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Journal Articles

Apex Part 2 Trial in Progress: A Phase 2 Open-Label Clinical Study of Bezuclastinib in Adult Patients with Advanced Systemic Mastocytosis

Isaac Goncalves, Stephen Fuller, Jason Gotlib, Pankit Vachhani, Vinod Pullarkat, Daniel J. DeAngelo, Saskia K. Klein, Wolfgang R. Sperr, Karin Hartmann, Khalid Shoumariyeh, Jens Panse, Teng Fong Ng, Miguel Piris-Villaespesa, Tsewang Tashi, Anthony M. Hunter, Prithviraj Bose, Cecilia Y. Arana Yi, Manish Jain, Helena Pomares, Tracy I. George, Jay Patel, Cristina Papayannidis, Minakshi S. Taparia, Bulai Livideanu Cridtina, Juliana Schwaab, Ingunn Dybedal, Jonathan Lambert, Tania Jain, Ewa Wierzbicka-Hainaut, Olivier Hermine, Massimiliano Bonifacio, Gabriela S. Hobbs, Michael W. Deininger, Amanda Pilla, Marcus Carden, Deepti H. Radia
Journal: Blood
Blood (2024) 144 (Supplement 1): 4569.1.
https://doi.org/10.1182/blood-2024-194550
Published: 2024
Journal Articles

Apex Part 1: Updated Assessment of Bezuclastinib (CGT9486), a Selective KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM)

Daniel J. DeAngelo, Jason Gotlib, Vinod Pullarkat, Pankit Vachhani, Tsewang Tashi, Stephanie Lee, Gary J. Schiller, Anthony M. Hunter, Miguel Piris-Villaespesa, Helena Pomares, Bulai Livideanu Cridtina, Khalid Shoumariyeh, Jonathan Lambert, Tracy I. George, Jay Patel, Cristina Papayannidis, Tania Jain, Michael W. Deininger, Andreas Reiter, Gabriela S. Hobbs, Lei Sun, Deepak Nagendra, Jenna Zhang, Amanda Pilla, Kim Dishman, Marcus Carden, Deepti H. Radia
Journal: Blood
Blood (2024) 144 (Supplement 1): 659.
https://doi.org/10.1182/blood-2024-193678
Published: 2024
Journal Articles

Real World Efficacy and Safety of Momelotinib for Myelofibrosis: Evaluation of a UK-Wide Study Confirms 40% Anaemia Response Rate in a Non-Clinical Trial Cohort

Alexandros Rampotas, Elena Torre, Luke Carter-Brzezinski, Andrea Duminuco, Llywelyn Cadman-Davies, Ashlyn Chee, Fotios Panitsas, Samah Alimam, Dragana Milojkovic, Richard Kaczmarski, Louise Fraser, Rebecca Frewin, Kate Foley, Catherine Hockings, Alesia Khan, Rhys Williams, Jennifer Ryan, Kawai Yip, Kyaw Htin Thaw, Amna Sheikh, Frances Wadelin, Anna L Godfrey, Chun Huat Teh, Andrew J. Wilson, Jonathan Lambert, Adam J Mead, Donal P McLornan, Andrew J Innes, Andrew McGregor, Tim Somervaille, Claire Harrison, Patrick Harrington, Bethan Psaila
Journal: Blood
Blood (2024) 144 (Supplement 1): 1804.
https://doi.org/10.1182/blood-2024-207251
Published: 2024
Journal Articles

Development of a First-in-Class CAR-T Therapy Against Calreticulin-Mutant Neoplasms and Evaluation in the Relevant Human Tissue Environment

Alexandros Rampotas, Zoe Wong, Isaac Gannon, Camelia Benlabiod, Yuqi Shen, Charlotte Brierley, Aude-Anais Olijnik, Saif Khan, Nawshad Hayder, Gordon Weng-Kit Cheung, Marina Mitsikakou, Manuel Rodriguez-Justo, Abdullah O Khan, Adam J Mead, Jonathan Lambert, Claire Roddie, Bethan Psaila, Martin A Pule
Journal: Blood
Blood (2024) 144 (Supplement 1): 871.
https://doi.org/10.1182/blood-2024-204953
Published: 2024
Journal Articles

Outcomes and characteristics of nonmelanoma skin cancers in patients with myeloproliferative neoplasms on ruxolitinib

Clinical Trials & Observations
Alex Rampotas, Luke Carter-Brzezinski, Tim C. P. Somervaille, James Forryan, Fotios Panitsas, Claire Harrison, Ruth Witherall, Andrew J. Innes, Louise Wallis, Naumann M. Butt, Bethan Psaila, Adam J. Mead, Matthew Carter, Anna L. Godfrey, Heather Laing, Mamta Garg, Sebastian Francis, Joanne Ewing, Chun Huat Teh, Hannah Bibi Cowen, Peter Dyer, Conall McConville, Frances Wadelin, Ali Sahra, Andrew McGregor, Elizabeth Kulakov, Donal P. McLornan, Jonathan Lambert
Journal: Blood
Blood (2024) 143 (2): 178–182.
https://doi.org/10.1182/blood.2023022345
Published: 2024
Includes: Supplemental data
Journal Articles

A Real World, Single-Centre Study of Young Adult Patients with Philadelphia Negative Myeloproliferative Neoplasms

Dipal Mehta, Holly Theaker, Donal P McLornan, Jonathan Lambert, Andrew J. Wilson, Hugo Ferreira, Syeda Ahmed, Aisha Roble, Samah Alimam
Journal: Blood
Blood (2023) 142 (Supplement 1): 6402.
https://doi.org/10.1182/blood-2023-189502
Published: 2023
Journal Articles

Safety and Efficacy of Bezuclastinib (CGT9486), a Novel, Highly Selective, Potent KIT D816V Tyrosine Kinase Inhibitor, in Patients with Advanced Systemic Mastocytosis (AdvSM): Results from Part 1 of the Phase 2 Apex Trial

Pankit Vachhani, Tsewang Tashi, Gary J. Schiller, Stephanie Lee, Miguel Piris Villaespesa, Helena Pomares, Cristina Bulai Livideanu, Jonathan Lambert, Anthony M. Hunter, Tracy I. George, Cristina Papayannidis, Khalid Shoumariyeh, Rita Petroro, Jenna Zhang, Amanda Pilla, Hina Jolin, Rachael Easton, Vinod Pullarkat
Journal: Blood
Blood (2023) 142 (Supplement 1): 4567.
https://doi.org/10.1182/blood-2023-178885
Published: 2023
Journal Articles

Real World, Single-Centre Experience of Pregnancy in Patients with Philadelphia Negative Myeloproliferative Neoplasms

Holly Theaker, Jonathan Lambert, Donal P McLornan, Andrew J. Wilson, Syeda Ahmed, Aisha Roble, Samah Alimam
Journal: Blood
Blood (2023) 142 (Supplement 1): 6391.
https://doi.org/10.1182/blood-2023-189297
Published: 2023
Journal Articles

A Comparison of Overall Survival with Brexucabtagene Autoleucel (Brexu-cel) CAR T-Cell Therapy (ZUMA-2) and Standard of Care (SCHOLAR-2) in Patients with Relapsed/Refractory Mantle Cell Lymphoma (R/R MCL) Previously Treated with a Covalent Bruton Tyrosine Kinase Inhibitor (BTKi)

Georg Hess, Martin Dreyling, Lucie Oberic, Eva Gine, Pier Luigi Zinzani, Kim M. Linton, Adam Vilmar, Mats Jerkeman, Jenny MH Chen, Anke Ohler, Stephan Stilgenbauer, Catherine Thieblemont, Jonathan Lambert, Vittorio Ruggero Zilioli, Juan-Manuel Sancho, Ana Jimenez-Ubieto, Luca Fischer, Toby A. Eyre, Sam Keeping, Julie E Park, James J Wu, Rubina Siddiqi, John Reitan, Gab Castaigne, Gilles Salles
Journal: Blood
Blood (2022) 140 (Supplement 1): 10296–10299.
https://doi.org/10.1182/blood-2022-162638
Published: 2022
Journal Articles

Biallelic Deleterious Germline SH2B3 Variants Cause a Novel Clinical Syndrome of Myeloproliferation and Multi-Organ Autoimmunity

Piers Blombery, Vahid Pazhakh, Adriana Albuquerque, Jesmeen Maimaris, Lingge Tu, Brenda Briones, Florence Evans, Ella Thompson, Ben Carpenter, Julie Curtin, Jonathan Lambert, Siobhan Burns, Graham John Lieschke
Journal: Blood
Blood (2022) 140 (Supplement 1): 992–993.
https://doi.org/10.1182/blood-2022-163097
Published: 2022
Journal Articles

Disease Characteristics and Outcomes of Non-Melanoma Skin Cancers in Myeloproliferative Neoplasm (MPN) Patients Treated with Ruxolitinib

Alexandros Rampotas, Luke Carter-Brzezinski, Tim C.P Somervaille, James Forryan, Bethan Psaila, Adam J Mead, Mamta Garg, Heather Laing, Louise Wallis, Nauman M Butt, Conal McConville, Ali Sahra, Andrew McGregor, Hannah Cowan, Andrew J. Innes, Joanne Ewing, Matthew Carter, Peter Dyer, Chun Huat Teh, Sebastian Francis, Frances Wadelin, Claire Harrison, Anna L Godfrey, Elizabeth Kulakov, Donal P. McLornan, Jonathan Lambert
Journal: Blood
Blood (2022) 140 (Supplement 1): 9721–9723.
https://doi.org/10.1182/blood-2022-162417
Published: 2022
Journal Articles

Pelabresib (CPI-0610) As Add-on to Ruxolitinib in Myelofibrosis: Durability of Response and Safety Beyond Week 24 in the Phase 2 MANIFEST Study

Claire Harrison, Marina Kremyanskaya, Prithviraj Bose, Vikas Gupta, Raajit K Rampal, Jonathan Lambert, Moshe Talpaz, Alessandro Vannucchi, Andrew Kuykendall, Jean-Jacques Kiladjian, Srdan Verstovsek, Ruben Mesa, Gozde Colak, Sandra Klein, Soumik Dutta, John Mascarenhas
Journal: Blood
Blood (2022) 140 (Supplement 1): 9659–9662.
https://doi.org/10.1182/blood-2022-157735
Published: 2022
Journal Articles

The Use of Avapritinib in Advanced Systemic Mastocytosis: Report of an Open-Label Compassionate Use Program in the United Kingdom

Christopher J. Saunders, Chandan Saha, Priya Sriskandarajah, Helen Cashman, Andrew J Wilson, Jonathan Lambert, Matthew Lawes, David Tucker, Simone Green, Manish Jain, Victoria Stables, Juanah Addada, Theingi Yin, Huw Roddie, Bethan Psaila, Deepti H. Radia
Journal: Blood
Blood (2022) 140 (Supplement 1): 3976–3977.
https://doi.org/10.1182/blood-2022-166073
Published: 2022
Journal Articles

Single Centre Analysis of JAK2 V617F and Exon 12 Negative Idiopathic Erythrocytosis

Kushani Ediriwickrema, Andrew J Wilson, Jenny O'Nions, Mallika Sekhar, Syeda Ahmed, Aisha Roble, Emma Louise Shambrook, Jonathan Lambert, Samah Alimam
Journal: Blood
Blood (2021) 138 (Supplement 1): 4620.
https://doi.org/10.1182/blood-2021-152361
Published: 2021
Journal Articles

JAK2 ex13InDel drives oncogenic transformation and is associated with chronic eosinophilic leukemia and polycythemia vera

Ami B. Patel, Anca Franzini, Emilie Leroy, Soo Jin Kim, Anthony D. Pomicter, Lidvine Genet, Michael Xiao, Dongqing Yan, Jonathan M. Ahmann, Archana M. Agarwal, Phillip Clair, Juanah Addada, Jonathan Lambert, Matthew Salmon, Gerald J. Gleich, Nicholas C. P. Cross, Stefan N. Constantinescu, Thomas O’Hare, Josef T. Prchal, Michael W. Deininger
Journal: Blood
Blood (2019) 134 (26): 2388–2398.
https://doi.org/10.1182/blood.2019001385
Published: 2019
Includes: Supplemental data
Journal Articles

R-BAC Maintains High Response Rate in Mantle Cell Lymphoma Following Relapse on BTK Inhibitor Therapy

Rory McCulloch, FRCPath, MRCP, MBBS, Carlo Visco, Rebecca Frewin, Neil Phillips, Toby A. Eyre, David Tucker, MD, Francesca M. Quaglia, Annabel McMillan, Jonathan Lambert, Nicola Crosbie, Simon Rule
Journal: Blood
Blood (2019) 134 (Supplement_1): 3989.
https://doi.org/10.1182/blood-2019-129829
Published: 2019
Journal Articles

Ibrutinib at First Relapse for Mantle Cell Lymphoma: A United Kingdom Real World Analysis of Outcomes in 169 Patients

Rory McCulloch, FRCPath, MRCP, MBBS, Simon Rule, Toby A. Eyre, Harshita Goradia, Simon Bolam, MD, Thomas Creasey, MBBS, David Tucker, MD, Michelle Furtado, Oliver Miles, Samuel Harrison, Amir Shenouda, Andrew Robinson, Matthew Wilson, MD BSc, MRCP, Annabel McMillan, Nimish Shah, Graham McIlroy, MD, David Dutton, MD, Adam Bond, Luke Attwell, Alexander Langridge, Helen Parry, MB ChB, MRCP, PhD, John Willan, Gavin Campbell, FRCP,FRCPath, Deborah Turner, David Lewis, PhD FRCPath, BSc, Helen McCarthy, MBBS, PhD, Jonathan Lambert, Pamela McKay, MD, Neil Phillips, Shankara Paneesha, MD, Wendy Osborne, MD, Mark Bishton, Nicola Crosbie
Journal: Blood
Blood (2019) 134 (Supplement_1): 3993.
https://doi.org/10.1182/blood-2019-125947
Published: 2019
Journal Articles

Excess Late Gastrointestinal Toxicity Associated with Leam Conditioning Compared to BEAM for Autologous Stem Cell Transplantation in Lymphoma, a Single Institution Experience

Jaimal Kothari, FRCPath, Michael Foley, MBBS, Karl S Peggs, Kirsty Thomson, Emma Morris, FRCPath, Kirit M Ardeshna, MD FRCPath, Andres E. Virchis, FRCPath, David C Linch, FMedSci, Jonathan Lambert, FRCPath
Journal: Blood
Blood (2014) 124 (21): 5898.
https://doi.org/10.1182/blood.V124.21.5898.5898
Published: 2014
Journal Articles

Treatment Of Non-Hodgkin’s Lymphoma With Secondary Central Nervous System Involvement: Encouraging Response Rates Using CNS-Penetrating Idaram Chemotherapy

Paul M Maciocia, MRCP, Mohsin Badat, MB BChir, Simon Cheesman, Jonathan Lambert, MD, Martin Pule, MD, David C. Linch, FRCP, Kirit M Ardeshna, FRCPath
Journal: Blood
Blood (2013) 122 (21): 4367.
https://doi.org/10.1182/blood.V122.21.4367.4367
Published: 2013
Journal Articles

Autologous Stem Cell Transplantation Using BEAM Conditioning Is Highly Effective in Patients with Follicular Lymphoma Regardless of Prior Rituximab Exposure

Jaimal Kothari, MD, Antonia Ljubic, BSc, Karl S Peggs, MD, Kirsty Thomson, MD, Emma Morris, MD, Andres E. Virchis, MD, Jonathan Lambert, MD, Anthony H Goldstone, MD, David C Linch, MD FMedSci, Kirit M Ardeshna, MD
Journal: Blood
Blood (2011) 118 (21): 2025.
https://doi.org/10.1182/blood.V118.21.2025.2025
Published: 2011