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Journal Articles

Title: Clonal Hematopoiesis and Germline Predisposition in High-Risk Leukemia Pedigrees

Afaf Osman, Julie Feusier, Brian Avery, Deborah M. Stephens, Michael Madsen, Justin Williams, Tony Pomicter, Brandt Jones, Adam Clayton, Philippe Szankasi, Jay Patel, Ramiro Garzon, Nicola J Camp
Journal: Blood
Blood (2024) 144 (Supplement 1): 1296.
https://doi.org/10.1182/blood-2024-198528
Published: 2024
Journal Articles

Updated Efficacy and Safety Results of Patients Receiving Selected 100mg Bezuclastinib Dose and Participating in the Open-Label Extension of Summit: A Randomized, Double-Blind, Placebo Controlled Phase 2 Clinical Trial of Bezuclastinib in Adult Patients with Nonadvanced Systemic Mastocytosis

Lindsay A.M. Rein, Daniel J. DeAngelo, Brian Modena, Stephen Oh, Bulai Livideanu Cridtina, Celalettin Ustun, Nathan Boggs, Michael Manning, Anthony M. Hunter, Cem Akin, Arnold Kirshenbaum, Ingunn Dybedal, Cecilia Y. Arana Yi, Richard Herrscher, Mariana Castells, Frederick Lansigan, Tracy I. George, Jay Patel, Lei Sun, Nisha Shah, Jenna Zhang, Amanda Pilla, Priya Singh, Marcus Carden, Frank Siebenhaar, Prithviraj Bose
Journal: Blood
Blood (2024) 144 (Supplement 1): 4556.
https://doi.org/10.1182/blood-2024-194551
Published: 2024
Journal Articles

Apex Part 2 Trial in Progress: A Phase 2 Open-Label Clinical Study of Bezuclastinib in Adult Patients with Advanced Systemic Mastocytosis

Isaac Goncalves, Stephen Fuller, Jason Gotlib, Pankit Vachhani, Vinod Pullarkat, Daniel J. DeAngelo, Saskia K. Klein, Wolfgang R. Sperr, Karin Hartmann, Khalid Shoumariyeh, Jens Panse, Teng Fong Ng, Miguel Piris-Villaespesa, Tsewang Tashi, Anthony M. Hunter, Prithviraj Bose, Cecilia Y. Arana Yi, Manish Jain, Helena Pomares, Tracy I. George, Jay Patel, Cristina Papayannidis, Minakshi S. Taparia, Bulai Livideanu Cridtina, Juliana Schwaab, Ingunn Dybedal, Jonathan Lambert, Tania Jain, Ewa Wierzbicka-Hainaut, Olivier Hermine, Massimiliano Bonifacio, Gabriela S. Hobbs, Michael W. Deininger, Amanda Pilla, Marcus Carden, Deepti H. Radia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4569.1.
https://doi.org/10.1182/blood-2024-194550
Published: 2024
Journal Articles

Apex Part 1: Updated Assessment of Bezuclastinib (CGT9486), a Selective KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM)

Daniel J. DeAngelo, Jason Gotlib, Vinod Pullarkat, Pankit Vachhani, Tsewang Tashi, Stephanie Lee, Gary J. Schiller, Anthony M. Hunter, Miguel Piris-Villaespesa, Helena Pomares, Bulai Livideanu Cridtina, Khalid Shoumariyeh, Jonathan Lambert, Tracy I. George, Jay Patel, Cristina Papayannidis, Tania Jain, Michael W. Deininger, Andreas Reiter, Gabriela S. Hobbs, Lei Sun, Deepak Nagendra, Jenna Zhang, Amanda Pilla, Kim Dishman, Marcus Carden, Deepti H. Radia
Journal: Blood
Blood (2024) 144 (Supplement 1): 659.
https://doi.org/10.1182/blood-2024-193678
Published: 2024
Journal Articles

Changes of the Mutational Landscape in Relapsed Acute Myeloid Leukemia

Franck Rapaport, PhD, Marc Robert de Massy, Adil al Hinai, Mathijs A. Sanders, PhD, Todd Hricik, Caroline Sheridan, Tak C Lee, M.S., Yaseswini Neelamraju, Jay Patel, Stephen S. Chung, MD, Michael W. Becker, MD, Ian D Lewis, MBBS, PhD FRACP, FRCPA, Richard D'Andrea, PhD, Lars Bullinger, MD, Konstanze Döhner, MD, Hartmut Döhner, MD, Monica L. Guzman, PhD, Gail J. Roboz, Martin Carroll, MD, Christopher Y. Park, MD PhD, Christopher E. Mason, PhD, Ari Melnick, MD, Ross L. Levine, MD, Peter J.M. Valk, PhD, Francine E. Garrett-Bakelman, MD PhD
Journal: Blood
Blood (2016) 128 (22): 599.
https://doi.org/10.1182/blood.V128.22.599.599
Published: 2016
Journal Articles

Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

Jie He, Omar Abdel-Wahab, Michelle K. Nahas, Kai Wang, Raajit K. Rampal, Andrew M. Intlekofer, Jay Patel, Andrei Krivstov, Garrett M. Frampton, Lauren E. Young, Shan Zhong, Mark Bailey, Jared R. White, Steven Roels, Jason Deffenbaugh, Alex Fichtenholtz, Timothy Brennan, Mark Rosenzweig, Kimberly Pelak, Kristina M. Knapp, Kristina W. Brennan, Amy L. Donahue, Geneva Young, Lazaro Garcia, Selmira T. Beckstrom, Mandy Zhao, Emily White, Vera Banning, Jamie Buell, Kiel Iwanik, Jeffrey S. Ross, Deborah Morosini, Anas Younes, Alan M. Hanash, Elisabeth Paietta, Kathryn Roberts, Charles Mullighan, Ahmet Dogan, Scott A. Armstrong, Tariq Mughal, Jo-Anne Vergilio, Elaine Labrecque, Rachel Erlich, Christine Vietz, Roman Yelensky, Philip J. Stephens, Vincent A. Miller, Marcel R. M. van den Brink, Geoff A. Otto, Doron Lipson, Ross L. Levine
Journal: Blood
Blood (2016) 127 (24): 3004–3014.
https://doi.org/10.1182/blood-2015-08-664649
Published: 2016
Includes: Supplemental data
Journal Articles

Divergent Dynamics of Epigenetic and Genetic Heterogeneity in Relapsed Acute Myeloid Leukemia

Francine E. Garrett-Bakelman, MD PhD, Sheng Li, PhD, Stephen S. Chung, MD, Todd Hricik, Rapaport Franck, Jay Patel, Richard Dillon, MA, MRCP, FRCPath, Priyanka Vijay, Anna L Brown, PhD, Alexander E. Perl, MD, B. Joy Cannon, Mathijs A. Sanders, PhD, Peter J M Valk, PhD, Lars Bullinger, MD, Selina Luger, MD, Michael W. Becker, MD, Ian D. Lewis, MBBS PhDFRACP FRCPA, L. Bik To, MD, Richard J D'Andrea, PhD, David Grimwade, MD PhD, Ruud Delwel, PhD, Bob Lowenberg, MD PhD, Hartmut Dohner, MD, Konstanze Dohner, MD, Duane C Hassane, PhD, Monica L. Guzman, PhD, Gail J Roboz, MD, Martin Carroll, MD, Christopher Y. Park, MD, PhD, Donna S. Neuberg, Sc.D., Ross L. Levine, MD, Christopher Mason, PhD, Ari Melnick, MD
Journal: Blood
Blood (2015) 126 (23): 306.
https://doi.org/10.1182/blood.V126.23.306.306
Published: 2015
Journal Articles

Integrated DNA/RNA Profiling for Somatic Alterations in Adult B-Cell ALL

Franck Rapaport, PhD, Jay Patel, Jie He, PhD, Timothy A Brennan, MS, Michelle Nahas, PhD, Sohail Balassubramanian, MS, Geoff Otto, PhD, Doron Lipson, PhD, Phil Stephens, PhD, Vincent A. Miller, MD, Janis Racevskis, MD, Mark R Litzow, MD, Peter H. Wiernik, MD, Anthony H. Goldstone, FRCP, FRCPath, Selina Luger, MD, Marcel van den Brink, MD PhD, Agnes Viale, PhD, Jacob M. Rowe, MD, Martin S. Tallman, MD, Ari Melnick, MD, Elisabeth Paietta, PhD, Mithat Gonen, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2015) 126 (23): 1422.
https://doi.org/10.1182/blood.V126.23.1422.1422
Published: 2015
Journal Articles

Genetic analysis of patients with leukemic transformation of myeloproliferative neoplasms shows recurrent SRSF2 mutations that are associated with adverse outcome

Su-Jiang Zhang, Raajit Rampal, Taghi Manshouri, Jay Patel, Nana Mensah, Andrew Kayserian, Todd Hricik, Adriana Heguy, Cyrus Hedvat, Mithat Gönen, Hagop Kantarjian, Ross L. Levine, Omar Abdel-Wahab, Srdan Verstovsek
Journal: Blood
Blood (2012) 119 (19): 4480–4485.
https://doi.org/10.1182/blood-2011-11-390252
Published: 2012
Includes: Supplemental data
Journal Articles

High Throughput Transcriptome Sequencing of Pediatric Relapsed Acute Lymphoblastic Leukemia (ALL) Identifies Relapse Specific Mutations and Expression

Julia A. Meyer, BSc, Laura E. Hogan, MD, Jinhua Wang, PhD, Jun J. Yang, PhD, Jay Patel, BSc, Ross L. Levine, MD, Stephen P. Hunger, MD, Elizabeth Raetz, MD, Christopher Mason, PhD, William L. Carroll, MD
Journal: Blood
Blood (2010) 116 (21): 3233.
https://doi.org/10.1182/blood.V116.21.3233.3233
Published: 2010
Journal Articles

A Single Dose Filgastrim In the Treatment of Chemotherapy Induced Neutropenia

Kuppuswamy Jagarlamudi, MD, Meena Ahluwalia, MD, Jay Patel, MD, Arunbhai G. Patel, MD
Journal: Blood
Blood (2010) 116 (21): 4774.
https://doi.org/10.1182/blood.V116.21.4774.4774
Published: 2010
Journal Articles

Concomitant Analysis of EZH2 and ASXL1 Mutations In Myelofibrosis, Chronic Myelomonocytic Leukemia and Blast-Phase Myeloproliferative Neoplasms

Omar Abdel-Wahab, Animesh Pardanani, MBBS, PhD, Jay Patel, Terra Lasho, MT, (ASCP), Adriana Heguy, Ross Levine, MD, Ayalew Tefferi, MD
Journal: Blood
Blood (2010) 116 (21): 3070.
https://doi.org/10.1182/blood.V116.21.3070.3070
Published: 2010
Journal Articles

Efficacy of the JAK2 inhibitor INCB16562 in a murine model of MPLW515L-induced thrombocytosis and myelofibrosis

Priya Koppikar, Omar Abdel-Wahab, Cyrus Hedvat, Sachie Marubayashi, Jay Patel, Aviva Goel, Nicole Kucine, Jeffrey R. Gardner, Andrew P. Combs, Kris Vaddi, Patrick J. Haley, Timothy C. Burn, Mark Rupar, Jacqueline F. Bromberg, Mark L. Heaney, Elisa de Stanchina, Jordan S. Fridman, Ross L. Levine
Journal: Blood
Blood (2010) 115 (14): 2919–2927.
https://doi.org/10.1182/blood-2009-04-218842
Published: 2010
Includes: Supplemental data
Journal Articles

TET2 and ASXL1 Mutations in Leukemic Transformation of Chronic Myeloproliferative Neoplasms.

Omar Abdel-Wahab, Taghi Manshouri, Jay Patel, Kelly Harris, Jin Juan Yao, MD, PhD, Cyrus V. Hedvat, MD, PhD, Adriana Heguy, Carlos Bueso-Ramos, Hagop M. Kantarjian, MD, Ross L. Levine, MD, Srdan Verstovsek, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 2894.
https://doi.org/10.1182/blood.V114.22.2894.2894
Published: 2009
Journal Articles

Genetic characterization of TET1, TET2, and TET3 alterations in myeloid malignancies

Brief Report
Omar Abdel-Wahab, Ann Mullally, Cyrus Hedvat, Guillermo Garcia-Manero, Jay Patel, Martha Wadleigh, Sebastien Malinge, JinJuan Yao, Outi Kilpivaara, Rukhmi Bhat, Kety Huberman, Sabrena Thomas, Igor Dolgalev, Adriana Heguy, Elisabeth Paietta, Michelle M. Le Beau, Miloslav Beran, Martin S. Tallman, Benjamin L. Ebert, Hagop M. Kantarjian, Richard M. Stone, D. Gary Gilliland, John D. Crispino, Ross L. Levine
Journal: Blood
Blood (2009) 114 (1): 144–147.
https://doi.org/10.1182/blood-2009-03-210039
Published: 2009
Includes: Supplemental data