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Heidi Altmann
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Journal Articles

FLT3-ITD Driven CMTM6 Expression Contributes to Immune Escape of Acute Myeloid Leukemia

Melissa Zwick, Bastian Zinkel, Corinna Spohr, Tamina Rückert, Sebastian Halbach, Khalid Shoumariyeh, Lukas M. Braun, Annika Nelde, Melanie Maerklin, Samuel J. Holzmayer, Sandra Duquesne, Alexandra Emilia Schlaak, Patricia Otto-Mora, Bertram Bengsch, Marcel Schiff, Sandra Kissel, Marie Follo, Heidi Altmann, Désirée Kunadt, Anna Lena Illert, Juliane S. Walz, Gerd Walz, Justus Duyster, Johannes Schetelig, Tilman Brummer, Robert Zeiser, Natalie Koehler
Journal: Blood
Blood (2024) 144 (Supplement 1): 3392.
https://doi.org/10.1182/blood-2024-201449
Published: 2024
Journal Articles

Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Daria Frank, Pradeep Kumar Patnana, Jan Vorwerk, Lianghao Mao, Lavanya Mokada Gopal, Noelle Jung, Thorben Hennig, Leo Ruhnke, Joris Maximillian Frenz, Maithreyan Kuppusamy, Robert Autry, Lanying Wei, Kaiyan Sun, Helal Mohammed Mohammed Ahmed, Axel Künstner, Hauke Busch, Heiko Müller, Stephan Hutter, Gregor Hoermann, Longlong Liu, Xiaoqing Xie, Yahya Al-Matary, Subbaiah Chary Nimmagadda, Fiorella Charles Cano, Michael Heuser, Felicitas Thol, Gudrun Göhring, Doris Steinemann, Jürgen Thomale, Theo Leitner, Anja Fischer, Roland Rad, Christoph Röllig, Heidi Altmann, Desiree Kunadt, Wolfgang E. Berdel, Jana Hüve, Felix Neumann, Jürgen Klingauf, Virginie Calderon, Bertram Opalka, Ulrich Dührsen, Frank Rosenbauer, Martin Dugas, Julian Varghese, Hans Christian Reinhardt, Nikolas von Bubnoff, Tarik Möröy, Georg Lenz, Aarif M. N. Batcha, Marianna Giorgi, Murugan Selvam, Eunice Wang, Shannon K. McWeeney, Jeffrey W. Tyner, Friedrich Stölzel, Matthias Mann, Ashok Kumar Jayavelu, Cyrus Khandanpour
Journal: Blood
Blood (2023) 142 (25): 2175–2191.
https://doi.org/10.1182/blood.2022015752
Published: 2023
Includes: Supplemental data
Journal Articles

Spatially Resolved Transcriptomics Unveils Unique T-Cell Dysfunctional States and Prognostic Gene Expression Signatures in TP53 -Mutated Acute Myeloid Leukemia

Jayakumar Vadakekolathu, Heidi Altmann, Manja Wobus, Malte von Bonin, Marc Schmitz, Gustavo B. Baretton, Robert Zeiser, Martin Bornhäuser, Sergio Rutella
Journal: Blood
Blood (2023) 142 (Supplement 1): 291.
https://doi.org/10.1182/blood-2023-174871
Published: 2023
Journal Articles

Prevalence, Clinical and Molecular Features, and Prognostic Value of Tetraploidy/Near-Tetraploidy in Patients with Acute Myeloid Leukemia

Leo Ruhnke, Julia Frimmel, Christoph Röllig, Brigitte Mohr, Heidi Altmann, David Poitz, Sven Zukunft, Katrin Schranz, Sebastian Vosberg, Karsten Spiekermann, Michael von Bergwelt, Edgar Jost, Sabine Dressler, Kerstin Schäfer-Eckart, Triantafyllos Chavakis, Daniela Aust, Korinna Jöhrens, Gustavo Baretton, Martin Bornhäuser, Philipp A. Greif, Friedrich Stölzel, Sylvia Herold, Lisa Wagenführ
Journal: Blood
Blood (2022) 140 (Supplement 1): 3454–3455.
https://doi.org/10.1182/blood-2022-166271
Published: 2022
Journal Articles

Transcriptomic Features of Immune Exhaustion and Senescence Predict Outcomes and Define Checkpoint Blockade-Unresponsive Microenvironments in Acute Myeloid Leukemia

Sergio Rutella, Jayakumar Vadakekolathu, Francesco Mazziotta, Stephen Reeder, Tung On Yau, Rupkatha Mukhopadhyay, Heidi Altmann, Michael Kramer, Hanna A. Knaus, Joshua F. Zeidner, Vedran Radojcic, Andrea Arruda, Mark D. Minden, Sarah K Tasian, Martin Bornhäuser, Ivana Gojo, Leo Luznik
Journal: Blood
Blood (2021) 138 (Supplement 1): 223.
https://doi.org/10.1182/blood-2021-145854
Published: 2021
Journal Articles

An Immune Senescence and Exhaustion-Related RNA Profile Predicts Clinical Outcomes in Acute Myeloid Leukemia

Jayakumar Vadakekolathu, PhD, Tung On Yau, Heidi Altmann, PhD, Sarah E. Church, PhD, Hanna A Knaus, MD, Mark D. Minden, Jan K Davidson-Moncada, MDPhD, Sarah K Tasian, MD, Martin Bornhäuser, MD, Ivana Gojo, MD, Leo Luznik, MD, Sergio Rutella, MDPhDFRCPath
Journal: Blood
Blood (2020) 136 (Supplement 1): 26–27.
https://doi.org/10.1182/blood-2020-134779
Published: 2020
Journal Articles

Immune Landscapes Predict Chemotherapy Resistance and Anti-Leukemic Activity of Flotetuzumab, an Investigational CD123×CD3 Bispecific Dart® Molecule, in Patients with Relapsed/Refractory Acute Myeloid Leukemia

Jayakumar Vadakekolathu, PhD, Mark D. Minden, MD PhD, Tressa Hood, MSc, Sarah E. Church, PhD, Stephen Reeder, BSc, Heidi Altmann, PhD, Amy H Sullivan, BSc, Elena J Viboch, MSc, Tasleema Patel, Narmin Ibrahimova, Sarah E. Warren, PhD, Andrea Arruda, Marc Schmitz, MD, Yan Liang, PhD, Alessandra Cesano, MD PhD, A. Graham Pockley, PhD, Peter Valk, PhD, Bob Löwenberg, MD PhD, Martin Bornhäuser, MD, Sarah K. Tasian, MD, Michael P. Rettig, PhD, Jan K Davidson-Moncada, MD PhD, John F. DiPersio, MD PhD, Sergio Rutella, MDPhDFRCPath
Journal: Blood
Blood (2019) 134 (Supplement_1): 460.
https://doi.org/10.1182/blood-2019-121870
Published: 2019
Journal Articles

Mutant TET2 Allele Dosage Affects Response to 5-Azacitidine in Acute Myeloid Leukemia

Friedrich Stoelzel, MD, Sarah Elizabeth Fordham, PhD BSc, Wei Yu Lin, PhD, Helen Blair, PhD, Leo Ruhnke, MD, Desireé Kunadt, MD, Brigitte Mohr, PhD, Claire Elstob, PhD, Daniel Allsop, MD, Devi Nandana, BSc, Emmanouela-Niki Soura, MPhil, Catherine Park, PhD, Mohd Fadly, PhD, Thahira Rahman, PhD, Olaf Heidenreich, Heidi Altmann, PhD, Gail Jones, MD, Tobias Menne, MD PhD, Manja Wobus, PhD, Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Helen Marr, PhD, Kenan Onel, MD PhD, Manja Meggendorfer, PhD, Torsten Haferlach, MD, Martin Bornhäuser, MD, James M. Allan
Journal: Blood
Blood (2019) 134 (Supplement_1): 113.
https://doi.org/10.1182/blood-2019-123047
Published: 2019
Journal Articles

The Genes for Tissue Factor F3 and Nuclear Receptor 4A Are Down-Regulated in Early Death Acute Promyelocytic Leukemia Patients

Miriam Frech, PhD, Kathleen Stabla, Andrea Nist, PhD, Marco Mernberger, PhD, Heidi Altmann, PhD, Uwe Platzbecker, Christian Thiede, MD, Prema Erramsetti, Sabine Teichler, PhD, Cornelia Brendel, MD, Richard F. Schlenk, MD, Thorsten Stiewe, MD, Andreas Neubauer, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3902.
https://doi.org/10.1182/blood-2018-99-112978
Published: 2018
Journal Articles

Real World Data on Decitabine Treatment in 296 Patients with Acute Myeloid Leukemia: Outcome and Impact of TP53 Mutations

Christoph Rollig, MD MSC, Jan Moritz Middeke, MD, Sebastian Stasik, Armin Zebisch, MD, Heinz Sill, MD, Michael Kramer, M.Sc., Sebastian Scholl, MD, Andreas Hochhaus, MD, Edgar Jost, Tim H. Brümmendorf, MD, Ralph Naumann, MD, Björn Steffen, Hubert Serve, Heidi Altmann, Volker Kunzmann, MD PhD, Hermann Einsele, Stefani Barbara Parmentier, MD, Markus Schaich, MD, Andreas Burchert, MD, Andreas Neubauer, MD, Frank Heits, MD, Wolfgang E. Berdel, Katja Sockel, MD, Friedrich Stoelzel, MD, Uwe Platzbecker, MD, Gerhard Ehninger, Martin Bornhäuser, MD, Johannes Schetelig, MD, Christian Thiede, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 3896.
https://doi.org/10.1182/blood.V130.Suppl_1.3896.3896
Published: 2017