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Tim C.P Somervaille
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Journal Articles

Iadademstat Combination with Azacitidine Is a Safe and Effective Treatment in First Line Acute Myeloid Leukemia. Final Results of the Alice Trial

Olga Salamero, Tim C.P Somervaille, Antonieta Molero, Evelyn Acuña-Cruz, Jose A. Perez-Simon, Rosa Coll, Montserrat Arnan, Brayan Merchan, Ana Perez, Isabel Cano, Rebeca Rodríguez-Veiga, Mabel Arevalo, Sonia Gutierrez, Carlos Buesa, Douglas V Faller, Francesc Bosch, Pau Montesinos
Journal: Blood
Blood (2022) 140 (Supplement 1): 1711–1713.
https://doi.org/10.1182/blood-2022-168945
Published: 2022
Journal Articles

Potent Pre-Clinical and Early Phase Clinical Activity of EP300/CBP Bromodomain Inhibitor CCS1477 in Multiple Myeloma

Luciano Nicosia, Nigel Brooks, Fabio Amaral, Oliver Sinclair, Neil A Pegg, William West, Tomasz Knurowski, Kris Frese, Karen Clegg, James Cavet, Emma Searle, Tim C.P Somervaille
Journal: Blood
Blood (2022) 140 (Supplement 1): 852–853.
https://doi.org/10.1182/blood-2022-157535
Published: 2022
Journal Articles

Therapeutic Targeting of EP300/CBP By Bromodomain Inhibition in Acute Myeloid Leukemia

Luciano Nicosia, Gary J Spencer, Nigel Brooks, Fabio Amaral, Naseer Basma, John Chadwick, Bradley Revell, Bettina Wingelhofer, Alba Maiques-Diaz, Filippo Ciceri, Daniel H Wiseman, Neil A Pegg, William West, Tomasz Knurowski, Kris Frese, Karen Clegg, Victoria Louise Campbell, Mhairi Copland, Emma Searle, Tim C.P Somervaille
Journal: Blood
Blood (2022) 140 (Supplement 1): 8774–8775.
https://doi.org/10.1182/blood-2022-166260
Published: 2022
Journal Articles

The Functional and Molecular Alterations in Human Bone Marrow Mesenchymal Stem Cells in Chronic Myelomonocytic Leukemia

Joanna A Storer, Tim C.P Somervaille, Daniel H Wiseman, Kiran Batta
Journal: Blood
Blood (2022) 140 (Supplement 1): 5782–5783.
https://doi.org/10.1182/blood-2022-166138
Published: 2022
Journal Articles

A Three Gene Leukemic Stem Cell Signature Score Is Robustly Prognostic in Chronic Myelomonocytic Leukemia

Yu-Hung Wang, Chi-Yuan Yao, Chien-Chin Lin, Kristian Gurashi, Fabio Amaral, Andres Jerez, Tim C.P Somervaille, Hsin-An Hou, Wen-Chien Chou, Kiran Batta, Hwei-Fang Tien, Daniel H Wiseman
Journal: Blood
Blood (2022) 140 (Supplement 1): 1104–1105.
https://doi.org/10.1182/blood-2022-165449
Published: 2022
Journal Articles

Disease Characteristics and Outcomes of Non-Melanoma Skin Cancers in Myeloproliferative Neoplasm (MPN) Patients Treated with Ruxolitinib

Alexandros Rampotas, Luke Carter-Brzezinski, Tim C.P Somervaille, James Forryan, Bethan Psaila, Adam J Mead, Mamta Garg, Heather Laing, Louise Wallis, Nauman M Butt, Conal McConville, Ali Sahra, Andrew McGregor, Hannah Cowan, Andrew J. Innes, Joanne Ewing, Matthew Carter, Peter Dyer, Chun Huat Teh, Sebastian Francis, Frances Wadelin, Claire Harrison, Anna L Godfrey, Elizabeth Kulakov, Donal P. McLornan, Jonathan Lambert
Journal: Blood
Blood (2022) 140 (Supplement 1): 9721–9723.
https://doi.org/10.1182/blood-2022-162417
Published: 2022
Journal Articles

Integrative Analysis of Blast Phase Chronic Myelomonocytic Leukemia Reveals Distinct Transformation Phenotypes Predictive of Drug Response

Kristian Gurashi, Yu-Hung Wang, Tim C.P Somervaille, Kiran Batta, Daniel H Wiseman
Journal: Blood
Blood (2022) 140 (Supplement 1): 213–214.
https://doi.org/10.1182/blood-2022-168831
Published: 2022
Journal Articles

Multi-Omic Analysis of Chronic Myelomonocytic Leukaemia Monocytes Reveals Immune Dysregulation Mediated By TGF-β Activation

Hasse M Bossenbroek, Tim C.P Somervaille, Daniel H Wiseman, Kiran Batta
Journal: Blood
Blood (2021) 138 (Supplement 1): 2589.
https://doi.org/10.1182/blood-2021-152366
Published: 2021
Journal Articles

Multiomic Single-Cell Sequencing Reveals Patterns of Disease Evolution and Acute Transformation in Chronic Myelomonocytic Leukaemia

Kristian Gurashi, John Weightman, Syed M Baker, Kevin Rouault-Pierre, Wolfgang Breitweister, Tim C.P Somervaille, Kiran Batta, Daniel H Wiseman
Journal: Blood
Blood (2021) 138 (Supplement 1): 2586.
https://doi.org/10.1182/blood-2021-153540
Published: 2021
Journal Articles

CCS1477, a Novel p300/CBP Bromodomain Inhibitor, Enhances Efficacy of Azacitidine and Venetoclax in Pre-Clinical Models of Acute Myeloid Leukaemia and Lymphoma

Nigel Brooks, Tomasz Knurowski, Andrew Hughes, Karen Clegg, William West, Neil A Pegg, Gary J Spencer, John Chadwick, Tim C.P Somervaille
Journal: Blood
Blood (2021) 138 (Supplement 1): 3291.
https://doi.org/10.1182/blood-2021-148295
Published: 2021
Journal Articles

Iadademstat in Combination with Azacitidine Generates Robust and Long Lasting Responses in AML Patients (ALICE Trial)

Olga Salamero, Tim C.P Somervaille, Antonieta Molero, Evelyn Acuña-Cruz, Jose Pérez-Simón, Rosa Coll, Montserrat Arnan Sangerman, Brayan Merchan, Ana Perez, Isabel Cano, Rebeca Rodríguez-Veiga, Sonia Gutierrez, Carlos Buesa, Francesc Bosch, Pau Montesinos
Journal: Blood
Blood (2021) 138 (Supplement 1): 3376.
https://doi.org/10.1182/blood-2021-152183
Published: 2021
Journal Articles

Robust Efficacy Signals in Elderly AML Patients Treated with Iadademstat in Combination with Azacitidine (ALICE Phase IIa Trial)

Olga Salamero, MD, Tim C.P Somervaille, PhD FRCP, FRCPath, Antonieta Molero, MD, Evelyn Acuña, MD, Ana Perez, MD, Isabel Cano, MD, Rebeca Rodríguez-Veiga, MD, Sonia Gutierrez, Roger Bullock, MD, Carlos Buesa, PhD, Francesc Bosch, MD PhD, Pau Montesinos, MD PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 22.
https://doi.org/10.1182/blood-2020-134310
Published: 2020
Journal Articles

Phazar: A Phase Ib Study to Assess the Safety and Tolerability of Ruxolitinib in Combination with Azacitidine in Advanced Phase Myeloproliferative Neoplasms (MPN), Including Myelodysplastic Syndromes (MDS) or Acute Myeloid Leukaemia (AML) Arising from MPN [ISRCTN16783472]

Mark W. Drummond, PhD FRCPath, Charlotte Gaskell, BSc, MSc, Claire Harrison, DM, FRCP, FRCPath, Adam J. Mead, MD PhD, Christina Yap, PhD CStat, Aimee E Jackson, BSc, MSc, Jennifer Byrne, FRCP, FRCPath, PhD, Fiona J Clark, FRCP, FRCPath, Srinivasan Narayanan, FRCP, FRCPath, David Bowen, MD, Tim C.P Somervaille, PhD FRCP, FRCPath, Emma Gudgin, MBBS, MRCP, FRCPath, PhD, Dragana Milojkovic, Rachel S Fletcher, PhD, Charlotte K Brierley, MRCP, MD, Steve Knapper, BMBCh, MRCP, FRCPath, DM
Journal: Blood
Blood (2020) 136 (Supplement 1): 2–3.
https://doi.org/10.1182/blood-2020-138437
Published: 2020
Journal Articles

Leukemia Stem Cells in Murine MLL−AF9 AML Are Downstream Myeloid Lineage Cells That Have Acquired Stem−Like Biological and Genetic Properties.

Tim C.P. Somervaille, MD, PhD, Michael L. Cleary, MD
Journal: Blood
Blood (2006) 108 (11): 771.
https://doi.org/10.1182/blood.V108.11.771.771
Published: 2006