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Hanna A. Knaus
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Journal Articles

CD8+ T-cell Differentiation and Dysfunction Inform Treatment Response in Acute Myeloid Leukemia

Francesco Mazziotta, Luca Biavati, Joseph Cataquiz Rimando, Sergio Rutella, Nicholas Borcherding, Sonali Parbhoo, Rupkatha Mukhopadhyay, Hanna A. Knaus, Peter Valent, Hubert Hackl, Ivan Borrello, Bruce R Blazar, Katerina Hatzi, Ivana Gojo, Leo Luznik
Journal: Blood
Blood blood.2023021680.
https://doi.org/10.1182/blood.2023021680
Published: 2024
Includes: Supplemental data
Journal Articles

Bone Marrow GZMK + IL7R + Progenitor-Exhausted CD8 + T Cells Correlate with Sustained Clinical Remission in Patients with Acute Myeloid Leukemia (AML) Undergoing Chemotherapy

Francesco Mazziotta, Luca Biavati, Rupkatha Mukhopadhyay, Hanna A. Knaus, Ivan M. Borrello, Ivana Gojo, Leo Luznik
Journal: Blood
Blood (2021) 138 (Supplement 1): 521.
https://doi.org/10.1182/blood-2021-149150
Published: 2021
Journal Articles

Transcriptomic Features of Immune Exhaustion and Senescence Predict Outcomes and Define Checkpoint Blockade-Unresponsive Microenvironments in Acute Myeloid Leukemia

Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung On Yau, Rupkatha Mukhopadhyay, Heidi Altmann, Michael Kramer, Hanna A. Knaus, Joshua F. Zeidner, Vedran Radojcic, Andrea Arruda, Mark D. Minden, Sarah K Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik
Journal: Blood
Blood (2021) 138 (Supplement 1): 223.
https://doi.org/10.1182/blood-2021-145854
Published: 2021
Journal Articles

An Immune Senescence and Exhaustion-Related RNA Profile Predicts Clinical Outcomes in Acute Myeloid Leukemia

Jayakumar Vadakekolathu, PhD, Tung On Yau, Heidi Altmann, PhD, Sarah E. Church, PhD, Hanna A Knaus, MD, Mark D. Minden, Jan K Davidson-Moncada, MDPhD, Sarah K Tasian, MD, Martin Bornhäuser, MD, Ivana Gojo, MD, Leo Luznik, MD, Sergio Rutella, MDPhDFRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
https://doi.org/10.1182/blood-2020-134779
Published: 2020
Journal Articles

A Signature of T Cell Exhaustion Is Enriched in the Bone Marrow (BM) of AML Patients and Shared with Immune Exhaustion Signatures of Solid Tumors

Hanna A. Knaus, MD, Hubert Hackl, Amanda Blackford, Sofia Berglund, Raul Montiel-Esparza, Joshua F Zeidner, MD, Ivana Gojo, MD, Leo Luznik, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2711.
https://doi.org/10.1182/blood-2019-128742
Published: 2019
Journal Articles

Acute Myeloid Leukemia (AML) Blasts Influence the Gene Expression Signature and Co-Signaling Receptor Expression of CD8 + T Cells

Hanna A. Knaus, MD, Sofia Berglund, MD PhD, Hubert Hackl, PhD, Raúl Montiel-Esparza, MD, Mark J. Levis, MD PhD, Judith E Karp, MD, Ivana Gojo, MD, Leo Luznik, MD
Journal: Blood
Blood (2016) 128 (22): 1700.
https://doi.org/10.1182/blood.V128.22.1700.1700
Published: 2016
Journal Articles

Phase 1 Study of Pomalidomide Given at the Time of Early Lymphocyte Recovery after Induction Timed Sequential Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML) and High-Risk Myelodysplastic Syndrome (HR-MDS)

Joshua F. Zeidner, MD, Raul Montiel-Esparza, MD, Hanna A. Knaus, MD, Sofia Berglund, MD PhD, Amer M. Zeidan, MBBS, MHS, Shannon R. McCurdy, MD, Gabrielle T Prince, MD, Lukasz P Gondek, MD PhD, Gabriel Ghiaur, MD PhD, Margaret M. Showel, MD, Amy E. DeZern, MD MHS, Keith W. Pratz, MD, B. Douglas Smith, MD, Mark J. Levis, MD PhD, Matthew C Foster, MD, Katarzyna Jamieson, MD, Hendrik W. Van Deventer, MD, Howard Streicher, MD, Judith E. Karp, MD, Leo Luznik, MD, Ivana Gojo, MD
Journal: Blood
Blood (2016) 128 (22): 2820.
https://doi.org/10.1182/blood.V128.22.2820.2820
Published: 2016
Journal Articles

Immune Modulation with Pomalidomide after Induction Chemotherapy in Newly Diagnosed Acute Myeloid Leukemia (AML)

Raúl Montiel-Esparza, MD, Hanna A. Knaus, MD, Joshua F. Zeidner, MD, Ante Vulic, MD, Gabrielle T. Prince, MD, B. Douglas Smith, MD, Mark J. Levis, MD PhD, Howard Streicher, MD, Judith E. Karp, MD, Leo Luznik, MD, Ivana Gojo, MD
Journal: Blood
Blood (2015) 126 (23): 1351.
https://doi.org/10.1182/blood.V126.23.1351.1351
Published: 2015
Journal Articles

Tracking Effector T Cell Dynamics and Immune Inhibitory Receptors in Patients with Acute Myeloid Leukemia (AML)

Hanna A. Knaus, MD, Raúl Montiel-Esparza, MD, Joshua F. Zeidner, MD, Amanda Blackford, ScM, Christopher G. Kanakry, MD, Ante Vulic, MD, Mark J. Levis, MD PhD, Judith E. Karp, MD, Leo Luznik, MD, Ivana Gojo, MD
Journal: Blood
Blood (2015) 126 (23): 3849.
https://doi.org/10.1182/blood.V126.23.3849.3849
Published: 2015
Journal Articles

Stabilization of Myelodysplastic Syndromes (MDS) Following Hypomethylating Agent (HMAs) Failure Using the Immune Checkpoint Inhibitor Ipilimumab: A Phase I Trial

Amer M. Zeidan, MBBS, MHS, Joshua F. Zeidner, MD, Amy Duffield, MD, Hanna A. Knaus, MD, Anna Ferguson, BSN, RN, Katherine Sheldon, Amy E. DeZern, MD MHS, Ivana Gojo, MD, Steven D. Gore, MD, Howard Streicher, MD, Leo Luznik, B. Douglas Smith
Journal: Blood
Blood (2015) 126 (23): 1666.
https://doi.org/10.1182/blood.V126.23.1666.1666
Published: 2015
Journal Articles

Characterization of Immune Evasion Mechanisms at Diagnosis and after Chemotherapy in Patients with Acute Myeloid Leukemia

Hanna A. Knaus, MD, Joshua F. Zeidner, MD, Raul Montiel Esparza, MD, Christopher G. Kanakry, Sudipto Ganguly, PhD, Ante Vulic, MD, Amanda Blackford, MS, B. Douglas Smith, MD, Judith E. Karp, MD, Leo Luznik, MD, Ivana Gojo, MD
Journal: Blood
Blood (2014) 124 (21): 1065.
https://doi.org/10.1182/blood.V124.21.1065.1065
Published: 2014