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Asxl1 loss cooperates with oncogenic Nras in mice to reprogram the immune microenvironment and drive leukemic transformation

Xiaona You, Fabao Liu, Moritz Binder, Alexis Vedder, Terra Lasho, Zhi Wen, Xin Gao, Evan Flietner, Adhithi Rajagopalan, Yun Zhou, Christy Finke, Abhishek Mangaonkar, Ruiqi Liao, Guangyao Kong, Erik A. Ranheim, Nathalie Droin, Anthony M. Hunter, Sergey Nikolaev, Maria Balasis, Omar Abdel-Wahab, Ross L. Levine, Britta Will, Kalyan Vara Ganesh Nadiminti, David Yang, Klaus Geissler, Eric Solary, Wei Xu, Eric Padron, Mrinal M. Patnaik, Jing Zhang
Journal: Blood
Blood (2022) 139 (7): 1066–1079.
https://doi.org/10.1182/blood.2021012519
Published: 2022
Includes: Supplemental data
Journal Articles

Expression of Nras Q61R and MYC transgene in germinal center B cells induces a highly malignant multiple myeloma in mice

Zhi Wen, Adhithi Rajagopalan, Evan D. Flietner, Grant Yun, Marta Chesi, Quinlan Furumo, Robert T. Burns, Athanasios Papadas, Erik A. Ranheim, Adam C. Pagenkopf, Zachary T. Morrow, Remington Finn, Yun Zhou, Shuyi Li, Xiaona You, Jeffrey Jensen, Mei Yu, Alexander Cicala, James Menting, Constantine S. Mitsiades, Natalie S. Callander, P. Leif Bergsagel, Demin Wang, Fotis Asimakopoulos, Jing Zhang
Journal: Blood
Blood (2021) 137 (1): 61–74.
https://doi.org/10.1182/blood.2020007156
Published: 2021
Includes: Supplemental data
Journal Articles

Developing Novel Targeted Therapies Using the High-Risk Vq Myeloma Model

Evan Flietner, BS, Zhi Wen, PhD, Adhithi Rajagopalan, BS, Joshua Wiesner, BS, Xiaona You, PhD, Yun Zhou, MS, Terra Lasho, PhD, Mrinal M. Patnaik, MDMBBS, Demin Wang, PhD, Robert Burns, MD, Natalie S. Callander, MD, Fotis Asimakopoulos, PhDMBBChir,, Jing Zhang, PhD
Journal: Blood
Blood (2020) 136 (Supplement 1): 10–11.
https://doi.org/10.1182/blood-2020-137148
Published: 2020
Journal Articles

YY1 Promotes SCF/c-Kit Signaling and HSC Self-Renewal in Fetal Hematopoiesis

Deependra Kumar Singh, PhD, Zhanping Lu, PhD, Shuai Jia, PhD, Xiaona You, PhD, Jing Zhang, PhD, Xuan Pan, PhD DVM
Journal: Blood
Blood (2020) 136 (Supplement 1): 27.
https://doi.org/10.1182/blood-2020-137254
Published: 2020
Journal Articles

Loss of Asxl1 Cooperates with Oncogenic Nras to Drive CMML Progression

Xiaona You, PhD, Zhi Wen, PhD, Guangyao Kong, Adhithi Rajagopalan, BS, Erik A. Ranheim, MD PhD, Yun Zhou, MS, Mrinal M Patnaik, MDMBBS, Jing Zhang, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3790.
https://doi.org/10.1182/blood-2019-131347
Published: 2019
Journal Articles

Unique dependence on Sos1 in Kras G12D -induced leukemogenesis

Brief Report
Xiaona You, Guangyao Kong, Erik A. Ranheim, David Yang, Yun Zhou, Jing Zhang
Journal: Blood
Blood (2018) 132 (24): 2575–2579.
https://doi.org/10.1182/blood-2018-09-874107
Published: 2018
Includes: Supplemental data
Journal Articles

Canonical Notch Signaling Is Required for Kras G12D -Induced Myeloproliferative Neoplasm

Xiaona You, PhD, Guangyao Kong, Zhi Wen, Yuan-I Chang, Erik A. Ranheim, MD PhD, Eric Padron, MD, Jing Zhang, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1220.
https://doi.org/10.1182/blood.V130.Suppl_1.1220.1220
Published: 2017
Journal Articles

Loss of Sos1 Inhibits Oncogenic Kras-Induced Hyperactivation of Wild-Type Ras during Leukemogenesis

Xiaona You, PhD, Guangyao Kong, PhD, Erik A. Ranheim, MD, Yun Zhou, Jing Zhang
Journal: Blood
Blood (2016) 128 (22): 1543.
https://doi.org/10.1182/blood.V128.22.1543.1543
Published: 2016
Journal Articles

Kras Is Critical for B Cell Lymphopoiesis

Yongwei Zheng, PhD, Yuhong Chen, PhD, Xiaona You, PhD, Mei Yu, PhD, Guoping Fu, PhD, Xinlin Su, Wen Zhu, Zhihong Wu, Jing Zhang, PhD, Renren Wen, PhD, Demin Wang, PhD
Journal: Blood
Blood (2015) 126 (23): 3588.
https://doi.org/10.1182/blood.V126.23.3588.3588
Published: 2015
Journal Articles

Kras Is Critical for CD8 T Cell Antiviral Function

Yuhong Chen, PhD, Yongwei Zheng, PhD, Xiaona You, PhD, Gang Xin, PhD, Mei Yu, PhD, Guoping Fu, PhD, Fen Zhou, Wen Zhu, Weiguo Cui, PhD, Jing Zhang, PhD, Renren Wen, PhD, Demin Wang, PhD
Journal: Blood
Blood (2015) 126 (23): 284.
https://doi.org/10.1182/blood.V126.23.284.284
Published: 2015