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Journal Articles

Apex Part 2 Trial in Progress: A Phase 2 Open-Label Clinical Study of Bezuclastinib in Adult Patients with Advanced Systemic Mastocytosis

Isaac Goncalves, Stephen Fuller, Jason Gotlib, Pankit Vachhani, Vinod Pullarkat, Daniel J. DeAngelo, Saskia K. Klein, Wolfgang R. Sperr, Karin Hartmann, Khalid Shoumariyeh, Jens Panse, Teng Fong Ng, Miguel Piris-Villaespesa, Tsewang Tashi, Anthony M. Hunter, Prithviraj Bose, Cecilia Y. Arana Yi, Manish Jain, Helena Pomares, Tracy I. George, Jay Patel, Cristina Papayannidis, Minakshi S. Taparia, Bulai Livideanu Cridtina, Juliana Schwaab, Ingunn Dybedal, Jonathan Lambert, Tania Jain, Ewa Wierzbicka-Hainaut, Olivier Hermine, Massimiliano Bonifacio, Gabriela S. Hobbs, Michael W. Deininger, Amanda Pilla, Marcus Carden, Deepti H. Radia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4569.1.
https://doi.org/10.1182/blood-2024-194550
Published: 2024
Journal Articles

Apex Part 1: Updated Assessment of Bezuclastinib (CGT9486), a Selective KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM)

Daniel J. DeAngelo, Jason Gotlib, Vinod Pullarkat, Pankit Vachhani, Tsewang Tashi, Stephanie Lee, Gary J. Schiller, Anthony M. Hunter, Miguel Piris-Villaespesa, Helena Pomares, Bulai Livideanu Cridtina, Khalid Shoumariyeh, Jonathan Lambert, Tracy I. George, Jay Patel, Cristina Papayannidis, Tania Jain, Michael W. Deininger, Andreas Reiter, Gabriela S. Hobbs, Lei Sun, Deepak Nagendra, Jenna Zhang, Amanda Pilla, Kim Dishman, Marcus Carden, Deepti H. Radia
Journal: Blood
Blood (2024) 144 (Supplement 1): 659.
https://doi.org/10.1182/blood-2024-193678
Published: 2024
Journal Articles

Mutational Landscape of SH2B3 -Mutated Hematologic Malignancies

Natalie Wossidlo, Khalid Shoumariyeh, Constance Regina Baer, Wolfgang Kern, Claudia Haferlach, Torsten Haferlach, Manja Meggendorfer
Journal: Blood
Blood (2024) 144 (Supplement 1): 6689.
https://doi.org/10.1182/blood-2024-205394
Published: 2024
Journal Articles

SMARCC1 Controls the Oncogenic NOTCH1 Transcriptional Program in T-Cell Acute Lymphoblastic Leukemia

Khalid Shoumariyeh, Xiaoyang Sun, Teresa Poggio, Geoffroy Andrieux, Tatjan Schmitz, Stephan de Bra, Omid Fotouhi, Sheikh Nizamuddin, Uta Sabine Sabine Martens, Justus Duyster, Marc Timmers, Melanie Boerries, Cornelius Miething
Journal: Blood
Blood (2024) 144 (Supplement 1): 5760.
https://doi.org/10.1182/blood-2024-210721
Published: 2024
Journal Articles

FLT3-ITD Driven CMTM6 Expression Contributes to Immune Escape of Acute Myeloid Leukemia

Melissa Zwick, Bastian Zinkel, Corinna Spohr, Tamina Rückert, Sebastian Halbach, Khalid Shoumariyeh, Lukas M. Braun, Annika Nelde, Melanie Maerklin, Samuel J. Holzmayer, Sandra Duquesne, Alexandra Emilia Schlaak, Patricia Otto-Mora, Bertram Bengsch, Marcel Schiff, Sandra Kissel, Marie Follo, Heidi Altmann, Désirée Kunadt, Anna Lena Illert, Juliane S. Walz, Gerd Walz, Justus Duyster, Johannes Schetelig, Tilman Brummer, Robert Zeiser, Natalie Koehler
Journal: Blood
Blood (2024) 144 (Supplement 1): 3392.
https://doi.org/10.1182/blood-2024-201449
Published: 2024
Journal Articles

SPARC Stabilizes Integrin α4-VCAM-1 Interactions and Is Regulated By Intracellular Rac in NPM1 -Mutated AML

Driti Ashok, Dennis Raith, Martin Helmstädter, Geoffroy Andrieux, Séverine Kayser, Sangya Chatterjee, Judith Treiber, Khalid Shoumariyeh, Tim Struessmann, Valentin Wenger, Julian Rapp, Jesus Duque Afonso, Michael Lübbert, Robert Zeiser, Melanie Boerries, Justus Duyster, Tanja Nicole Hartmann
Journal: Blood
Blood (2024) 144 (Supplement 1): 1298.
https://doi.org/10.1182/blood-2024-205323
Published: 2024
Journal Articles

Safety and Efficacy of Bezuclastinib (CGT9486), a Novel, Highly Selective, Potent KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM): Results from Part 1 of the Phase 2 Apex Trial

Pankit Vachhani, Tsewang Tashi, Gary J. Schiller, Stephanie Lee, Miguel Piris Villaespesa, Helena Pomares, Cristina Bulai Livideanu, Jonathan Lambert, Anthony M. Hunter, Tracy I. George, Cristina Papayannidis, Khalid Shoumariyeh, Rita Petroro, Jenna Zhang, Amanda Pilla, Hina Jolin, Rachael Easton, Vinod Pullarkat
Journal: Blood
Blood (2023) 142 (Supplement 1): 4567.
https://doi.org/10.1182/blood-2023-178885
Published: 2023
Journal Articles

CD49d Shapes B Cell Receptor Responsiveness and Tissue Distribution in an Aggressive Chronic Lymphocytic Leukemia Murine Model

Laura Polcik, Danielle-Justine Danner, Riccardo Bomben, Tamara Bittolo, Lixia Li, Driti Ashok, Sandra Kissel, Natalie Koehler, Andrea Härzschel, Geoffroy Andrieux, Melanie Boerries, Sophia Engel, Theresa Haslauer, Jan Hoepner, Nadja Zaborsky, Richard Greil, Cornelius Miething, Khalid Shoumariyeh, Jesus Duque Afonso, Justus Duyster, Antonella Zucchetto, Valter Gattei, Tanja Nicole Hartmann
Journal: Blood
Blood (2023) 142 (Supplement 1): 81.
https://doi.org/10.1182/blood-2023-179726
Published: 2023
Journal Articles

Allogeneic Hematopoietic Stem Cell Transplantation in Advanced Systemic Mastocytosis

Deborah Christen, Johannes Lübke, Anne Kaiser, Juliana Schwaab, Khalid Shoumariyeh, Madlen Jentzsch, Katja Sockel, Judith Schaffrath, Francis A. Ayuk, Matthias Stelljes, Inken Hilgendorf, Elisa Sala, Jennifer Kaivers, Stefan Schönland, Christoph Wittke, Bernd Hertenstein, Markus P. Radsak, Ulrich Kaiser, Valeska Brückl, Nicolaus Kröger, Stefan Klein, Wolf-Karsten Hofmann, Tim H. Brümmendorf, Edgar Jost, Jens Panse, Andreas Reiter
Journal: Blood
Blood (2023) 142 (Supplement 1): 3605.
https://doi.org/10.1182/blood-2023-178304
Published: 2023
Journal Articles

Targeting MDM2 enhances antileukemia immunity after allogeneic transplantation via MHC-II and TRAIL-R1/2 upregulation

Jenny N. H. G. Ho, Dominik Schmidt, Theresa Lowinus, Jeongmin Ryoo, Elaine-Pashupati Dopfer, Nicolás Gonzalo Núñez, Sara Costa-Pereira, Cristina Toffalori, Marco Punta, Viktor Fetsch, Tobias Wertheimer, Marie-Claire Rittmann, Lukas M. Braun, Marie Follo, Christelle Briere, Janaki Manoja Vinnakota, Marlene Langenbach, Felicitas Koppers, Khalid Shoumariyeh, Helena Engel, Tamina Rückert, Melanie Märklin, Samuel Holzmayer, Anna L. Illert, Federica Magon, Geoffroy Andrieux, Sandra Duquesne, Dietmar Pfeifer, Julian Staniek, Marta Rizzi, Cornelius Miething, Natalie Köhler, Justus Duyster, Hans D. Menssen, Melanie Boerries, Joerg M. Buescher, Nina Cabezas-Wallscheid, Bruce R. Blazar, Petya Apostolova, Luca Vago, Erika L. Pearce, Burkhard Becher, Robert Zeiser
Journal: Blood
Blood (2022) 140 (10): 1167–1181.
https://doi.org/10.1182/blood.2022016082
Published: 2022
Includes: Supplemental data
Journal Articles

The Fanconi Anemia-Associated Protein NIPA Is Essential for the Nuclear Abundance of FANCD2

Stefanie Kreutmair, Miriam Erlacher, Geoffroy Andrieux, Rouzanna Istvanffy, Alina Rudorf, Melissa Zwick, Tamina Rückert, Milena Pantic, Teresa Poggio, Khalid Shoumariyeh, MD, Tony Andreas Müller, Hiroyuki Kawaguchi, Marie Follo, Cathrin Klingeberg, Marcin Wlodarski, Irith Baumann, Dietmar Pfeifer, Michal Kulinski, Martina Rudelius, Simone Lemeer, Bernhard Kuster, Christine Dierks, Christian Peschel, Nina Cabezas-Wallscheid, Jesus Duque-Afonso, Robert Zeiser, MD, Michael Cleary, Detlev Schindler, Annette Schmitt-Graeff, Melanie Boerries, Charlotte M. Niemeyer, MD, Robert A.J. Oostendorp, Justus Duyster, MD, Anna Lena Illert
Journal: Blood
Blood (2019) 134 (Supplement_1): 3741.
https://doi.org/10.1182/blood-2019-125973
Published: 2019
Journal Articles

KIT D816 Mutated / CBF-Negative Acute Myeloid Leukemia (AML): A New Poor-Risk Subtype Associated with Systemic Mastocytosis (SM-AML)

Mohamad Jawhar, Konstanze Döhner, MD, Sebastian Kreil, Juliana Schwaab, Khalid Shoumariyeh, MD, Manja Meggendorfer, PhD, Lambert L.F. Span, Stephan Fuhrmann, Nicole Naumann, Hans-Peter Horny, Karl Sotlar, Boris Kubuschok, Nikolas von Bubnoff, Karsten Spiekermann, MD, Michael Heuser, MD, Georgia Metzgeroth, MD, Alice Fabarius, Stefan A Klein, MD, Wolf-Karsten Hofmann, Hanneke Kluin-Nelemans, Torsten Haferlach, MD, Hartmut Döhner, MD, Nicholas C.P. Cross, Wolfgang R. Sperr, Peter Valent, Andreas Reiter, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1535.
https://doi.org/10.1182/blood-2018-99-115895
Published: 2018
Journal Articles

Functional Characterization of Epigenetic Modifiers of Demethylating Therapy in AML

Desiree Melanie Redhaber, Laurent Phely, Sophia Ehrenfeld, MSc, Pia Veratti, Silvia Schäfer, Jan Mitschke, Jessica Beckert, Khalid Shoumariyeh, Justus Duyster, Prof., Cornelius Miething, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1465.
https://doi.org/10.1182/blood-2018-99-116818
Published: 2018
Journal Articles

Metabolic Reprogramming Overcomes T Cell Inhibition By AML Cells

Franziska Maria Uhl, MSc, Sophia Chen, MD, David O'Sullivan, PhD, Michael Buck, PhD, Jörg Büscher, PhD, Dietmar Pfeifer, Jürgen Finke, MD, Justus Duyster, Prof., Hartmut Bertz, MD, Khalid Shoumariyeh, MD, Melanie Börries, PhD, Gesa Richter, MSc, Tobias Madl, PhD, Erika L. Pearce, PhD, Robert Zeiser, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3328.
https://doi.org/10.1182/blood-2018-99-112897
Published: 2018
Journal Articles

Towards Improved Models of NPM-ALK Induced T-Cell Lymphoma

Sophia Ehrenfeld, MSc, Khalid Shoumariyeh, Teresa Poggio, Robin Khan, Desiree Melanie Redhaber, Stefanie Kreutmair, MD, Cathrin Klingeberg, Anna Lena Illert, MD, Justus Duyster, Prof., Cornelius Miething, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1342.
https://doi.org/10.1182/blood-2018-99-115872
Published: 2018
Journal Articles

Checkpoint Inhibition in CSF3R Mutated Chronic Neutrophilic Leukemia

Stefanie Kreutmair, MD, Teresa Poggio, Chuanjiang Yu, Sivahari Prasad Gorantla, Khalid Shoumariyeh, Dietmar Pfeifer, Michael Lubbert, MD PhD, Karsten Spiekermann, MD, Robert Zeiser, MD, Justus Duyster, Prof., Anna Lena Illert, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3056.
https://doi.org/10.1182/blood-2018-99-113847
Published: 2018
Journal Articles

Distinct Diagnostic and Clinical Features of Bone Marrow Mastocytosis: A Study of the Registry of the European Competence Network on Mastocytosis (ECNM)

Massimiliano Bonifacio, MD, Patrizia Bonadonna, MD, Hanneke Oude Elberink, MD, Björn van Anrooij, MD, Aleksandra Górska, MD, Magdalena Lange, MD, Emir Hadzijusufovic, DVM, Luigi Scaffidi, Ilaria Tanasi, MD, Cecelia Perkins, Virginia Valeria Ferretti, Anja Illerhaus, PhD, Thilo Jakob, MD, Roberta Parente, MD, Mohamad Jawhar, MD, Francesca Caroppo, MD, Alexander Zink, MD, Alex Kilbertus, MD, Akif Selim Yavuz, MD, Michael Doubek, MD PhD, Hans Hagglund, MD PhD, Jens P. Panse, MD, Vito Sabato, MD PhD, Elisabeth Aberer, MD, Nadja Jaekel, MD, Peter Vandenberghe, MD PhD, David Fuchs, MD, Knut Brockow, MD, Anna Belloni Fortina, MD, Andreas Reiter, MD, Massimo Triggiani, MD, Khalid Shoumariyeh, MD, Karin Hartmann, MD, Chiara Elena, Olivier Hermine, MD PhD, Jason Gotlib, MD, Marek Niedoszytko, MD, Hanneke Kluin-Nelemans, MD PhD, Wolfgang R. Sperr, MD, Peter Valent, MD, Roberta Zanotti, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4200.
https://doi.org/10.1182/blood.V130.Suppl_1.4200.4200
Published: 2017
Journal Articles

Systemic Mastocytosis with Associated Acute Myeloid Leukemia (SM-AML): a Poor-Risk Multi-Mutated Disease That Follows a Distinct Diagnostic Algorithm and Requires High-Dose Stem Cell-Targeting Therapy

Mohamad Jawhar, MD, Sebastian Kreil, MD, Juliana Schwaab, Khalid Shoumariyeh, MD, Lambert L.F. Span, Stephan Fuhrmann, Nicole Naumann, Florian Nolte, MD, Daniela Heidenreich, MD, Nadine Z. Müller, MD, Hans-Peter Horny, Karl Sotlar, Torsten Haferlach, MD, Boris Kubuschok, Karsten Spiekermann, Michael Heuser, MD, Georgia Metzgeroth, MD, Alice Fabarius, Stefan Klein, MD, Wolf-Karsten Hofmann, MD, Nicholas C.P. Cross, PhD, Manja Meggendorfer, PhD, Hanneke Kluin-Nelemans, MD PhD, Wolfgang R. Sperr, MD, Peter Valent, MD, Andreas Reiter, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2916.
https://doi.org/10.1182/blood.V130.Suppl_1.2916.2916
Published: 2017
Journal Articles

Characterization of the Procoagulant Activity of Two Different Microparticle Species.

Ludwig Traby, Marietta Kollars, Khalid Shoumariyeh, Ansgar Weltermann, Paul Alexander Kyrle, Sabine Eichinger, Daniel Lechner
Journal: Blood
Blood (2010) 116 (21): 1143.
https://doi.org/10.1182/blood.V116.21.1143.1143
Published: 2010