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Ivan Alvarez-Twose
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Journal Articles

Ultra-Sensitive KIT testing Uncovers Previously Undetected KIT mutations in Patients with Indolent Systemic Mastocytosis: Results from the Pioneer Trial

Deepti H. Radia, Tsewang Tashi, Ivan Alvarez-Twose, Patrizia Bonadonna, Hanneke Oude Elberink, Sonia Cerquozzi, Tracy I. George, Guang Yang, Mark Rosenzweig, Hui-Min Lin, Ben Lampson, Rachel L. Erlich, Jason Gotlib
Journal: Blood
Blood (2024) 144 (Supplement 1): 3164.
https://doi.org/10.1182/blood-2024-207798
Published: 2024
Journal Articles

Overall Survival and Duration of Treatment in Patients with Advanced Systemic Mastocytosis Receiving Avapritinib Versus Midostaurin or Best Available Therapy in a Real-World Setting

Andreas Reiter, Jason Gotlib, Iván Álvarez-Twose, Deepti H. Radia, Johannes Luebke, Priyanka J. Bobbili, Aolin Wang, Saša Dimitrijević, Erin Sullivan, Juliana Schwaab, Ilene A. Galinsky, Cecelia Perkins, Wolfgang R. Sperr, Priya Sriskandarajah, Manasi Mohan, Teshawna Badu, Mei Sheng Duh, Peter Valent, Daniel J. DeAngelo
Journal: Blood
Blood (2024) 144 (Supplement 1): 1801.
https://doi.org/10.1182/blood-2024-204015
Published: 2024
Journal Articles

Elenestinib, an Investigational, Next Generation KIT D816V Inhibitor, Reduces Mast Cell Burden, Improves Symptoms, and Has a Favorable Safety Profile in Patients with Indolent Systemic Mastocytosis: Analysis of the Harbor Trial

Tsewang Tashi, Olivier Hermine, Mariana Castells, Mar Guilarte, Vito Sabato, Marcus Maurer, Jens Panse, Ivan Alvarez-Twose, Renata Cabral, Robert Bird, Stéphane Barete, Laurence Bouillet, Maud Hermans, Paul Van Daele, David González-De-Olano, Elizabeth A. Griffiths, Joseph Jurcic, Ingunn Dybedal, Gandhi Laurent Damaj, Philippe Schafhausen, Chiara Elena, Tse-Chieh Teh, Pankit Vachhani, Caroline Labe, Saranya Venugopal, Kevin He, Javier Muñoz-González, Ben Lampson, Robyn Scherber, Prithviraj Bose, Clive Grattan, Thanai Pongdee, Tracy I. George, Cristina Bulai Livideanu
Journal: Blood
Blood (2023) 142 (Supplement 1): 76.
https://doi.org/10.1182/blood-2023-188904
Published: 2023
Journal Articles

Frequency and prognostic impact of blood-circulating tumor mast cells in mastocytosis

Clinical Trials & Observations
Ana Henriques, Javier I. Muñoz-González, Laura Sánchez-Muñoz, Almudena Matito, Lidia Torres-Rivera, María Jara-Acevedo, Carolina Caldas, Andrea Mayado, Alba Pérez-Pons, Andrés C. García-Montero, Iván Álvarez-Twose, Alberto Orfao
Journal: Blood
Blood (2022) 139 (4): 572–583.
https://doi.org/10.1182/blood.2021012694
Published: 2022
Includes: Supplemental data
Journal Articles

Pioneer Part 2: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study to Evaluate Safety and Efficacy of Avapritinib in Indolent Systemic Mastocytosis

Cem Akin, MDPhD, Hanneke Oude Elberink, MD PhD, Jason Gotlib, MD MS, Vito Sabato, MD PhD, Karin Hartmann, MD, Sigurd Broesby-Olsen, MD, Mariana Castells, MD PhD, Tsewang Tashi, MD, Mark L Heaney, MD, Tracy I. George, MD, Frank Siebenhaar, MD, Deepti H. Radia, MRCPI, FRCPath, Massimo Triggiani, MD PhD, Paul van Daele, MD, Daniel J. DeAngelo, MD PhD, Iván Alvarez-Twose, MD PhD, Andreas Reiter, MD, Peter Vadas, MD PhD, Patrizia Bonadonna, MD, Paggy Hew, MS, Hui-Min Lin, PhD, Maria Roche, MS, Marcus Maurer, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 41–42.
https://doi.org/10.1182/blood-2020-136632
Published: 2020
Journal Articles

Pioneer: A Randomized, Double-Blind, Placebo-Controlled, Phase 2 Study of Avapritinib in Patients with Indolent or Smoldering Systemic Mastocytosis with Symptoms Inadequately Controlled with Standard Therapy

Cem Akin, MD PhD, Vito Sabato, Jason Gotlib, MD MS, Mariana Castells, Michael W. Deininger, Hanneke Oude Elberink, Mark L Heaney, Paul van Daele, Deepti Radia, Massimo Triggiani, Daniel J. DeAngelo, MD, Iván Alvarez-Twose, Sigurd Broesby-Olsen, Tracy I. George, MD, Karin Hartmann, Siebenhaar Frank, Andreas Reiter, Peter Vadas, Patrizia Bonadonna, Jens P. Panse, Petra Staubach-Renz, Knut Brockow, Diamant Thaci, Hui-Min Lin, Andrew Morrison, Brenton Mar, Marcus Maurer
Journal: Blood
Blood (2019) 134 (Supplement_1): 2950.
https://doi.org/10.1182/blood-2019-126035
Published: 2019
Journal Articles

Frequency and prognostic impact of KIT and other genetic variants in indolent systemic mastocytosis

Javier I. Muñoz-González, Iván Álvarez-Twose, María Jara-Acevedo, Ana Henriques, Esther Viñas, Carlos Prieto, Laura Sánchez-Muñoz, Carolina Caldas, Andrea Mayado, Almudena Matito, Noelia Dasilva-Freire, Alberto Orfao, Andrés C. García-Montero
Journal: Blood
Blood (2019) 134 (5): 456–468.
https://doi.org/10.1182/blood.2018886507
Published: 2019
Includes: Supplemental data
Journal Articles

KIT D816V–mutated bone marrow mesenchymal stem cells in indolent systemic mastocytosis are associated with disease progression

Andres C. Garcia-Montero, Maria Jara-Acevedo, Ivan Alvarez-Twose, Cristina Teodosio, Laura Sanchez-Muñoz, Carmen Muñiz, Javier I. Muñoz-Gonzalez, Andrea Mayado, Almudena Matito, Carolina Caldas, Jose M. Morgado, Luis Escribano, Alberto Orfao
Journal: Blood
Blood (2016) 127 (6): 761–768.
https://doi.org/10.1182/blood-2015-07-655100
Published: 2016
Journal Articles

KIT D816V Mutation Positive Bone Marrow Mesenchymal Stem Cells in Indolent Systemic Mastocytosis Are Associated with Disease Progression

Andres C Garcia-Montero, PhD, Maria Jara-Acevedo, MSc, Ivan Alvarez-Twose, MD, Cristina Teodosio, Laura Sanchez-Muñoz, Javier Ignacio Muñoz-Gonzalez, Andrea Mayado, Almudena Matito, MD PhD, Carolina Caldas, Jose M Morgado, MSc, Luis Escribano, MD PhD, Alberto Orfao, MD PhD
Journal: Blood
Blood (2015) 126 (23): 4058.
https://doi.org/10.1182/blood.V126.23.4058.4058
Published: 2015