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Manja Wobus
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Journal Articles

Specific Gut Microbiome Changes in Myelodysplastic Neoplasms Linked to Inflammation

Ekaterina Balaian, Fabian Springer, Katja Sockel, Manja Wobus, Maria Uhlig, Matthias Wolfgang Groß, Sebastian Zeissig, Martin Bornhaeuser, Triantafyllos Chavakis, Georg Zeller
Journal: Blood
Blood (2024) 144 (Supplement 1): 6692.
https://doi.org/10.1182/blood-2024-207847
Published: 2024
Journal Articles

Spatially Resolved Transcriptomics Unveils Unique T-Cell Dysfunctional States and Prognostic Gene Expression Signatures in TP53 -Mutated Acute Myeloid Leukemia

Jayakumar Vadakekolathu, Heidi Altmann, Manja Wobus, Malte von Bonin, Marc Schmitz, Gustavo B. Baretton, Robert Zeiser, Martin Bornhäuser, Sergio Rutella
Journal: Blood
Blood (2023) 142 (Supplement 1): 291.
https://doi.org/10.1182/blood-2023-174871
Published: 2023
Journal Articles

Tasquinimod Improves Erythropoiesis and Mitigates Bone Loss in Myelodysplastic Mice

Manja Wobus, Heike Weidner, Kristin Möbus, Anna-Lena Baumann, Ivonne Habermann, Tolga Danismaz, Ekaterina Balaian, Marie Törngren, Helena Eriksson, Eva Bondesson, Martina Rauner, Martin Bornhaeuser, Katja Sockel
Journal: Blood
Blood (2023) 142 (Supplement 1): 2798.
https://doi.org/10.1182/blood-2023-185642
Published: 2023
Journal Articles

Gut Microbiome, Metabolome and Immune Changes in Myelodysplastic Syndromes

Ekaterina Balaian, Nikolai Karcher, Katja Sockel, Uta Oelschlägel, Alexander Funk, Manja Wobus, Maria Uhlig, Matthias W. Groß, Sebastian Zeissig, Martin Bornhaeuser, Triantafyllos Chavakis, Georg Zeller
Journal: Blood
Blood (2022) 140 (Supplement 1): 12301–12302.
https://doi.org/10.1182/blood-2022-165481
Published: 2022
Journal Articles

Targeting S100A9 in the Inflammatory Myelodysplastic Hematopoietic Niche Reprograms the Functional Properties of CD271 + Mesenchymal Stromal Cells

Manja Wobus, Ekaterina Balaian, Triantafyllos Chavakis, Alexander Funk, Thomas Krüger, Uwe Platzbecker, Marie Törngren, Helena Eriksson, Eva Bondesson, Martin Bornhäuser, Katja Sockel
Journal: Blood
Blood (2022) 140 (Supplement 1): 4028–4029.
https://doi.org/10.1182/blood-2022-168866
Published: 2022
Journal Articles

Targeting the Inflammatory Niche in MDS By Tasquinimod Restores Hematopoietic Support and Suppresses Immune-Checkpoint Expression in Vitro

Manja Wobus, Ekaterina Balaian, Uta Oelschlaegel, Russell Towers, Kristin Möbus, Ivonne Habermann, Rebekka Wehner, Friedrich Stölzel, Triantafyllos Chavakis, Marie Törngren, Helena Eriksson, Uwe Platzbecker, Christoph Röllig, Martin Bornhäuser, Katja Sockel
Journal: Blood
Blood (2021) 138 (Supplement 1): 2596.
https://doi.org/10.1182/blood-2021-150455
Published: 2021
Journal Articles

Mutant TET2 Allele Dosage Affects Response to 5-Azacitidine in Acute Myeloid Leukemia

Friedrich Stoelzel, MD, Sarah Elizabeth Fordham, PhD BSc, Wei Yu Lin, PhD, Helen Blair, PhD, Leo Ruhnke, MD, Desireé Kunadt, MD, Brigitte Mohr, PhD, Claire Elstob, PhD, Daniel Allsop, MD, Devi Nandana, BSc, Emmanouela-Niki Soura, MPhil, Catherine Park, PhD, Mohd Fadly, PhD, Thahira Rahman, PhD, Olaf Heidenreich, Heidi Altmann, PhD, Gail Jones, MD, Tobias Menne, MD PhD, Manja Wobus, PhD, Graham Jackson, MA, MB BS, FRCP, FRCPath, MD, Helen Marr, PhD, Kenan Onel, MD PhD, Manja Meggendorfer, PhD, Torsten Haferlach, MD, Martin Bornhäuser, MD, James M. Allan
Journal: Blood
Blood (2019) 134 (Supplement_1): 113.
https://doi.org/10.1182/blood-2019-123047
Published: 2019
Journal Articles

Altered Structure and Function of Mesenchymal Stromal Cell-Derived Extracellular Matrix in MDS Can be Restored By Luspatercept

Manja Wobus, PhD, Anna Mies, Valentina Magno, PhD, Cindy Welzel, Susann Winter, PhD, Friedrich Stoelzel, MD, Carsten Werner, PhD, Martin Bornhaeuser, MD, Uwe Platzbecker, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1699.
https://doi.org/10.1182/blood-2019-129814
Published: 2019
Journal Articles

Impairment of the Stromal SDF-1-Mediated Hematopoietic Support By GDF-11 in MDS Is Rescued By Luspatercept

Manja Wobus, Anna Mies, Nandini Asokan, Uta Oelschlaegel, Susann Winter, Martina Rauner, PhD, Lorenz Hofbauer, Martin Bornhäuser, Uwe Platzbecker
Journal: Blood
Blood (2018) 132 (Supplement 1): 939.
https://doi.org/10.1182/blood-2018-99-114536
Published: 2018
Journal Articles

Histone Deacetylase Inhibitors As Enhancers of Human Hematopoietic Stem Cell Activity

Manja Wobus, PhD, Guruchandar Arulmozhivarman, Martin Kraeter, Jens Friedrichs, Martin Stoeter, Martin Bornhaeuser
Journal: Blood
Blood (2016) 128 (22): 5044.
https://doi.org/10.1182/blood.V128.22.5044.5044
Published: 2016
Journal Articles

Interaction of Tumor Cells with the Hematopoietic Stem and Progenitor Cell Niche

Abhishek Dhawan, MSc, Jens Friedrichs, PhD, Laura Bray, PhD, Lorenz C. Hofbauer, MD, Manja Wobus, PhD, Martin Bornhäuser, MD
Journal: Blood
Blood (2014) 124 (21): 5139.
https://doi.org/10.1182/blood.V124.21.5139.5139
Published: 2014
Journal Articles

CD97 Expression in Acute Myeloid Leukemia Is Associated with FLT3-ITD Mutation Status

Manja Wobus, PhD, Martin Bornhäuser, MD, Claudia Ortlepp, PhD, Angela Jacobi, PhD, Gerhard Ehninger, MD, Christian Thiede, MD, Uta Oelschlägel, PhD
Journal: Blood
Blood (2014) 124 (21): 1001.
https://doi.org/10.1182/blood.V124.21.1001.1001
Published: 2014
Journal Articles

Hypoxia Alters the Main Characteristics of the Hematopoietic Stem and Progenitor Cell Microenvironment in Vitro

Manja Wobus, PhD, Jing Duohui, PhD, David M Poitz, PhD, Katrin Müller, Rainer Ordemann, MD, Gerhard Ehninger, MD, Martin Bornhäuser
Journal: Blood
Blood (2011) 118 (21): 4803.
https://doi.org/10.1182/blood.V118.21.4803.4803
Published: 2011
Journal Articles

Lenalidomide Modulates the Phenotype and Function of Human Mesenchymal Stromal Cells From Healthy Donors and MDS Patients.

Manja Wobus, Gwendolin Dünnebier, Silvia Feldmann, Gerhard Ehninger, Martin Bornhauser, Uwe Platzbecker
Journal: Blood
Blood (2009) 114 (22): 3816.
https://doi.org/10.1182/blood.V114.22.3816.3816
Published: 2009
Journal Articles

Hypoxia Increases IL-8 Secretion of Mesenchymal Stroma Cells Affecting Migratory Capacity in An Autocrine Manner

Manja Wobus, Katrin Mueller, Gerhard Ehninger, MD, Martin Bornhaeuser
Journal: Blood
Blood (2008) 112 (11): 4752.
https://doi.org/10.1182/blood.V112.11.4752.4752
Published: 2008