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Journal Articles

Nuclear Receptor NR2E3 Activates Both Wild-Type and Mutated p53 in Multiple Myeloma Cells

Zhi Wen, Adam Bissonnette, Luke F. Moat, Yidan Wang, Benita S. Katzenellenbogen, John A Katzenellenbogen, Sung Hoon Kim, Abdul Shour, Adedayo A Onitilo
Journal: Blood
Blood (2024) 144 (Supplement 1): 6840.
https://doi.org/10.1182/blood-2024-199846
Published: 2024
Journal Articles

Inhibiting FOXM1 Sensitizes Myeloma Cells to BCL2 Inhibitor Venetoclax By Repressing MYC Pathway

Vivian Zhou, Luke Moat, Manya Yu, Deepak Parashar, Abdul Shour, Liang Zhang, Terrie Kitchner, Sanjay Shukla, Song Guo, Gene Ananiev, Benita S. Katzenellenbogen, John Katzenellenbogen, Adedayo Onitilo, Siegfried Janz, Zhi Wen
Journal: Blood
Blood (2023) 142 (Supplement 1): 1950.
https://doi.org/10.1182/blood-2023-180268
Published: 2023
Journal Articles

Genomic and Transcriptional Profiling Stratifies Vq Myeloma Lines into Two Clusters with Distinct Risk Signatures and Drug Responses

Evan Flietner, Mei Yu, Adhithi Rajagopalan, Yun Zhou, Yubin Feng, Anthony Veltri, Terra Lasho, Zhi Wen, Yuqian Sun, Robert Burns, Mrinal M. Patnaik, Natalie Callander, Fotis Asimakopoulos, Demin Wang, Jing Zhang
Journal: Blood
Blood (2022) 140 (Supplement 1): 9935–9936.
https://doi.org/10.1182/blood-2022-162827
Published: 2022
Journal Articles

Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation

Xiaona You, Fabao Liu, Moritz Binder, Alexis Vedder, Terra Lasho, Zhi Wen, Xin Gao, Evan Flietner, Adhithi Rajagopalan, Yun Zhou, Christy Finke, Abhishek Mangaonkar, Ruiqi Liao, Guangyao Kong, Erik A. Ranheim, Nathalie Droin, Anthony M. Hunter, Sergey Nikolaev, Maria Balasis, Omar Abdel-Wahab, Ross L. Levine, Britta Will, Kalyan Vara Ganesh Nadiminti, David Yang, Klaus Geissler, Eric Solary, Wei Xu, Eric Padron, Mrinal M. Patnaik, Jing Zhang
Journal: Blood
Blood (2022) 139 (7): 1066–1079.
https://doi.org/10.1182/blood.2021012519
Published: 2022
Includes: Supplemental data
Journal Articles

Nras Q61R/+ and Kras −/− cooperate to downregulate Rasgrp1 and promote lympho-myeloid leukemia in early T-cell precursors

Zhi Wen, Grant Yun, Alexander Hebert, Guangyao Kong, Erik A. Ranheim, Remington Finn, Adhithi Rajagoplan, Shuyi Li, Yun Zhou, Mei Yu, Alisa Damnernsawad, Jeroen P. Roose, Joshua J. Coon, Renren Wen, Demin Wang, Jing Zhang
Journal: Blood
Blood (2021) 137 (23): 3259–3271.
https://doi.org/10.1182/blood.2020009082
Published: 2021
Includes: Supplemental data
Journal Articles

Expression of Nras Q61R and MYC transgene in germinal center B cells induces a highly malignant multiple myeloma in mice

Zhi Wen, Adhithi Rajagopalan, Evan D. Flietner, Grant Yun, Marta Chesi, Quinlan Furumo, Robert T. Burns, Athanasios Papadas, Erik A. Ranheim, Adam C. Pagenkopf, Zachary T. Morrow, Remington Finn, Yun Zhou, Shuyi Li, Xiaona You, Jeffrey Jensen, Mei Yu, Alexander Cicala, James Menting, Constantine S. Mitsiades, Natalie S. Callander, P. Leif Bergsagel, Demin Wang, Fotis Asimakopoulos, Jing Zhang
Journal: Blood
Blood (2021) 137 (1): 61–74.
https://doi.org/10.1182/blood.2020007156
Published: 2021
Includes: Supplemental data
Journal Articles

Developing Novel Targeted Therapies Using the High-Risk Vq Myeloma Model

Evan Flietner, BS, Zhi Wen, PhD, Adhithi Rajagopalan, BS, Joshua Wiesner, BS, Xiaona You, PhD, Yun Zhou, MS, Terra Lasho, PhD, Mrinal M. Patnaik, MDMBBS, Demin Wang, PhD, Robert Burns, MD, Natalie S. Callander, MD, Fotis Asimakopoulos, PhDMBBChir,, Jing Zhang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-137148
Published: 2020
Journal Articles

Versican Proteolytic Fragments (Matrikines) Regulate the Intratumoral Dendritic Cell Milieu In Vivo: Implications for in Situ Tumor Vaccination

Athanasios Papadas, MD, Evan Flietner, BS, Zachary Morrow, BS, Joshua Wiesner, Alexander Cicala, Adam Pagenkopf, BS, Chelsea L. Hope, PhD, Adhithi Rajagopalan, BS, Zhi Wen, PhD, Philip Emmerich, Dustin Deming, Shigeki Miyamoto, PhD, Peiman Hematti, MD, Natalie Scott Callander, MD, Alexander Rakhmilevich, Mario Otto, MD PhD, Christian M. Capitini, MD, Jing Zhang, PhD, Fotis Asimakopoulos, PhDMBBChir,
Journal: Blood
Blood (2019) 134 (Supplement_1): 1210.
https://doi.org/10.1182/blood-2019-131582
Published: 2019
Journal Articles

Loss of Asxl1 Cooperates with Oncogenic Nras to Drive CMML Progression

Xiaona You, PhD, Zhi Wen, PhD, Guangyao Kong, Adhithi Rajagopalan, BS, Erik A. Ranheim, MD PhD, Yun Zhou, MS, Mrinal M Patnaik, MDMBBS, Jing Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3790.
https://doi.org/10.1182/blood-2019-131347
Published: 2019
Journal Articles

Reconstructing the Clonal and Mutational Architecture of Myeloma through Avian Leukosis Virus (ALV)-Mediated Genome Editing

Zachary Morrow, BS, Alexander Cicala, Evan Flietner, BS, Athanasios Papadas, MD, Adam Pagenkopf, BS, Zhi Wen, PhD, Adhithi Rajagopalan, BS, Poulikos Poulikakos, PhD, Natalie Scott Callander, MD, Marta Chesi, PhD, P. Leif Bergsagel, MD, Jing Zhang, PhD, Fotios Asimakopoulos, PhD MBBChir,
Journal: Blood
Blood (2018) 132 (Supplement 1): 4480.
https://doi.org/10.1182/blood-2018-99-115288
Published: 2018
Journal Articles

Mice Expressing MYC and Nras Q61R in Germinal Center B Cells Develop Highly Aggressive Multiple Myeloma

Adhithi Rajagopalan, BS, Zhi Wen, PhD, Quinlan Furumo, Erik A. Ranheim, MD PhD, Remington Finn, Evan Flietner, BS, Grant Yun, Yun Zhou, MS, Mei Yu, PhD, Natalie Scott Callander, MD, Marta Chesi, PhD, P. Leif Bergsagel, MD, Robert Burns, PhD, Demin Wang, PhD, Fotios Asimakopoulos, PhDMBBChir,, Jing Zhang, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1006.
https://doi.org/10.1182/blood-2018-99-116757
Published: 2018
Journal Articles

Canonical Notch Signaling Is Required for Kras G12D -Induced Myeloproliferative Neoplasm

Xiaona You, PhD, Guangyao Kong, Zhi Wen, Yuan-I Chang, Erik A. Ranheim, MD PhD, Eric Padron, MD, Jing Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1220.
https://doi.org/10.1182/blood.V130.Suppl_1.1220.1220
Published: 2017
Journal Articles

Wild-Type Kras Inhibits Nras Q61R/+ -Induced Leukemias

Zhi Wen, PhD MD, Jing Zhang, PhD
Journal: Blood
Blood (2015) 126 (23): 1249.
https://doi.org/10.1182/blood.V126.23.1249.1249
Published: 2015
Journal Articles

Studies on the Effects of Berbamine on the Human Leukemia Cell Line NB4.

Xiao-ying Zhao, Zhi-wen He, Dong Wu, Rong-zhen Xu
Journal: Blood
Blood (2005) 106 (11): 4422.
https://doi.org/10.1182/blood.V106.11.4422.4422
Published: 2005
Journal Articles

Use of Arsenic Trioxide (As 2 O 3 ) in the Treatment of Acute Promyelocytic Leukemia (APL): II. Clinical Efficacy and Pharmacokinetics in Relapsed Patients

Zhi-Xiang Shen, Guo-Qiang Chen, Jian-Hua Ni, Xiu-Shong Li, Shu-Min Xiong, Qian-Yao Qiu, Jun Zhu, Wei Tang, Guan-Lin Sun, Kan-Qi Yang, Yu Chen, Li Zhou, Zhi-Wen Fang, Yan-Ting Wang, Jun Ma, Peng Zhang, Ting-Dong Zhang, Sai-Juan Chen, Zhu Chen, Zhen-Yi Wang
Journal: Blood
Blood (1997) 89 (9): 3354–3360.
https://doi.org/10.1182/blood.V89.9.3354
Published: 1997