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Journal Articles

Phosphoglycerate Mutase 1 Promotes Leukemia Metabolism by Coordinating Glycolysis and Biosynthesis, and Represnts a Therapuetic Target in Leukemia Treatment

Taro Hitosugi, PhD, Lu Zhou, PhD, Jun Fan, PhD, Martha Arellano, MD, Hanna J. Khoury, MD, Benjamin H. Lee, MD, PhD, Titus Boggon, PhD, Sumin Kang, PhD, Chuan He, Jing Chen, PhD
Journal: Blood
Blood (2012) 120 (21): 860.
https://doi.org/10.1182/blood.V120.21.860.860
Published: 2012
Journal Articles

p90RSK2 is essential for FLT3-ITD– but dispensable for BCR-ABL–induced myeloid leukemia

Shannon Elf, Dean Blevins, Lingtao Jin, Tae-Wook Chung, Ifor R. Williams, Benjamin H. Lee, Jian-Xin Lin, Warren J. Leonard, Jack Taunton, Hanna J. Khoury, Sumin Kang
Journal: Blood
Blood (2011) 117 (25): 6885–6894.
https://doi.org/10.1182/blood-2010-10-315721
Published: 2011
Includes: Supplemental data
Journal Articles

Leukemogenic Tyrosine Kinases Inhibit PKM2 to Promote the Warburg Effect and Tumor Growth

Taro Hitosugi, PhD, Sumin Kang, PhD, Matthew Vander Heiden, MD/PhD, Tea-wook Chung, PhD, Shannon Elf, Katherine Lythgoe, Shaozhong Dong, PhD, Sagar Lonial, MD, Xu Wang, PhD, Georgia Chen, PhD, Jianxin Xie, PhD, Ting-Lei Gu, PhD, Roberto Polakiewicz, PhD, Johannes L. Roesel, PhD, Titus Boggon, PhD, Fadlo Khuri, MD, D. Gary Gilliland, MD, PhD, Lewis Cantley, PhD, Jonathan L. Kaufman, MD, Jing Chen, PhD
Journal: Blood
Blood (2010) 116 (21): 3142.
https://doi.org/10.1182/blood.V116.21.3142.3142
Published: 2010
Journal Articles

p90RSK2 Is Essential for FLT3-ITD-, but Dispensable for BCR-ABL-Induced Myeloid Leukemia

Shannon Elf, Tae-Wook Chung, PhD, Dean P. Blevins, Ifor Williams, MD, PhD, H. Jean Khoury, MD, Jack Taunton, PhD, Sumin Kang, PhD
Journal: Blood
Blood (2010) 116 (21): 1716.
https://doi.org/10.1182/blood.V116.21.1716.1716
Published: 2010
Journal Articles

FGFR3 Associates with and Tyrosine-Phosphorylates p90RSK2, Leading to RSK2 Activation That Mediates Hematopoietic Transformation

Sumin Kang, Shannon Elf, Shaozhong Dong, Taro Hitosugi, Ailan Guo, Hong Ruan, Sagar Lonial, Hanna Khoury, Ifor Williams, Gerard Karsenty, André Hanauer, Ting-Lei Gu, Jing Chen
Journal: Blood
Blood (2008) 112 (11): 3722.
https://doi.org/10.1182/blood.V112.11.3722.3722
Published: 2008
Journal Articles

p90RSK2 as a Therapeutic Target in Treatment of FGFR3-Expressing t(4;14) Multiple Myeloma.

Sumin Kang, PhD, Shaozhong Dong, PhD, Tinglei Gu, PhD, Ailan Guo, PhD, Michael S. Cohen, PhD, Sagar Lonial, MD, PhD, Petet Leif Bergsagel, MD, PhD, Jack Taunton, PhD, Roberto D. Polakiewicz, PhD, Jing Chen, PhD
Journal: Blood
Blood (2007) 110 (11): 253.
https://doi.org/10.1182/blood.V110.11.253.253
Published: 2007
Journal Articles

Targeting 14-3-3 Sensitizes Native and Mutant BCR-ABL to Inhibition with U0126, Rapamycin and Bcl-2 Inhibitor GX15-070.

Shaozhong Dong, PhD, Sumin Kang, PhD, Sagar Lonial, MD, Hanna Jean Khoury, MD, Jean Viallet, PhD, Jing Chen, PhD
Journal: Blood
Blood (2007) 110 (11): 2920.
https://doi.org/10.1182/blood.V110.11.2920.2920
Published: 2007
Journal Articles

14–3-3 integrates prosurvival signals mediated by the AKT and MAPK pathways in ZNF198-FGFR1–transformed hematopoietic cells

Shaozhong Dong, Sumin Kang, Ting-Lei Gu, Sean Kardar, Haian Fu, Sagar Lonial, Hanna Jean Khoury, Fadlo Khuri, Jing Chen
Journal: Blood
Blood (2007) 110 (1): 360–369.
https://doi.org/10.1182/blood-2006-12-065615
Published: 2007
Journal Articles

14-3-3 Integrates Pro-Survival Signals in Hematopoietic Cells Transformed by Diverse Leukemogenic Tyrosine Kinases, and Represents a Common Target.

Shaozhong Dong, PhD, Sumin Kang, PhD, Ting-lei Gu, PhD, Sean Kardar, Sagar Lonial, MD, H. Jean Khoury, MD, Fadlo Khuri, MD, Haian Fu, PhD, Jing Chen, PhD
Journal: Blood
Blood (2006) 108 (11): 1138.
https://doi.org/10.1182/blood.V108.11.1138.1138
Published: 2006
Journal Articles

FGFR3 Activates RSK2 To Mediate Hematopoietic Transformation through Both Tyrosine Phosphorylation of RSK2 and Activation of the MEK/ERK Pathway.

Sumin Kang, PhD, Shaozhong Dong, PhD, Ting-lei Gu, PhD, Michael S. Cohen, Sagar Lonial, MD, H. Jean Khoury, PhD, D. Gary Gilliland, MD, PhD, Jack Taunton, PhD, Roberto D. Polakiewicz, PhD, Jing Chen, PhD
Journal: Blood
Blood (2006) 108 (11): 514.
https://doi.org/10.1182/blood.V108.11.514.514
Published: 2006