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Journal Articles

Apex Part 1: Updated Assessment of Bezuclastinib (CGT9486), a Selective KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM)

Daniel J. DeAngelo, Jason Gotlib, Vinod Pullarkat, Pankit Vachhani, Tsewang Tashi, Stephanie Lee, Gary J. Schiller, Anthony M. Hunter, Miguel Piris-Villaespesa, Helena Pomares, Bulai Livideanu Cridtina, Khalid Shoumariyeh, Jonathan Lambert, Tracy I. George, Jay Patel, Cristina Papayannidis, Tania Jain, Michael W. Deininger, Andreas Reiter, Gabriela S. Hobbs, Lei Sun, Deepak Nagendra, Jenna Zhang, Amanda Pilla, Kim Dishman, Marcus Carden, Deepti H. Radia
Journal: Blood
Blood (2024) 144 (Supplement 1): 659.
https://doi.org/10.1182/blood-2024-193678
Published: 2024
Journal Articles

Updated Efficacy and Safety Results of Patients Receiving Selected 100mg Bezuclastinib Dose and Participating in the Open-Label Extension of Summit: A Randomized, Double-Blind, Placebo Controlled Phase 2 Clinical Trial of Bezuclastinib in Adult Patients with Nonadvanced Systemic Mastocytosis

Lindsay A.M. Rein, Daniel J. DeAngelo, Brian Modena, Stephen Oh, Bulai Livideanu Cridtina, Celalettin Ustun, Nathan Boggs, Michael Manning, Anthony M. Hunter, Cem Akin, Arnold Kirshenbaum, Ingunn Dybedal, Cecilia Y. Arana Yi, Richard Herrscher, Mariana Castells, Frederick Lansigan, Tracy I. George, Jay Patel, Lei Sun, Nisha Shah, Jenna Zhang, Amanda Pilla, Priya Singh, Marcus Carden, Frank Siebenhaar, Prithviraj Bose
Journal: Blood
Blood (2024) 144 (Supplement 1): 4556.
https://doi.org/10.1182/blood-2024-194551
Published: 2024
Journal Articles

Preliminary Safety and Efficacy from Apex, a Phase 2 Study of Bezuclastinib (CGT9486), a Novel, Highly Selective, Potent KIT D816V Tyrosine Kinase Inhibitor, in Adults with Advanced Systemic Mastocytosis (AdvSM)

Daniel J. DeAngelo, Vinod A. Pullarkat, Miguel Piris-Villaespesa, Tracy I. George, Jay L. Patel, Celalettin Ustun, Prithviraj Bose, Mark L Heaney, Jessica Sachs, Lei Sun, Amanda Pilla, Benjamin Exter, Hina A. Jolin, Tsewang Tashi
Journal: Blood
Blood (2022) 140 (Supplement 1): 1512–1513.
https://doi.org/10.1182/blood-2022-156311
Published: 2022
Journal Articles

The Long Non-Coding RNA MALAT1 Is Necessary for Hematopoietic Stem and Progenitor Cell Expansion and Preleukemic Myeloproliferation in TET2 Deficient Myeloid Neoplasms

Nana Adjoa Ben-Crentsil, Ariel Quintana-Gonzalez, Maria E Balasis, Hannah Newman, Traci L. Kruer, Lei Sun, Christopher Letson, Abhishek Dhawan, Chetasi Talati, Meghan Ferrall-Fairbanks, Alexis Vedder, Kathy McGraw, Rami S. Komrokji, Li Ma, Eric Padron
Journal: Blood
Blood (2022) 140 (Supplement 1): 1991–1993.
https://doi.org/10.1182/blood-2022-156670
Published: 2022
Journal Articles

A Dose Escalation Phase Ia Study of Anti-CD20 Antibody Drug Conjugate, MRG001 in Relapsed/Refractory Advanced Non-Hodgkin Lymphom

Yuqin Song, Ye Guo, Zhao Wang, Meng Wu, Wei Peng, Lei Sun, Jinghui Sun, Maggie Li, Jun Zhu
Journal: Blood
Blood (2021) 138 (Supplement 1): 2490.
https://doi.org/10.1182/blood-2021-144829
Published: 2021
Journal Articles

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1

Roger Belizaire, Sebastian H. J. Koochaki, Namrata D. Udeshi, Alexis Vedder, Lei Sun, Tanya Svinkina, Christina Hartigan, Marie McConkey, Veronica Kovalcik, Amanuel Bizuayehu, Caroline Stanclift, Monica Schenone, Steven A. Carr, Eric Padron, Benjamin L. Ebert
Journal: Blood
Blood (2021) 137 (16): 2209–2220.
https://doi.org/10.1182/blood.2020006528
Published: 2021
Includes: Supplemental data
Journal Articles

Oncogenic Mechanisms of CBL E3 Ubiquitin Ligase Mutations in Myeloid Malignancies

Roger Belizaire, MD PhD, Sebastian Koochaki, BS, MS, Namrata Udeshi, PhD, Alexis Vedder, BS, Lei Sun, Monica Schenone, PhD, Steven Carr, PhD, Eric Padron, MD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 563.
https://doi.org/10.1182/blood-2019-122503
Published: 2019
Journal Articles

Cathelicidin Antimicrobial Peptide Expression Is Inversely Associated with Absolute Neutrophil Counts in Pediatric HCT Recipients

Jos Domen, PhD, Hung-Wen Yeh, PhD, Nancy L Shreve, Lei Sun, MD, Yongwu Li, MD, Katrina D Walters, CCRC, Jignesh Dalal, MD, Rakesh K. Goyal, MBBS,MDMRCP
Journal: Blood
Blood (2019) 134 (Supplement_1): 3294.
https://doi.org/10.1182/blood-2019-131471
Published: 2019
Journal Articles

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

Maria E Balasis, Alexis Vedder, BS, Lei Sun, Ariel Quintana, PhD, Abhishek Dhawan, Hannah Newman, BS, Jane Merlevede, Kathy McGraw, PhD, Traci Kruer, PhD, Nana Ben-Crentsil, Jeffrey S Painter, BS, Nathalie Droin, PhD, Thomas Cluzeau, MD PhD, Christopher Letson, BS, Sheng Wei, MD, Rami S. Komrokji, MD, Hailing Zhang, MD, A. Robert MacLeod, PhD, Alan F. List, MD, Eric Solary, MD PhD, Pearlie K. Epling-Burnette, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1692.
https://doi.org/10.1182/blood-2019-128573
Published: 2019
Journal Articles

Id1 Ablation Protects Hematopoietic Stem Cells from Stress-Induced Exhaustion and Aging

Shweta Singh, Satyendra Singh, Stephen Gadomski, Lei Sun, Serguei Kozlov, Alex Pfaennenstein, Lino Tessarollo, Kimberly Klarmann, Jonathan Keller, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 4943.
https://doi.org/10.1182/blood.V130.Suppl_1.4943.4943
Published: 2017
Journal Articles

Id2 Is Required for the Self-Renewal and Proliferation of Hematopoietic Stem Cells

Lei Sun, PhD
Journal: Blood
Blood (2015) 126 (23): 1173.
https://doi.org/10.1182/blood.V126.23.1173.1173
Published: 2015
Journal Articles

Targeting Human B-Precursor Acute Lymphoblastic Leukemia Cells with Recombinant Human CD19 Ligand

Fatih M. Uckun, MD, PhD, Lei Sun, PhD, Hong Ma, Ph.D., Sanjive Qazi, Ph.D., Ilker Dibirdik, Ph.D., Zahide Ozer, Ph.D.
Journal: Blood
Blood (2010) 116 (21): 599.
https://doi.org/10.1182/blood.V116.21.599.599
Published: 2010
Journal Articles

CYLD regulates angiogenesis by mediating vascular endothelial cell migration

Jinmin Gao, Lei Sun, Lihong Huo, Min Liu, Dengwen Li, Jun Zhou
Journal: Blood
Blood (2010) 115 (20): 4130–4137.
https://doi.org/10.1182/blood-2009-10-248526
Published: 2010
Includes: Supplemental data
Journal Articles

Biology and Treatment of Childhood T-Lineage Acute Lymphoblastic Leukemia

Fatih M. Uckun, Martha G. Sensel, Lei Sun, Peter G. Steinherz, Michael E. Trigg, Nyla A. Heerema, Harland N. Sather, Gregory H. Reaman, Paul S. Gaynon
Journal: Blood
Blood (1998) 91 (3): 735–746.
https://doi.org/10.1182/blood.V91.3.735
Published: 1998