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Journal Articles

Genome-Wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells

Jon C Aster, MD, PhD, Hongfang Wang, Ph.D., James Zou, Yumi Yashiro-Ohtani, Ph.D., Bo Zhao, Ph.D., Eric Johannsen, MD, Jonathan Schug, Ph.D., Stephen C. Blacklow, MD, PhD, Elliott Kieff, MD, PhD, Warren S. Pear, MD, PhD

Blood (2011) 118 (21): 5236.

https://doi.org/10.1182/blood.V118.21.5236.5236

Published: 2011

Journal Articles

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Giovanni Roti, MD.Ph.D, Annie Carlton, B.S., Kenneth N. Ross, Ph.D, Michele Markstein, Ph.D, Kostandin Pajcini, Ph.D, Norbert Perrimon, Ph.D, Andrew L. Kung, MD, PhD, Warren S. Pear, MD, PhD, Stephen C. Blacklow, MD, PhD, Jon C Aster, MD, PhD, Kimberly Stegmaier, MD

Blood (2011) 118 (21): 555.

https://doi.org/10.1182/blood.V118.21.555.555

Published: 2011

Journal Articles

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

Todd D. Ashworth, Warren S. Pear, Mark Y. Chiang, Stephen C. Blacklow, Jérôme Mastio, Lanwei Xu, Michelle Kelliher, Philippe Kastner, Susan Chan, Jon C. Aster

Blood (2010) 116 (25): 5455–5464.

https://doi.org/10.1182/blood-2010-05-286328

Published: 2010

Includes: Supplemental data

Journal Articles

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

Karen Keeshan, Will Bailis, Priya H. Dedhia, Maria E. Vega, Olga Shestova, Lanwei Xu, Kristin Toscano, Sacha N. Uljon, Stephen C. Blacklow, Warren S. Pear

Blood (2010) 116 (23): 4948–4957.

https://doi.org/10.1182/blood-2009-10-247361

Published: 2010

Includes: Supplemental data

Journal Articles

Critical Functions for Notch Dimerization In T Cell Transformation.

Hudan Liu, Ph.D., Anthony Chi, Kelly Arnett, Ph.D., Mark Chiang, MD, PhD, Lanwei Xu, M.D., Olga Shestova, Ph.D., Hongfang Wang, Ph.D., Avinash Bhandoola, M.D., Ph.D., Jon C Aster, MD, PhD, Stephen C. Blacklow, MD, PhD, Warren S. Pear, MD, PhD

Blood (2010) 116 (21): 3647.

https://doi.org/10.1182/blood.V116.21.3647.3647

Published: 2010

Journal Articles

Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia

Priya H. Dedhia, Karen Keeshan, Sacha Uljon, Lanwei Xu, Maria E. Vega, Olga Shestova, Meirav Zaks-Zilberman, Candice Romany, Stephen C. Blacklow, Warren S. Pear

Blood (2010) 116 (8): 1321–1328.

https://doi.org/10.1182/blood-2009-07-229450

Published: 2010

Includes: Supplemental data

Journal Articles

Expression-Based Screen Identifies the Calcium Channel Antagonist Bepridil as a Notch1 Modulator in T-ALL.

Giovanni Roti, MD, Kenneth N. Ross, PhD, Adolfo A. Ferrando, MD, PhD, Stephen C Blacklow, M.D., Ph.D., Jon Aster, MD, PhD, Kimberly Stegmaier, MD

Blood (2009) 114 (22): 366.

https://doi.org/10.1182/blood.V114.22.366.366

Published: 2009

Journal Articles

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

Wendy R. Gordon, Monideepa Roy, Didem Vardar-Ulu, Megan Garfinkel, Marc R. Mansour, Jon C. Aster, Stephen C. Blacklow

Blood (2009) 113 (18): 4381–4390.

https://doi.org/10.1182/blood-2008-08-174748

Published: 2009

Includes: Supplemental data

Journal Articles

Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia

Priya Dedhia, Karen Keeshan, Maria Vega, Sacha Uljon, M.D., Ph.D., Lanwei Xu, Olga Shestova, Candice Romany, Stephen C Blacklow, M.D., Ph.D., Warren S. Pear, MD, PhD

Blood (2008) 112 (11): 2950.

https://doi.org/10.1182/blood.V112.11.2950.2950

Published: 2008

Journal Articles

Structure of the Notch1 Negative Regulatory Region: Implications for Normal Activation and Pathogenic Signaling in T-ALL

Wendy Ryan Gordon, Ph.D., Mondeepa Roy, Ph.D., Didem Vardar-Ulu, Ph.D., Megan Garfinkel, Marc R Mansour, M.D., Jon C Aster, M.D., Ph.D., Stephen C Blacklow, M.D., Ph.D.

Blood (2008) 112 (11): 3798.

https://doi.org/10.1182/blood.V112.11.3798.3798

Published: 2008

Journal Articles

Functional Analysis of Leukemia-Associated Mutations Involving the Heterodimerization Domain of NOTCH1.

Cheryll Sanchez-Irizarry, Michael Malecki, Woojoong Lee, Mina Xu, Stephen C. Blacklow, MD, PhD, Jon C. Aster, MD, PhD

Blood (2005) 106 (11): 843.

https://doi.org/10.1182/blood.V106.11.843.843

Published: 2005

Journal Articles

Gain-of-Function NOTCH1 Mutations Occur Frequently in Human T Cell Acute Lymphoblastic Leukemia.

Andrew P. Weng, MD, PhD, Adolfo A. Ferrando, MD, PhD, Woojoong Lee, John P. Morris, IV, Lewis B. Silverman, MD, C Sanchez-Irizarry, Stephen C. Blacklow, MD, PhD, Thomas Look, MD, Jon C. Aster, MD, PhD

Blood (2004) 104 (11): 4.

https://doi.org/10.1182/blood.V104.11.4.4

Published: 2004

NARROW

Genome-Wide Analysis Reveals Conserved and Divergent Features of Notch1/RBPJ Binding in Human and Murine T Lymphoblastic Leukemia Cells

Intersecting High-Throughput Screens Identifies SERCA As a Target for Modulating NOTCH1 In Hematopoietic Malignancies

Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1

Transformation by Tribbles homolog 2 (Trib2) requires both the Trib2 kinase domain and COP1 binding

Critical Functions for Notch Dimerization In T Cell Transformation.

Differential ability of Tribbles family members to promote degradation of C/EBPα and induce acute myelogenous leukemia

Expression-Based Screen Identifies the Calcium Channel Antagonist Bepridil as a Notch1 Modulator in T-ALL.

Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL

Trib1 and Trib2 but Not Trib3 Degrade C/EBPá and Induce Acute Myelogenous Leukemia

Structure of the Notch1 Negative Regulatory Region: Implications for Normal Activation and Pathogenic Signaling in T-ALL

Functional Analysis of Leukemia-Associated Mutations Involving the Heterodimerization Domain of NOTCH1.

Gain-of-Function NOTCH1 Mutations Occur Frequently in Human T Cell Acute Lymphoblastic Leukemia.

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American Society of Hematology

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ASH Publications

American Society of Hematology

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