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Journal Articles

Dynamics of Overall and Organ-Specific Responses to Axatilimab in Chronic Graft-Versus-Host Disease: Analysis from the Agave-201 Study

Hannah Choe, Amandeep Salhotra, Nosha Farhadfar, Mi Kwon, Britnie Thomas, Vedran Radojcic, Chuan Tian, Shuyuan Lou, Daniel Wolff, Stephanie J. Lee

Blood (2024) 144 (Supplement 1): 98.

https://doi.org/10.1182/blood-2024-209965

Published: 2024

Journal Articles

Safety and Efficacy of Axatilimab at 3 Different Doses in Patients with Chronic Graft-Versus-Host Disease (AGAVE-201)

Blood (2023) 142 (Supplement 1): 1.

https://doi.org/10.1182/blood-2023-186963

Published: 2023

Journal Articles

Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning

Shannon R. McCurdy, Vedran Radojcic, Hua-Ling Tsai, Ante Vulic, Elizabeth Thompson, Sanja Ivcevic, Christopher G. Kanakry, Jonathan D. Powell, Brian Lohman, Djamilatou Adom, Sophie Paczesny, Kenneth R. Cooke, Richard J. Jones, Ravi Varadhan, Heather J. Symons, Leo Luznik

Blood (2022) 139 (4): 608–623.

https://doi.org/10.1182/blood.2021013054

Published: 2022

Includes: Supplemental data

Journal Articles

Safety, Tolerability, and Efficacy of Axatilimab, a CSF-1R Humanized Antibody, for Chronic Graft-Versus-Host Disease after 2 or More Lines of Systemic Treatment

Stephanie J. Lee, Mukta Arora, Zachariah Defilipp, Mohammad Issam Abu Zaid, Antonio Di Stasi, Vedran Radojcic, Michael L. Meyers, Hope Qamoos, Peter Ordentlich, Christine Quaranto, Aaron Schmitt, Yu Gu, Amandeep Salhotra, Iskra Pusic, Carrie Lynn Kitko

Blood (2021) 138 (Supplement 1): 263.

https://doi.org/10.1182/blood-2021-146050

Published: 2021

Journal Articles

Transcriptomic Features of Immune Exhaustion and Senescence Predict Outcomes and Define Checkpoint Blockade-Unresponsive Microenvironments in Acute Myeloid Leukemia

Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung On Yau, Rupkatha Mukhopadhyay, Heidi Altmann, Michael Kramer, Hanna A. Knaus, Joshua F. Zeidner, Vedran Radojcic, Andrea Arruda, Mark D. Minden, Sarah K Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik

Blood (2021) 138 (Supplement 1): 223.

https://doi.org/10.1182/blood-2021-145854

Published: 2021

Journal Articles

BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation

Wei Jia, Jonathan C. Poe, Hsuan Su, Sarah Anand, Glenn K. Matsushima, Jeffrey C. Rathmell, Ivan Maillard, Vedran Radojcic, Kazuhiro Imai, Nancy J. Reyes, Diana M. Cardona, Zhiguo Li, Amy N. Suthers, Itaevia M. Curry-Chisolm, Rachel A. DiCioccio, Daniel R. Saban, Benny J. Chen, Nelson J. Chao, Stefanie Sarantopoulos

Blood (2021) 137 (18): 2544–2557.

https://doi.org/10.1182/blood.2020008040

Published: 2021

Includes: Supplemental data

Journal Articles

PTCY keeps on giving!

Vedran Radojcic, Leo Luznik

Blood (2019) 134 (11): 848–849.

https://doi.org/10.1182/blood.2019002284

Published: 2019

Journal Articles

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice

Vedran Radojcic, Katelyn Paz, Jooho Chung, Jing Du, Eric T. Perkey, Ryan Flynn, Sanja Ivcevic, Michael Zaiken, Ann Friedman, Minhong Yan, Maria A. Pletneva, Stefanie Sarantopoulos, Christian W. Siebel, Bruce R. Blazar, Ivan Maillard

Blood (2018) 132 (20): 2188–2200.

https://doi.org/10.1182/blood-2018-03-841155

Published: 2018

Includes: Supplemental data

Journal Articles

Notching up B-cell pathology in chronic GVHD

Vedran Radojcic, Leo Luznik

Blood (2017) 130 (19): 2053–2054.

https://doi.org/10.1182/blood-2017-09-805366

Published: 2017

Journal Articles

Therapeutic Outcomes of Patients with Acute Erythroid Leukemia Treated with Hypomethylating Agents

Richard King, MD, Ashley Crouch, B.S., Vedran Radojcic, MD, Bernard Lawrence Marini, PharmD, Anthony J. Perissinotti, PharmD, Dale L. Bixby, MD PhD

Blood (2016) 128 (22): 5203.

https://doi.org/10.1182/blood.V128.22.5203.5203

Published: 2016

Journal Articles

Notch Signaling Mediated By Dll1/4 Notch Ligands Controls the Pathogenesis of Both Multi-Organ System Non-Sclerodermatous and Sclerodermatous Chronic Graft-Versus-Host Disease

Vedran Radojcic, MD, Ryan P Flynn, PhD, Jooho Chung, BS, Jing Du, Eric Perkey, BS, Katelyn Paz, Michael Zaiken, Ann Friedman, Minhong Yan, PhD, Christian W. Siebel, PhD, Bruce R. Blazar, MD, Ivan Maillard, MD PhD

Blood (2016) 128 (22): 805.

https://doi.org/10.1182/blood.V128.22.805.805

Published: 2016

Journal Articles

Phase 1 Study of Carfilzomib for the Prevention of Relapse and Graft-Versus-Host Disease in Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies

Attaphol Pawarode, MD, Steven Goldstein, MD, Daniel R. Couriel, MD, Thomas Braun, PhD, John M. Magenau, MD, Mary Mansour Riwes, DO, Brian Parkin, Vedran Radojcic, MD, David Frame, PharmD, Sung Choi, MD, James Connelly, MD, John E. Levine, MD MS, Gregory A. Yanik, MD, Pavan Reddy, MD

Blood (2015) 126 (23): 1907.

https://doi.org/10.1182/blood.V126.23.1907.1907

Published: 2015

Journal Articles

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

Jooho Chung, BS, Christen L. Ebens, MDMPH, Vedran Radojcic, MD, Ute Koch, PhD, Ann Friedman, BS, Ivy T. Tran, BS, Qian Chai, PhD, Lucas Onder, PhD, Minhong Yan, PhD, Pavan Reddy, MD, Bruce R. Blazar, MD, Burkhard Ludewig, PhD, Christian W. Siebel, PhD, Freddy Radtke, PhD, Ivan Maillard, MD PhD

Blood (2014) 124 (21): 841.

https://doi.org/10.1182/blood.V124.21.841.841

Published: 2014

Journal Articles

In Vivo Blockade of Individual Notch Ligands and Receptors Provides a New Targeted Therapeutic Approach In Graft-Versus-Host Disease

Ivy T Tran, BS, Ashley R Sandy, BS, Alexis Carulli, BS, Gloria T Shan, BS, Vedran Radojcic, MD, Ann Friedman, BS, Amy Shelton, Linda C Samuelson, PhD, Minhong Yan, PhD, Christian W Siebel, PhD, Ivan Maillard, MD, PhD

Blood (2011) 118 (21): 819.

https://doi.org/10.1182/blood.V118.21.819.819

Published: 2011

Journal Articles

Notch signaling is a critical regulator of allogeneic CD4 + T-cell responses mediating graft-versus-host disease

Yi Zhang, Ashley R. Sandy, Jina Wang, Vedran Radojcic, Gloria T. Shan, Ivy T. Tran, Ann Friedman, Koji Kato, Shan He, Shuaiying Cui, Elizabeth Hexner, Dale M. Frank, Stephen G. Emerson, Warren S. Pear, Ivan Maillard

Blood (2011) 117 (1): 299–308.

https://doi.org/10.1182/blood-2010-03-271940

Published: 2011

Includes: Supplemental data

Journal Articles

Critical Role of CD4+Foxp3+ T Cells In Gvhd Prevention with High-Dose Posttransplant Cyclophosphamide (Cy).

Sudipto Ganguly, PhD, Ephraim Fuchs, MD, Vedran Radojcic, MD, Leo Luznik, MD

Blood (2010) 116 (21): 3749.

https://doi.org/10.1182/blood.V116.21.3749.3749

Published: 2010

Journal Articles

STAT3 Signaling in Donor-Derived CD4 + T-Cells Plays a Critical Role in the Induction of Acute and Chronic GVHD in Murine Models of alloBMT.

Vedran Radojcic, MD, Maria A. Pletneva, BSc, Hung-Rong Yen, MD, Timothy J. Harris, Bsc, Drew M. Pardoll, MD, PhD, Charles G. Drake, MD, PhD, Leo Luznik, MD

Blood (2007) 110 (11): 2179.

https://doi.org/10.1182/blood.V110.11.2179.2179

Published: 2007

Journal Articles

Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse

Nadira Durakovic, Vedran Radojcic, Mario Skarica, Karl B. Bezak, Jonathan D. Powell, Ephraim J. Fuchs, Leo Luznik

Blood (2007) 109 (10): 4564–4574.

https://doi.org/10.1182/blood-2006-09-048124

Published: 2007

Includes: Supplemental data

NARROW

Dynamics of Overall and Organ-Specific Responses to Axatilimab in Chronic Graft-Versus-Host Disease: Analysis from the Agave-201 Study

Safety and Efficacy of Axatilimab at 3 Different Doses in Patients with Chronic Graft-Versus-Host Disease (AGAVE-201)

Signatures of GVHD and relapse after posttransplant cyclophosphamide revealed by immune profiling and machine learning

Safety, Tolerability, and Efficacy of Axatilimab, a CSF-1R Humanized Antibody, for Chronic Graft-Versus-Host Disease after 2 or More Lines of Systemic Treatment

Transcriptomic Features of Immune Exhaustion and Senescence Predict Outcomes and Define Checkpoint Blockade-Unresponsive Microenvironments in Acute Myeloid Leukemia

BAFF promotes heightened BCR responsiveness and manifestations of chronic GVHD after allogeneic stem cell transplantation

PTCY keeps on giving!

Notch signaling mediated by Delta-like ligands 1 and 4 controls the pathogenesis of chronic GVHD in mice

Notching up B-cell pathology in chronic GVHD

Therapeutic Outcomes of Patients with Acute Erythroid Leukemia Treated with Hypomethylating Agents

Notch Signaling Mediated By Dll1/4 Notch Ligands Controls the Pathogenesis of Both Multi-Organ System Non-Sclerodermatous and Sclerodermatous Chronic Graft-Versus-Host Disease

Phase 1 Study of Carfilzomib for the Prevention of Relapse and Graft-Versus-Host Disease in Allogeneic Hematopoietic Cell Transplantation for High-Risk Hematologic Malignancies

Delta-like Ligands Expressed By Stromal Cells in Secondary Lymphoid Organs Deliver an Early Pulse of Notch Signaling and Drive T Cell Pathogenicity in Acute Graft-Versus-Host Disease

In Vivo Blockade of Individual Notch Ligands and Receptors Provides a New Targeted Therapeutic Approach In Graft-Versus-Host Disease

Notch signaling is a critical regulator of allogeneic CD4 + T-cell responses mediating graft-versus-host disease

Critical Role of CD4+Foxp3+ T Cells In Gvhd Prevention with High-Dose Posttransplant Cyclophosphamide (Cy).

STAT3 Signaling in Donor-Derived CD4 + T-Cells Plays a Critical Role in the Induction of Acute and Chronic GVHD in Murine Models of alloBMT.

Factors governing the activation of adoptively transferred donor T cells infused after allogeneic bone marrow transplantation in the mouse

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American Society of Hematology

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American Society of Hematology

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