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Journal Articles

Redefining Prognosis in Patients with KIT D816V Positive Advanced Systemic Mastocytosis on KIT Inhibitors

Johannes Luebke, Nicole Naumann, Georgia Metzgeroth, Hans-Peter Horny, Karl Sotlar, Martina Rudelius, Alice Fabarius, Wolf-Karsten Hofmann, Juliana Schwaab, Andreas Reiter
Journal: Blood
Blood (2024) 144 (Supplement 1): 660.
https://doi.org/10.1182/blood-2024-193760
Published: 2024
Journal Articles

Predicting the Clinical Course of Treatment with Midostaurin in Patients with Advanced Systemic Mastocytosis

Johannes Lübke, Nicole Naumann, Timo Brand, Hans-Peter Horny, Martina Rudelius, Karl Sotlar, Georgia Metzgeroth, Alice Fabarius, Wolf-Karsten Hofmann, Juliana Schwaab, Andreas Reiter
Journal: Blood
Blood (2023) 142 (Supplement 1): 1834.
https://doi.org/10.1182/blood-2023-182322
Published: 2023
Journal Articles

Response and Resistance to Cladribine in Patients with Advanced Systemic Mastocytosis: A Registry-Based Analysis

Johannes Lübke, Nicole Naumann, Sebastian Kreil, Georgia Metzgeroth, Hans-Peter Horny, Karl Sotlar, Nicholas C.P. Cross, Alice Fabarius, Peter Valent, Wolf-Karsten Hofmann, Juliana Schwaab, Andreas Reiter
Journal: Blood
Blood (2022) 140 (Supplement 1): 3970–3971.
https://doi.org/10.1182/blood-2022-163650
Published: 2022
Journal Articles

Comparison of RNA-Based Versus DNA-Based Quantitative KIT D816V Mutation Analysis Reveals Significant Disparity in Patients with Advanced Systemic Mastocytosis

Mohamad Jawhar, Nicole Naumann, Johannes Lübke, Juliana Schwaab, Oliver Hofmann, Thomas Kielsgaard Kristensen, Karl Sotlar, Verena Haselmann, Sven Schneider, Georgia Metzgeroth, Henning D. Popp, Alice Fabarius, PhD, Peter Bugert, Wolf-Karsten Hofmann, MD PhD, Andreas Reiter
Journal: Blood
Blood (2019) 134 (Supplement_1): 2955.
https://doi.org/10.1182/blood-2019-128811
Published: 2019
Journal Articles

A New Prognostic Score for Advanced Systemic Mastocytosis Based on Clinical and Genetic Characteristics of 210 Consecutive Patients

Mohamad Jawhar, Juliana Schwaab, Nicole Naumann, Georgia Metzgeroth, MD, Hans-Peter Horny, Karl Sotlar, Manja Meggendorfer, PhD, Torsten Haferlach, MD, Nicholas C.P. Cross, Alice Fabarius, Wolf-Karsten Hofmann, Peter Valent, Andreas Reiter, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 349.
https://doi.org/10.1182/blood-2018-99-115804
Published: 2018
Journal Articles

KIT D816 Mutated / CBF-Negative Acute Myeloid Leukemia (AML): A New Poor-Risk Subtype Associated with Systemic Mastocytosis (SM-AML)

Mohamad Jawhar, Konstanze Döhner, MD, Sebastian Kreil, Juliana Schwaab, Khalid Shoumariyeh, MD, Manja Meggendorfer, PhD, Lambert L.F. Span, Stephan Fuhrmann, Nicole Naumann, Hans-Peter Horny, Karl Sotlar, Boris Kubuschok, Nikolas von Bubnoff, Karsten Spiekermann, MD, Michael Heuser, MD, Georgia Metzgeroth, MD, Alice Fabarius, Stefan A Klein, MD, Wolf-Karsten Hofmann, Hanneke Kluin-Nelemans, Torsten Haferlach, MD, Hartmut Döhner, MD, Nicholas C.P. Cross, Wolfgang R. Sperr, Peter Valent, Andreas Reiter, MD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1535.
https://doi.org/10.1182/blood-2018-99-115895
Published: 2018
Journal Articles

Systemic Mastocytosis with Associated Acute Myeloid Leukemia (SM-AML): a Poor-Risk Multi-Mutated Disease That Follows a Distinct Diagnostic Algorithm and Requires High-Dose Stem Cell-Targeting Therapy

Mohamad Jawhar, MD, Sebastian Kreil, MD, Juliana Schwaab, Khalid Shoumariyeh, MD, Lambert L.F. Span, Stephan Fuhrmann, Nicole Naumann, Florian Nolte, MD, Daniela Heidenreich, MD, Nadine Z. Müller, MD, Hans-Peter Horny, Karl Sotlar, Torsten Haferlach, MD, Boris Kubuschok, Karsten Spiekermann, Michael Heuser, MD, Georgia Metzgeroth, MD, Alice Fabarius, Stefan Klein, MD, Wolf-Karsten Hofmann, MD, Nicholas C.P. Cross, PhD, Manja Meggendorfer, PhD, Hanneke Kluin-Nelemans, MD PhD, Wolfgang R. Sperr, MD, Peter Valent, MD, Andreas Reiter, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2916.
https://doi.org/10.1182/blood.V130.Suppl_1.2916.2916
Published: 2017
Journal Articles

Response and progression on midostaurin in advanced systemic mastocytosis: KIT D816V and other molecular markers

Clinical Trials & Observations
Mohamad Jawhar, Juliana Schwaab, Nicole Naumann, Hans-Peter Horny, Karl Sotlar, Torsten Haferlach, Georgia Metzgeroth, Alice Fabarius, Peter Valent, Wolf-Karsten Hofmann, Nicholas C. P. Cross, Manja Meggendorfer, Andreas Reiter
Journal: Blood
Blood (2017) 130 (2): 137–145.
https://doi.org/10.1182/blood-2017-01-764423
Published: 2017
Journal Articles

Mast Cell Leukemia: Clinical Heterogeneity, Molecular Aberrations, Treatment Responses, Survival, and Prognostic Factors

Mohamad Jawhar, MD, Juliana Schwaab, MD, Manja Meggendorfer, PhD, Nicole Naumann, Hans-Peter Horny, MD, Karl Sotlar, MD, Torsten Haferlach, MD, Karla Schmitt, MD, Alice Fabarius, PhD, Peter Valent, MD, Wolf-Karsten Hofmann, MD, Nicholas C.P. Cross, PhD, Georgia Metzgeroth, MD, Andreas Reiter, MD
Journal: Blood
Blood (2016) 128 (22): 3109.
https://doi.org/10.1182/blood.V128.22.3109.3109
Published: 2016
Journal Articles

Impact of Molecular Markers on Response and Resistance in Midostaurin-Treated Patients with Advanced Systemic Mastocytosis

Mohamad Jawhar, MD, Juliana Schwaab, MD, Nicole Naumann, Sebastian Kluger, Hans-Peter Horny, MD, Karl Sotlar, MD, Torsten Haferlach, MD, Georgia Metzgeroth, MD, Alice Fabarius, PhD, Peter Valent, MD, Wolf-Karsten Hofmann, MD, Nicholas C.P. Cross, PhD, Manja Meggendorfer, PhD, Andreas Reiter, MD
Journal: Blood
Blood (2016) 128 (22): 945.
https://doi.org/10.1182/blood.V128.22.945.945
Published: 2016
Journal Articles

Incidence and Prognostic Impact of Cytogenetics in Combination with Molecular Aberrations in Patients with Systemic Mastocytosis

Nicole Naumann, Mohamad Jawhar, MD, Juliana Schwaab, MD, Georgia Metzgeroth, MD, Henning D Popp, MD, Nada Khaled, MD, Hans-Peter Horny, MD, Karl Sotlar, MD, Peter Valent, MD, Claudia Haferlach, MD, Gudrun Göhring, MD, Brigitte Schlegelberger, Prof, MD, Manja Meggendorfer, PhD, Nicholas C.P. Cross, PhD, Wolf-Karsten Hofmann, MD, Andreas Reiter, MD, Alice Fabarius, PhD
Journal: Blood
Blood (2016) 128 (22): 947.
https://doi.org/10.1182/blood.V128.22.947.947
Published: 2016
Journal Articles

Identification of the Ki-1 antigen (CD30) as a novel therapeutic target in systemic mastocytosis

Katharina Blatt, Sabine Cerny-Reiterer, Juliana Schwaab, Karl Sotlar, Gregor Eisenwort, Gabriele Stefanzl, Gregor Hoermann, Matthias Mayerhofer, Mathias Schneeweiss, Sylvia Knapp, Thomas Rülicke, Emir Hadzijusufovic, Karin Bauer, Dubravka Smiljkovic, Michael Willmann, Andreas Reiter, Hans-Peter Horny, Peter Valent
Journal: Blood
Blood (2015) 126 (26): 2832–2841.
https://doi.org/10.1182/blood-2015-03-637728
Published: 2015
Includes: Supplemental data
Journal Articles

Correlation of CD30 Expression on Neoplastic Mast Cells in Systemic Mastocytosis Assessed By Immunohistochemistry Versus Multiparameter Flow Cytometry and Correlation to Clinical Parameters

Frauke Bellos, MD, Karl Sotlar, MD, Susanne Schnittger, PhD, Claudia Haferlach, MD, Torsten Haferlach, Wolfgang Kern, MD
Journal: Blood
Blood (2015) 126 (23): 1616.
https://doi.org/10.1182/blood.V126.23.1616.1616
Published: 2015
Journal Articles

Additional Mutations in SRSF2, ASXL1 and/or RUNX1 Identify a High Risk Group of Patients with KIT D816V + Advanced Systemic Mastocytosis

Mohamad Jawhar, Juliana Schwaab, MD, Susanne Schnittger, PhD, Manja Meggendorfer, PhD, Karl Sotlar, MD, Hans-Peter Horny, MD, Georgia Metzgeroth, MD, Sebastian Kluger, Nicole Naumann, Claudia Haferlach, MD, Torsten Haferlach, Peter Valent, MD, Wolf-Karsten Hofmann, MD, Alice Charlotte Fabarius, PhD, Nicholas C.P. Cross, PhD, Andreas Reiter, MD
Journal: Blood
Blood (2015) 126 (23): 349.
https://doi.org/10.1182/blood.V126.23.349.349
Published: 2015
Journal Articles

Molecular Profiling of Myeloid Progenitor Cells in Multi-Mutated Advanced Systemic Mastocytosis Identifies KIT D816V As a Distinct and Late Event

Mohamad Jawhar, MD, Juliana Schwaab, MD, Susanne Schnittger, PhD, Karl Sotlar, MD, Hans Peter Horny, MD, Georgia Metzgeroth, Sven Schneider, MD, Nadine Müller, Nicole Naumann, Christoph Walz, MD, Torsten Haferlach, Peter Valent, MD, Wolf-Karsten Hofmann, MD, Nicholas C.P. Cross, PhD, Alice Fabarius, PhD, Andreas Reiter, MD
Journal: Blood
Blood (2014) 124 (21): 3216.
https://doi.org/10.1182/blood.V124.21.3216.3216
Published: 2014
Journal Articles

Midostaurin (PKC412) Demonstrates a High Rate of Durable Responses in Patients with Advanced Systemic Mastocytosis: Results from the Fully Accrued Global Phase 2 CPKC412D2201 Trial

Jason Gotlib, MD MS, Hanneke C. Kluin-Nelemans, MD PhD, Tracy I. George, MD, Cem Akin, MD PhD, Karl Sotlar, MD, Olivier Hermine, MD PhD, Farrukh Awan, MD MS, Elizabeth O Hexner, MD, Michael Mauro, MD, David Sternberg, MD PhD, Matthieu Villeneuve, Fabienne Emery-Salbert, MSc, Eric Stanek, PharmD, Karin Hartmann, MD, Hans-Peter Horny, MD, Peter Valent, MD, Andreas Reiter, MD
Journal: Blood
Blood (2014) 124 (21): 636.
https://doi.org/10.1182/blood.V124.21.636.636
Published: 2014
Journal Articles

The FIP1L1-PDGFRA fusion gene and the KIT D816V mutation are coexisting in a small subset of myeloid/lymphoid neoplasms with eosinophilia

Annette Hildegard Schmitt-Graeff, Philipp Erben, Juliane Schwaab, Beate Vollmer-Kary, Georgia Metzgeroth, Karl Sotlar, Hans-Peter Horny, Hans-H Kreipe, Paul Fisch, Andreas Reiter
Journal: Blood
Blood (2014) 123 (4): 595–597.
https://doi.org/10.1182/blood-2013-10-530642
Published: 2014
Journal Articles

Identification Of The Ki-1 Antigen (CD30) As a Novel Marker and Potential Therapeutic Target In Neoplastic Mast Cells In Advanced Systemic Mastocytosis

Katharina Blatt, MSc, Ph.D., Sabine Cerny-Reiterer, D.V.M, Karl Sotlar, M.D., Schwaab Juliana, M.D., Gregor Hoermann, M.D., Ph.D., Matthias Mayerhofer, M.D., Emir Hadzijusufovic, DVM, Michael Willmann, D.V.M., Andreas Reiter, MD, Hans-Peter Horny, MD, Peter Valent
Journal: Blood
Blood (2013) 122 (21): 3773.
https://doi.org/10.1182/blood.V122.21.3773.3773
Published: 2013
Journal Articles

Durable Responses and Improved Quality Of Life With Midostaurin (PKC412) In Advanced Systemic Mastocytosis (SM): Updated Stage 1 Results Of The Global D2201 Trial

Jason Gotlib, MD, Hanneke C. Kluin-Nelemans, MD, PhD, Tracy I. George, MD, Cem Akin, MD, PhD, Karl Sotlar, MD, Olivier Hermine, Farrukh Awan, MD, MS, Elizabeth Hexner, MD, Michael Mauro, MD, Rodica Morariu, MD, Margaret Squier, MD, PhD, Matthieu Villeneuve, Fabienne Emery-Salbert, MSc, John Coombs, PharmD, MBA, Karin Hartmann, MD, Hans-Peter Horny, MD, Peter Valent, MD, Andreas Reiter, MD
Journal: Blood
Blood (2013) 122 (21): 106.
https://doi.org/10.1182/blood.V122.21.106.106
Published: 2013
Journal Articles

Mutational Complexity Is Related To Disease Severity In Systemic Mastocytosis

Juliana Schwaab, MD, Susanne Schnittger, PhD, Karl Sotlar, MD, Christoph Walz, Alice Fabarius, PhD, Markus Pfirrmann, PhD, Alexander Kohlmann, PhD, Vera Grossmann, MSc, Manja Meggendorfer, PhD, Hans Peter Horny, MD, Peter Valent, Mohamad Jawhar, MD, Martina Teichmann, MD, Georgia Metzgeroth, MD, Philipp Erben, MD, Thomas Ernst, Andreas Hochhaus, MD, Torsten Haferlach, MD, Wolf-Karsten Hofmann, MD, Nicholas C.P. Cross, PhD, Andreas Reiter, MD
Journal: Blood
Blood (2013) 122 (21): 4094.
https://doi.org/10.1182/blood.V122.21.4094.4094
Published: 2013