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Gary J Spencer
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Journal Articles

Therapeutic Targeting of EP300/CBP By Bromodomain Inhibition in Acute Myeloid Leukemia

Luciano Nicosia, Gary J Spencer, Nigel Brooks, Fabio Amaral, Naseer Basma, John Chadwick, Bradley Revell, Bettina Wingelhofer, Alba Maiques-Diaz, Filippo Ciceri, Daniel H Wiseman, Neil A Pegg, William West, Tomasz Knurowski, Kris Frese, Karen Clegg, Victoria Louise Campbell, Mhairi Copland, Emma Searle, Tim C.P Somervaille
Journal: Blood
Blood (2022) 140 (Supplement 1): 8774–8775.
https://doi.org/10.1182/blood-2022-166260
Published: 2022
Journal Articles

CCS1477, a Novel p300/CBP Bromodomain Inhibitor, Enhances Efficacy of Azacitidine and Venetoclax in Pre-Clinical Models of Acute Myeloid Leukaemia and Lymphoma

Nigel Brooks, Tomasz Knurowski, Andrew Hughes, Karen Clegg, William West, Neil A Pegg, Gary J Spencer, John Chadwick, Tim C.P Somervaille
Journal: Blood
Blood (2021) 138 (Supplement 1): 3291.
https://doi.org/10.1182/blood-2021-148295
Published: 2021
Journal Articles

CCS1477: A Novel Small Molecule Inhibitor of p300/CBP Bromodomain for the Treatment of Acute Myeloid Leukaemia and Multiple Myeloma

Nigel Brooks, PhD, Meera Raja, PhD, Barbara W Young, PhD, Gary J Spencer, PhD, Tim CP Somervaille, MD PhD, Neil A Pegg, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2560.
https://doi.org/10.1182/blood-2019-124707
Published: 2019
Journal Articles

FOXC1 Is Derepressed to Functional Effect in Human Acute Myeloid Leukemia

Tim D D Somerville, BSc, Xu Huang, PhD, James T Lynch, PhD, Gary J Spencer, PhD, Tim C P Somervaille, PhD FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 889.
https://doi.org/10.1182/blood.V124.21.889.889
Published: 2014
Journal Articles

Pharmacological Inhibitors of LSD1 Promote Differentiation of Myeloid Leukemia Cells through a Mechanism Independent of Histone Demethylation

James T Lynch, PhD, Gary J Spencer, PhD, William J Harris, PhD, Alba Maiques-Díaz, PhD, Filippo Ciceri, PhD, Xu Huang, PhD, Tim C P Somervaille, PhD FRCP, FRCPath
Journal: Blood
Blood (2014) 124 (21): 267.
https://doi.org/10.1182/blood.V124.21.267.267
Published: 2014