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Journal Articles

Developing a Safer Anti-CD44v6 Chimeric Antigen Receptor T Cell Against Hematological Cancers By Mitigating on-Target Off-Tumor Toxicity

Dennis Awuah, Lawrence Stern, Ian Schrack, Tae Yoon Kim, Joseph Cohen, Ryan Urak, Christian Huynh, Wen-Chung Chang, Stephen J Forman, Xiuli Wang

Blood (2021) 138 (Supplement 1): 2796.

https://doi.org/10.1182/blood-2021-153927

Published: 2021

Journal Articles

CD19/BAFF-R Dual-Targeted CAR T Cells for the Treatment of Mixed Antigen-Negative Variants of Acute Lymphoblastic Leukemia

Xiuli Wang, Zhenyuan Dong, Wen-Chung Chang, Wesley Cheng, Vibhuti Vyas, Dennis Awuah, Soung-chul Cha, Aaron Anderson, Mary C. Clark, Stephen J Forman, Larry W. Kwak, Hong Qin

Blood (2021) 138 (Supplement 1): 2783.

https://doi.org/10.1182/blood-2021-151293

Published: 2021

Journal Articles

CD19-CAR Therapy Using Naive/Memory or Central Memory T Cells Integrated into the Autologous Stem Cell Transplant Regimen for Patients with B-NHL

Leslie Popplewell, MD, Xiuli Wang, PhD, Suzette Blanchard, PhD, Jamie Wagner, BS, Araceli Naranjo, BS, Arencibia Adria, BS, Jinny Paul, PhD, Laura Lim, Wen-Chung Chang, PhD, Elizabeth E Budde, MD PhD, Sandra Thomas, PhD, Christine Brown, PhD, Stephen J Forman

Blood (2018) 132 (Supplement 1): 610.

https://doi.org/10.1182/blood-2018-99-119650

Published: 2018

Journal Articles

Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor Redirected-T Cells Against Multiple Myeloma

Xiuli Wang, MD PhD, Ryan Urak, MS, Miriam Walter, MS, Lihong Weng, MD, Laura Lim, BS, Ching Wong, BS, Wen-Chung Chang, MS, Sandra H. Thomas, PhD, Myo Htut, MD, Amrita Krishnan, MD, Stephen J. Forman, MD

Blood (2016) 128 (22): 812.

https://doi.org/10.1182/blood.V128.22.812.812

Published: 2016

Journal Articles

Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL

Blood (2016) 127 (24): 2980–2990.

https://doi.org/10.1182/blood-2015-12-686725

Published: 2016

Includes: Supplemental data

Journal Articles

Phase I Studies of Cellular Immunotherapy Using Central Memory Derived-CD19-Specific T Cells Following Autologous Stem Cell Transplantation for Patients with High-Risk Intermediate Grade B-Lineage Non-Hodgkin Lymphoma

Leslie Popplewell, MD, Xiuli Wang, PhD, Araceli Naranjo, BS, Suzette Blanchard, PhD, Jamie Wagner, BS, ChingLam Wong, BS, Ryan Urak, MS, Wen-Chung Chang, MS, Samer K Khaled, MD, Tanya Siddiqi, MD, Elizabeth E. Budde, MD PhD, Jingying Xu, PhD, Brenda Chang, BS, Sandra H. Thomas, PhD, Stanley R. Riddell, MD, Christine Brown, PhD, Michael C Jensen, MD, Stephen J. Forman, MD

Blood (2015) 126 (23): 930.

https://doi.org/10.1182/blood.V126.23.930.930

Published: 2015

Journal Articles

Ex Vivo AKT Inhibition Promotes the Generation of Potent CD19CAR T Cells for Adoptive Immunotherapy

Ryan Urak, MS, ChingLam Wong, BS, Wen-Chung Chang, MS, Elizabeth E. Budde, MD PhD, Christine Brown, PhD, Sandra H. Thomas, PhD, Stephen J. Forman, MD, Xiuli Wang, PhD

Blood (2015) 126 (23): 3086.

https://doi.org/10.1182/blood.V126.23.3086.3086

Published: 2015

Journal Articles

CS-1 Re-Directed Central Memory T Cell Therapy for Multiple Myeloma

Xiuli Wang, PhD, ChingLam W Wong, BS, Ryan Urak, MS, Wen-Chung Chang, MS, Elizabeth E. Budde, MD PhD, Christine Brown, PhD, Stephen J. Forman, MD

Blood (2014) 124 (21): 1114.

https://doi.org/10.1182/blood.V124.21.1114.1114

Published: 2014

Journal Articles

Targeting Of Leukemia Stem Cells By Interfering With Niches Using CD44 Variant 6 Chimeric Antigen Receptor Redirected Central Memory T Cells

Xiuli Wang, PhD, ChingLam W Wong, BS, Ryan Urak, MS, Armen Mardiros, MS, Wen-Chung Chang, MS, Ellie Taus, BS, Lihua E Budde, MD, PhD, Julie R Ostberg, Ph.D, Christine Brown, PhD, Stephen J. Forman, MD

Blood (2013) 122 (21): 4497.

https://doi.org/10.1182/blood.V122.21.4497.4497

Published: 2013

Journal Articles

Truncated Cell-Surface CD19 As a Conditional Suicide Switch For Adoptive T Cell Immunotherapy

Lihua Elizabeth Budde, MD, PhD, Armen Mardiros, MS, Wen-Chung Chang, MS, Xiuli Wang, MD, PhD, Carolina Berger, MD, Christine Brown, PhD, Stanley R Riddell, MD, Oliver W. Press, MD, PhD, Stephen J. Forman, MD

Blood (2013) 122 (21): 1660.

https://doi.org/10.1182/blood.V122.21.1660.1660

Published: 2013

Journal Articles

T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

Armen Mardiros, Cedric Dos Santos, Tinisha McDonald, Christine E. Brown, Xiuli Wang, L. Elizabeth Budde, Lauren Hoffman, Brenda Aguilar, Wen-Chung Chang, William Bretzlaff, Brenda Chang, Mahesh Jonnalagadda, Renate Starr, Julie R. Ostberg, Michael C. Jensen, Ravi Bhatia, Stephen J. Forman

Blood (2013) 122 (18): 3138–3148.

https://doi.org/10.1182/blood-2012-12-474056

Published: 2013

Includes: Supplemental data

Journal Articles

Enhanced Antitumor Efficacy of Adoptively Transferred CD19-Redirected CMV Specific Central Memory T Cells by CMV Vaccine.

Xiuli Wang, MD, PhD, Winnie Wong, B.S, Wen-Chung Chang, MS, Don Diamond, PhD, Michael C. Jensen, MD, Christine Brown, PhD, John Zaia, MD, Stephen J. Forman, MD

Blood (2012) 120 (21): 3014.

https://doi.org/10.1182/blood.V120.21.3014.3014

Published: 2012

Journal Articles

CD123-Specific Chimeric Antigen Receptor Redirected T Cells Exhibit Potent Cytolytic Activity and Multiple Effector Functions Against Acute Myeloid Leukemia without Altering Normal Hematopoietic Colony Formation in Vitro

Armen Mardiros, MS, Cedric Dos Santos, Ph.D, Tinisha McDonald, BS, Christine Brown, PhD, Xiuli Wang, MD, PhD, Wen-Chung Chang, MS, Julie R Ostberg, Ph.D, Ravi Bhatia, MD, Michael C. Jensen, MD, Stephen J. Forman, MD

Blood (2012) 120 (21): 950.

https://doi.org/10.1182/blood.V120.21.950.950

Published: 2012

Journal Articles

Adoptively Transferred Central Memory Derived Human CD8+Effectors Exhibit Superior Engraftment Fitness Over Their Naïve T Cell Derived Counterparts

Xiuli Wang, MD, PhD, ChingLam W Wong, BS, Brenda Aguilar, BS, Wen-Chung Chang, MS, Julie R Ostberg, PhD, Stanley R. Riddell, MD, Stephen J. Forman, MD, Michael C. Jensen, MD

Blood (2011) 118 (21): 2982.

https://doi.org/10.1182/blood.V118.21.2982.2982

Published: 2011

Journal Articles

A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells

Xiuli Wang, Wen-Chung Chang, ChingLam W. Wong, David Colcher, Mark Sherman, Julie R. Ostberg, Stephen J. Forman, Stanley R. Riddell, Michael C. Jensen

Blood (2011) 118 (5): 1255–1263.

https://doi.org/10.1182/blood-2011-02-337360

Published: 2011

Includes: Supplemental data

Journal Articles

The B-cell tumor–associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor

Michael Hudecek, Thomas M. Schmitt, Sivasubramanian Baskar, Maria Teresa Lupo-Stanghellini, Tetsuya Nishida, Tori N. Yamamoto, Marie Bleakley, Cameron J. Turtle, Wen-Chung Chang, Harvey A. Greisman, Brent Wood, David G. Maloney, Michael C. Jensen, Christoph Rader, Stanley R. Riddell

Blood (2010) 116 (22): 4532–4541.

https://doi.org/10.1182/blood-2010-05-283309

Published: 2010

Includes: Supplemental data

Journal Articles

An Engineered Cell Surface Polypeptide for Selection, Tracking and Ablation of Genetically Modified Hematopoietically Derived Cells Based on Human EGFR.

Xiuli Wang, MD, PhD, Wen-Chung Chang, MS, ChingLam W Wong, BS, David Colcher, PhD, Mark Sherman, PhD, Julie R Ostberg, PhD, Stanley R. Riddell, MD, Stephen Forman, MD, Michael C Jensen, MD

Blood (2010) 116 (21): 1469.

https://doi.org/10.1182/blood.V116.21.1469.1469

Published: 2010

Journal Articles

CD8 + T Cells Engineered to Express a ROR1-Specific Chimeric Antigen Receptor Specifically Recognize ROR1 Positive B Cell Tumors.

Michael Hudecek, MD, Thomas M Schmitt, PhD, Sivasubramanian Baskar, PhD, Wen-Chung Chang, David G Maloney, MD, PhD, Michael C Jensen, M.D., Christoph M. Rader, Ph.D., Stanley Riddell, MD

Blood (2009) 114 (22): 930.

https://doi.org/10.1182/blood.V114.22.930.930

Published: 2009

Journal Articles

Artificial Antigen Presenting Cell Can Be Used To Propagate Genetically Modified CD19-Specific T Cells through Chimeric Antigen Receptor.

Tontanai Numbenjapon, MD, Lisa Marie A. Serrano, BS, Simon Olivares, BS, Wen-Chung Chang, BS, Harjeet Singh, PhD, Claudia M. Kowolik, PhD, Sergio Gonzalez, BS, Nancy Gonzalez, BS, Laurence J.N. Cooper, MD/PhD

Blood (2005) 106 (11): 1295.

https://doi.org/10.1182/blood.V106.11.1295.1295

Published: 2005

Journal Articles

Enhanced antilymphoma efficacy of CD19-redirected influenza MP1–specific CTLs by cotransfer of T cells modified to present influenza MP1

Laurence J. N. Cooper, Zaid Al-Kadhimi, Lisa Marie Serrano, Timothy Pfeiffer, Simon Olivares, Adrian Castro, Wen-Chung Chang, Sergio Gonzalez, David Smith, Stephen J. Forman, Michael C. Jensen

Blood (2005) 105 (4): 1622–1631.

https://doi.org/10.1182/blood-2004-03-1208

Published: 2005

NARROW

Developing a Safer Anti-CD44v6 Chimeric Antigen Receptor T Cell Against Hematological Cancers By Mitigating on-Target Off-Tumor Toxicity

CD19/BAFF-R Dual-Targeted CAR T Cells for the Treatment of Mixed Antigen-Negative Variants of Acute Lymphoblastic Leukemia

CD19-CAR Therapy Using Naive/Memory or Central Memory T Cells Integrated into the Autologous Stem Cell Transplant Regimen for Patients with B-NHL

Lenalidomide Enhances the Function of CS1 Chimeric Antigen Receptor Redirected-T Cells Against Multiple Myeloma

Phase 1 studies of central memory–derived CD19 CAR T–cell therapy following autologous HSCT in patients with B-cell NHL

Phase I Studies of Cellular Immunotherapy Using Central Memory Derived-CD19-Specific T Cells Following Autologous Stem Cell Transplantation for Patients with High-Risk Intermediate Grade B-Lineage Non-Hodgkin Lymphoma

Ex Vivo AKT Inhibition Promotes the Generation of Potent CD19CAR T Cells for Adoptive Immunotherapy

CS-1 Re-Directed Central Memory T Cell Therapy for Multiple Myeloma

Targeting Of Leukemia Stem Cells By Interfering With Niches Using CD44 Variant 6 Chimeric Antigen Receptor Redirected Central Memory T Cells

Truncated Cell-Surface CD19 As a Conditional Suicide Switch For Adoptive T Cell Immunotherapy

T cells expressing CD123-specific chimeric antigen receptors exhibit specific cytolytic effector functions and antitumor effects against human acute myeloid leukemia

Enhanced Antitumor Efficacy of Adoptively Transferred CD19-Redirected CMV Specific Central Memory T Cells by CMV Vaccine.

CD123-Specific Chimeric Antigen Receptor Redirected T Cells Exhibit Potent Cytolytic Activity and Multiple Effector Functions Against Acute Myeloid Leukemia without Altering Normal Hematopoietic Colony Formation in Vitro

Adoptively Transferred Central Memory Derived Human CD8+Effectors Exhibit Superior Engraftment Fitness Over Their Naïve T Cell Derived Counterparts

A transgene-encoded cell surface polypeptide for selection, in vivo tracking, and ablation of engineered cells

The B-cell tumor–associated antigen ROR1 can be targeted with T cells modified to express a ROR1-specific chimeric antigen receptor

An Engineered Cell Surface Polypeptide for Selection, Tracking and Ablation of Genetically Modified Hematopoietically Derived Cells Based on Human EGFR.

CD8 + T Cells Engineered to Express a ROR1-Specific Chimeric Antigen Receptor Specifically Recognize ROR1 Positive B Cell Tumors.

Artificial Antigen Presenting Cell Can Be Used To Propagate Genetically Modified CD19-Specific T Cells through Chimeric Antigen Receptor.

Enhanced antilymphoma efficacy of CD19-redirected influenza MP1–specific CTLs by cotransfer of T cells modified to present influenza MP1

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American Society of Hematology

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American Society of Hematology

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