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Journal Articles

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML

Roger Mulet-Lazaro, Stanley van Herk, Claudia Erpelinck, Eric Bindels, Mathijs A. Sanders, Carlo Vermeulen, Ivo Renkens, Peter Valk, Ari M. Melnick, Jeroen de Ridder, Michael Rehli, Claudia Gebhard, Ruud Delwel, Bas J. Wouters

Blood (2021) 138 (2): 160–177.

https://doi.org/10.1182/blood.2020009244

Published: 2021

Includes: Supplemental data

Journal Articles

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells

Kimihito C. Kawabata, Hongliang Zong, Cem Meydan, Sarah Wyman, Bas J. Wouters, Mayumi Sugita, Srinjoy Goswami, Michael Albert, Winnie Yip, Gail J. Roboz, Zhengming Chen, Ruud Delwel, Martin Carroll, Christopher E. Mason, Ari Melnick, Monica L. Guzman

Blood (2021) 137 (6): 812–825.

https://doi.org/10.1182/blood.2019001745

Published: 2021

Includes: Supplemental data

Journal Articles

Hitting the target in IDH2 mutant AML

Bas J. Wouters

Blood (2017) 130 (6): 693–694.

https://doi.org/10.1182/blood-2017-06-790394

Published: 2017

Journal Articles

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

Bas J. Wouters, Ruud Delwel

Blood (2016) 127 (1): 42–52.

https://doi.org/10.1182/blood-2015-07-604512

Published: 2016

Journal Articles

Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers

Veronika Rockova, Saman Abbas, Bas J. Wouters, Claudia A. J. Erpelinck, H. Berna Beverloo, Ruud Delwel, Wim L. J. van Putten, Bob Löwenberg, Peter J. M. Valk

Blood (2011) 118 (4): 1069–1076.

https://doi.org/10.1182/blood-2011-02-334748

Published: 2011

Includes: Supplemental data

Journal Articles

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity

Erdogan Taskesen, Lars Bullinger, Andrea Corbacioglu, Mathijs A. Sanders, Claudia A. J. Erpelinck, Bas J. Wouters, Sonja C. van der Poel-van de Luytgaarde, Frederik Damm, Jürgen Krauter, Arnold Ganser, Richard F. Schlenk, Bob Löwenberg, Ruud Delwel, Hartmut Döhner, Peter J. M. Valk, Konstanze Döhner

Blood (2011) 117 (8): 2469–2475.

https://doi.org/10.1182/blood-2010-09-307280

Published: 2011

Includes: Supplemental data

Journal Articles

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status

Fernando P. G. Silva, Sigrid M. A. Swagemakers, Claudia Erpelinck-Verschueren, Bas J. Wouters, Ruud Delwel, Harry Vrieling, Peter van der Spek, Peter J. M. Valk, Micheline Giphart-Gassler

Blood (2009) 114 (14): 3001–3007.

https://doi.org/10.1182/blood-2009-03-211334

Published: 2009

Includes: Supplemental data

Journal Articles

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

Bas J. Wouters, Bob Löwenberg, Claudia A. J. Erpelinck-Verschueren, Wim L. J. van Putten, Peter J. M. Valk, Ruud Delwel

Blood (2009) 113 (13): 3088–3091.

https://doi.org/10.1182/blood-2008-09-179895

Published: 2009

Includes: Supplemental data

Journal Articles

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features

Maria E. Figueroa, Bas J. Wouters, Lucy Skrabanek, Jacob Glass, Yushan Li, Claudia A. J. Erpelinck-Verschueren, Anton W. Langerak, Bob Löwenberg, Melissa Fazzari, John M. Greally, Peter J. M. Valk, Ari Melnick, Ruud Delwel

Blood (2009) 113 (12): 2795–2804.

https://doi.org/10.1182/blood-2008-08-172387

Published: 2009

Includes: Supplemental data

Journal Articles

A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects

Bas J. Wouters, Bob Löwenberg, Ruud Delwel

Blood (2009) 113 (2): 291–298.

https://doi.org/10.1182/blood-2008-04-153239

Published: 2009

Journal Articles

Double, but Not Single, CEBPA mutations Define a Subgroup of Acute Myeloid Leukemia with Favorable Outcome and a Distinct Gene Expression Profile

Bas J. Wouters, Claudia A.J. Erpelinck-Verschueren, Bob Lowenberg, Peter J.M. Valk, Ruud Delwel

Blood (2008) 112 (11): 141.

https://doi.org/10.1182/blood.V112.11.141.141

Published: 2008

Journal Articles

Genetic vs. Epigenetic Disruption of the CEBPA Locus Yields Epigenomically and Biologically Distinct Leukemia Phenotypes.

Maria E. Figueroa, MD, Bas J. Wouters, MD, Yushan Li, Peter Valk, PhD, Bob Lowenberg, MD, PhD, Ari M. Melnick, MD, Ruud Delwel, PhD

Blood (2007) 110 (11): 2117.

https://doi.org/10.1182/blood.V110.11.2117.2117

Published: 2007

Journal Articles

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

Bas J. Wouters, Meritxell Alberich Jordà, Karen Keeshan, Irene Louwers, Claudia A. J. Erpelinck-Verschueren, Dennis Tielemans, Anton W. Langerak, Yiping He, Yumi Yashiro-Ohtani, Pu Zhang, Christopher J. Hetherington, Roel G. W. Verhaak, Peter J. M. Valk, Bob Löwenberg, Daniel G. Tenen, Warren S. Pear, Ruud Delwel

Blood (2007) 110 (10): 3706–3714.

https://doi.org/10.1182/blood-2007-02-073486

Published: 2007

Includes: Supplemental data

Journal Articles

A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling–based clustering of AML

Bas J. Wouters, Irene Louwers, Peter J. M. Valk, Bob Löwenberg, Ruud Delwel

Blood (2007) 109 (1): 389–390.

https://doi.org/10.1182/blood-2006-08-042325

Published: 2007

Journal Articles

Tribbles Homolog 2 (Trib2) Inactivates C/EBPalpha and Causes Acute Myelogenous Leukemia.

Karen Keeshan, PhD, Yiping He, PhD, Bas J. Wouters, Olga Shestova, Lanwei Xu, Hong Sai, Carlos G. Rodriguez, Ivan Maillard, Peter Valk, Martin Carroll, Jon C. Aster, Rudd Delwel, Warren S. Pear

Blood (2006) 108 (11): 776.

https://doi.org/10.1182/blood.V108.11.776.776

Published: 2006

Journal Articles

Identification of a Subgroup of Biphenotypic Myeloid/T-Cell Acute Leukemias with a CEBPA-Mutant Gene Expression Profile, Frequent CEBPA Promoter Hypermethylation and NOTCH1 Mutations.

Bas J. Wouters, MD, Irene Louwers, Claudia A.J. Erpelinck-Verschueren, Peter J.M. Valk, PhD, Dennis Tielemans, Anton W. Langerak, PhD, Daniel G. Tenen, MD PhD, Warren S. Pear, MD PhD, Bob Lowenberg, MD PhD, Ruud Delwel, PhD

Blood (2006) 108 (11): 2237.

https://doi.org/10.1182/blood.V108.11.2237.2237

Published: 2006

Journal Articles

Unique Gene Expression Profiles of AML Patients with CEBPA Mutations.

Bas J. Wouters, MD, Claudia A. Erpelinck, Peter J. Valk, PhD, Roel G. Verhaak, M.Sc, Bob Löwenberg, MD, PhD, Ruud Delwel, PhD

Blood (2005) 106 (11): 745.

https://doi.org/10.1182/blood.V106.11.745.745

Published: 2005

NARROW

Allele-specific expression of GATA2 due to epigenetic dysregulation in CEBPA double-mutant AML

BCL6 maintains survival and self-renewal of primary human acute myeloid leukemia cells

Hitting the target in IDH2 mutant AML

Epigenetics and approaches to targeted epigenetic therapy in acute myeloid leukemia

Risk stratification of intermediate-risk acute myeloid leukemia: integrative analysis of a multitude of gene mutation and gene expression markers

Prognostic impact, concurrent genetic mutations, and gene expression features of AML with CEBPA mutations in a cohort of 1182 cytogenetically normal AML patients: further evidence for CEBPA double mutant AML as a distinctive disease entity

Gene expression profiling of minimally differentiated acute myeloid leukemia: M0 is a distinct entity subdivided by RUNX1 mutation status

Double CEBPA mutations, but not single CEBPA mutations, define a subgroup of acute myeloid leukemia with a distinctive gene expression profile that is uniquely associated with a favorable outcome

Genome-wide epigenetic analysis delineates a biologically distinct immature acute leukemia with myeloid/T-lymphoid features

A decade of genome-wide gene expression profiling in acute myeloid leukemia: flashback and prospects

Double, but Not Single, CEBPA mutations Define a Subgroup of Acute Myeloid Leukemia with Favorable Outcome and a Distinct Gene Expression Profile

Genetic vs. Epigenetic Disruption of the CEBPA Locus Yields Epigenomically and Biologically Distinct Leukemia Phenotypes.

Distinct gene expression profiles of acute myeloid/T-lymphoid leukemia with silenced CEBPA and mutations in NOTCH1

A recurrent in-frame insertion in a CEBPA transactivation domain is a polymorphism rather than a mutation that does not affect gene expression profiling–based clustering of AML

Tribbles Homolog 2 (Trib2) Inactivates C/EBPalpha and Causes Acute Myelogenous Leukemia.

Identification of a Subgroup of Biphenotypic Myeloid/T-Cell Acute Leukemias with a CEBPA-Mutant Gene Expression Profile, Frequent CEBPA Promoter Hypermethylation and NOTCH1 Mutations.

Unique Gene Expression Profiles of AML Patients with CEBPA Mutations.

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American Society of Hematology

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American Society of Hematology

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