Page 1 | Search Results | Blood | American Society of Hematology

1-20 of 61

Sort by

Sort Order Select

Journal Articles

Trib1 Inhibition Promotes the Klr Effector State and Augments Checkpoint Blockade to Enhance T Cell Function during T Cell Exhaustion

Susan E. McClory, Oishi Bardhan, Kelly S. Rome, Lanwei Xu, Phyllis A. Gimotty, Martha S. Jordan, Warren S. Pear

Blood (2022) 140 (Supplement 1): 5492–5493.

https://doi.org/10.1182/blood-2022-165346

Published: 2022

Journal Articles

Stromal Notch Ligands Drive Notch2-Dependent Transdifferentiation of Follicular B Cells into Marginal Zone-like B Cells in Lymphopenic Environments

Daniela Gómez Atria, PhD, Brian T. Gaudette, PhD, Eric Perkey, BS, Jennifer Londregan, BS, Samantha Kelly, BS, Burkhard Ludewig, PhD, Chris Siebel, PhD BA, Russell J. H. Ryan, MD, Warren S. Pear, MDPhD, David Allman, PhD, Ivan Maillard, MDPhD

Blood (2020) 136 (Supplement 1): 38–39.

https://doi.org/10.1182/blood-2020-142474

Published: 2020

Journal Articles

Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program

Ethan A. Mack, Sarah J. Stein, Kelly S. Rome, Lanwei Xu, Gerald B. Wertheim, Rossana C. N. Melo, Warren S. Pear

Blood (2019) 133 (22): 2413–2426.

https://doi.org/10.1182/blood.2018872218

Published: 2019

Includes: Supplemental data

Journal Articles

Can genetics resolve what Notch does in HSCs?

Ivan Maillard, Warren S. Pear

Blood (2018) 131 (15): 1633–1635.

https://doi.org/10.1182/blood-2018-02-829069

Published: 2018

Journal Articles

Downregulating Notch Counteracts Kras G12D -Induced ERK Activation and Oxidative Phosphorylation in Myeloproliferative Neoplasm

Guangyao Kong, PhD, Yuan-I Chang, PhD, Jingfang Zhang, PhD, Erik A. Ranheim, MD, Xinmin Zhang, Yun Zhou, Yangang Liu, Lan Zhou, MD PhD, Warren S. Pear, MD PhD, Jing Zhang, PhD

Blood (2016) 128 (22): 1565.

https://doi.org/10.1182/blood.V128.22.1565.1565

Published: 2016

Journal Articles

Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling

Russell J.H. Ryan, MD, Jelena Petrovic, PhD, Dylan Rausch, BS, Caleb Lareau, BS, Winston Lee, MD PhD, Laura Donohue, BS, Amanda L. Christie, BS, Shawn Gillespie, BS, Michael J. Kluk, MD PhD, Valentina Nardi, MD, Robert B. Faryabi, PhD, Ephraim P. Hochberg, MD, David M. Weinstock, MD, Bradley E. Bernstein, MD PhD, Jon C. Aster, MD PhD, Warren S. Pear, MD PhD

Blood (2016) 128 (22): 457.

https://doi.org/10.1182/blood.V128.22.457.457

Published: 2016

Journal Articles

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia

Mark Y. Chiang, Qing Wang, Anna C. Gormley, Sarah J. Stein, Lanwei Xu, Olga Shestova, Jon C. Aster, Warren S. Pear

Blood (2016) 128 (18): 2229–2240.

https://doi.org/10.1182/blood-2016-01-692855

Published: 2016

Includes: Supplemental data

Journal Articles

Modular Domains within a Super Enhancer Determine Drug Resistance in Leukemia

Yumi Ohtani, PhD, Shuquan Xu, MSc, Jelena Petrovic, Lanwei Xu, MD, Jon C Aster, MDPhD, Warren S. Pear, MD PhD

Blood (2015) 126 (23): 44.

https://doi.org/10.1182/blood.V126.23.44.44

Published: 2015

Journal Articles

Downregulating Notch Signaling in Kras G12D/+ Mice Inhibits Both T-Cell Leukemia and Myeloproliferative Neoplasm in a Cell-Autonomous Manner

Guangyao Kong, PhD, Yuan-I Chang, PhD, Erik A. Ranheim, MD, Yun Zhou, Yangang Liu, Paul Lambert, PhD, Lan Zhou, MD PhD, Pamela Stanley, PhD, Warren S. Pear, MD PhD, Jing Zhang, PhD

Blood (2014) 124 (21): 261.

https://doi.org/10.1182/blood.V124.21.261.261

Published: 2014

Journal Articles

Alternative Super-Enhancer States Determine MYC Sensitivity to Notch and Brd4 Inhibitors in T Lymphoblastic Leukemia/Lymphoma

Hongfang Wang, PhD, Yumi Yashiro-Ohtani, PhD, Chongzhi Zang, PhD, Yinling Joey Wong, MS, Will Bailis, PhD, Birgit Knoechel, MD PhD, Bradley Bernstein, MD PhD, Steve Blacklow, MD PhD, X. Shirley Liu, PhD, Warren S. Pear, MD PhD, Jon C Aster, MD PhD

Blood (2014) 124 (21): 863.

https://doi.org/10.1182/blood.V124.21.863.863

Published: 2014

Journal Articles

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

Monique Dail, PhD, Jason Wong, Jessica Lawrence, Daniel O'Connor, Joy Nakitandwe, PhD., Shann-Ching Chen, PhD, Keiko Akagi, Leslie Lee, Jon C. Aster, MD, PhD, Warren S. Pear, MD, PhD, Deepak Sampath, PhD, James R. Downing, MD, Kevin Shannon, MD

Blood (2013) 122 (21): 2677.

https://doi.org/10.1182/blood.V122.21.2677.2677

Published: 2013

Journal Articles

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

Mark Y. Chiang, Olga Shestova, Lanwei Xu, Jon C. Aster, Warren S. Pear

Blood (2013) 121 (6): 905–917.

https://doi.org/10.1182/blood-2012-03-416503

Published: 2013

Includes: Supplemental data

Journal Articles

Genome-Wide Analysis of NOTCH1, ETS Family Factors, and RUNX1 Binding in Human T Lymphoblastic Leukemia Cells Reveals Distinct Regulatory Elements

Hongfang Wang, PhD, Chongzhi Zang, Ph.D, Len Taing, Hoifung Wong, Yumi Yashiro-Ohtani, Ph.D., Stephen Blacklow, MD. PhD., Warren S. Pear, MD, PhD, X. Shirley Liu, Ph.D, Jon C Aster, MD, PhD

Blood (2012) 120 (21): 1277.

https://doi.org/10.1182/blood.V120.21.1277.1277

Published: 2012

Journal Articles

Notch and PI3K: how is the road traveled?

Will Bailis, Warren S. Pear

Blood (2012) 120 (7): 1349–1350.

https://doi.org/10.1182/blood-2012-06-435099

Published: 2012

Journal Articles

Genome-Wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells

Jon C Aster, MD, PhD, Hongfang Wang, Ph.D., James Zou, Yumi Yashiro-Ohtani, Ph.D., Bo Zhao, Ph.D., Eric Johannsen, MD, Jonathan Schug, Ph.D., Stephen C. Blacklow, MD, PhD, Elliott Kieff, MD, PhD, Warren S. Pear, MD, PhD

Blood (2011) 118 (21): 5236.

https://doi.org/10.1182/blood.V118.21.5236.5236

Published: 2011

Journal Articles

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Giovanni Roti, MD.Ph.D, Annie Carlton, B.S., Kenneth N. Ross, Ph.D, Michele Markstein, Ph.D, Kostandin Pajcini, Ph.D, Norbert Perrimon, Ph.D, Andrew L. Kung, MD, PhD, Warren S. Pear, MD, PhD, Stephen C. Blacklow, MD, PhD, Jon C Aster, MD, PhD, Kimberly Stegmaier, MD

Blood (2011) 118 (21): 555.

https://doi.org/10.1182/blood.V118.21.555.555

Published: 2011

Journal Articles

Identification of Flt3 + CD150 − myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential

Anthony W. S. Chi, Alejandro Chavez, Lanwei Xu, Brittany N. Weber, Olga Shestova, Andras Schaffer, Gerald Wertheim, Warren S. Pear, David Izon, Avinash Bhandoola

Blood (2011) 118 (10): 2723–2732.

https://doi.org/10.1182/blood-2010-09-309989

Published: 2011

Includes: Supplemental data

Journal Articles

Notch signaling is a critical regulator of allogeneic CD4 + T-cell responses mediating graft-versus-host disease

Yi Zhang, Ashley R. Sandy, Jina Wang, Vedran Radojcic, Gloria T. Shan, Ivy T. Tran, Ann Friedman, Koji Kato, Shan He, Shuaiying Cui, Elizabeth Hexner, Dale M. Frank, Stephen G. Emerson, Warren S. Pear, Ivan Maillard

Blood (2011) 117 (1): 299–308.

https://doi.org/10.1182/blood-2010-03-271940

Published: 2011

Includes: Supplemental data

Journal Articles

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

Todd D. Ashworth, Warren S. Pear, Mark Y. Chiang, Stephen C. Blacklow, Jérôme Mastio, Lanwei Xu, Michelle Kelliher, Philippe Kastner, Susan Chan, Jon C. Aster

Blood (2010) 116 (25): 5455–5464.

https://doi.org/10.1182/blood-2010-05-286328

Published: 2010

Includes: Supplemental data

Journal Articles

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

Karen Keeshan, Will Bailis, Priya H. Dedhia, Maria E. Vega, Olga Shestova, Lanwei Xu, Kristin Toscano, Sacha N. Uljon, Stephen C. Blacklow, Warren S. Pear

Blood (2010) 116 (23): 4948–4957.

https://doi.org/10.1182/blood-2009-10-247361

Published: 2010

Includes: Supplemental data

NARROW

Trib1 Inhibition Promotes the Klr Effector State and Augments Checkpoint Blockade to Enhance T Cell Function during T Cell Exhaustion

Stromal Notch Ligands Drive Notch2-Dependent Transdifferentiation of Follicular B Cells into Marginal Zone-like B Cells in Lymphopenic Environments

Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program

Can genetics resolve what Notch does in HSCs?

Downregulating Notch Counteracts Kras G12D -Induced ERK Activation and Oxidative Phosphorylation in Myeloproliferative Neoplasm

Notch-Regulated Enhancers in B-Cell Lymphoma Activate MYC and Potentiate B-Cell Receptor Signaling

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia

Modular Domains within a Super Enhancer Determine Drug Resistance in Leukemia

Downregulating Notch Signaling in Kras G12D/+ Mice Inhibits Both T-Cell Leukemia and Myeloproliferative Neoplasm in a Cell-Autonomous Manner

Alternative Super-Enhancer States Determine MYC Sensitivity to Notch and Brd4 Inhibitors in T Lymphoblastic Leukemia/Lymphoma

Preclinical Testing Of a PI3K Inhibitor In T Lineage Leukemia: Target Validation and Notch1/Myc Down-Regulation In Drug Resistant Clones

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

Genome-Wide Analysis of NOTCH1, ETS Family Factors, and RUNX1 Binding in Human T Lymphoblastic Leukemia Cells Reveals Distinct Regulatory Elements

Notch and PI3K: how is the road traveled?

Genome-Wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Identification of Flt3 + CD150 − myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential

Notch signaling is a critical regulator of allogeneic CD4 + T-cell responses mediating graft-versus-host disease

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

Email alerts

ASH Publications

American Society of Hematology

Email alerts

ASH Publications

American Society of Hematology

This Feature Is Available To Subscribers Only