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Journal Articles

Trib1 Inhibition Promotes the Klr Effector State and Augments Checkpoint Blockade to Enhance T Cell Function during T Cell Exhaustion

Susan E. McClory, Oishi Bardhan, Kelly S. Rome, Lanwei Xu, Phyllis A. Gimotty, Martha S. Jordan, Warren S. Pear

Blood (2022) 140 (Supplement 1): 5492–5493.

https://doi.org/10.1182/blood-2022-165346

Published: 2022

Journal Articles

Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program

Ethan A. Mack, Sarah J. Stein, Kelly S. Rome, Lanwei Xu, Gerald B. Wertheim, Rossana C. N. Melo, Warren S. Pear

Blood (2019) 133 (22): 2413–2426.

https://doi.org/10.1182/blood.2018872218

Published: 2019

Includes: Supplemental data

Journal Articles

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia

Mark Y. Chiang, Qing Wang, Anna C. Gormley, Sarah J. Stein, Lanwei Xu, Olga Shestova, Jon C. Aster, Warren S. Pear

Blood (2016) 128 (18): 2229–2240.

https://doi.org/10.1182/blood-2016-01-692855

Published: 2016

Includes: Supplemental data

Journal Articles

Modular Domains within a Super Enhancer Determine Drug Resistance in Leukemia

Yumi Ohtani, PhD, Shuquan Xu, MSc, Jelena Petrovic, Lanwei Xu, MD, Jon C Aster, MDPhD, Warren S. Pear, MD PhD

Blood (2015) 126 (23): 44.

https://doi.org/10.1182/blood.V126.23.44.44

Published: 2015

Journal Articles

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

Mark Y. Chiang, Olga Shestova, Lanwei Xu, Jon C. Aster, Warren S. Pear

Blood (2013) 121 (6): 905–917.

https://doi.org/10.1182/blood-2012-03-416503

Published: 2013

Includes: Supplemental data

Journal Articles

Identification of Flt3 + CD150 − myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential

Anthony W. S. Chi, Alejandro Chavez, Lanwei Xu, Brittany N. Weber, Olga Shestova, Andras Schaffer, Gerald Wertheim, Warren S. Pear, David Izon, Avinash Bhandoola

Blood (2011) 118 (10): 2723–2732.

https://doi.org/10.1182/blood-2010-09-309989

Published: 2011

Includes: Supplemental data

Journal Articles

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

Todd D. Ashworth, Warren S. Pear, Mark Y. Chiang, Stephen C. Blacklow, Jérôme Mastio, Lanwei Xu, Michelle Kelliher, Philippe Kastner, Susan Chan, Jon C. Aster

Blood (2010) 116 (25): 5455–5464.

https://doi.org/10.1182/blood-2010-05-286328

Published: 2010

Includes: Supplemental data

Journal Articles

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

Karen Keeshan, Will Bailis, Priya H. Dedhia, Maria E. Vega, Olga Shestova, Lanwei Xu, Kristin Toscano, Sacha N. Uljon, Stephen C. Blacklow, Warren S. Pear

Blood (2010) 116 (23): 4948–4957.

https://doi.org/10.1182/blood-2009-10-247361

Published: 2010

Includes: Supplemental data

Journal Articles

Critical Functions for Notch Dimerization In T Cell Transformation.

Hudan Liu, Ph.D., Anthony Chi, Kelly Arnett, Ph.D., Mark Chiang, MD, PhD, Lanwei Xu, M.D., Olga Shestova, Ph.D., Hongfang Wang, Ph.D., Avinash Bhandoola, M.D., Ph.D., Jon C Aster, MD, PhD, Stephen C. Blacklow, MD, PhD, Warren S. Pear, MD, PhD

Blood (2010) 116 (21): 3647.

https://doi.org/10.1182/blood.V116.21.3647.3647

Published: 2010

Journal Articles

Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia

Priya H. Dedhia, Karen Keeshan, Sacha Uljon, Lanwei Xu, Maria E. Vega, Olga Shestova, Meirav Zaks-Zilberman, Candice Romany, Stephen C. Blacklow, Warren S. Pear

Blood (2010) 116 (8): 1321–1328.

https://doi.org/10.1182/blood-2009-07-229450

Published: 2010

Includes: Supplemental data

Journal Articles

Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia

Priya Dedhia, Karen Keeshan, Maria Vega, Sacha Uljon, M.D., Ph.D., Lanwei Xu, Olga Shestova, Candice Romany, Stephen C Blacklow, M.D., Ph.D., Warren S. Pear, MD, PhD

Blood (2008) 112 (11): 2950.

https://doi.org/10.1182/blood.V112.11.2950.2950

Published: 2008

Journal Articles

Tribbles Homolog 2 (Trib2) Inactivates C/EBPalpha and Causes Acute Myelogenous Leukemia.

Karen Keeshan, PhD, Yiping He, PhD, Bas J. Wouters, Olga Shestova, Lanwei Xu, Hong Sai, Carlos G. Rodriguez, Ivan Maillard, Peter Valk, Martin Carroll, Jon C. Aster, Rudd Delwel, Warren S. Pear

Blood (2006) 108 (11): 776.

https://doi.org/10.1182/blood.V108.11.776.776

Published: 2006

Journal Articles

Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation

Ivan Maillard, Benjamin A. Schwarz, Arivazhagan Sambandam, Terry Fang, Olga Shestova, Lanwei Xu, Avinash Bhandoola, Warren S. Pear

Blood (2006) 107 (9): 3511–3519.

https://doi.org/10.1182/blood-2005-08-3454

Published: 2006

Journal Articles

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

Patrick A. Zweidler-McKay, Yiping He, Lanwei Xu, Carlos G. Rodriguez, Fredrick G. Karnell, Andrea C. Carpenter, Jon C. Aster, David Allman, Warren S. Pear

Blood (2005) 106 (12): 3898–3906.

https://doi.org/10.1182/blood-2005-01-0355

Published: 2005

Journal Articles

Intrathymic and Extrathymic Notch-Dependent T Lineage Checkpoints during Normal Development and after Bone Marrow Transplantation.

Ivan Maillard, MDPhD, Arivazhagan Sambandan, PhD, Valerie P. Zediak, Benjamin Schwarz, Lanwei Xu, MD, Jon C. Aster, MDPhD, Warren S. Pear, MDPhD, Avinash Bhandoola, MDPhD

Blood (2004) 104 (11): 1190.

https://doi.org/10.1182/blood.V104.11.1190.1190

Published: 2004

Journal Articles

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions

Ivan Maillard, Andrew P. Weng, Andrea C. Carpenter, Carlos G. Rodriguez, Hong Sai, Lanwei Xu, David Allman, Jon C. Aster, Warren S. Pear

Blood (2004) 104 (6): 1696–1702.

https://doi.org/10.1182/blood-2004-02-0514

Published: 2004

Journal Articles

The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia–like disease by bcr/abl

Yiping He, Jason A. Wertheim, Lanwei Xu, Juli P. Miller, Fredrick G. Karnell, John K. Choi, Ruibao Ren, Warren S. Pear

Blood (2002) 99 (8): 2957–2968.

https://doi.org/10.1182/blood.V99.8.2957

Published: 2002

Journal Articles

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

Warren S. Pear, Juli P. Miller, Lanwei Xu, John C. Pui, Benny Soffer, Robert C. Quackenbush, Ann Marie Pendergast, Roderick Bronson, Jon C. Aster, Martin L. Scott, David Baltimore

Blood (1998) 92 (10): 3780–3792.

https://doi.org/10.1182/blood.V92.10.3780

Published: 1998

NARROW

Trib1 Inhibition Promotes the Klr Effector State and Augments Checkpoint Blockade to Enhance T Cell Function during T Cell Exhaustion

Trib1 regulates eosinophil lineage commitment and identity by restraining the neutrophil program

High selective pressure for Notch1 mutations that induce Myc in T-cell acute lymphoblastic leukemia

Modular Domains within a Super Enhancer Determine Drug Resistance in Leukemia

Divergent effects of supraphysiologic Notch signals on leukemia stem cells and hematopoietic stem cells

Identification of Flt3 + CD150 − myeloid progenitors in adult mouse bone marrow that harbor T lymphoid developmental potential

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

Critical Functions for Notch Dimerization In T Cell Transformation.

Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia

Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia

Tribbles Homolog 2 (Trib2) Inactivates C/EBPalpha and Causes Acute Myelogenous Leukemia.

Notch-dependent T-lineage commitment occurs at extrathymic sites following bone marrow transplantation

Notch signaling is a potent inducer of growth arrest and apoptosis in a wide range of B-cell malignancies

Intrathymic and Extrathymic Notch-Dependent T Lineage Checkpoints during Normal Development and after Bone Marrow Transplantation.

Mastermind critically regulates Notch-mediated lymphoid cell fate decisions

The coiled-coil domain and Tyr177 of bcr are required to induce a murine chronic myelogenous leukemia–like disease by bcr/abl

Efficient and Rapid Induction of a Chronic Myelogenous Leukemia-Like Myeloproliferative Disease in Mice Receiving P210 bcr/abl-Transduced Bone Marrow

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American Society of Hematology

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American Society of Hematology

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