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Journal Articles

Acute resistance to BET inhibitors remodels compensatory transcriptional programs via p300 coactivation

Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Aaron Gallego-Crespo, Malte Andreas Behrendt, Maria Saura-Pañella, Aarti Tarkar, Benedict Schubert, Haiyang Yun, Sarah J. Horton, Shuchi Agrawal-Singh, Dr, Patricia S Hähnel, Faisal Basheer, Dave Lugo, Ioanna Eleftheriadou, Olena Barbash, Arindam Dhar, Michael Kühn, Borhane Guezguez, Matthias Theobald, Thomas Kindler, Paolo Gallipoli, Paul Sung-Hao Yeh, Mark A. Dawson, Rab K Prinjha, Brian JP Huntly, Daniel Sasca
Journal: Blood
Blood blood.2022019306.
https://doi.org/10.1182/blood.2022019306
Published: 2024
Includes: Supplemental data
Journal Articles

The Transcriptional Activators p300/Crebbp Are Context-Dependent Functional Repressors of Interferon Genes, Offering Therapeutic Promise in AML

Markus Meyerhöfer, Viral Shah, Aarón Gallego-Crespo, Malte Andreas Behrendt, Yawen Zhou, Maria Saura-Pañella, Björn Häupl, Thomas Kindler, Matthias Theobald, Falk Butter, George S Vassiliou, Michael Kühn, Brian J P Huntly, Thomas Oellerich, Daniel Sasca
Journal: Blood
Blood (2024) 144 (Supplement 1): 152.
https://doi.org/10.1182/blood-2024-194781
Published: 2024
Journal Articles

Acute Resistance to BET Inhibitors Remodels Compensatory Transcriptional Programs Via p300 Co-Activation

Viral Shah, George Giotopoulos, Hikari Osaki, Markus Meyerhöfer, Eshwar Meduri, Aarón Gallego-Crespo, Malte Andreas Behrendt, Maria Saura-Pañella, Benedict Schubert, Haiyang Yun, Sarah J Horton, Shuchi Agrawal Singh, Patricia S Hähnel, Faisal Basheer, Dave Lugo, Michael Kühn, Borhane Guezguez, Matthias Theobald, Thomas Kindler, Paolo Gallipoli, Paul Yeh, Mark A. Dawson, Rab Prinjha, Brian J P Huntly, Daniel Sasca
Journal: Blood
Blood (2024) 144 (Supplement 1): 722.
https://doi.org/10.1182/blood-2024-202515
Published: 2024
Journal Articles

The Menin Inhibitor Ziftomenib (KO-539) Synergizes with Agents Targeting Chromatin Regulation or Apoptosis and Sensitizes AML with MLL Rearrangement or NPM1 Mutation to Venetoclax

Johanna Rausch, Margarita M. Dzama, Nadezda Dolgikh, Hanna Stiller, Stephan Bohl, Catharina Lahrmann, Kerstin Kunz, Linda Kessler, Hakim Echchannaoui, Chun-Wei David Chen, Thomas Kindler, Francis Burrows, Matthias Theobald, Daniel Sasca, Scott A. Armstrong, Michael Kuehn
Journal: Blood
Blood (2022) 140 (Supplement 1): 6226–6227.
https://doi.org/10.1182/blood-2022-167566
Published: 2022
Journal Articles

Genomic Landscape and Molecular Risk in Patients with Advanced Myelofibrosis Treated within the Multicenter Phase Ib/II MPNSG0212 (POMINC) Trial

Ekaterina Panina, Steffen Koschmieder, Florian H. Heidel, Andreas Hochhaus, Holger Hebart, Susanne Isfort, Frank G. Rücker, Andreas Reiter, Markus Bangerter, Cornelius Waller, Christoph Scheid, Denise Wolleschak, Joachim R. Goethert, Philippe Schafhausen, Thomas Kindler, Markus P. Radsak, Norbert Gattermann, Robert Möhle, Nikolas von Bubnoff, Tim H Brümmendorf, Hartmut Döhner, Martin Griesshammer, Frank Stegelmann, Konstanze Döhner
Journal: Blood
Blood (2021) 138 (Supplement 1): 4637.
https://doi.org/10.1182/blood-2021-150361
Published: 2021
Journal Articles

Impact of gemtuzumab ozogamicin on MRD and relapse risk in patients with NPM1 -mutated AML: results from the AMLSG 09-09 trial

Clinical Trials & Observations
Silke Kapp-Schwoerer, Daniela Weber, Andrea Corbacioglu, Verena I. Gaidzik, Peter Paschka, Jan Krönke, Frauke Theis, Frank G. Rücker, Maria-Veronica Teleanu, Ekaterina Panina, Nikolaus Jahn, Julia Herzig, Lena Kubanek, Anika Schrade, Gudrun Göhring, Walter Fiedler, Thomas Kindler, Thomas Schroeder, Karin T. Mayer, Michael Lübbert, Mohammed Wattad, Katharina S. Götze, Heinz A. Horst, Elisabeth Koller, Gerald Wulf, Jan Schleicher, Martin Bentz, Jürgen Krauter, Lars Bullinger, Julia Krzykalla, Axel Benner, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (26): 3041–3050.
https://doi.org/10.1182/blood.2020005998
Published: 2020
Includes: Supplemental data
Journal Articles

Synergistic targeting of FLT3 mutations in AML via combined menin-MLL and FLT3 inhibition

Margarita M. Dzama, Marlene Steiner, Johanna Rausch, Daniel Sasca, Jonas Schönfeld, Kerstin Kunz, Martha C. Taubert, Gerard M. McGeehan, Chun-Wei Chen, Annalisa Mupo, Patricia Hähnel, Matthias Theobald, Thomas Kindler, Richard P. Koche, George S. Vassiliou, Scott A. Armstrong, Michael W. M. Kühn
Journal: Blood
Blood (2020) 136 (21): 2442–2456.
https://doi.org/10.1182/blood.2020005037
Published: 2020
Includes: Supplemental data
Journal Articles

Next-Generation Sequencing (NGS)-Based Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia with FLT3 Internal Tandem Duplication ( FLT3 -ITD + AML) Treated with Additional Midostaurin

Julia K. Herzig, PhD, Frank G. Rücker, MD, Laura K. Schmalbrock, MD, Tamara J. Blätte, PhD, Daniela Weber, MSc, Sabrina Skambraks, Silke Kapp-Schwoerer, MD, Andrea Corbacioglu, PhD, Verena I Gaidzik, MD, Peter Paschka, MD, Ekaterina Panina, MD, Nikolaus Jahn, MD, Anika Schrade, PhD, Frauke Theis, MD, Sibylle Cocciardi, PhD, Walter Fiedler, MD, Helmut R. Salih, Gerald Wulf, MD, Hans Salwender, MD, Thomas Schroeder, Katharina S. Götze, Thomas Kindler, MD, Michael Luebbert, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Hartmut Döhner, Lars Bullinger, MD, Konstanze Döhner
Journal: Blood
Blood (2020) 136 (Supplement 1): 21–22.
https://doi.org/10.1182/blood-2020-137568
Published: 2020
Journal Articles

Updated Results from the German Mpnsg-0212 Combination Trial: Ruxolitinib Plus Pomalidomide in Myelofibrosis with Anemia

Frank Stegelmann, MD, Steffen Koschmieder, Susanne Isfort, Andreas Hochhaus, MD, Florian H. Heidel, Holger Hebart, Markus Bangerter, Denise Wolleschak, Christoph Scheid, MD, Joachim R Göthert, PD, MD, Philippe Schafhausen, Thomas Kindler, MD, Markus P. Radsak, MD, Robert Möhle, MD, Cornelius Waller, Nikolas von Bubnoff, Andreas Reiter, Hartmut Döhner, MD, Martin Griesshammer, MD, Konstanze Döhner
Journal: Blood
Blood (2019) 134 (Supplement_1): 672.
https://doi.org/10.1182/blood-2019-127859
Published: 2019
Journal Articles

Combined Targeting of the Menin-MLL1 Chromatin Complex and FLT3 As a Novel Therapeutic Concept Against NPM1 Mutant or MLL -Rearranged AML with Mutated FLT3

Margarita M. Dzama, MSc, Martha C. Taubert, MSc, Kerstin Kunz, Johanna Rausch, MD, Chun-Wei David Chen, PhD, Annalisa Mupo, PhD, Patricia Hähnel, PhD, Matthias Theobald, MD PhD, Thomas Kindler, MD, Richard P. Koche, PhD, George S. Vassiliou, FRCPath, MRCP, PhD, Scott A. Armstrong, MD PhD, Michael W.M. Kühn, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1441.
https://doi.org/10.1182/blood-2019-122847
Published: 2019
Journal Articles

Measurable Residual Disease (MRD) Monitoring in Acute Myeloid Leukemia (AML) with t(8;21)(q22;q22.1) RUNX1 - RUNX1T1 Identifies Patients at High Risk of Relapse: Results of the AML Study Group (AMLSG)

Frank G. Rücker, MD, Mridul Agrawal, MDMSc, Andrea Corbacioglu, PhD, Daniela Weber, Silke Kapp-Schwoerer, MD, Verena I. Gaidzik, MD, Nikolaus Jahn, MD, Thomas Schroeder, MD, Mohammad Wattad, MD, Michael Lübbert, Elisabeth Koller, MD, Thomas Kindler, MD, Katharina Götze, Mark Ringhoffer, MD, Jörg Westermann, MD, Walter Fiedler, MD, Heinz A. Horst, MD, Richard Greil, MD, Roland Schroers, Karin Mayer, MD, Thomas Heinicke, MD, Jürgen Krauter, MD, Richard F. Schlenk, MD, Felicitas Thol, MD, Michael Heuser, MD, Arnold Ganser, MD, Lars Bullinger, Peter Paschka, MD, Hartmut Döhner, MD, Konstanze Döhner
Journal: Blood
Blood (2019) 134 (Supplement_1): 2740.
https://doi.org/10.1182/blood-2019-125584
Published: 2019
Journal Articles

Measurable residual disease monitoring in acute myeloid leukemia with t(8;21)(q22;q22.1): results from the AML Study Group

Frank G. Rücker, Mridul Agrawal, Andrea Corbacioglu, Daniela Weber, Silke Kapp-Schwoerer, Verena I. Gaidzik, Nikolaus Jahn, Thomas Schroeder, Mohammed Wattad, Michael Lübbert, Elisabeth Koller, Thomas Kindler, Katharina Götze, Mark Ringhoffer, Jörg Westermann, Walter Fiedler, Heinz A. Horst, Richard Greil, Roland Schroers, Karin Mayer, Thomas Heinicke, Jürgen Krauter, Richard F. Schlenk, Felicitas Thol, Michael Heuser, Arnold Ganser, Lars Bullinger, Peter Paschka, Hartmut Döhner, Konstanze Döhner
Journal: Blood
Blood (2019) 134 (19): 1608–1618.
https://doi.org/10.1182/blood.2019001425
Published: 2019
Includes: Supplemental data
Journal Articles

NCAM1 (CD56) promotes leukemogenesis and confers drug resistance in AML

Daniel Sasca, Jakub Szybinski, Andrea Schüler, Viral Shah, Jan Heidelberger, Patricia S. Haehnel, Anna Dolnik, Oliver Kriege, Eva-Marie Fehr, Wolf H. Gebhardt, George Reid, Claudia Scholl, Matthias Theobald, Lars Bullinger, Petra Beli, Thomas Kindler
Journal: Blood
Blood (2019) 133 (21): 2305–2319.
https://doi.org/10.1182/blood-2018-12-889725
Published: 2019
Includes: Supplemental data
Journal Articles

Midostaurin added to chemotherapy and continued single-agent maintenance therapy in acute myeloid leukemia with FLT3 -ITD

Clinical Trials & Observations
Richard F. Schlenk, Daniela Weber, Walter Fiedler, Helmut R. Salih, Gerald Wulf, Hans Salwender, Thomas Schroeder, Thomas Kindler, Michael Lübbert, Dominik Wolf, Jörg Westermann, Doris Kraemer, Katharina S. Götze, Heinz-August Horst, Jürgen Krauter, Michael Girschikofsky, Mark Ringhoffer, Thomas Südhoff, Gerhard Held, Hans-Günter Derigs, Roland Schroers, Richard Greil, Martin Grießhammer, Elisabeth Lange, Alexander Burchardt, Uwe Martens, Bernd Hertenstein, Lore Marretta, Michael Heuser, Felicitas Thol, Verena I. Gaidzik, Wolfgang Herr, Julia Krzykalla, Axel Benner, Konstanze Döhner, Arnold Ganser, Peter Paschka, Hartmut Döhner
Journal: Blood
Blood (2019) 133 (8): 840–851.
https://doi.org/10.1182/blood-2018-08-869453
Published: 2019
Includes: Supplemental data
Journal Articles

Gemtuzumab Ozogamicin in NPM1 -Mutated Acute Myeloid Leukemia (AML): Results from the Prospective Randomized AMLSG 09-09 Phase-III Study

Richard F. Schlenk, MD, Peter Paschka, MD, Julia Krzykalla, MSc, Daniela Weber, MSc, Silke Kapp-Schwoerer, MD, Verena I. Gaidzik, MD, Claudia Leis, Walter Fiedler, MD, Thomas Kindler, MD, Thomas Schroeder, MD, Karin Mayer, MD, Michael Lübbert, Mohammed Amen Wattad, MD, Katharina S. Götze, MD, Heinz A. Horst, MD, Elisabeth Koller, MD, Gerald Wulf, MD, Jan Schleicher, MD, Martin Bentz, MD, Richard Greil, MD, Bernd Hertenstein, MD, Jürgen Krauter, MD, Uwe Martens, MD, David Nachbaur, MD, Maisun Abu Samra, MD, Michael Girschikofsky, MD, Axel Benner, Felicitas Thol, MD, Michael Heuser, MD, Arnold Ganser, MD, Konstanze Döhner, MD, Hartmut Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 81.
https://doi.org/10.1182/blood-2018-99-113442
Published: 2018
Journal Articles

Assessment of Treatment Effects By Measurable Residual Disease Monitoring in NPM1 -Mutated AML Patients Randomized for Gemtuzumab-Ozogamicin (GO) within the AMLSG 09-09 Trial of the German-Austrian AML Study Group (AMLSG)

Silke Kapp-Schwoerer, MD, Daniela Weber, MSc, Andrea Corbacioglu, PhD, Verena I. Gaidzik, MD, Peter Paschka, MD, Jan Krönke, MD, Maria-Veronica Teleanu, MD, Frauke Theis, Frank G. Rücker, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, MD PhD, Walter Fiedler, MD, Thomas Kindler, MD, Thomas Michael Schroeder, MD PhD, Karin Mayer, MD, Michael Lübbert, Mohammed Amen Wattad, MD, Katharina S. Götze, MD, Heinz A. Horst, MD, Elisabeth Koller, MD, Gerald Wulf, MD, Jan Schleicher, MD, Martin Bentz, MD, Jürgen Krauter, MD, Julia Krzykalla, MSc, Axel Benner, Richard F. Schlenk, MD, Felicitas Thol, MD, Michael Heuser, MD, Arnold Ganser, MD, Hartmut Döhner, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 991.
https://doi.org/10.1182/blood-2018-99-114648
Published: 2018
Journal Articles

Assessment of the Genomic Landscape of Intermediate Risk Acute Myeloid Leukemia As Defined By 2010 ELN Risk Classification

Ekaterina Panina, MD, Frank G. Rücker, MD, Lars Bullinger, MD, Anna Dolnik, PhD, Julia Herzig, PhD, Tamara J. Blätte, MSc, Verena I. Gaidzik, MD, Peter Paschka, MD, Maria-Veronica Teleanu, MD, Nikolaus Jahn, MD, Laura K. Schmalbrock, MD, Daniela Weber, MSc, Lena Kubanek, Thomas Kindler, MD, Jörg Westermann, MD, Michael Lubbert, MD PhD, Helmut R. Salih, MD, Felicitas Thol, MD, Michael Heuser, MD, Arnold Ganser, MD, Hartmut Döhner, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 994.
https://doi.org/10.1182/blood-2018-99-114671
Published: 2018
Journal Articles

Monitoring of FLT3 Phosphorylation and FLT3 Ligand Levels in Patients with FLT3 -ITD Mutated Acute Myeloid Leukemia (AML) Treated with Midostaurin within the AMLSG 16-10 Trial of the German-Austrian Study Group

Frauke Theis, Daniela Weber, MSc, Frank G. Rücker, MD, Peter Paschka, MD, Verena I. Gaidzik, MD, Felicitas Thol, MD, Michael Heuser, MD, Walter Fiedler, MD, Gerald Wulf, MD, Michael Lübbert, MD PhD, Helmut R. Salih, MD, Thomas Michael Schroeder, MD PhD, Katharina S. Götze, MD, Hans Jürgen Salwender, MD, Thomas Kindler, MD, Heinz-August Horst, MD, Mark Ringhoffer, MD, Dominik Wolf‎, MD, Jürgen Krauter, MD, Richard F. Schlenk, MD, Lars Bullinger, MD, Arnold Ganser, MD, Hartmut Döhner, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1501.
https://doi.org/10.1182/blood-2018-99-114588
Published: 2018
Journal Articles

CHIPing out PPM1D-mutant hematopoiesis

Thomas Kindler
Journal: Blood
Blood (2018) 132 (11): 1087–1088.
https://doi.org/10.1182/blood-2018-07-861716
Published: 2018
Journal Articles

Clinical Relevance of Alternatively Spliced Isoform AML1-ETO9a in Adult Patients with t(8;21)(q22;q22.1) Acute Myeloid Leukemia (AML): A Study of the German-Austrian AML Study Group (AMLSG)

Mridul Agrawal, MDMSc, Andrea Corbacioglu, PhD, Daniela Weber, MSc, Verena I. Gaidzik, MD, Marianne Habdank, Nikolaus Jahn, MD, Thomas Michael Schroeder, MD, Thomas Kindler, MD, Mohammed Amen Wattad, MD, Michael Lübbert, Walter Fiedler, MD, Katharina S. Götze, MD, Mark Ringhoffer, MD, Jan Schleicher, MD, Elisabeth Lange, MD, Michael Pfreundschuh, MD, Martin Griesshammer, Richard Greil, MD, Heinz Kirchen, MD, Elisabeth Koller, MD, Felicitas Thol, MD, Jurgen Krauter, MD, Richard F. Schlenk, MD, Michael Heuser, MD, Arnold Ganser, MD, Lars Bullinger, MD, Peter Paschka, MD, Hartmut Döhner, MD, Konstanze Döhner, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2685.
https://doi.org/10.1182/blood.V130.Suppl_1.2685.2685
Published: 2017