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Alexis Vedder
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Journal Articles

The Long Non-Coding RNA MALAT1 Is Necessary for Hematopoietic Stem and Progenitor Cell Expansion and Preleukemic Myeloproliferation in TET2 Deficient Myeloid Neoplasms

Nana Adjoa Ben-Crentsil, Ariel Quintana-Gonzalez, Maria E Balasis, Hannah Newman, Traci L. Kruer, Lei Sun, Christopher Letson, Abhishek Dhawan, Chetasi Talati, Meghan Ferrall-Fairbanks, Alexis Vedder, Kathy McGraw, Rami S. Komrokji, Li Ma, Eric Padron
Journal: Blood
Blood (2022) 140 (Supplement 1): 1991–1993.
https://doi.org/10.1182/blood-2022-156670
Published: 2022
Journal Articles

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation

Xiaona You, Fabao Liu, Moritz Binder, Alexis Vedder, Terra Lasho, Zhi Wen, Xin Gao, Evan Flietner, Adhithi Rajagopalan, Yun Zhou, Christy Finke, Abhishek Mangaonkar, Ruiqi Liao, Guangyao Kong, Erik A. Ranheim, Nathalie Droin, Anthony M. Hunter, Sergey Nikolaev, Maria Balasis, Omar Abdel-Wahab, Ross L. Levine, Britta Will, Kalyan Vara Ganesh Nadiminti, David Yang, Klaus Geissler, Eric Solary, Wei Xu, Eric Padron, Mrinal M. Patnaik, Jing Zhang
Journal: Blood
Blood (2022) 139 (7): 1066–1079.
https://doi.org/10.1182/blood.2021012519
Published: 2022
Includes: Supplemental data
Journal Articles

CBL mutations drive PI3K/AKT signaling via increased interaction with LYN and PIK3R1

Roger Belizaire, Sebastian H. J. Koochaki, Namrata D. Udeshi, Alexis Vedder, Lei Sun, Tanya Svinkina, Christina Hartigan, Marie McConkey, Veronica Kovalcik, Amanuel Bizuayehu, Caroline Stanclift, Monica Schenone, Steven A. Carr, Eric Padron, Benjamin L. Ebert
Journal: Blood
Blood (2021) 137 (16): 2209–2220.
https://doi.org/10.1182/blood.2020006528
Published: 2021
Includes: Supplemental data
Journal Articles

Tfeb Links MYC Signaling to Epigenetic Control of Acute Myeloid Leukemia Cell Death and Differentiation

Seongseok Yun, MDPhD, Nicole D. Vincelette, PhD, Mario Fernandez, Xiaoqing Yu, PhD, Chunying Yang, Taro Hitosugi, PhD, Chia-Ho Cheng, PhD, Audrey Freischel, Ling Zhang, MD, Gregory Watson, PhD, Weimin Li, Hsin-An Hou, MD PhD, Franz Xaver Schaub, PhD, Alexis Vedder, BS, Ling Cen, PhD, Kathy McGraw, PhD, Daniel Murphy, PhD, Andrea Ballabio, Scott H. Kaufmann, MD PhD, Anders Berglund, John L. Cleveland, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 12–13.
https://doi.org/10.1182/blood-2020-137209
Published: 2020
Journal Articles

Depletion of the Long Non-Coding RNA MALAT1 primes Chronic Myelomonocytic Leukemia (CMML) for Differentiation Therapy with All- Trans retinoic Acid (ATRA) through the Transcription Factor CREB

Maria E Balasis, Alexis Vedder, BS, Lei Sun, Ariel Quintana, PhD, Abhishek Dhawan, Hannah Newman, BS, Jane Merlevede, Kathy McGraw, PhD, Traci Kruer, PhD, Nana Ben-Crentsil, Jeffrey S Painter, BS, Nathalie Droin, PhD, Thomas Cluzeau, MD PhD, Christopher Letson, BS, Sheng Wei, MD, Rami S. Komrokji, MD, Hailing Zhang, MD, A. Robert MacLeod, PhD, Alan F. List, MD, Eric Solary, MD PhD, Pearlie K. Epling-Burnette, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 1692.
https://doi.org/10.1182/blood-2019-128573
Published: 2019
Journal Articles

Oncogenic Mechanisms of CBL E3 Ubiquitin Ligase Mutations in Myeloid Malignancies

Roger Belizaire, MD PhD, Sebastian Koochaki, BS, MS, Namrata Udeshi, PhD, Alexis Vedder, BS, Lei Sun, Monica Schenone, PhD, Steven Carr, PhD, Eric Padron, MD, Benjamin L. Ebert, MD PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 563.
https://doi.org/10.1182/blood-2019-122503
Published: 2019
Journal Articles

Bromodomain and Extra Terminal Domain (BET) Inhibitors Sensitize Chronic Myelomonocytic Leukemia (CMML) to PIM Inhibition Via Downregulation of Mir-33a

Christopher Letson, BS, Alexis Vedder, BS, Ariel Quintana, PhD, Phillip Liu, PhD, Brett Reid, Maria E Balasis, Hannah Newman, BS, Traci Kruer, PhD, Luciana L Almada, PhD, Guolin Zhang, PhD, Martin Fernandez-Zapico, MD, Mrinal M Patnaik, MDMBBS, Jeffrey E. Lancet, MD, Rami S. Komrokji, MD, P.K. Epling-Burnette, PharmD, PhD, Alan F. List, MD, Eric B. Haura, MD, Gary W. Reuther, Thomas A. Sellers, PhD, Holly K. Koblish, PhD, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4220.
https://doi.org/10.1182/blood-2019-128165
Published: 2019
Journal Articles

Patient Derived Xenografts (PDX) Recapitulate Ruxolitinib Clinical Trial Responses and Identify a Novel Combination Therapy for Chronic Myelomonocytic Leukemia (CMML)

Hannah Newman, BS, Anthony M. Hunter, MD, Christopher Letson, BS, Amy E. DeZern, MD, Maria E Balasis, William Dominguez-Viqueira, PhD, Alexis Vedder, BS, Traci Kruer, PhD, Jeffrey E. Lancet, MD, Alan F. List, MD, Gail J. Roboz, MD, David P. Steensma, MD, Mikkael A. Sekeres, MD MS, Rami S. Komrokji, MD, Eric Padron, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 2984.
https://doi.org/10.1182/blood-2019-128541
Published: 2019
Journal Articles

Robust patient-derived xenografts of MDS/MPN overlap syndromes capture the unique characteristics of CMML and JMML

Akihide Yoshimi, Maria E. Balasis, Alexis Vedder, Kira Feldman, Yan Ma, Hailing Zhang, Stanley Chun-Wei Lee, Christopher Letson, Sandrine Niyongere, Sydney X. Lu, Markus Ball, Justin Taylor, Qing Zhang, Yulong Zhao, Salma Youssef, Young Rock Chung, Xiao Jing Zhang, Benjamin H. Durham, Wendy Yang, Alan F. List, Mignon L. Loh, Virginia Klimek, Michael F. Berger, Elliot Stieglitz, Eric Padron, Omar Abdel-Wahab
Journal: Blood
Blood (2017) 130 (4): 397–407.
https://doi.org/10.1182/blood-2017-01-763219
Published: 2017
Includes: Supplemental data