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Journal Articles

Integrated genomic DNA/RNA profiling of hematologic malignancies in the clinical setting

Jie He, Omar Abdel-Wahab, Michelle K. Nahas, Kai Wang, Raajit K. Rampal, Andrew M. Intlekofer, Jay Patel, Andrei Krivstov, Garrett M. Frampton, Lauren E. Young, Shan Zhong, Mark Bailey, Jared R. White, Steven Roels, Jason Deffenbaugh, Alex Fichtenholtz, Timothy Brennan, Mark Rosenzweig, Kimberly Pelak, Kristina M. Knapp, Kristina W. Brennan, Amy L. Donahue, Geneva Young, Lazaro Garcia, Selmira T. Beckstrom, Mandy Zhao, Emily White, Vera Banning, Jamie Buell, Kiel Iwanik, Jeffrey S. Ross, Deborah Morosini, Anas Younes, Alan M. Hanash, Elisabeth Paietta, Kathryn Roberts, Charles Mullighan, Ahmet Dogan, Scott A. Armstrong, Tariq Mughal, Jo-Anne Vergilio, Elaine Labrecque, Rachel Erlich, Christine Vietz, Roman Yelensky, Philip J. Stephens, Vincent A. Miller, Marcel R. M. van den Brink, Geoff A. Otto, Doron Lipson, Ross L. Levine
Journal: Blood
Blood (2016) 127 (24): 3004–3014.
https://doi.org/10.1182/blood-2015-08-664649
Published: 2016
Includes: Supplemental data
Journal Articles

Comprehensive Genomic Profiling (CGP) of Angioimmunoblastic T-Cell Lymphoma (AITL) to Prospectively Inform Diagnosis and Clinical Management

Samantha Morley, PhD, Jie He, PhD, Andrew M. Intlekofer, MD PhD, Mark Bailey, MS, Michelle Nahas, PhD, Doron Lipson, PhD, Roman Yelensky, PhD, Jeffrey Ross, MD, Siraj Ali, MD PhD, Rachel Erlich, PhD, Phil Stephens, PhD, Vincent A. Miller, MD, Jo-Anne Vergilio, MD, Tariq I Mughal, MD
Journal: Blood
Blood (2015) 126 (23): 3898.
https://doi.org/10.1182/blood.V126.23.3898.3898
Published: 2015
Journal Articles

Novel Chromatin Modifying Gene Alterations and Significant Survival Association of ATM and P53 in Mantle Cell Lymphoma

Kai Wang, MDPhD, Michelle K. Nahas, PhD, Roman Yelensky, PhD, Geoff A. Otto, PhD, Doron Lipson, PhD, Jie He, PhD, Jeff Ross, MD, Phil J Stephens, PhD, Kar Fai Chow, MD, Tania Zielonka, Pritish K Bhattacharyya, MD, Ewelina A Protomastro, MS, Tatyana Feldman, MD, Anthony R. Mato, MD MSCE, Alan P Skarbnik, MD, Coleen Bejot, APN, Gabriella Gadaleta, NP, Andrew L Pecora, MD FACP, Vincent A. Miller, MD, Andre Goy, MD MS
Journal: Blood
Blood (2014) 124 (21): 3033.
https://doi.org/10.1182/blood.V124.21.3033.3033
Published: 2014
Journal Articles

Patient Derived Xenograft (PDX) Models Recapitulate the Genomic-Driver Composition of Acute Leukemia Samples

Andrei V. Krivtsov, PhD, Xujun Wang, MD, Noushin Rahnamay Farnoud, PhD, Michael Hadler, MSc, Marta Sanchez Martin, Kristina M. Knapp, BS, Eytan M. Stein, Doron Lipson, PhD, Michelle K. Nahas, PhD, Philip J. Stephens, PhD, Eric M Sanford, BS, Kai Wang, MDPhD, Garrett M Frampton, PhD, Tim Brennan, PhD, Geoff A. Otto, PhD, Roman Yelensky, PhD, Vincent Miller, MD, Ross L. Levine, MD, Adolfo A. Ferrando, MD PhD, Scott A. Armstrong, MD PhD
Journal: Blood
Blood (2014) 124 (21): 286.
https://doi.org/10.1182/blood.V124.21.286.286
Published: 2014
Journal Articles

Genomic Profiling Combining DNA and RNA Analysis of 112 Formalin-Fixed Paraffin-Embedded Diffuse Large B Cell Lymphoma Specimens Identifies a High Frequency of Clinically Relevant Genomic Alterations

Andrew M. Intlekofer, MD PhD, Patrick Hilden, MS, Venkatraman E. Seshan, PhD, Amanda R. Copeland, MSN, Ross L. Levine, MD, Andrew D. Zelenetz, MD PhD, Julie Teruya-Feldstein, MD, Ahmet Dogan, MD PhD, Maria Lia Palomba, MD, Craig H. Moskowitz, MD, Marcel R. M. van den Brink, MD PhD, Kristina M. Knapp, BS, Janine D. Pichardo, BS, Kristina W. Brennan, BS, Geneva Young, BS, Jie He, PhD, Michelle K. Nahas, PhD, Roman Yelensky, PhD, Geoff A. Otto, PhD, Doron Lipson, PhD, Philip J. Stephens, PhD, Vincent A. Miller, MD, Anas Younes, MD
Journal: Blood
Blood (2014) 124 (21): 704.
https://doi.org/10.1182/blood.V124.21.704.704
Published: 2014
Journal Articles

Genomic Analysis of Serial Samples from CLL Patients Identifies Clonal Events Associated with Disease Progression

Jeffrey R Gardner, BS, MBA, Michelle Nahas, PhD, Jie He, PhD, Shlomzion Aumann, Mithat Gonen, Minal Patel, Kristina M. Knapp, BS, Maria Lia Palomba, MD, Roman Yelensky, PhD, Amy L Donahue, MS, Geoff Otto, PhD, Maria Arcila, MD, Nicole Lamanna, Mark G. Frattini, MD PhD, Ahmet Dogan, MD PhD, Jae H Park, MD, Doron Lipson, PhD, Martin S. Tallman, MD, Ross L. Levine, MD, Philip J. Stephens, PhD, Marcel R. M. van den Brink, MD PhD, Mark L Heaney, MD PhD, Vincent A. Miller, MD, Andrew D. Zelenetz, MD PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2014) 124 (21): 1954.
https://doi.org/10.1182/blood.V124.21.1954.1954
Published: 2014
Journal Articles

Genomic Alterations of Histone Modification Genes Are Significantly Less Common in Non-Hodgkin Lymphomas of Adolescents and Young Adults Compared to Older Patients

Kai Wang, MDPhD, Deborah Morosini, MD, Roman Yelensky, PhD, Norma Palma, PhD, Adrienne Johnson, MS, Doron Lipson, PhD, Juliann Chmielecki, PhD, Siraj Ali, MDPhD, Jeffrey S Ross, MD, Philip J. Stephens, PhD, Vincent Miller, MD
Journal: Blood
Blood (2014) 124 (21): 1684.
https://doi.org/10.1182/blood.V124.21.1684.1684
Published: 2014
Journal Articles

Clinical Utility of Comprehensive Profiling of Genomic Alterations in Hematologic Malignancies

Jie He, PhD, Jose A. Bufill, MD, Michelle K. Nahas, PhD, Kai Wang, MDPhD, Lauren E Young, MS, Kristina M. Knapp, Kristina W. Brennan, BS, Amy L Donahue, MS, Geneva Young, BS, Jeffrey S Ross, MD, Deborah Morosini, MD, Marcel R. M. van den Brink, MD PhD, Omar Abdel-Wahab, MD, Raajit K. Rampal, MD PhD, Andrew M. Intlekofer, MD PhD, Ahmet Dogan, MD PhD, Scott Armstrong, MD PhD, Roman Yelensky, PhD, Geoff Otto, PhD, Doron Lipson, PhD, Philip J. Stephens, PhD, Vincent A. Miller, MD, Ross L. Levine, MD
Journal: Blood
Blood (2014) 124 (21): 1072.
https://doi.org/10.1182/blood.V124.21.1072.1072
Published: 2014
Journal Articles

Extensive High-Depth Sequencing Of Longitudinal CLL Samples Identifies Frequent Mutations In MAP Kinase Signaling and Novel Mutations Activating Notch and Beta-Catenin

Jeffrey R Gardner, MBA, Michelle K. Nahas, PhD, Jie He, PhD, Minal Patel, Kristina M. Knapp, BS, M. Lia Palomba, MD, Roman Yelensky, PhD, Amy L Donahue, MS, Geoff A. Otto, PhD, Maria Arcila, MD, Ahmet Dogan, MD, PhD, Jae H Park, MD, Andrew D. Zelenetz, MD, PhD, Doron Lipson, PhD, Martin S. Tallman, MD, Ross L. Levine, MD, Philip J. Stephens, PhD, Marcel R. M. van den Brink, MD, PhD, Vincent A. Miller, MD, Mark L Heaney, MD, PhD, Omar Abdel-Wahab, MD
Journal: Blood
Blood (2013) 122 (21): 2858.
https://doi.org/10.1182/blood.V122.21.2858.2858
Published: 2013
Journal Articles

Mutational Profiling Of Myeloid Malignancies For Prediction Of Disease Relapse Following Allogeneic Stem Cell Transplantation

Alan M Hanash, MD, PhD, Sean M. Devlin, PhD, Molly Maloy, MA, Kristina M. Knapp, BS, Vincent A. Miller, MD, Doron Lipson, PhD, Philip J. Stephens, PhD, Geoff A Otto, PhD, Roman Yelensky, PhD, Michelle K. Nahas, PhD, Kai Wang, MD PhD, Ross L. Levine, MD, Marcel R.M. van den Brink, MD, PhD, Ann A. Jakubowski, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 2096.
https://doi.org/10.1182/blood.V122.21.2096.2096
Published: 2013
Journal Articles

Integrated Genetic Profiling Of JAK2 Wildtype Chronic-Phase Myeloproliferative Neoplasms

Raajit K. Rampal, M.D., Ph.D., Sean M. Devlin, PhD, Jay P. Patel, Kristina M. Knapp, BS, Minal Patel, Joel R Greenbowe, BS, Lauren E Young, MS, Jie He, PhD, Kai Wang, MD PhD, Michelle K. Nahas, PhD, Roman Yelensky, PhD, Geoff A. Otto, PhD, Doron Lipson, PhD, Philip J. Stephens, PhD, Vincent A. Miller, MD, Ross L. Levine, MD
Journal: Blood
Blood (2013) 122 (21): 1588.
https://doi.org/10.1182/blood.V122.21.1588.1588
Published: 2013
Journal Articles

High-Throughput Mutational Profiling Of Post-Myeloproliferative Neoplasm Acute Myeloid Leukemia Reveals Frequent Mutations In NRAS In JAK2 V617F-Negative Post-MPN AML

Raajit K. Rampal, M.D., Ph.D, Sean M. Devlin, PhD, Anna Sophia Mckenney, B.S. M.P.H., Kristina M. Knapp, BS, Minal Patel, Kai Wang, MD PhD, Michelle K. Nahas, PhD, Roman Yelensky, PhD, Geoff A. Otto, PhD, Doron Lipson, PhD, Philip J. Stephens, PhD, Vincent A. Miller, MD, Taghi Manshouri, Ph.D., Srdan Verstovsek, MD, PhD, Ross L. Levine, MD
Journal: Blood
Blood (2013) 122 (21): 4098.
https://doi.org/10.1182/blood.V122.21.4098.4098
Published: 2013
Journal Articles

Profiling Genomic Alterations Of Diffuse Large B-Cell Lymphoma (DLBCL) At Diagnosis, Relapse, and Transformation, Using a Novel Clinical Diagnostic Targeted Sequencing Platform

Andrew M. Intlekofer, MD, PhD, Venkatraman E. Sheshan, PhD, Ross L. Levine, MD, Andrew D. Zelenetz, MD, PhD, Julie Teruya-Feldstein, MD, Ahmet Dogan, MD, PhD, Maria Lia Palomba, MD, Craig H. Moskowitz, MD, Marcel R. M. van den Brink, MD, PhD, Kristina M. Knapp, BS, Amanda R. M. Copeland, MSN, Janine D. Pichardo, BS, Kristina W. Brennan, BS, Geneva Young, BS, Jie He, PhD, Michelle K. Nahas, PhD, Roman Yelensky, PhD, Geoff A. Otto, PhD, Doron Lipson, PhD, Philip J. Stephens, PhD, Vincent A. Miller, MD, Anas Younes, MD
Journal: Blood
Blood (2013) 122 (21): 1761.
https://doi.org/10.1182/blood.V122.21.1761.1761
Published: 2013
Journal Articles

Comprehensive Mutational Profiling In Myelodysplastic Syndromes Treated With Decitabine and Tretinoin

Alan H. Shih, MD PhD, Sean M. Devlin, PhD, Emily K. Dolezal, Kristina M. Knapp, BS, Kai Wang, MD PhD, Eric M. Sanford, BS, Tim Brennan, PhD, Roman Yelensky, PhD, Michelle Nahas, PhD, Geoff A Otto, PhD, Doron Lipson, PhD, Philip J Stephens, PhD, Vincent Miller, MD, Marcel R.M. van den Brink, MD, PhD, Ross L. Levine, MD, Stephen Nimer, MD, Virginia M. Klimek, M.D
Journal: Blood
Blood (2013) 122 (21): 2791.
https://doi.org/10.1182/blood.V122.21.2791.2791
Published: 2013
Journal Articles

Patient Derived Xenograft (PDX) Models Faithfully Recapitulate The Genetic Composition Of Primary AML

Andrei V. Krivtsov, PhD, Wang Xujun, MD, Noushin Rahnamay Farnoud, PhD, Michael Hadler, MSc, Kristina M. Knapp, BS, Eytan M Stein, MD, Martin S. Tallman, MD, Amy L Donahue, MS, Doron Lipson, PhD, Michelle K. Nahas, PhD, Philip J. Stephens, PhD, Eric M Sanford, BS, Kai Wang, MD PhD, Garrett M Frampton, PhD, Tim Brennan, PhD, Geoff A. Otto, PhD, Roman Yelensky, PhD, Vincent A. Miller, MD, Ross L. Levine, MD, Scott A. Armstrong, MD, PhD
Journal: Blood
Blood (2013) 122 (21): 1328.
https://doi.org/10.1182/blood.V122.21.1328.1328
Published: 2013
Journal Articles

Overview Of The Genomic Landscape Of High Risk Diffuse Large B-Cell Lymphoma Using Targeted DNA and RNA Sequencing

Kai Wang, MD PhD, Michelle Nahas, PhD, Anthony R Mato, MD, MSCE, Amy L Donahue, MS, Jie He, PhD, Geoff A Otto, PhD, Doron Lipson, PhD, Roman Yelensky, PhD, Jeff Ross, MD, Phil Stephens, PhD, Kar Fai Chow, MD, Tania Zielonka, Pritish K. Bhattacharyya, MD, Ewelina Protomastro, BS, Tatyana Feldman, MD, Andrew L. Pecora, MD, Vincent Miller, MD, Andre Goy, MD
Journal: Blood
Blood (2013) 122 (21): 501.
https://doi.org/10.1182/blood.V122.21.501.501
Published: 2013
Journal Articles

Pilot Study To Evaluate The Prevalence Of Actionable Oncogenic Mutations In Patients With Relapsed Refractory Multiple Myeloma

Alexander Lesokhin, MD, Mithat Gonen, Kaitlyn Redling, Nikoletta Lendvai, MD PhD, Hani Hassoun, MD, Heather Landau, MD, David J Chung, MD PhD, Guenther Koehne, MD, PhD, Minal Patel, Kristina W. Brennan, BS, Kai Wang, MD PhD, Eric M Sanford, BS, Tim Brennan, PhD, Geoff A. Otto, PhD, Michelle K. Nahas, PhD, Doron Lipson, PhD, Philip J. Stephens, PhD, Roman Yelensky, PhD, Vincent A. Miller, MD, Marcel Van Den Brink, MD, PhD, Ross L. Levine, MD, Ahmet Dogan, MD, PhD, Sergio A Giralt, MD
Journal: Blood
Blood (2013) 122 (21): 755.
https://doi.org/10.1182/blood.V122.21.755.755
Published: 2013
Journal Articles

Identification Of Actionable Genomic Alterations In Hematologic Malignancies By a Clinical Next Generation Sequencing-Based Assay

Doron Lipson, PhD, Michelle K Nahas, PhD, Geoff A. Otto, PhD, Roman Yelensky, PhD, Omar Abdel-Wahab, MD, Kai Wang, MD PhD, Jie He, PhD, Andrew M. Intlekofer, MD, PhD, Raajit K. Rampal, M.D., Ph.D., Timothy A Brennan, MS, Kristina M. Knapp, BS, Kristina W Brennan, BS, Geneva Young, BS, Amy L Donahue, MS, Eric M Sanford, BS, Joel R Greenbowe, BS, Garrett M Frampton, PhD, Alex Fichtenholtz, PhD, Lauren E Young, MS, Rachel L Erlich, PhD, Alex Parker, PhD, David Klimstra, Ahmet Dogan, MD, PhD, Jeffrey S Ross, MD, Scott A. Armstrong, MD, PhD, Philip J. Stephens, PhD, Marcel R. M. van den Brink, MD, PhD, Vincent A. Miller, MD, Ross L. Levine, MD
Journal: Blood
Blood (2013) 122 (21): 230.
https://doi.org/10.1182/blood.V122.21.230.230
Published: 2013
Journal Articles

Targeted genomic sequencing of pediatric Burkitt lymphoma identifies recurrent alterations in antiapoptotic and chromatin-remodeling genes

Brief Report
Lisa Giulino-Roth, Kai Wang, Theresa Y. MacDonald, Susan Mathew, Yifang Tam, Maureen T. Cronin, Gary Palmer, Norma Lucena-Silva, Francisco Pedrosa, Marcia Pedrosa, Julie Teruya-Feldstein, Govind Bhagat, Bachir Alobeid, Lorenzo Leoncini, Cristiana Bellan, Emily Rogena, Kerice A. Pinkney, Mark A. Rubin, Raul C. Ribeiro, Roman Yelensky, Wayne Tam, Philip J. Stephens, Ethel Cesarman
Journal: Blood
Blood (2012) 120 (26): 5181–5184.
https://doi.org/10.1182/blood-2012-06-437624
Published: 2012
Includes: Supplemental data
Journal Articles

Novel Genomic Alterations in MCL1 and ARID1A Identified in Pediatric Burkitt Lymphoma Using Targeted High-Throughput Sequencing

Lisa Giulino Roth, MD, Kai Wang, PhD, Theresa MacDonald, Susan Mathew, PhD, YiFang Tam, MD, Maureen T Cronin, PhD, Gary Palmer, MD, JD, MBA, MPH, Norma Lucena-Silva, PhD, Francisco Pedrosa, MD, Marcia Pedrosa, MD, Julie Teruya-Feldstein, MD, Govind Bhagat, MBBS, Bachir Alobeid, MD, Lorenzo Leoncini, MD, Cristiana Bellan, MD, Emily Rogena, Mark A Rubin, MD, Raul Ribeiro, MD, Roman Yelensky, PhD, Wayne Tam, MD, PhD, Philip Stephens, PhD, Ethel Cesarman, MD, PhD
Journal: Blood
Blood (2012) 120 (21): 899.
https://doi.org/10.1182/blood.V120.21.899.899
Published: 2012