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Journal Articles

In Vivo Antileukemic Activity of Ost-01 in Acute Myeloid Leukemia (AML): A Novel Natural Product (NP) from Baccharis Coridifolia

Hyunjun Kang, Dinh Hoa Hoang, Melissa Valerio, Khyatiben V. Pathak, Lianjun Zhang, Ralf Buettner, Fang Chen, Katrina Estrella, William Graff, Ya-Huei Kuo, Bin Zhang, Patrick Pirrotte, Le Xuan Truong Nguyen, Guido Marcucci
Journal: Blood
Blood (2023) 142 (Supplement 1): 1565.
https://doi.org/10.1182/blood-2023-187736
Published: 2023
Journal Articles

Exploiting the Metabolic Vulnerability of Leukemic Stem Cells (LSCs) in Inv(16) Acute Myeloid Leukemia (AML) with the Combination of Miristen, a Mir-126 Inhibitor, and Venetoclax

Lianjun Zhang, Dinh Hoa Hoang, Hyunjun Kang, Ying-Chieh Chen, Yu-Hsuan Fu, Khyatiben V. Pathak, Melissa Valerio, Fang Chen, Katrina Estrella, Ralf Buettner, Bin Zhang, Patrick Pirrotte, Guido Marcucci, Ya-Huei Kuo, Le Xuan Truong Nguyen
Journal: Blood
Blood (2023) 142 (Supplement 1): 2953.
https://doi.org/10.1182/blood-2023-186936
Published: 2023
Journal Articles

Targeting the Methionine-MAT2A-SAM Axis of Acute Myeloid Leukemia with a Combination of Venetoclax and 8-Chloro-Adenosine or 8-Amino-Adenosine

Jiamin Guo, Ralf Buettner, Li Du, Yanzhong Yang, Zhenlong Li, Steve T Rosen
Journal: Blood
Blood (2022) 140 (Supplement 1): 3056–3057.
https://doi.org/10.1182/blood-2022-167606
Published: 2022
Journal Articles

Venetoclax Synergizes with the RNA-Directed Nucleoside Analog 8-Chloro-Adenosine in Acute Myeloid Leukemia in Vitro and In Vivo

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Corey James Morales, BA, BS, Lisa S Chen, PhD, Timothy Synold, PhD, Dinh Hoa Hoang, BS, Bin Amber Zhang, PhD, Lucy Ghoda, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22–23.
https://doi.org/10.1182/blood-2020-143240
Published: 2020
Journal Articles

Antileukemic Activity of 8-Chloro-Adenosine (8-Cl-Ado) Is Mediated By Mir-155 Degradation and ErbB3 Binding Protein (Ebp1)-Dependent p53 Activation: A Novel Therapeutic Approach for FLT3-ITD Acute Myeloid Leukemia (AML)

Ralf Buettner, PhD, Le Xuan Truong Nguyen, PhD, Bijender Kumar, PhD, Corey James Morales, BA, BS, Chao Liu, PhD, Lisa S Chen, PhD, Tea Pemovska, PhD, Ryan Thompson, BS, Ling Li, PhD, Dinh Hoa Hoang, BS, Bin Zhang, PhD, Lucy Ghoda, PhD, Claudia Kowolik, PhD, Mika Kontro, MD, Krister Wennerberg, PhD, Calum Leitch, PhD, Xiaochun Yu, MD PhD, Ching-Cheng Chen, PhD, David Horne, PhD, Varsha Gandhi, PhD, Vinod A. Pullarkat, MD, Guido Marcucci, Steven T Rosen
Journal: Blood
Blood (2018) 132 (Supplement 1): 3938.
https://doi.org/10.1182/blood-2018-99-119880
Published: 2018
Journal Articles

Repurposing Leflunomide for Relapsed/Refractory Multiple Myeloma: Final Analysis of a Phase 1 Study

Michael Rosenzweig, Joycelynne Palmer, Ni-Chun Tsai, Ralf Buettner, PhD, Lupe Duarte, Myo Htut, Chatchada Karanes, Nitya Nathwani, MD, Flavia Pichiorri, PhD, Firoozeh Sahebi, Tim Synold, Xiwei Wu, James F Sanchez, Amrita Krishnan, MD, Stephen J Forman, Steven T Rosen
Journal: Blood
Blood (2018) 132 (Supplement 1): 2007.
https://doi.org/10.1182/blood-2018-99-120042
Published: 2018
Journal Articles

CD84: A Potential Novel Therapeutic Target in Multiple Myeloma

Emine Gulsen Gunes, PhD, Hadas Lewinsky, Domenico Viola, Enrico Caserta, Michael Rosenzweig, Myo Htut, James F Sanchez, PhD, Ralf Buettner, PhD, Guido Marcucci, Jonathan J Keats, PhD, Amrita Krishnan, MD, Steven T Rosen, Idit Shachar, Flavia Pichiorri, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1924.
https://doi.org/10.1182/blood-2018-99-119655
Published: 2018
Journal Articles

Copper 64–labeled daratumumab as a PET/CT imaging tracer for multiple myeloma

Brief Report
Enrico Caserta, Junie Chea, Megan Minnix, Erasmus K. Poku, Domenico Viola, Steven Vonderfecht, Paul Yazaki, Desiree Crow, Jihane Khalife, James F. Sanchez, Joycelynne M. Palmer, Susanta Hui, Nadia Carlesso, Jonathan Keats, Young Kim, Ralf Buettner, Guido Marcucci, Steven Rosen, John Shively, David Colcher, Amrita Krishnan, Flavia Pichiorri
Journal: Blood
Blood (2018) 131 (7): 741–745.
https://doi.org/10.1182/blood-2017-09-807263
Published: 2018
Includes: Multimedia, Supplemental data
Journal Articles

Repurposing Leflunomide for Relapsed/Refractory Multiple Myeloma: A Phase 1 Trial

Michael Rosenzweig, MD, Joycelynne M. Palmer, PhD, Ni-Chun Tsai, MS, Ralf Buettner, PhD, Lupe Duarte, Myo Htut, Chatchada Karanes, Nitya Nathwani, Flavia Pichiorri, PhD, Firoozeh Sahebi, George Somlo, Tim Synold, PhD, Xiwei Wu, PhD, Amrita Krishnan, MD, Stephen J. Forman, MD FACP, Steven T. Rosen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3144.
https://doi.org/10.1182/blood.V130.Suppl_1.3144.3144
Published: 2017
Journal Articles

Leflunomide Inhibits c-Myc Signaling and Impairs Myeloma Cell Growth

Ralf Buettner, PhD, Corey James Morales, BA, BS, Enrico Caserta, PhD, Domenico Viola, BS, Joycelynne M. Palmer, PhD, Xiwei Wu, PhD, Nagarajan Vaidehi, PhD, Hongzhi Li, PhD, Tim Synold, PhD, Amrita Krishnan, MD, Flavia Pichiorri, PhD, Michael Rosenzweig, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4426.
https://doi.org/10.1182/blood.V130.Suppl_1.4426.4426
Published: 2017
Journal Articles

8-Chloro-Adenosine Inhibits Molecular Poor-Risk Acute Myeloid Leukemia (AML) and Leukemic Stem Cells (LSC) Growth and Synergizes with the BCL-2 Inhibitor Venetoclax (ABT-199)

Ralf Buettner, PhD, Ching-Cheng Chen, PhD, Bijender Kumar, PhD, Corey Morales, BA, BS, Lisa S Chen, PhD, Krister Wennerberg, PhD, Ryan Thompson, MS, Tea Pemovska, MSc, Ling Li, PhD, Bin Zhang, PhD, Claudia Kowolik, PhD, Mika Kontro, MD, Calum Leitch, MD, David Horne, PhD, Joycelynne Palmer, PhD, Varsha Gandhi, PhD, Guido Marcucci, MD, Vinod Pullarkat, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2016) 128 (22): 2758.
https://doi.org/10.1182/blood.V128.22.2758.2758
Published: 2016
Journal Articles

Repurposing Leflunomide for Multiple Myeloma Treatment

Ralf Buettner, PhD, Corey Morales, BA, BS, Natalie Perret, Joycelynne Palmer, PhD, Amrita Krishnan, Michael Rosenzweig, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2016) 128 (22): 5667.
https://doi.org/10.1182/blood.V128.22.5667.5667
Published: 2016
Journal Articles

Serum-resistant CpG-STAT3 decoy for targeting survival and immune checkpoint signaling in acute myeloid leukemia

Qifang Zhang, Dewan Md Sakib Hossain, Priyanka Duttagupta, Dayson Moreira, Xingli Zhao, Haejung Won, Ralf Buettner, Sergey Nechaev, Marcin Majka, Bin Zhang, Qi Cai, Piotr Swiderski, Ya-Huei Kuo, Stephen Forman, Guido Marcucci, Marcin Kortylewski
Journal: Blood
Blood (2016) 127 (13): 1687–1700.
https://doi.org/10.1182/blood-2015-08-665604
Published: 2016
Includes: Supplemental data
Journal Articles

8-Chloro-Adenosine Inhibits Molecular Poor-Risk Acute Myeloid Leukemia (AML) and Leukemic Stem Cells (LSC) Growth Via Novel RNA- and ATP-Directed Mechanisms: A Novel Therapeutic Approach for AML

Ralf Buettner, PhD, Ching-Cheng Chen, PhD, Bijender Kumar, PhD, Lisa S Chen, PhD, Krister Wennerberg, PhD, Ryan Thompson, MS, Tea Pemovska, MSc, Ling Li, PhD, Varsha Gandhi, PhD, Guido Marcucci, MD, Vinod Pullarkat, MD, Steven T. Rosen, MD
Journal: Blood
Blood (2015) 126 (23): 792.
https://doi.org/10.1182/blood.V126.23.792.792
Published: 2015