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Journal Articles

Ruxolitinib for pediatric patients with treatment-naïve and steroid-refractory acute graft-versus-host disease: the REACH4 study

Clinical Trials & Observations
Franco Locatelli, Hyoung Jin Kang, Bénédicte Bruno, Virginie Gandemer, Fanny Rialland, Maura Faraci, Yoshiyuki Takahashi, Katsuyoshi Koh, Henrique Bittencourt, Grace Cleary, Christine Rosko, Xuechan Li, Annie St Pierre, Anirudh Prahallad, Cristina Diaz-de-Heredia
Journal: Blood
Blood (2024) 144 (20): 2095–2106.
https://doi.org/10.1182/blood.2023022565
Published: 2024
Includes: Supplemental data
Journal Articles

Uncovering Therapeutic Vulnerabilities in Adverse-Risk Pediatric Acute Myeloid Leukemia

Sabrina Halim, Noémie Sultan, Sophie Cardin, Verena Gress, Billy Ta, Nehme El-Hachem, Emma Rose Cheetham, Carolina Marmolejo, Anne-Cécile Soufflet, Louise Laramée, Melanie Bilodeau, Vincent-Philippe Lavallee, Catherine Goudie, Henrique Bittencourt, Brian T. Wilhelm, Frederic Barabe, Josée Hébert, Sonia Cellot
Journal: Blood
Blood (2024) 144 (Supplement 1): 5778.
https://doi.org/10.1182/blood-2024-203878
Published: 2024
Journal Articles

Outcome of Infants Treated on Total Therapy for Infants with Acute Lymphoblastic Leukemia I: Results from a Non-Randomized Multi-Center Study

Tanja A. Gruber, Minxuan Huang, Sima Jeha, Rebecca J. Deyell, Victor A. Lewis, Bill H. Chang, Eric J. Lowe, Jamie Frediani, Catherine Vezina, Bruno Michon, Nathan Gossai, Erin H. Breese, Thai Hoa Tran, Norman J. Lacayo, Christine Bolen, Sunil J. Desai, Jennifer L. Pauley, Emily Ashcraft, Cheng Cheng, Kirk R. Schultz, Krysta Schils, Linda C. Stork, Van Thu Huynh, Michael Richards, Yoav H. Messinger, Henrique Bittencourt, Terzah M. Horton, Uma Athale, Duncan Stearns, Deborah E. Schiff, Paul S. Gaynon
Journal: Blood
Blood (2023) 142 (Supplement 1): 823.
https://doi.org/10.1182/blood-2023-177798
Published: 2023
Journal Articles

Safety and Efficacy of Axatilimab at 3 Different Doses in Patients with Chronic Graft-Versus-Host Disease (AGAVE-201)

Daniel Wolff, Corey Cutler, Stephanie J. Lee, Iskra Pusic, Henrique Bittencourt, Jennifer White, Mehdi Hamadani, Sally Arai, Amandeep Salhotra, Jose A. Pérez-Simón, Amin Alousi, Hannah Choe, Mi Kwon, Arancha Bermúdez, Inho Kim, Gerard Socié, Vedran Radojcic, Timothy O'Toole, Chuan Tian, Peter Ordentlich, Zachariah DeFilipp, Carrie L. Kitko
Journal: Blood
Blood (2023) 142 (Supplement 1): 1.
https://doi.org/10.1182/blood-2023-186963
Published: 2023
Journal Articles

Trends of Obesity over Time and Its Prognostic Significance in Children and Adolescents with Newly-Diagnosed Acute Lymphoblastic Leukemia in Canada: A Population-Based Study

Samuel Sassine, Marie-Claude Pelland-Marcotte, André Ilinca, Uma Athale, Henrique Bittencourt, Lynette Bowes, Josée Brossard, Sara J. Israels, Johnston Donna, Ketan Kulkarni, Sarah McKillop, Meera Rayar, Roona Sinha, Tony Truong, Catherine Vezina, Laura Wheaton, Alexandra Zorzi, Lillian Sung, Thai Hoa Tran
Journal: Blood
Blood (2023) 142 (Supplement 1): 3760.
https://doi.org/10.1182/blood-2023-178401
Published: 2023
Journal Articles

Ruxolitinib in Pediatric Patients with Treatment- Naïve or Steroid-Refractory Acute Graft-Versus-Host Disease: Primary Findings from the Phase I/II REACH4 Study

Franco Locatelli, Hyoung Jin Kang, Bénédicte Bruno, Virginie Gandemer, Fanny Rialland, Maura Faraci, Yoshiyuki Takahashi, Katsuyoshi Koh, Henrique Bittencourt, Grace Cleary, Christine Rosko, Pantelia Roussou, Annie St. Pierre, Anirudh Prahallad, Cristina Díaz-de-Heredia
Journal: Blood
Blood (2022) 140 (Supplement 1): 1376–1378.
https://doi.org/10.1182/blood-2022-155708
Published: 2022
Journal Articles

Metabolomic identification of α-ketoglutaric acid elevation in pediatric chronic graft-versus-host disease

Clinical Trials & Observations
Divya Subburaj, Bernard Ng, Amina Kariminia, Sayeh Abdossamadi, Madeline Lauener, Eneida R. Nemecek, Jacob Rozmus, Sandhya Kharbanda, Carrie L. Kitko, Victor A. Lewis, Tal Schechter-Finklestein, David A. Jacobsohn, Andrew C. Harris, Michael A. Pulsipher, Henrique Bittencourt, Sung Won Choi, Emi H. Caywood, Kimberly A. Kasow, Monica Bhatia, Benjamin R. Oshrine, Donald Coulter, Joseph H. Chewning, Michael Joyce, Anna B. Pawlowska, Gail C. Megason, Anita Lawitschka, Elena Ostroumov, Ramon Klein Geltink, Geoffrey D. E. Cuvelier, Kirk R. Schultz
Journal: Blood
Blood (2022) 139 (2): 287–299.
https://doi.org/10.1182/blood.2021013244
Published: 2022
Includes: Supplemental data
Journal Articles

Tisagenlecleucel Therapy Is Safe and Effective for Children with Down Syndrome with ALL in First Relapse

Joerg Krueger, Johann K Hitzler, Stephanie Audrey Mourad, Mylene Bassal, Elizabeth Cairney, Bruce N. Crooks, Angela Punnett, Sarah Alexander, Muhammad Ali, Henrique Bittencourt, James A. Whitlock, Sumit Gupta
Journal: Blood
Blood (2021) 138 (Supplement 1): 4820.
https://doi.org/10.1182/blood-2021-153262
Published: 2021
Journal Articles

Umbilical Cord Blood Transplantation after Graft Failure from a Previous Hematopoietic Stem Cell Transplantation

Fernanda Volt, Annalisa Ruggeri, Graziana Maria Scigliuolo, Regis Peffault De Latour, Marc Bierings, Amal Al-Seraihy, Henrique Bittencourt, Helene Labussiere-Wallet, Vanderson Rocha, Chantal Kenzey, Barbara Cappelli, Hanadi Rafii, Eliane Gluckman, Renato Luiz Guerino-Cunha
Journal: Blood
Blood (2021) 138 (Supplement 1): 1785.
https://doi.org/10.1182/blood-2021-145287
Published: 2021
Journal Articles

Gene Expression Analysis of CML Patients across the Age Spectrum

Minyoung Youn, Stephanie M. Smith, Alex Gia Lee, Hee-Don Chae, Elizabeth Spiteri, Jason Erdmann, Ilana Galperin, Lara C. Murphy, Michele Donato, Parveen Abidi, Henrique Bittencourt, Norman J. Lacayo, Gary Dahl, Catherine Aftandilian, Kara L. Davis, Jairo A. Matthews, Steven M. Kornblau, Min Huang, Nathan Sumarsono, Michele Redell, Cecilia H. Fu, I-Ming L Chen, Todd A. Alonzo, Elizabeth A. Eklund, Jason Gotlib, Purvesh Khatri, Alejandro Sweet-Cordero, Nobuko Hijiya, Kathleen M. Sakamoto
Journal: Blood
Blood (2021) 138 (Supplement 1): 1473.
https://doi.org/10.1182/blood-2021-148701
Published: 2021
Journal Articles

Comparison of the Transcriptomic Signatures in Pediatric and Adult CML

Minyoung Youn, PhD, Hee-Don Chae, PhD, Stephanie M. Smith, MD, Alex Gia Lee, PhD, Lara C. Murphy, MD, Michele Donato, PhD, Alejandro Sweet-Cordero, Parveen Abidi, PhD, Henrique Bittencourt, MD PhD, Norman J. Lacayo, MD, Gary Dahl, Catherine Aftandilian, MD, Kara L Davis, DO, Jairo A. Matthews, Steven M. Kornblau, MD, Min Huang, PhD, Nathan Sumarsono, BS, Michele Redell, MD, Cecilia H. Fu, MD, I-Ming L Chen, Todd A. Alonzo, PhD, Elizabeth A. Eklund, MD, Jason Gotlib, MD MS, Purvesh Khatri, PhD, Nobuko Hijiya, MD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 39–40.
https://doi.org/10.1182/blood-2020-142270
Published: 2020
Journal Articles

Venetoclax Alone or in Combination with Chemotherapy: Responses in Pediatric Patients with Relapsed/Refractory Acute Myeloid Leukemia with Heterogeneous Genomic Profiles

Seth E. Karol, MD, Henrique Bittencourt, MD PhD, Daniel A. Morgenstern, MD, Margaret E. Macy, MD, Seong Lin Khaw, MD, Todd M. Cooper, DO, Arnaud Petit, MD PhD, Giridharan Ramsingh, MD, Bo Tong, PhD, Kristina Unnebrink, PhD, Deeksha Vishwamitra, PhD, Fengjiao Dunbar, PhD, Betty A. Prine, BS, Tammy L. Palenski, PhD, Andrew E. Place, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 30–31.
https://doi.org/10.1182/blood-2020-136999
Published: 2020
Journal Articles

Naïve Helper T-Cell and Regulatory T- and NK-Cell Subsets Are Associated with Pediatric Chronic Graft-Versus-Host Disease: Results of the ABLE / PBMTC 1202 Study

Geoff D.E. Cuvelier, MD, Amina Kariminia, PhD, Eneida R. Nemecek, MDMBA,MSc, Carrie Kitko, MD, Justin T. Wahlstrom, MD, Andrew C Harris, MD, Henrique Bittencourt, MD PhD, Victor A. Lewis, MD, Michael A Pulsipher, MD, Tal Schechter-Finkelstein, MD, Sung W. Choi, MD, Emi Caywood, MD, Monica Bhatia, MD, Kimberly A. Kasow, DO, David Jacobsohn, MD, Benjamin Oshrine, MD, Sonali Chaudhury, MD, Joseph H. Chewning, MD, Flower Allyson, MD, Don W. Coulter, MD, Michael J. Joyce, MD, Sureyya Savasan, MD, Anna Pawlowska, MD, Gail Megason, MD, David Mitchell, MD, Alexandra Cheerva, MD, Anita Lawitschka, MD, Bernard Ng, PhD, Kirk R. Schultz, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-139031
Published: 2020
Journal Articles

Immune profile differences between chronic GVHD and late acute GVHD: results of the ABLE/PBMTC 1202 studies

Clinical Trials & Observations
Kirk R. Schultz, Amina Kariminia, Bernard Ng, Sayeh Abdossamadi, Madeline Lauener, Eneida R. Nemecek, Justin T. Wahlstrom, Carrie L. Kitko, Victor A. Lewis, Tal Schechter, David A. Jacobsohn, Andrew C. Harris, Michael A. Pulsipher, Henrique Bittencourt, Sung Won Choi, Emi H. Caywood, Kimberly A. Kasow, Monica Bhatia, Benjamin R. Oshrine, Allyson Flower, Sonali Chaudhury, Donald Coulter, Joseph H. Chewning, Michael Joyce, Sureyya Savasan, Anna B. Pawlowska, Gail C. Megason, David Mitchell, Alexandra C. Cheerva, Anita Lawitschka, Shima Azadpour, Elena Ostroumov, Peter Subrt, Anat Halevy, Sara Mostafavi, Geoffrey D. E. Cuvelier
Journal: Blood
Blood (2020) 135 (15): 1287–1298.
https://doi.org/10.1182/blood.2019003186
Published: 2020
Includes: Supplemental data
Journal Articles

Safety, Efficacy, and PK of the BCL2 Inhibitor Venetoclax in Combination with Chemotherapy in Pediatric and Young Adult Patients with Relapsed/Refractory Acute Myeloid Leukemia and Acute Lymphoblastic Leukemia: Phase 1 Study

Seth E Karol, MD, Todd M Cooper, DO, Henrique Bittencourt, Lia Gore, MD, Maureen M O'Brien, MD, Christopher Fraser, MD, Marion Gambart, MD, Gunnar Cario, MD PhD, Christian Michel Zwaan, MD PhD, Jean-Pierre Bourquin, MD PhD, Mignon L. Loh, MD, Hubert Caron, MD PhD, Betty Prine, Ahmed Hamed Salem, PhD FCP, Kristina Unnebrink, Bo Tong, PhD, Tammy Palenski, PhD, Andrew E. Place, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2649.
https://doi.org/10.1182/blood-2019-129805
Published: 2019
Journal Articles

Impact of Modifying Conditioning and Immunosuppressive Strategies in Allogeneic Hematopoietic Stem Cell Transplantation in Children with Acute Lymphoblastic Leukemia

Nawar Dakhallah, MD, Mylène Beauchemin, Johanne Richer, Sonia Cellot, MD PhD, Pierre Teira, MD, Michel Duval, MD, Henrique Bittencourt
Journal: Blood
Blood (2019) 134 (Supplement_1): 5714.
https://doi.org/10.1182/blood-2019-122988
Published: 2019
Journal Articles

Benefits and challenges with diagnosing chronic and late acute GVHD in children using the NIH consensus criteria

CME
Geoffrey D. E. Cuvelier, Eneida R. Nemecek, Justin T. Wahlstrom, Carrie L. Kitko, Victor A. Lewis, Tal Schechter, David A. Jacobsohn, Andrew C. Harris, Michael A. Pulsipher, Henrique Bittencourt, Sung Won Choi, Emi H. Caywood, Kimberly A. Kasow, Monica Bhatia, Benjamin R. Oshrine, Allyson Flower, Sonali Chaudhury, Donald Coulter, Joseph H. Chewning, Michael Joyce, Süreyya Savaşan, Anna B. Pawlowska, Gail C. Megason, David Mitchell, Alexandra C. Cheerva, Anita Lawitschka, Lori J. West, Bo Pan, Yazid N. Al Hamarneh, Anat Halevy, Kirk R. Schultz
Journal: Blood
Blood (2019) 134 (3): 304–316.
https://doi.org/10.1182/blood.2019000216
Published: 2019
Includes: Supplemental data
Journal Articles

Comparison of the Transcriptomic Signature of Pediatric Vs. Adult CML and Normal Bone Marrow Stem Cells

Hee-Don Chae, PhD, Lara C. Murphy, MD, Michele Donato, PhD, Alex G. Lee, PhD, E. Alejandro Sweet-Cordero, MD PhD, Parveen Abidi, PhD, Henrique Bittencourt, MD PhD, Norman J. Lacayo, MD, Gary Van Houten Dahl, MD, Catherine Aftandilian, MD, Kara L. Davis, DO, Min Huang, PhD, Nathan Sumarsono, BS, Michele Redell, MD PhD, Cecilia H. Fu, MD, I-Ming L. Chen, DVM, MS, Todd A Alonzo, PhD, Elizabeth A. Eklund, MD, Jason R. Gotlib, MD MS, Purvesh Khatri, PhD, Nobuko Hijiya, MD, Kathleen M. Sakamoto, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 4246.
https://doi.org/10.1182/blood-2018-99-119974
Published: 2018
Journal Articles

Updated Analysis of the Efficacy and Safety of Tisagenlecleucel in Pediatric and Young Adult Patients with Relapsed/Refractory (r/r) Acute Lymphoblastic Leukemia

Stephan A. Grupp, MD PhD, Shannon L. Maude, MD PhD, Susana Rives, MD PhD, Andre Baruchel, MD, Michael W. Boyer, MD, Henrique Bittencourt, MD PhD, Peter Bader, MD PhD, Jochen Büchner, MDPhD, Theodore W. Laetsch, MD, Heather Stefanski, MDPhD, Gary Douglas Myers, MD, Muna Qayed, MD MSc, Michael A. Pulsipher, MD, Barbara De Moerloose, MD PhD, Gregory A. Yanik, MD, Kara L. Davis, DO, Paul L. Martin, MD PhD, Eneida R. Nemecek, MD, Christina Peters, MD, Joerg Krueger, MD, Adriana Balduzzi, MD, Nicolas Boissel, MD PhD, Francoise Marie Mechinaud, MD FRACP, Mimi Leung, Lamis K. Eldjerou, MD, Lan Yi, PhD, Karen Thudium Mueller, PharmD,MSc, Eric Bleickardt, MD, Hidefumi Hiramatsu, MD, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 895.
https://doi.org/10.1182/blood-2018-99-112599
Published: 2018
Journal Articles

A phase 1 study of azacitidine combined with chemotherapy in childhood leukemia: a report from the TACL consortium

Clinical Trials & Observations
Weili Sun, Timothy Triche, Jr, Jemily Malvar, Paul Gaynon, Richard Sposto, Xiaojing Yang, Henrique Bittencourt, Andrew E. Place, Yoav Messinger, Chris Fraser, Luciano Dalla-Pozza, Bodour Salhia, Peter Jones, Alan S. Wayne, Lia Gore, Todd M. Cooper, Gangning Liang
Journal: Blood
Blood (2018) 131 (10): 1145–1148.
https://doi.org/10.1182/blood-2017-09-803809
Published: 2018
Includes: Supplemental data