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Journal Articles

Overcoming NOTCH1-Driven Chemoresistance in T-Cell Acute Lymphoblastic Leukemia Via Metabolic Intervention with Oxphos Inhibitor

Natalia Baran, PhDMD, Alessia Lodi, PhD, Yogesh Dhungana, PhD, Shannon RENEE Sweeney, PhD, Pandey Renu, PhD, Shelley Herbrich, PhD, Fieke W Hoff, BSc, Anna Skwarska, PhD, Mecit Kaplan, MS, Vinitha Mary Kuruvilla, MSc, Antonio Cavazos, MSc, Marc Warmoes, PhD, Shanti Rojas-Sutterlin, PhD, Andre Haman, PhD, Diogo Troggian Veiga, PhD, Ken Furudate, DDM, PhD, Helen Ma, MS, Karine Harutyunyan, PhD, Wentao Yang, Mihai Gagea, MDPhD, Di Du, PhD, May Daher, Luciana Melo Garcia, MD, Sujan Piya, PhD, Vivian Ruvolo, MS, Sriram Shanmugavelandy, Ningping Feng, PhD, Jason P Gay, MS, Ondrej Havranek, MDPhD, Jared Henderson, MS, Katarzyna Tomczak, PhD, Marcin Kaminski, PhD, Daniel Herranz, PharmD, Adolfo Ferrando, MD, PhD, Elias Jabbour, MD, Maria E Di Francesco, PhD, David T. Teachey, MD, Terzah M. Horton, MD PhD, Katayoun Rezvani, MD PhD, Jun J. Yang, PhD, Steven M. Kornblau, MD, Eric Davis, MD, Koichi Takahashi, MD PhD, Michael Andreeff, MD PhD, Joseph R Marszalek, PhD, Philip Lorenzi, PhD, Jiyang Yu, PhD, Stefano Tiziani, PhD, Trang Hoang, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 18–20.
https://doi.org/10.1182/blood-2020-136801
Published: 2020
Journal Articles

Mitochondrial Oxphos As Survival Mechanism of Minimal Residual AML Cells after Induction Chemotherapy : Survival Benefit By Complex I Inhibition with Iacs-010759

Lina Han, PhD, Antonio Cavazos, Natalia Baran, PhDMD, Qi Zhang, PhD, Vinitha Mary Kuruvilla, MSc, Jason P Gay, MS, Ningping Feng, PhD, Venkata Lokesh Battula, PhD, Hagop M. Kantarjian, MD, Naval G. Daver, MD, Joseph R Marszalek, PhD, Michael Andreeff, MD PhD, Marina Y Konopleva, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 5161.
https://doi.org/10.1182/blood-2019-124475
Published: 2019
Journal Articles

Glutaminase Inhibition Overcomes Acquired Resistance to Mitochondrial Complex I in NOTCH1-Driven T-Cell Acute Lymphoblastic Leukemias (T-ALL) Via Block of Glutamine Driven Reductive Metabolism

Natalia Baran, PhDMD, Alessia Lodi, PhD, Shannon Renee Sweeney, PhD, Vinitha Mary Kuruvilla, MSc, Antonio Cavazos, Daniel Herranz, PharmD, Anna Skwarska, PhD, Marc Warmoes, PhD, Eric Davis, MD, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason P Gay, MS, Marcin Kaminski, PhD, Sergej Konoplev, Elias Jabbour, MD, Adolfo A. Ferrando, MD PhD, Maria E Di Francesco, PhD, Philip Lorenzi, Joseph R Marszalek, PhD, Stefano Tiziani, PhD, Marina Y Konopleva, MD PhD, Pandey Renu, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 806.
https://doi.org/10.1182/blood-2019-128930
Published: 2019
Journal Articles

A Novel Patient-Derived Xenograft Model of Secondary CD20 - CNS Lymphoma for Mechanistic and Therapeutic Exploration

Liang Zhang, MD PhD, Hui Zhang, Hui Guo, PhD, Yuting Sun, PhD, Ningping Feng, PhD, Joseph R Marszalek, PhD, Makhdum Ahmed, MDPhDMPH, Krystle Nomie, PhD, Michael Wang, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1669.
https://doi.org/10.1182/blood-2018-99-112205
Published: 2018
Journal Articles

Mitochondrial Complex I Inhibitor Iacs-010759 Reverses the NOTCH1-Driven Metabolic Reprogramming in T-ALL Via Blockade of Oxidative Phosphorylation: Synergy with Chemotherapy and Glutaminase Inhibition

Natalia Baran, PhDMD, Alessia Lodi, PhD, Shannon Renee Sweeney, MS, Pandey Renu, PhD, Vinitha Mary Kuruvilla, Antonio Cavazos, MSc, Daniel Herranz, PharmD, Anna Skwarska, PhD, Marc Warmoes, PhD, R. Eric Davis, MD, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason P Gay, MS, Sergej Naumovich Konoplev, MD PhD, Marcin Kaminski, PhD, Jeffrey J Kovacs, PhD, Di Du, PhD, Elias J. Jabbour, MD, Adolfo A. Ferrando, MD PhD, Maria E Di Francesco, PhD, Philip L Lorenzi, PhD, Joseph R Marszalek, PhD, Stefano Tiziani, PhD, Marina Y. Konopleva, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4020.
https://doi.org/10.1182/blood-2018-99-117310
Published: 2018
Journal Articles

Inhibition of Oxphos with Iacs-010759 Depletes AML Leukemia Initiating Cells (LIC) in Vitro and Improves Survival in Pre-Clinical AML Models

Natalia Baran, PhD MD, Lina Han, PhD, Shannon Renee Sweeney, MS, Alessia Lodi, PhD, Shelley Herbrich, MS, Antonio Cavazos, MSc, Helen Ma, MS, Jason P Gay, MS, Ningping Feng, PhD, Hsiang-Chun Chen, PhD, Marcin Kaminski, PhD, Kenneth Dunner, Jr., AS, BS, Guilin Tang, MD, Gheath Alatrash, DO, PhD, Jennifer Molina, PhD, Monica L. Guzman, PhD, Jing Ning, PhD, Stefano Tiziani, PhD, Joseph R Marszalek, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1350.
https://doi.org/10.1182/blood.V130.Suppl_1.1350.1350
Published: 2017
Journal Articles

Targeting Residual Chemotherapy-Resistant Acute Myeloid Leukemia Cells By a Novel Oxphos Inhibitor IACS010759

Lina Han, PhD, Antonio Cavazos, MSc, Natalia Baran, PhD MD, Qi Zhang, PhD MD, Vinitha Mary Kuruvilla, Jason P Gay, MS, Ningping Feng, PhD, Venkata Lokesh Battula, PhD, Michael Andreeff, MD PhD, Hagop M. Kantarjian, MD, Naval Daver, MD, Joseph R Marszalek, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2623.
https://doi.org/10.1182/blood.V130.Suppl_1.2623.2623
Published: 2017
Journal Articles

Mitochondrial Complex I Inhibition with Iacs-010759 in T-ALL Preclinical Models

Natalia Baran, PhD, Jennifer Molina, PhD, Antonio Cavazos, MS, Karine Harutyunyan, PhD, Ningping Feng, PhD, Jason Gay, MS, Sujan Piya, PhD, Sriram Shanmuga Velandy, MS, Elias J. Jabbour, MD, Michael Andreeff, MD PhD, Stefano Tiziani, PhD, Adolfo A. Ferrando, MD PhD, Patrick Zweidler-McKay, MD PhD, M. Emilia Di Francesco, PhD, Joseph R. Marszalek, PhD, Marina Konopleva, MD PhD
Journal: Blood
Blood (2016) 128 (22): 4028.
https://doi.org/10.1182/blood.V128.22.4028.4028
Published: 2016
Journal Articles

Targeting Oxphos Pathway Against Ibrutinib Resistance to Mantle Cell Lymphoma

Yang Liu, PhD, Taylor Bell, Hui Zhang, Yuting Sun, Carrie J Li, Ningping Feng, PhD, Shengjian Huang, Hui Guo, MD PhD, Jack Wang, Makhdum Ahmed, MD MPH, Victoria Zhang, Laura T Lam, PhD, Krystle Nomie, PhD, Liang Zhang, MD PhD, Maria E Di Francesco, Joe Marszalek, Michael Wang, MD
Journal: Blood
Blood (2016) 128 (22): 290.
https://doi.org/10.1182/blood.V128.22.290.290
Published: 2016
Journal Articles

Novel Nanomolar Potency Mitochondrial Complex I Inhibitor Iacs-1131 Selectively Kills Oxphos-Dependent AML Cells

Polina Matre, PhD, Marina Protopopova, Ningping Feng, Jason Gay, Jennifer Greer, Juliana Velez, Hong Mu, MD PhD, Alessia Lodi, Surendar Tadi, Shannon Sweeney, Michael Andreeff, MD PhD, Stefano Tiziani, M. Emilia DiFrancesco, Joseph Marszalek, Marina Konopleva, MD PhD
Journal: Blood
Blood (2014) 124 (21): 622.
https://doi.org/10.1182/blood.V124.21.622.622
Published: 2014