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Journal Articles

Evaluation of Cell Surface Markers and Targets in Leukemic Stem Cells (LSC) Reveals Distinct Expression Profiles, Unique Drug Effects, and Specific Checkpoint Regulation in AML LSC and CML LSC

Irina Sadovnik, MSc, Harald Herrmann, MD, Katharina Blatt, MSc, PhD, Gregor Eisenwort, MD PhD, Niklas Mueller, MD, Gabriele Stefanzl, Gregor Hoermann, Susanne Herndlhofer, Karin Bauer, PhD, Barbara Peter, DVM, Rene Gaupmann, MD, Axel Schulenburg, MD, Wolfgang R. Sperr, MD, Peter Valent, MD

Blood (2016) 128 (22): 4234.

https://doi.org/10.1182/blood.V128.22.4234.4234

Published: 2016

Journal Articles

Combined Targeting of STAT3 and STAT5: A Novel Approach to Overcome Drug Resistance in Ph + Cml

Karoline V Gleixner, MD, Mathias A Schneeweiss, MD, Harald Herrmann, MD, Katharina Blatt, MSc, PhD, Daniela Berger, Gregor Eisenwort, MD PhD, Georg Greiner, MD, Konstantin Byrgazov, PhD, Gregor Hoermann, Marina Konopleva, MD PhD, Islam Waliul, Patrick T Gunning, PhD, Hiroshi Maeda, PhD, Richard Moriggl, PhD, Michael W. Deininger, MD PhD, Thomas Lion, PhD, Michael Andreeff, MD PhD, Peter Valent, MD

Blood (2016) 128 (22): 4241.

https://doi.org/10.1182/blood.V128.22.4241.4241

Published: 2016

Journal Articles

The Multi-Kinase Inhibitor DCC-2618 Inhibits Proliferation and Survival of Neoplastic Mast Cells and Other Cell Types Involved in Systemic Mastocytosis

Mathias A Schneeweiss, MD, Barbara Peter, DVM, Katharina Blatt, MSc,PhD, Daniela Berger, Gabriele Stefanzl, Emir Hadzijusufovic, DVM, Karoline V Gleixner, MD, Peter Valent, MD

Blood (2016) 128 (22): 1965.

https://doi.org/10.1182/blood.V128.22.1965.1965

Published: 2016

Journal Articles

Identification of the Ki-1 antigen (CD30) as a novel therapeutic target in systemic mastocytosis

Katharina Blatt, Sabine Cerny-Reiterer, Juliana Schwaab, Karl Sotlar, Gregor Eisenwort, Gabriele Stefanzl, Gregor Hoermann, Matthias Mayerhofer, Mathias Schneeweiss, Sylvia Knapp, Thomas Rülicke, Emir Hadzijusufovic, Karin Bauer, Dubravka Smiljkovic, Michael Willmann, Andreas Reiter, Hans-Peter Horny, Peter Valent

Blood (2015) 126 (26): 2832–2841.

https://doi.org/10.1182/blood-2015-03-637728

Published: 2015

Includes: Supplemental data

Journal Articles

Identification of a Neoplastic Stem Cell in Human Mast Cell Leukemia

Gregor Eisenwort, MD PhD, Barbara Peter, D.V.M., Katharina Blatt, MSc, PhD, Sabine Cerny-Reiterer, DVM, Gregor Hoermann, MD PhD, Irina Sadovnik, MSc, Martin Bilban, MD, Thomas Rülicke, D.V.M., Michael Willmann, D.V.M., Juliana Schwaab, MD, Andreas Reiter, MD, Wolfgang R Sperr, MD, Christine Mannhalter, PhD, Peter Valent, MD

Blood (2014) 124 (21): 817.

https://doi.org/10.1182/blood.V124.21.817.817

Published: 2014

Journal Articles

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection

Blood (2014) 124 (1): 111–120.

https://doi.org/10.1182/blood-2013-10-534685

Published: 2014

Includes: Supplemental data

Journal Articles

Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia

Harald Herrmann, Irina Sadovnik, Sabine Cerny-Reiterer, Thomas Rülicke, Gabriele Stefanzl, Michael Willmann, Gregor Hoermann, Martin Bilban, Katharina Blatt, Susanne Herndlhofer, Matthias Mayerhofer, Berthold Streubel, Wolfgang R. Sperr, Tessa L. Holyoake, Christine Mannhalter, Peter Valent

Blood (2014) 123 (25): 3951–3962.

https://doi.org/10.1182/blood-2013-10-536078

Published: 2014

Includes: Supplemental data

Journal Articles

Imatinib Inhibits SCF-Induced Development Of Human Mast Cells In Vitro and Induces Profound and Selective Mast Cell Deficiency In Patients With Ph+ CML

Sabine Cerny-Reiterer, D.V.M, Anja Rabenhorst, Msc, Ph.D., Gabriele Stefanzl, Msc, Susanne Herndlhofer, Katharina Blatt, MSc, Ph.D., Gregor Hoermann, M.D., Ph.D., Leonhard Muellauer, M.D., Sigrid Baumgartner, M.D., Christine Beham-Schmid, M.D., Wolfgang R Sperr, M.D., Werner Linkesch, M.D., Christine Mannhalter, M.D., Michel Arock, PharmD, Ph.D, Karin Hartmann, M.D., Peter Valent

Blood (2013) 122 (21): 3988.

https://doi.org/10.1182/blood.V122.21.3988.3988

Published: 2013

Journal Articles

Bromodomain-Containing Protein 4 (BRD4): A Novel Marker and Drug Target Expressed In Neoplastic Cells In Advanced Mast Cell Neoplasms

Ghaith Wedeh, Emir Hadzijusufovic, DVM, Sabine Cerny-Reiterer, D.V.M, Harald Herrmann, M.D., Katharina Blatt, MSc, Ph.D., Gregor Eisenwort, M.D., Ph.D, Gregor Hoermann, M.D., Ph.D., Wolfgang R Sperr, M.D., Leonhard Müllauer, M.D., Christopher R. Vakoc, M.D., Ph.D., James E Bradner, MD, Hans-Peter Horny, MD, Michael Willmann, D.V.M., Johannes Zuber, MD, Michel Arock, PharmD, Ph.D, Peter Valent

Blood (2013) 122 (21): 3747.

https://doi.org/10.1182/blood.V122.21.3747.3747

Published: 2013

Journal Articles

Phenotyping Of Leukemic Stem Cells In Ph+ ALL and Ph- ALL Reveals Unique Profiles Of Markers and Targets In Distinct Disease Variants

Sabine Cerny-Reiterer, D.V.M, Katharina Blatt, MSc, Ph.D., Harald Herrmann, M.D., Gregor Eisenwort, M.D., Ph.D, Susanne Herndlhofer, Heinz Sill, M.D., Werner Rabitsch, MD, Christine Mannhalter, M.D., Alexander Hauswirth, M.D., Wolfgang R Sperr, M.D., Ulrich Jaeger, Peter Valent

Blood (2013) 122 (21): 1654.

https://doi.org/10.1182/blood.V122.21.1654.1654

Published: 2013

Journal Articles

Identification Of The Ki-1 Antigen (CD30) As a Novel Marker and Potential Therapeutic Target In Neoplastic Mast Cells In Advanced Systemic Mastocytosis

Katharina Blatt, MSc, Ph.D., Sabine Cerny-Reiterer, D.V.M, Karl Sotlar, M.D., Schwaab Juliana, M.D., Gregor Hoermann, M.D., Ph.D., Matthias Mayerhofer, M.D., Emir Hadzijusufovic, DVM, Michael Willmann, D.V.M., Andreas Reiter, MD, Hans-Peter Horny, MD, Peter Valent

Blood (2013) 122 (21): 3773.

https://doi.org/10.1182/blood.V122.21.3773.3773

Published: 2013

Journal Articles

The Oncogenic Transcription Factor STAT5 Triggers Aberrant Expression Of CD25 (IL-2RA) In Neoplastic Stem Cells In Ph + CML

Irina Sadovnik, M.Sc., Harald Herrmann, M.D., Sabine Cerny-Reiterer, D.V.M, Wolfgang Warsch, Ph.D., Andrea Hoelbl, Ph.D., Katharina Blatt, MSc, Ph.D., Barbara Peter, D.V.M., Gabriele Stefanzl, Msc, Gregor Hoermann, M.D., Ph.D., Susanne Herndlhofer, Berthold Streubel, M.D., Wolfgang R Sperr, M.D., Christine Mannhalter, Ph.D., Veronika Sexl, MD, Peter Valent

Blood (2013) 122 (21): 3979.

https://doi.org/10.1182/blood.V122.21.3979.3979

Published: 2013

Journal Articles

Identification of Campath-1 Antigen (CD52) As a Novel Therapeutic Target in Advanced Systemic Mastocytosis.

Gregor Hoermann, M.D., Ph.D., Katharina Blatt, MSc, Harald Herrmann, M.D., Sabine Cerny-Reiterer, D.V.M., Leonhard Müllauer, M.D., Peter Valent, MD, Matthias Mayerhofer, M.D.

Blood (2012) 120 (21): 2866.

https://doi.org/10.1182/blood.V120.21.2866.2866

Published: 2012

Journal Articles

5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS- demethylation and FAS re-expression, and synergism with FAS-ligand

Viviane Ghanim, Harald Herrmann, Gerwin Heller, Barbara Peter, Emir Hadzijusufovic, Katharina Blatt, Karina Schuch, Sabine Cerny-Reiterer, Irina Mirkina, Heidrun Karlic, Winfried F. Pickl, Sabine Zöchbauer-Müller, Peter Valent

Blood (2012) 119 (18): 4242–4252.

https://doi.org/10.1182/blood-2011-09-382770

Published: 2012

Includes: Supplemental data

Journal Articles

The Leukemic Stem Cell (LSC) in Ph + CML Is a CD34 + /CD38 − /Lin − Cell That Co-Expresses Dipeptidylpeptidase IV (CD26) and Disrupts LSC-Niche Interactions by Degrading the CXCR4 Ligand SDF-1α

Harald Herrmann, M.D., Irina Sadovnik, M.Sc., Sabine Cerny-Reiterer, D.V.M., Katharina Blatt, M.Sc., Viviane Ghanim, M.D., Susanne Herndlhofer, Gregor Hoermann, M.D., Thomas Rülicke, D.V.M., Michael Willmann, D.V.M., Gerlinde Mitterbauer-Hohendanner, M.D., Matthias Mayerhofer, M.D., Wolfgang R. Sperr, M.D., Peter Valent, M.D.

Blood (2011) 118 (21): 961.

https://doi.org/10.1182/blood.V118.21.961.961

Published: 2011

Journal Articles

5-Azacytidine and Decitabine Induce FAS Re-Expression, Exert Major Proapoptotic Effects, and Cooperate with the FAS Ligand in Producing Apoptosis in Neoplastic Human Mast Cells,

Viviane Ghanim, M.D., Harald Herrmann, MD, Emir Hadzijusufovic, DVM, Barbara Peter, D.V.M., Katharina Blatt, M.Sc., Karina Schuch, Sabine Cerny-Reiterer, D.V.M., Irina Mirkina, PhD, Gerwin Heller, PhD, Sabine Zöchbauer-Müller, MD, Heidrun Karlic, PhD, Winfried F Pickl, MD, Peter Valent, M.D.

Blood (2011) 118 (21): 3457.

https://doi.org/10.1182/blood.V118.21.3457.3457

Published: 2011

Journal Articles

5-Azacytidine and Decitabine Induce Demethylation and Re-Expression of FAS (CD95) and Promote Apoptosis in Neoplastic Cells in Acute Myeloid Leukemia (AML),

Heidrun Karlic, PhD, Rene Reitermaier, Viviane Ghanim, MD, Harald Herrmann, MD, Roman Thaler, M.Sc. PhD, Silvia Spitzer, Franz Varga, PhD, Irina Sadovnik, M.Sc., Katharina Blatt, M.Sc., Felix Keil, MD, Peter Valent, M.D., Michael Pfeilstöcker, MD

Blood (2011) 118 (21): 3463.

https://doi.org/10.1182/blood.V118.21.3463.3463

Published: 2011

Journal Articles

Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML,

Harald Herrmann, M.D., Katharina Blatt, M.Sc., Junwei Shi, Amy R. Rappaport, Karoline V. Gleixner, M.D., Sabine Cerny-Reiterer, D.V.M., Barbara Peter, D.V.M., Eric Wang, Wolfgang R. Sperr, M.D., James E. Bradner, MD, Scott W. Lowe, Ph.D., Christopher R. Vakoc, M.D., Ph.D., Johannes Zuber, M.D., Peter Valent, M.D.

Blood (2011) 118 (21): 3484.

https://doi.org/10.1182/blood.V118.21.3484.3484

Published: 2011

Journal Articles

Ponatinib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest and Apoptosis,

Karoline V. Gleixner, M.D., Katharina Blatt, M.Sc., Barbara Peter, D.V.M., Emir Hadzijusufovic, DVM, Peter Valent, M.D.

Blood (2011) 118 (21): 3497.

https://doi.org/10.1182/blood.V118.21.3497.3497

Published: 2011

Journal Articles

The Midostaurin (PKC412) Metabolite CGP52421 Shows Little Growth-Inhibitory Activity Against Against Neoplastic Mast Cells but Retains Inhibitory Effects on IgE-Dependent Activation and Histamine Release

Barbara Peter, D.V.M., Katharina Blatt, M.Sc., Gabriele Stefanzl, Emir Hadzijusufovic, DVM, Catherine Dutreix, Stefan H Gross, Johannes L Roesel, Peter Valent, M.D.

Blood (2011) 118 (21): 1417.

https://doi.org/10.1182/blood.V118.21.1417.1417

Published: 2011

NARROW

Evaluation of Cell Surface Markers and Targets in Leukemic Stem Cells (LSC) Reveals Distinct Expression Profiles, Unique Drug Effects, and Specific Checkpoint Regulation in AML LSC and CML LSC

Combined Targeting of STAT3 and STAT5: A Novel Approach to Overcome Drug Resistance in Ph + Cml

The Multi-Kinase Inhibitor DCC-2618 Inhibits Proliferation and Survival of Neoplastic Mast Cells and Other Cell Types Involved in Systemic Mastocytosis

Identification of the Ki-1 antigen (CD30) as a novel therapeutic target in systemic mastocytosis

Identification of a Neoplastic Stem Cell in Human Mast Cell Leukemia

A new human mast cell line expressing a functional IgE receptor converts to tumorigenic growth by KIT D816V transfection

Dipeptidylpeptidase IV (CD26) defines leukemic stem cells (LSC) in chronic myeloid leukemia

Imatinib Inhibits SCF-Induced Development Of Human Mast Cells In Vitro and Induces Profound and Selective Mast Cell Deficiency In Patients With Ph+ CML

Bromodomain-Containing Protein 4 (BRD4): A Novel Marker and Drug Target Expressed In Neoplastic Cells In Advanced Mast Cell Neoplasms

Phenotyping Of Leukemic Stem Cells In Ph+ ALL and Ph- ALL Reveals Unique Profiles Of Markers and Targets In Distinct Disease Variants

Identification Of The Ki-1 Antigen (CD30) As a Novel Marker and Potential Therapeutic Target In Neoplastic Mast Cells In Advanced Systemic Mastocytosis

The Oncogenic Transcription Factor STAT5 Triggers Aberrant Expression Of CD25 (IL-2RA) In Neoplastic Stem Cells In Ph + CML

Identification of Campath-1 Antigen (CD52) As a Novel Therapeutic Target in Advanced Systemic Mastocytosis.

5-azacytidine and decitabine exert proapoptotic effects on neoplastic mast cells: role of FAS- demethylation and FAS re-expression, and synergism with FAS-ligand

The Leukemic Stem Cell (LSC) in Ph + CML Is a CD34 + /CD38 − /Lin − Cell That Co-Expresses Dipeptidylpeptidase IV (CD26) and Disrupts LSC-Niche Interactions by Degrading the CXCR4 Ligand SDF-1α

5-Azacytidine and Decitabine Induce FAS Re-Expression, Exert Major Proapoptotic Effects, and Cooperate with the FAS Ligand in Producing Apoptosis in Neoplastic Human Mast Cells,

5-Azacytidine and Decitabine Induce Demethylation and Re-Expression of FAS (CD95) and Promote Apoptosis in Neoplastic Cells in Acute Myeloid Leukemia (AML),

Small-Molecule Inhibition of BRD4 Is a Novel Promising Approach to Therapeutically Target Leukemia Stem Cells in AML,

Ponatinib Exerts Growth-Inhibitory Effects on Neoplastic Mast Cells and Synergizes with Midostaurin in Producing Growth Arrest and Apoptosis,

The Midostaurin (PKC412) Metabolite CGP52421 Shows Little Growth-Inhibitory Activity Against Against Neoplastic Mast Cells but Retains Inhibitory Effects on IgE-Dependent Activation and Histamine Release

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American Society of Hematology

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ASH Publications

American Society of Hematology

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