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Shannon K. McWeeney
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Journal Articles

Combination with Palbociclib Overcomes Venetoclax Resistance Mechanisms and Outperforms Single Agent Efficacy in Acute Myeloid Leukemia

Melissa L Stewart, Jessica Gibbs, Daniel Bottomly, Andy Kaempf, Stephen E. Kurtz, Christopher A. Eide, Ariane Huang, Luca Sax, Nicola Long, Shannon K McWeeney, Bill H Chang, Jeffrey W. Tyner
Journal: Blood
Blood (2024) 144 (Supplement 1): 1566.
https://doi.org/10.1182/blood-2024-198516
Published: 2024
Journal Articles

Germ line variant GFI1-36N affects DNA repair and sensitizes AML cells to DNA damage and repair therapy

Daria Frank, Pradeep Kumar Patnana, Jan Vorwerk, Lianghao Mao, Lavanya Mokada Gopal, Noelle Jung, Thorben Hennig, Leo Ruhnke, Joris Maximillian Frenz, Maithreyan Kuppusamy, Robert Autry, Lanying Wei, Kaiyan Sun, Helal Mohammed Mohammed Ahmed, Axel Künstner, Hauke Busch, Heiko Müller, Stephan Hutter, Gregor Hoermann, Longlong Liu, Xiaoqing Xie, Yahya Al-Matary, Subbaiah Chary Nimmagadda, Fiorella Charles Cano, Michael Heuser, Felicitas Thol, Gudrun Göhring, Doris Steinemann, Jürgen Thomale, Theo Leitner, Anja Fischer, Roland Rad, Christoph Röllig, Heidi Altmann, Desiree Kunadt, Wolfgang E. Berdel, Jana Hüve, Felix Neumann, Jürgen Klingauf, Virginie Calderon, Bertram Opalka, Ulrich Dührsen, Frank Rosenbauer, Martin Dugas, Julian Varghese, Hans Christian Reinhardt, Nikolas von Bubnoff, Tarik Möröy, Georg Lenz, Aarif M. N. Batcha, Marianna Giorgi, Murugan Selvam, Eunice Wang, Shannon K. McWeeney, Jeffrey W. Tyner, Friedrich Stölzel, Matthias Mann, Ashok Kumar Jayavelu, Cyrus Khandanpour
Journal: Blood
Blood (2023) 142 (25): 2175–2191.
https://doi.org/10.1182/blood.2022015752
Published: 2023
Includes: Supplemental data
Journal Articles

Genomic Profiles and Associated Survival Prognosticators in Black Patients with Acute Myeloid Leukemia

Andrew Stiff, Deedra Nicolet, Maarten Fornerod, Ben Kelly, Katherine Miller, Krzysztof Mrózek, Isaiah Boateng, Bailee Nicole Kain, Elizabeth Garfinkle, Eileen Y Hu, Saranga Wijeratne, Gregory Wheeler, Christopher J. Walker, Jill Buss, Adrienne Heyrosa, Helee Desai, Andrea Laganson, Yazan Abu-Shihab, Hasan Abaza, Alice Mims, Christopher C. Oakes, Bethany L Mundy-Bosse, Andrew J Carroll, Bayard L Powell, Jonathan E Kolitz, Richard Stone, Electra D Paskett, Ross L Levine, Kamal Menghrajani, Debyani Chakravarty, Michael F. Berger, Nathan Salomonis, Daniel Bottomly, Shannon K McWeeney, Jeffrey W Tyner, John C. Byrd, H. Leighton Grimes, Elaine R Mardis, Ann-Kathrin Eisfeld
Journal: Blood
Blood (2023) 142 (Supplement 1): 837.
https://doi.org/10.1182/blood-2023-181876
Published: 2023
Journal Articles

A Rapid Test to Evaluate the Tumor Differentiation State of Acute Myeloid Leukemias

Stephen E. Kurtz, Christopher A. Eide, Nicola Long, Daniel Bottomly, Shannon K McWeeney, Akosha Taylor, Brian J. Druker, Sudarshan Anand, Curtis A. Lachowiez, Jeffrey W Tyner
Journal: Blood
Blood (2023) 142 (Supplement 1): 3643.
https://doi.org/10.1182/blood-2023-180105
Published: 2023
Journal Articles

Acute Myeloid Leukemia Differentiation State and Genotype Influence Anti-Apoptotic Protein Expression, Venetoclax Sensitivity, and Survival in AML

Curtis A. Lachowiez, Christopher A. Eide, Stephen E. Kurtz, Nicola Long, Manoj Rai, Wei Xie, Andy Kaempf, Daniel Bottomly, Rachel Cook, Gabrielle Meyers, Arpita Gandhi, Jessica T. Leonard, Brandon Hayes-Lattin, Laura F. Newell, Richard T Maziarz, Jennifer N. Saultz, Elie Traer, Theodore P Braun, Ronan T. Swords, Shannon K McWeeney, Jeffrey W Tyner
Journal: Blood
Blood (2023) 142 (Supplement 1): 978.
https://doi.org/10.1182/blood-2023-179527
Published: 2023
Journal Articles

Cebpβ/IL1/TNFα Positive Feedback Loop Drives Drug Resistance of BCL2 and MDM2 Inhibitors in Monocytic Leukemia Cells

Basil Allen, Daniel Bottomly, Anthony Wang, Thomas Koehnke, Lindsey Savoy, Peter Ryabini, Reid Chen, Kara Johnson, Stephen E. Kurtz, Anupriya Agarwal, Michelle Barton, Brian J. Druker, Ravi Majeti, Jeffrey W Tyner, Shannon K McWeeney, Haijiao Zhang
Journal: Blood
Blood (2023) 142 (Supplement 1): 2937.
https://doi.org/10.1182/blood-2023-178096
Published: 2023
Journal Articles

The Aryl Hydrocarbon Receptor Defines a Unique Genomic and Immune Signature in AML Characterized By Monocytic Differentiation, Venetoclax Resistance and Is Targetable By Ahr Antagonist

Jennifer N. Saultz, Daniel Bottomly, Faith Burns, Kaelan Byrd, Yoko Kosaka, Shannon K. McWeeney, Stephen E. Kurtz, Guang Fan, Andy Kaempf, Karen McGovern, Lei Wang, Marta Sanchez-Martin, Dan S Kaufman, Evan F. Lind, Jeffrey W. Tyner
Journal: Blood
Blood (2022) 140 (Supplement 1): 3071–3072.
https://doi.org/10.1182/blood-2022-163166
Published: 2022
Journal Articles

Defining Clinical and Molecular Biomarkers for Venetoclax-Based Drug Combinations to Augment AML Therapy

Christopher A. Eide, Stephen E. Kurtz, Andy Kaempf, Nicola Long, Sunil K Joshi, Tamilla Nechiporuk, Ariane Huang, Charles Dibb, Daniel Bottomly, Shannon K. McWeeney, Bill H. Chang, Brian J. Druker, Jeffrey W. Tyner
Journal: Blood
Blood (2022) 140 (Supplement 1): 1025–1027.
https://doi.org/10.1182/blood-2022-159264
Published: 2022
Journal Articles

Characterize Biomarkers and Mechanisms of Resistance for MDM2 Inhibitors in AML

Lindsey Savoy, Daniel Bottomly, Reid Chen, Basil Allen, Jeffrey W. Tyner, Shannon K. McWeeney, Haijiao Zhang
Journal: Blood
Blood (2022) 140 (Supplement 1): 8778–8779.
https://doi.org/10.1182/blood-2022-157622
Published: 2022
Journal Articles

MS4A3 promotes differentiation in chronic myeloid leukemia by enhancing common β-chain cytokine receptor endocytosis

Helong Zhao, Anthony D. Pomicter, Anna M. Eiring, Anca Franzini, Jonathan Ahmann, Jae-Yeon Hwang, Anna Senina, Bret Helton, Siddharth Iyer, Dongqing Yan, Jamshid S. Khorashad, Matthew S. Zabriskie, Anupriya Agarwal, Hannah M. Redwine, Amber D. Bowler, Phillip M. Clair, Shannon K. McWeeney, Brian J. Druker, Jeffrey W. Tyner, Derek L. Stirewalt, Vivian G. Oehler, Sooryanarayana Varambally, Kristofer C. Berrett, Jeffery M. Vahrenkamp, Jason Gertz, Katherine E. Varley, Jerald P. Radich, Michael W. Deininger
Journal: Blood
Blood (2022) 139 (5): 761–778.
https://doi.org/10.1182/blood.2021011802
Published: 2022
Includes: Supplemental data
Journal Articles

MS4A3 Promotes Differentiation in Chronic Myeloid Leukemia By Enhancing Common β Chain Cytokine Receptor Endocytosis

Helong Zhao, Anthony D. Pomicter, Anna M. Eiring, Anca Franzini, Jonathan Ahmann, Jae-Yeon Hwang, Anna V. Senina, Bret Helton, Siddharth Iyer, Dongqing Yan, Jamshid Khorashad, Matthew S. Zabriskie, Anupriya Agarwal, Hannah M Redwine, Amber D. Bowler, Phillip M. Clair, Shannon K. McWeeney, Brian J. Druker, Jeffrey W. Tyner, Derek Stirewalt, Vivian G. Oehler, Sooryanarayana Varambally, Kristofer Berrett, Jeffrey Vahrenkamp, Jason Gertz, Katherine Varley, Jerald P. Radich, Michael W. Deininger
Journal: Blood
Blood (2021) 138 (Supplement 1): 59.
https://doi.org/10.1182/blood-2021-151559
Published: 2021
Journal Articles

Abrogation of a Histone Chaperone Pathway Mitigates Inflammation-Driven AML Progression

Hsin-Yun Lin, Mona M.Hosseini, Marina Villamor, John McClatchy, Sophia Jeng, Fatma Eryildiz, Andrew Adey, Shannon K. McWeeney, Travis Stracker, Anupriya Agarwal
Journal: Blood
Blood (2021) 138 (Supplement 1): 2370.
https://doi.org/10.1182/blood-2021-151708
Published: 2021
Journal Articles

Associating Ex Vivo Drug Sensitivity with Differentiation Status Identifies Effective Drug Combinations for Acute Myeloid Leukemia

Christopher A. Eide, Stephen E. Kurtz, Andy Kaempf, Nicola Long, Daniel Bottomly, Olga Nikolova, Brian J. Druker, Shannon K. McWeeney, Jeffrey W. Tyner, Anupriya Agarwal
Journal: Blood
Blood (2021) 138 (Supplement 1): 1301.
https://doi.org/10.1182/blood-2021-152043
Published: 2021
Journal Articles

Aryl Hydrocarbon Receptor (AHR) Gene Expression in AML Is Associated with FLT3-ITD+ AML and HLA-E Induced Immune Resistance Reversed By Ik-364

Jennifer N. Saultz, Evan F. Lind, Jeffrey W. Tyner, Kaelan Byrd, Shannon K. McWeeney, Yoko Kosaka, Karen McGovern, Lei Wang, Marta Sanchez-Martin
Journal: Blood
Blood (2021) 138 (Supplement 1): 1161.
https://doi.org/10.1182/blood-2021-147589
Published: 2021
Journal Articles

A Functional Profiling of Microenvironmental Factors and Small Molecules Reveals Monocyte Chemoattractant Protein-1 Mediates Drug Resistance in Acute Myeloid Leukemia

Rucha V Modak, PhD, Sara J Gosline, Alisa Damnernsawad, PhD, Tamilla Nechiporuk, PhD, Ted Laderas, PhD, Guanming Wu, PhD, Paul Piehowski, Paul.Piehowski@pnnl.gov, Stephen E Kurtz, PhD, Christopher A. Eide, Jeffrey W. Tyner, PhD, Karin Rodland, rodland@ohsu.edu, Shannon K. McWeeney, PhD, Anupriya Agarwal, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 11–12.
https://doi.org/10.1182/blood-2020-141686
Published: 2020
Journal Articles

Evolution of Gilteritinib Resistance from Residual Disease to Relapse

Sunil K Joshi, BA, Tamilla Nechiporuk, PhD, Daniel Bottomly, Paul Piehowski, Paul.Piehowski@pnnl.gov, Julie Reisz, PhD, Janét Pittsenbarger, BA, Sara J Gosline, Andy Kaempf, MS, Yi-Ting Wang, Jamie Moon, Özgün Babur, Kevin M Watanabe-Smith, PhD, Emek Demir, Liu Tao, BS, PhD, Cristina E. Tognon, PhD, Angelo D'Alessandro, PhD, Jeffrey W. Tyner, PhD, Shannon K. McWeeney, PhD, Karin Rodland, rodland@ohsu.edu, Brian J. Druker, MD, Elie Traer
Journal: Blood
Blood (2020) 136 (Supplement 1): 4–5.
https://doi.org/10.1182/blood-2020-139084
Published: 2020
Journal Articles

Discovery and characterization of targetable NTRK point mutations in hematologic neoplasms

Sunil K. Joshi, Kristin Qian, William H. Bisson, Kevin Watanabe-Smith, Ariane Huang, Daniel Bottomly, Elie Traer, Jeffrey W. Tyner, Shannon K. McWeeney, Monika A. Davare, Brian J. Druker, Cristina E. Tognon
Journal: Blood
Blood (2020) 135 (24): 2159–2170.
https://doi.org/10.1182/blood.2019003691
Published: 2020
Includes: Supplemental data
Journal Articles

Myeloid-Lineage Enhancers Drive Oncogene Synergy and Represent a Novel Therapeutic Target in CSF3R-CEBPA Mutant AML

Theodore Braun, MD PhD, Cody Coblentz, Sarah A Carratt, PhD BS, Mariam Okhovat, PhD, Amy Foley, MEng., Zachary Schonrock, BS, Kimberly Nevonen, Rhonda E. Ries, MA, Shannon K. McWeeney, PhD, Claus Nerlov, PhD, Soheil Meshinchi, MD PhD, Lucia Carbone, PhD, Brian J. Druker, Julia E. Maxson, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 543.
https://doi.org/10.1182/blood-2019-124773
Published: 2019
Journal Articles

Framework to Identify and Prioritize Candidate Inherited Myeloid Malignancy Germline Variants Leveraging the BEAT AML Cohort

Daniel Bottomly, Nicola Long, Fei Yang, MD, Tiffany Lee, MD, Uma Borate, MD, Beth Wilmot, PhD, Adam S DuVall, MD, Andrea Monteblanco, BS, Karina Thiel-Klare, Gabby Dewson, BA, Richard D. Press, MD PhD, Cristina E. Tognon, Brian J. Druker, Jeffrey W. Tyner, Shannon K. McWeeney, PhD, Anupriya Agarwal, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1407.
https://doi.org/10.1182/blood-2019-132224
Published: 2019
Journal Articles

Genome-Wide CRISPR Screening in Acute Myeloid Leukemia Cells Identifies Genes in the PI3K/AKT/mTOR and MEK/ERK Pathways That Define Sensitivity to Trametinib

Tamilla Nechiporuk, PhD, Alisa Damnernsawad, PhD, Daniel Bottomly, MS, Quinlan Morrow, BS, Suyoun Choi, Sofia Beer, Stephen E Kurtz, PhD, Shannon K. McWeeney, PhD, Jeffrey W. Tyner
Journal: Blood
Blood (2019) 134 (Supplement_1): 1395.
https://doi.org/10.1182/blood-2019-129117
Published: 2019