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Journal Articles

Effect and mechanism of allopurinol in ALL maintenance therapy: Reducing hepatotoxicity and improving myelosuppression effect via TPMT inhibition and increased DNA-thioguanine levels

Free
Yanping Guan, Xiao-Li Zhang, Jian Wang, Min Huang, Libin Huang, Xueding Wang, Dun-Hua Zhou
Journal: Blood
Blood (2025) 146 (Supplement 1): 6852.
https://doi.org/10.1182/blood-2025-6852
Published: 2025
Journal Articles

Genetic evolution in CML patients from diagnosis to TKI failure: An analysis of 121 paired diagnosis and treatment failure samples

Free
Ying-Jung Huang, Ming-Chung Kuo, Tung-Liang Lin, Ming-Chun Ma, Chieh-Lin Jerry Teng, Young-Sen Yang, Tsai-Yun Chen, Chiu-Chen Chen, Cheng-Shyong Chang, Hung Chang, Ting-Yu Huang, Tung-Huei Lin, Yen-Min Huang, Su-Peng Yeh, Ming-Chung Wang, Lee-Yung Shih
Journal: Blood
Blood (2025) 146 (Supplement 1): 5555.
https://doi.org/10.1182/blood-2025-5555
Published: 2025
Journal Articles

iPSC-derived, multiplex-engineered CD8αβT cells deliver antigen-specific, potent, and durable tumor cytotoxicity without CD4αβT support – powering scalable, off-the-shelf allogeneic αβT cell therapy in hematological malignancies

Free
Chih-Lung Chen, Jhang-Sian Yu, Chia-Hung Lin, Po-Fan Chu, Lin-Yu Liao, Wan-Chen Tsai, Yi-Han Dai, Ming-Chin Ko, Annie Yi-Ting Lai, Chun-Yu Lin, Wei-Ting Chen, Ying-Tsen Tung, Kuan-Hung Chen, Shao-Ju Weng, Pei-Kai Chen, Yi-Chiao Tseng, Ke-Hsun Hsu, Fang-Pei Chang, Fu-Fei Hsu, Yi-Ting Lai, Shiou-Ling Jian, Chien-Yu Hsu, Darien Zhing Herr Chan, Yo-Cheun Lin, Jin-Yi Lu, Hsin-Hua Cho, Cheng-Kai Wang, Lee-Yieng Lim, Tzu-Chien Kuo, Yun Gao, Pei-Chun Wu, Ta-Hsun Liao, Lien-Szu Wu, Jen-Chih Chi, Ching-Ying Huang, Ao Hu, MinHong Yan, Haitao Wang, Alex Shih-Min Huang
Journal: Blood
Blood (2025) 146 (Supplement 1): 2327.
https://doi.org/10.1182/blood-2025-2327
Published: 2025
Journal Articles

Tumor-induced dendritic cell dysfunction impairs T-cell proliferation and confers poor prognosis in high-risk acute lymphoblastic leukemia

Free
Anil Kumar, Kory Hamane, Caroline Duault, Joao Rodrigues Lima-Junior, Da Hae Jung, Hanjun Qin, Sheyla Salcido, Min Huang, Xinying Guo, Adeleh Taghi Khani, Ashly Sanchez Ortiz, Lucy Ghoda, Guido Marcucci, Norman Lacayo, Kathleen Sakamoto, Christian Hurtz, Martin Carroll, Sarah Tasian, Huimin Geng, Lingyun Ji, Saro Armenian, Shai Izraeli, Holden Maecker, Xiwei Wu, Srividya Swaminathan
Journal: Blood
Blood (2025) 146 (Supplement 1): 5138.
https://doi.org/10.1182/blood-2025-5138
Published: 2025
Journal Articles

iPSC-Derived CAR-Gamma Delta T with Novel Combinatorial KO Demonstrated Extended Longevity and Profound Anti-Tumor Efficacy without Cytokine Support in Preclinical Studies

Free
Jhang-Sian Yu, Chia-Hung Lin, Ying-Tsen Tung, Fang-Pei Chang, Edward Po-Fan Chu, Shiou-Ling Jian, Fu-Fei Hsu, Ming-Chin Ko, Yi-Han Dai, Chieh-Teng Cheng, Tzu-Chien Kuo, I-Ting Chen, Ting-Yi Wu, Jin-Yi Lu, Ke-Hsun Hsu, Wei-Ting Chen, Darien Zhing Herr Chan, Yi-Ting Lai, Shao-Ju Weng, Liang-Yi Chen, Yuan-Yu Hsia, Yi-Hung Ou, Yo-Chuen Lin, Shih-Wen Huang, Yu-Chih Peng, Chien-Hsi Chen, Chien-Yu Hsu, Yi-Ting Lai, Chih-Lung Chen, Chun-Yu Lin, Lin-Yu Liao, Wan-Chen Tsai, Hsin-Hua Cho, Cheng-Kai Wang, Lee-Yieng Lim, Ji-Kuan Wang, Yao-Yu Chen, Chih-Kai Yin, Wen-Hao Wang, Tsung-Hao Yeh, Min-Ren Chiang, Ruyue Ji, Jen-Chih Chi, Lien-Szu Wu, Jennifer Huang, De-Kuan Chang, Alex Shih-Min Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 4790.
https://doi.org/10.1182/blood-2024-205086
Published: 2024
Journal Articles

Discovery of the Unique GMP-Grade iPSC Clones That Give Rise to Functional, High Purity, Matured CD8 Alpha Beta T or Gamma Delta T with Exponential Expansion Capacity

Free
Ying-Tsen Tung, Chih-Lung Chen, Annie Yi-Ting Lai, Chien-Yu Hsu, Chien-Hsi Chen, Po-Fan Chu, Lin-Yu Liao, Tzu-Chien Kuo, Chieh-Teng Cheng, Chun-Yu Lin, Wan-Chen Tsai, Wei-Ting Chen, Darien Zhing Herr Chan, Hsin-Hua Cho, Cheng-Kai Wang, Yo-Chuen Lin, Jin-Yi Lu, Lee-Yieng Lim, Jhang-Sian Yu, Ming-Chin Ko, Chia-Hung Lin, Yi-Han Dai, I-Ting Chen, Fang-Pei Chang, Shao-Ju Weng, Ting-Yi Wu, Yuan-Yu Hsia, Fu-Fei Hsu, Lillian Yi-Ting Lai, Shiou-Ling Jian, Shih-Wen Huang, Yu-Chih Peng, Ke-Hsun Hsu, Liang-Yi Chen, Ji-Kuan Wang, Yao-Yu Chen, Chih-Kai Yin, Yi-Hung Ou, Min-Ren Chiang, Wen-Hao Wang, Tsung-Hao Yeh, Xiaming Peng, Yang Shi, Pei Zhang, Ya-Chu Yu, Yun Gao, Yen-Hsien Lee, Pei-Chun Wu, Ta-Hsun Liao, De-Kuan Chang, Lien-Szu Wu, Jen-Chih Chi, Ching-Ying Huang, Alex Shih-Min Huang
Journal: Blood
Blood (2024) 144 (Supplement 1): 7195.
https://doi.org/10.1182/blood-2024-203106
Published: 2024
Journal Articles

Uridine Synthesis Is the Metabolic Vulnerability in Relapse-Associated B-ALL Cells with Active Pre-BCR Signaling

Free
Yuxuan Liu, Haowen Jiang, Lucille Stuani, Jolanda Sarno, Pablo Domizi, Milton Merchant, Dorra Jedoui, Astraea Jager, Min Huang, Norman J. Lacayo, Kathleen M. Sakamoto, Jiangbin Ye, Kara L. Davis
Journal: Blood
Blood (2023) 142 (Supplement 1): 4340.
https://doi.org/10.1182/blood-2023-186925
Published: 2023
Journal Articles

Gene Expression Analysis of CML Patients across the Age Spectrum

Free
Minyoung Youn, Stephanie M. Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara C. Murphy, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman J. Lacayo, Gary Dahl, Catherine Aftandilian, Kara L. Davis, Jairo A. Matthews, Steven M. Kornblau, Min Huang, Nathan Sumarsono, Michele Redell, Cecilia H. Fu, I-Ming L Chen, Todd A. Alonzo, Elizabeth A. Eklund, Jason Gotlib, Purvesh Khatri, Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M. Sakamoto
Journal: Blood
Blood (2021) 138 (Supplement 1): 1473.
https://doi.org/10.1182/blood-2021-148701
Published: 2021
Journal Articles

Activated natural killer cells predict poor clinical prognosis in high-risk B- and T-cell acute lymphoblastic leukemia

Free
Caroline Duault, Anil Kumar, Adeleh Taghi Khani, Sung June Lee, Lu Yang, Min Huang, Christian Hurtz, Bryan Manning, Lucy Ghoda, Tinisha McDonald, Norman J. Lacayo, Kathleen M. Sakamoto, Martin Carroll, Sarah K. Tasian, Guido Marcucci, Jianhua Yu, Michael A. Caligiuri, Holden T. Maecker, Srividya Swaminathan
Journal: Blood
Blood (2021) 138 (16): 1465–1480.
https://doi.org/10.1182/blood.2020009871
Published: 2021
Includes: Supplemental data
Journal Articles

Activated Natural Killer Cells Are Associated with Poor Clinical Prognosis in High-Risk B- and T- Cell Acute Lymphoblastic Leukemia

Free
Caroline Duault, PharmD, PhD, Anil Kumar, PhD, Adeleh Taghi Khani, PhD, Sung June Lee, BA, Lu Yang, PhD, Min Huang, PhD, Christian Hurtz, PhD, Bryan Manning, BS, Lucy Ghoda, PhD, Tinisha McDonald, BS, Norman J. Lacayo, MD, Kathleen M. Sakamoto, MD PhD, Martin P. Carroll, MD, Guido Marcucci, MD, Jianhua Yu, PhD, Michael A. Caligiuri, MD, Holden T. Maecker, PhD, Srividya Swaminathan, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39.
https://doi.org/10.1182/blood-2020-140044
Published: 2020
Journal Articles

Comparison of the Transcriptomic Signatures in Pediatric and Adult CML

Free
Minyoung Youn, PhD, Hee-Don Chae, PhD, Stephanie M. Smith, MD, Alex Gia Lee, PhD, Lara C. Murphy, MD, Michele Donato, PhD, Alejandro Sweet-Cordero, Parveen Abidi, PhD, Henrique Bittencourt, MD PhD, Norman J. Lacayo, MD, Gary Dahl, Catherine Aftandilian, MD, Kara L Davis, DO, Jairo A. Matthews, Steven M. Kornblau, MD, Min Huang, PhD, Nathan Sumarsono, BS, Michele Redell, MD, Cecilia H. Fu, MD, I-Ming L Chen, Todd A. Alonzo, PhD, Elizabeth A. Eklund, MD, Jason Gotlib, MD MS, Purvesh Khatri, PhD, Nobuko Hijiya, MD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-142270
Published: 2020
Journal Articles

Comparison of the Transcriptomic Signature of Pediatric Vs. Adult CML and Normal Bone Marrow Stem Cells

Free
Hee-Don Chae, PhD, Lara C. Murphy, MD, Michele Donato, PhD, Alex G. Lee, PhD, E. Alejandro Sweet-Cordero, MD PhD, Parveen Abidi, PhD, Henrique Bittencourt, MD PhD, Norman J. Lacayo, MD, Gary Van Houten Dahl, MD, Catherine Aftandilian, MD, Kara L. Davis, DO, Min Huang, PhD, Nathan Sumarsono, BS, Michele Redell, MD PhD, Cecilia H. Fu, MD, I-Ming L. Chen, DVM, MS, Todd A Alonzo, PhD, Elizabeth A. Eklund, MD, Jason R. Gotlib, MD MS, Purvesh Khatri, PhD, Nobuko Hijiya, MD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4246.
https://doi.org/10.1182/blood-2018-99-119974
Published: 2018
Journal Articles

Comparison of Molecular Responses between e14a2 and e13a2 BCR-ABL1 Transcripts in Patients with Chronic Myeloid Leukemia in Chronic Phase Treated with Front-Line Second Generation Tyrosine Kinase Inhibitors: Taiwan CML Study

Free
Yi-Jiun Su, MD, Ming-Chung Kuo, MD, Chieh-Lin Teng, MD, Tsai-Yun Chen, MD, Ming-Chun Ma, MD, Pei-Ching Hsiao, MD, Ming-Chung Wang, MD, Tung-Huei Lin, MS, Wen-Li Hwang, MD, Chih-Cheng Chen, MD, Youngsen Yang, MD, Sung-Nan Pei, MD, Yen-Min Huang, MD, Sin-Syue Li, MD, Ming-Yang Lee, MD, Hung-I Cheng, MD, Lee-Yung Shih, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1603.
https://doi.org/10.1182/blood.V130.Suppl_1.1603.1603
Published: 2017
Journal Articles

Preclinical Activity of a New Proteasome Inhibitor, MLN9708, in Acute Myelogenous Leukemias Expressing NPM1 Mutated Protein

Free
Jacqueline S Garcia, MD, Min Huang, Bruno C Medeiros, MD, Beverly S. Mitchell, MD
Journal: Blood
Blood (2014) 124 (21): 993.
https://doi.org/10.1182/blood.V124.21.993.993
Published: 2014
Journal Articles

Small Molecule Inhibitors of USP1 Target ID1 Degradation in Leukemic Cells and Cause Cytotoxicity

Free
Helena Mistry, Ph.D., Grace Hsieh, M.D., Sara Buhrlage, Ph.D, Min Huang, Ph.D., Eunmi Park, Ph.D., Gregory Cuny, Ph.D., Ilene Galinsky, ANP, Richard M. Stone, MD, Nathanael S Gray, PhD, Kalindi Parmar, PhD, Alan D. D'Andrea, MD
Journal: Blood
Blood (2013) 122 (21): 2906.
https://doi.org/10.1182/blood.V122.21.2906.2906
Published: 2013
Journal Articles

Activation Of Akt Enhances Ribosomal RNA Synthesis In AML Cells Through a Novel Isoform Of TIF-1A and Inhibition Of Filamin A Cleavage

Free
Le Xuan Truong Nguyen, PhD, Min Huang, Steven M. Chan, MD, PhD, Ravi Majeti, MD, PhD, Beverly S. Mitchell
Journal: Blood
Blood (2013) 122 (21): 1266.
https://doi.org/10.1182/blood.V122.21.1266.1266
Published: 2013
Journal Articles

Cysteine 288 Regulates NPMc+ Cytoplasmic Localization and Sensitizes Leukemic Cells to Bortezomib-Induced Apoptosis Through a Redox-Sensitive Mechanism

Free
Min Huang, Xinran Li, Beverly S. Mitchell
Journal: Blood
Blood (2012) 120 (21): 532.
https://doi.org/10.1182/blood.V120.21.532.532
Published: 2012
Journal Articles

Induction of apoptosis in IL-3–dependent hematopoietic cell lines by guanine nucleotide depletion

Free
Jing Jin Gu, Karen Gathy, Lalaine Santiago, Eric Chen, Min Huang, Lee M. Graves, Beverly S. Mitchell
Journal: Blood
Blood (2003) 101 (12): 4958–4965.
https://doi.org/10.1182/blood-2002-08-2547
Published: 2003