Bin Zhang, Piotr M. Swiderski, Stephen J. Forman, David Baltimore, Ling Li, Guido Marcucci, Mark P. Boldin, Marcin Kortylewski

Blood (2020) 135 (3): 167–180.

https://doi.org/10.1182/blood.2019002045

Published: 2020

Includes: Supplemental data

Journal Articles

Anti-MiR-126 Therapy for Inv(16) Acute Myeloid Leukemia

Lianjun Zhang, PhD, Le Xuan Truong Nguyen, PhD, Dijiong Wu, MD, Casey J Brewer, PhD, Xin He, PhD, Man Li, PhD, Dandan Zhao, MD, Guerry Jeanne Cook, PhD, Jing Qi, PhD, Herman Wu, BS, Bin Zhang, PhD, Ling Li, PhD, Marcin Kortylewski, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD

Blood (2019) 134 (Supplement_1): 3914.

https://doi.org/10.1182/blood-2019-123468

Published: 2019

Journal Articles

Targeted Marrow Radiation (TMI) Improves Therapeutic Efficacy of STAT3 Decoy Molecules By Augmenting Its Delivery and Immune Modulation in an AML Mouse Model

Srideshikan Sargur Madabushi, PhD, Darren Zuro, Yu-Lin SU, PhD, Paresh Vishwasrao, MSc, Jamison Brooks, B.S, Liliana E Parra, James F Sanchez, PhD, Jeffrey Wong, MD, Marcin Kortylewski, PhD, Susanta Hui, PhD, DABR.

Blood (2019) 134 (Supplement_1): 3929.

https://doi.org/10.1182/blood-2019-127470

Published: 2019

Journal Articles

FLT3-ITD Activates Cytoplasmic Drosha-Dependent Non-Canonical Mechanisms of Mir-155 Biogenesis in Acute Myeloid Leukemia

Le Xuan Truong Nguyen, PhD, Bin Zhang, PhD, Dinh Hoa Hoang, BS, Dandan Zhao, MD, Sergio Branciamore, Davide Maestrini, PhD, Yu-Lin SU, PhD, Sonia Rodriguez, PhD, Flavia Pichiorri, PhD, Steven Rosen, MD, Michael A. Caligiuri, MD, Stephen J. Forman, MD, Ling Li, PhD, Marcin Kortylewski, PhD, Russell Rockne, PhD, Ya-Huei Kuo, PhD, Nadia Carlesso, MD, Guido Marcucci, MD

Blood (2019) 134 (Supplement_1): 2722.

https://doi.org/10.1182/blood-2019-131871

Published: 2019

Journal Articles

STAT3 Inhibition Enables TLR9-Driven Differentiation of Cbfb/Myh11 acute Myeloid Leukemia Cells to Antigen-Presenting Cell Phenotype In Vivo

Marcin Kortylewski, PhD, Priyanka Duttagupta, PhD, Yu-Lin SU, PhD, Tomasz Adamus, Guido Marcucci

Blood (2018) 132 (Supplement 1): 4070.

https://doi.org/10.1182/blood-2018-99-119771

Published: 2018

Journal Articles

Targeted Delivery of CpG-Mir-146a Mimic Oligonucleotides As a Therapeutic Strategy to Reduce NF-Κb-Mediated Pathogenic Inflammation and Myeloid Leukemia Progression

Yu-Lin SU, PhD, Zhuoran Zhang, PhD, Mati Mann, PhD, Xiuli Wang, PhD, Le Xuan Truong Nguyen, PhD, Bin Zhang, PhD, Ling Li, PhD, Piotr Swiderski, PhD, Mark Boldin, MD PhD, Stephen J Forman, Guido Marcucci, Marcin Kortylewski, PhD

Blood (2018) 132 (Supplement 1): 3501.

https://doi.org/10.1182/blood-2018-99-115637

Published: 2018

Journal Articles

MiR-126 Promotes Leukemogenesis in Inv(16) Acute Myeloid Leukemia

Casey J Brewer, PhD, Guerry Jeanne Cook, PhD, Bin Zhang, PhD, Le Xuan Truong Nguyen, PhD, Jing Qi, PhD, Wei-Kai Hua, PhD, Qi Cai, PhD, Emily Carnahan, MS, Ayelet Marom, PhD, Ling Li, PhD, Marcin Kortylewski, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD

Blood (2017) 130 (Supplement 1): 301.

https://doi.org/10.1182/blood.V130.Suppl_1.301.301

Published: 2017

Journal Articles

Time Sequential Transcriptome Analysis Identifies Mir-126 As an Early Biomarker for Inv(16) Acute Myeloid Leukemia (AML) Disease Progression

Jing Qi, PhD, Guerry J Cook, Bin Zhang, PhD, Wei-Kai Hua, PhD, Cai Qi, Emily Carnahan, Ayelet Marom, Le Xuan Truong Nguyen, Yang Lu, Sergio Branciamore, Herman Wu, BS, Yate-Ching Yuan, Xiwei Wu, PhD, Ling Li, PhD, Anthony S. Stein, MD, Russell Rockne, Marcin Kortylewski, PhD, Guido Marcucci, MD, Ya-Huei Kuo, PhD

Blood (2016) 128 (22): 773.

https://doi.org/10.1182/blood.V128.22.773.773

Published: 2016

Journal Articles

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

Qifang Zhang, Dewan Md Sakib Hossain, Priyanka Duttagupta, Dayson Moreira, Xingli Zhao, Haejung Won, Ralf Buettner, Sergey Nechaev, Marcin Majka, Bin Zhang, Qi Cai, Piotr Swiderski, Ya-Huei Kuo, Stephen Forman, Guido Marcucci, Marcin Kortylewski

Blood (2016) 127 (13): 1687–1700.

https://doi.org/10.1182/blood-2015-08-665604

Published: 2016

Includes: Supplemental data

Journal Articles

Knockdown (KD) of Mir-126 Expression Enhances Tyrosine Kinase Inhibitor (TKI)-Mediated Targeting of Chronic Myelogenous Leukemia (CML) Stem Cells

Bin Zhang, PhD, Ling Li, PhD, Ching-Cheng Chen, PhD, Anthony S. Stein, MD, Haris Ali, MD, David S. Snyder, MD, Allen Lin, Adrienne Dorrance, PhD, Piotr Swiderski, PhD, Ravi Bhatia, MD, Danilo Perrotti, MD PhD, Stephen J. Forman, MD, Ya-Huei Kuo, PhD, Marcin Kortylewski, PhD, Guido Marcucci, MD

Blood (2015) 126 (23): 51.

https://doi.org/10.1182/blood.V126.23.51.51

Published: 2015

Journal Articles

A Novel Standardized Quantitative Suppression Assay Reveals a Diversity of Human Immune-Regulatory Cell Potency

Samantha Miner, Nancy F. Hensel, Bahey Salem, Neil Dunavin, MD, Kazushi Tanimoto, MD, Minoo Battiwalla, MD MS, Kit Lu, MD, Keyvan Keyvanfar, BS, Marianna Sabatino, David Stroncek, Patrick J Hanley, PhD, Catherine M. Bollard, MBChB, MD, Katayoun Rezvani, MD, PhD, Marcin Kortylewski, PhD, Pawel Muranski, MD, John Barrett, MD, Sawa Ito, MD

Blood (2014) 124 (21): 316.

https://doi.org/10.1182/blood.V124.21.316.316

Published: 2014

Journal Articles

Leukemia cell–targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity

Dewan Md Sakib Hossain, Cedric Dos Santos, Qifang Zhang, Anna Kozlowska, Hongjun Liu, Chan Gao, Dayson Moreira, Piotr Swiderski, Agnieszka Jozwiak, Justin Kline, Stephen Forman, Ravi Bhatia, Ya-Huei Kuo, Marcin Kortylewski

Blood (2014) 123 (1): 15–25.

https://doi.org/10.1182/blood-2013-07-517987

Published: 2014

Includes: Supplemental data

Journal Articles

In Vivo Targeting Of Acute Myeloid Leukemia Using CpG- Stat3 siRNA Results In T Cell-Dependent Tumor Eradication

Dewan Md Sakib Hossain, PhD, Cedric Dos Santos, PhD, Qifang Zhang, PhD, Anna Kozlowska, PhD, Hongjun Liu, Chan Gao, PhD, Dayson Moreira, PhD, Piotr Swiderski, PhD, Agnieszka Jozwiak, Justin Kline, MD, Stephen J. Forman, MD, Ravi Bhatia, MD, Ya-Huei Kuo, PhD, Marcin Kortylewski, PhD

Blood (2013) 122 (21): 4212.

https://doi.org/10.1182/blood.V122.21.4212.4212

Published: 2013

Journal Articles

TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo

Qifang Zhang, Dewan Md Sakib Hossain, Sergey Nechaev, Anna Kozlowska, Wang Zhang, Yong Liu, Claudia M. Kowolik, Piotr Swiderski, John J. Rossi, Stephen Forman, Sumanta Pal, Ravi Bhatia, Andrew Raubitschek, Hua Yu, Marcin Kortylewski

Blood (2013) 121 (8): 1304–1315.

https://doi.org/10.1182/blood-2012-07-442590

Published: 2013

Includes: Supplemental data

NARROW

Multidimensional Analysis of Relapsed Bone Marrow Reveals Cold Immune Microenvironment Post-TMLI in Acute Leukemia Transplant Patients

Mitochondrial RNA Methylation By METTL17 Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication in AML

Pharmacology of a CpG-Linked Anti-Mir-126 Oligonucleotide Targeting Acute Myeloid Leukemia (AML) in Rats and Non-Human Primates (NHP)

Acquired microRNA-142 Deficit Drives Escape Mechanisms of Anti-Leukemic Surveillance during Blast Crisis Transformation of Chronic Myeloid Leukemia (CML)

Targeting Leukemic Stem Cells in Acute Myeloid Leukemia Using a CpG-Linked Anti-Mir-126 Oligonucleotide

Revisiting TLR9 as a target for CLL therapy

Myeloid cell–targeted miR-146a mimic inhibits NF-κB–driven inflammation and leukemia progression in vivo

Anti-MiR-126 Therapy for Inv(16) Acute Myeloid Leukemia

Targeted Marrow Radiation (TMI) Improves Therapeutic Efficacy of STAT3 Decoy Molecules By Augmenting Its Delivery and Immune Modulation in an AML Mouse Model

FLT3-ITD Activates Cytoplasmic Drosha-Dependent Non-Canonical Mechanisms of Mir-155 Biogenesis in Acute Myeloid Leukemia

STAT3 Inhibition Enables TLR9-Driven Differentiation of Cbfb/Myh11 acute Myeloid Leukemia Cells to Antigen-Presenting Cell Phenotype In Vivo

Targeted Delivery of CpG-Mir-146a Mimic Oligonucleotides As a Therapeutic Strategy to Reduce NF-Κb-Mediated Pathogenic Inflammation and Myeloid Leukemia Progression

MiR-126 Promotes Leukemogenesis in Inv(16) Acute Myeloid Leukemia

Time Sequential Transcriptome Analysis Identifies Mir-126 As an Early Biomarker for Inv(16) Acute Myeloid Leukemia (AML) Disease Progression

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

Knockdown (KD) of Mir-126 Expression Enhances Tyrosine Kinase Inhibitor (TKI)-Mediated Targeting of Chronic Myelogenous Leukemia (CML) Stem Cells

A Novel Standardized Quantitative Suppression Assay Reveals a Diversity of Human Immune-Regulatory Cell Potency

Leukemia cell–targeted STAT3 silencing and TLR9 triggering generate systemic antitumor immunity

In Vivo Targeting Of Acute Myeloid Leukemia Using CpG- Stat3 siRNA Results In T Cell-Dependent Tumor Eradication

TLR9-mediated siRNA delivery for targeting of normal and malignant human hematopoietic cells in vivo

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American Society of Hematology

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ASH Publications

American Society of Hematology

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