1-20 of 36
Cem Akin
Close
Save search
Follow your search
Access your saved searches in your account
Would you like to receive an alert when new items match your search?
Close Modal
Sort by
Journal Articles

Updated Efficacy and Safety Results of Patients Receiving Selected 100mg Bezuclastinib Dose and Participating in the Open-Label Extension of Summit: A Randomized, Double-Blind, Placebo Controlled Phase 2 Clinical Trial of Bezuclastinib in Adult Patients with Nonadvanced Systemic Mastocytosis

Lindsay A.M. Rein, Daniel J. DeAngelo, Brian Modena, Stephen Oh, Bulai Livideanu Cridtina, Celalettin Ustun, Nathan Boggs, Michael Manning, Anthony M. Hunter, Cem Akin, Arnold Kirshenbaum, Ingunn Dybedal, Cecilia Y. Arana Yi, Richard Herrscher, Mariana Castells, Frederick Lansigan, Tracy I. George, Jay Patel, Lei Sun, Nisha Shah, Jenna Zhang, Amanda Pilla, Priya Singh, Marcus Carden, Frank Siebenhaar, Prithviraj Bose
Journal: Blood
Blood (2024) 144 (Supplement 1): 4556.
https://doi.org/10.1182/blood-2024-194551
Published: 2024
Journal Articles

Initial Results from Summit: An Ongoing, 3-Part, Multi-Center, Randomized, Double-Blind, Placebo-Controlled Phase 2 Clinical Study of Bezuclastinib in Adult Patients with Nonadvanced Systemic Mastocytosis (NonAdvSM)

Prithviraj Bose, Stephen T. Oh, Brian Modena, Anthony M. Hunter, Cem Akin, Mariana Castells, Michael Manning, Richard Herrscher, Frank Siebenhaar, Daniel J. DeAngelo, Tracy I. George, Benjamin Exter, Jenna Zhang, Amanda Pilla, Hina Jolin, Rachael Easton, Lindsay A.M Rein
Journal: Blood
Blood (2023) 142 (Supplement 1): 77.
https://doi.org/10.1182/blood-2023-178927
Published: 2023
Journal Articles

Summit: A 3-Part, Phase 2 Study of Bezuclastinib (CGT9486), an Oral, Selective, and Potent KIT D816V Inhibitor, in Adult Patients with Nonadvanced Systemic Mastocytosis (NonAdvSM)

Cem Akin, Frank Siebenhaar, Michael W. Deininger, Daniel J. DeAngelo, Tracy I. George, Mariana Castells, Matthew Giannetti, Jason Gotlib, Jessica Sachs, Amanda Pilla, Hina A. Jolin, Prithviraj Bose
Journal: Blood
Blood (2022) 140 (Supplement 1): 6838–6839.
https://doi.org/10.1182/blood-2022-156326
Published: 2022
Journal Articles

Pioneer Part 2: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate Safety and Efficacy of Avapritinib in Indolent Systemic Mastocytosis

Cem Akin, MDPhD, Hanneke Oude Elberink, MD PhD, Jason Gotlib, MD MS, Vito Sabato, MD PhD, Karin Hartmann, MD, Sigurd Broesby-Olsen, MD, Mariana Castells, MD PhD, Tsewang Tashi, MD, Mark L Heaney, MD, Tracy I. George, MD, Frank Siebenhaar, MD, Deepti H. Radia, MRCPI, FRCPath, Massimo Triggiani, MD PhD, Paul van Daele, MD, Daniel J. DeAngelo, MD PhD, Iván Alvarez-Twose, MD PhD, Andreas Reiter, MD, Peter Vadas, MD PhD, Patrizia Bonadonna, MD, Paggy Hew, MS, Hui-Min Lin, PhD, Maria Roche, MS, Marcus Maurer, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-136632
Published: 2020
Journal Articles

Increased Detection of KIT D816V Mutation in Peripheral Blood Samples from Patients with Indolent Systemic Mastocytosis (ISM) in the Phase 2 Pioneer Study Using a High Sensitivity Droplet Digital (dd) PCR Assay Compared with Next Generation Sequencing (NGS)

Tracy I. George, MD, Gerard Hoehn, PhD, Hui-Min Lin, PhD, Stephen Miller, PhD, Cem Akin, MDPhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 7–8.
https://doi.org/10.1182/blood-2020-136930
Published: 2020
Journal Articles

Pioneer: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis with Symptoms Inadequately Controlled with Standard Therapy

Cem Akin, MD PhD, Vito Sabato, Jason Gotlib, MD MS, Mariana Castells, Michael W. Deininger, Hanneke Oude Elberink, Mark L Heaney, Paul van Daele, Deepti Radia, Massimo Triggiani, Daniel J. DeAngelo, MD, Iván Alvarez-Twose, Sigurd Broesby-Olsen, Tracy I. George, MD, Karin Hartmann, Siebenhaar Frank, Andreas Reiter, Peter Vadas, Patrizia Bonadonna, Jens P. Panse, Petra Staubach-Renz, Knut Brockow, Diamant Thaci, Hui-Min Lin, Andrew Morrison, Brenton Mar, Marcus Maurer
Journal: Blood
Blood (2019) 134 (Supplement_1): 2950.
https://doi.org/10.1182/blood-2019-126035
Published: 2019
Journal Articles

Mastocytosis: 2016 updated WHO classification and novel emerging treatment concepts

Clinical Trials & Observations
Peter Valent, Cem Akin, Dean D. Metcalfe
Journal: Blood
Blood (2017) 129 (11): 1420–1427.
https://doi.org/10.1182/blood-2016-09-731893
Published: 2017
Includes: Supplemental data
Journal Articles

Cladribine for mastocytosis: benefits and risks

Cem Akin
Journal: Blood
Blood (2015) 126 (8): 931–932.
https://doi.org/10.1182/blood-2015-06-649525
Published: 2015
Journal Articles

Midostaurin (PKC412) Demonstrates a High Rate of Durable Responses in Patients with Advanced Systemic Mastocytosis: Results from the Fully Accrued Global Phase 2 CPKC412D2201 Trial

Jason Gotlib, MD MS, Hanneke C. Kluin-Nelemans, MD PhD, Tracy I. George, MD, Cem Akin, MD PhD, Karl Sotlar, MD, Olivier Hermine, MD PhD, Farrukh Awan, MD MS, Elizabeth O Hexner, MD, Michael Mauro, MD, David Sternberg, MD PhD, Matthieu Villeneuve, Fabienne Emery-Salbert, MSc, Eric Stanek, PharmD, Karin Hartmann, MD, Hans-Peter Horny, MD, Peter Valent, MD, Andreas Reiter, MD
Journal: Blood
Blood (2014) 124 (21): 636.
https://doi.org/10.1182/blood.V124.21.636.636
Published: 2014
Journal Articles

Allogeneic Hematopoietic Cell Transplantation Is Effective In Patients With Advanced Systemic Mastocytosis: A Multicenter Retrospective Analysis

Celalettin Ustun, Andreas Reiter, Bart L Scott, MD, Ryotaro Nakamura, Damaj Gandhi, Sebastian Kreil, Ryan Shanley, William J Hogan, MD, Miguel-Angel Perales, MD, Tsiporah B. Shore, Herrad Baurmann, Robert K Stuart, Bernd Gruhn, Michael Doubek, Jack W Hsu, Eleni Tholouli, Tanja Gromke, Lucy A Godley, Livio Pagano, MD, Andrew Gilman, Eva Maria Wagner, MD, Tor Shwayder, Martin Bornhaeuser, Esperanza B Papadopoulos, M.D., Alexandra Boehm, Gregory M Vercellotti, Maria Theresa Van Lint, Christoph Schmid, Werner Rabitsch, MD, Vinod Pullarkat, MD, A. John Barrett, MD, Olivier Hermine, MD, PhD, Hans Gustaf Hagglund, Wolfgang R Sperr, M.D., Uday R Popat, MD, Steven M. Devine, MD, H. Joachim Deeg, MD, Daniel J. Weisdorf, MD, Cem Akin, Peter Valent
Journal: Blood
Blood (2013) 122 (21): 2145.
https://doi.org/10.1182/blood.V122.21.2145.2145
Published: 2013
Journal Articles

Durable Responses and Improved Quality Of Life With Midostaurin (PKC412) In Advanced Systemic Mastocytosis (SM): Updated Stage 1 Results Of The Global D2201 Trial

Jason Gotlib, MD, Hanneke C. Kluin-Nelemans, MD, PhD, Tracy I. George, MD, Cem Akin, MD, PhD, Karl Sotlar, MD, Olivier Hermine, Farrukh Awan, MD, MS, Elizabeth Hexner, MD, Michael Mauro, MD, Rodica Morariu, MD, Margaret Squier, MD, PhD, Matthieu Villeneuve, Fabienne Emery-Salbert, MSc, John Coombs, PharmD, MBA, Karin Hartmann, MD, Hans-Peter Horny, MD, Peter Valent, MD, Andreas Reiter, MD
Journal: Blood
Blood (2013) 122 (21): 106.
https://doi.org/10.1182/blood.V122.21.106.106
Published: 2013
Journal Articles

International Working Group-Myeloproliferative Neoplasms Research and Treatment (IWG-MRT) & European Competence Network on Mastocytosis (ECNM) consensus response criteria in advanced systemic mastocytosis

Jason Gotlib, Animesh Pardanani, Cem Akin, Andreas Reiter, Tracy George, Olivier Hermine, Hanneke Kluin-Nelemans, Karin Hartmann, Wolfgang R. Sperr, Knut Brockow, Lawrence B. Schwartz, Alberto Orfao, Daniel J. DeAngelo, Michel Arock, Karl Sotlar, Hans-Peter Horny, Dean D. Metcalfe, Luis Escribano, Srdan Verstovsek, Ayalew Tefferi, Peter Valent
Journal: Blood
Blood (2013) 121 (13): 2393–2401.
https://doi.org/10.1182/blood-2012-09-458521
Published: 2013
Includes: Supplemental data
Journal Articles

KIT Inhibitor Midostaurin in Patients with Advanced Systemic Mastocytosis: Results of a Planned Interim Analysis of the Global CPKC412D2201 Trial

Jason Gotlib, MD, MS, Hanneke C. Kluin-Nelemans, MD, PhD, Tracy I. George, MD, Cem Akin, MD, PhD, Karl Sotlar, MD, Olivier Hermine, MD, PhD, Farrukh Awan, MD, MS, Elizabeth Hexner, MD, Michael J. Mauro, MD, Rodica Morariu, MD, Margaret Squier, MD, PhD, Matthieu Villeneuve, Fabienne Emery-Salbert, MSc, Karin Hartmann, MD, Hans-Peter Horny, MD, Peter Valent, MD, Andreas Reiter, MD
Journal: Blood
Blood (2012) 120 (21): 799.
https://doi.org/10.1182/blood.V120.21.799.799
Published: 2012
Journal Articles

How I treat patients with advanced systemic mastocytosis

Peter Valent, Wolfgang R. Sperr, Cem Akin
Journal: Blood
Blood (2010) 116 (26): 5812–5817.
https://doi.org/10.1182/blood-2010-08-292144
Published: 2010
Journal Articles

The classification of systemic mastocytosis should include mast cell leukemia (MCL) and systemic mastocytosis with a clonal hematologic non–mast cell lineage disease (SM-AHNMD)

Peter Valent, Michel Arock, Cem Akin, Wolfgang R. Sperr, Andreas Reiter, Karl Sotlar, Karin Hartmann, Tracy I. George, Knut Brockow, Hanneke C. Kluin-Nelemans, Jason Gotlib, Dean D. Metcalfe, Hans-Peter Horny
Journal: Blood
Blood (2010) 116 (5): 850–851.
https://doi.org/10.1182/blood-2010-05-285270
Published: 2010
Journal Articles

The KIT Tyrosine Kinase Inhibitor Midostaurine (PKC412) Exhibits a High Response Rate in Aggressive Systemic Mastocytosis (ASM): Interim Results of a Phase II Trial.

Jason Gotlib, Tracy I. George, Chris Corless, Andrea Linder, Alisa Ruddell, Cem Akin, Daniel J. DeAngelo, Ilana Kepten, Carlo Lanza, Heidrun Heinemann, Ophelia Yin, Neil Gallagher, Tim Graubert
Journal: Blood
Blood (2007) 110 (11): 3536.
https://doi.org/10.1182/blood.V110.11.3536.3536
Published: 2007
Journal Articles

Novel C-KIT Transcripts Identified in Mast Cell Leukemia: An Update of the Full Transcript and It’s Distribution.

Ozden Ozer, Yi D. Zhao, Kelly R. Ostler, Cem Akin, John Anastasi, James Vardiman, Lucy Godley
Journal: Blood
Blood (2007) 110 (11): 2396.
https://doi.org/10.1182/blood.V110.11.2396.2396
Published: 2007
Journal Articles

Phase II Study of Dasatinib (SPRYCEL™) in Philadelphia Chromosome-Negative Acute and Chronic Myeloid Diseases, Including Systemic Mastocytosis.

Srdan Verstovsek, MD, PhD, Tefferi Ayalew, M.D., Cortes Jorge, M.D., Susan O’Brien, M.D., Guillermo Garcia-Manero, M.D., Animesh Pardanani, M.D., Cem Akin, M.D., Stefan Faderl, M.D., Deborah Thomas, M.D., Hagop Kantarjian, M.D.
Journal: Blood
Blood (2007) 110 (11): 3551.
https://doi.org/10.1182/blood.V110.11.3551.3551
Published: 2007
Journal Articles

Demonstration of an aberrant mast-cell population with clonal markers in a subset of patients with “idiopathic” anaphylaxis

Brief Report
Cem Akin, Linda M. Scott, Can N. Kocabas, Nataliya Kushnir-Sukhov, Erica Brittain, Pierre Noel, Dean D. Metcalfe
Journal: Blood
Blood (2007) 110 (7): 2331–2333.
https://doi.org/10.1182/blood-2006-06-028100
Published: 2007
Journal Articles

What does a basophil do?

Cem Akin
Journal: Blood
Blood (2007) 110 (3): 790–791.
https://doi.org/10.1182/blood-2007-04-085233
Published: 2007