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James C Mulloy
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Journal Articles

Mitochondrial RNA Methylation By METTL17 Rewires Metabolism and Regulates Retrograde Mitochondrial-Nuclear Communication in AML

Xueer Wang, Honghai Zhang, Lei Dong, Xiaoxu Zhang, Meilin Xue, Lili Ren, Hongjie Bi, Lucy Y. Ghoda, Mark Wunderlich, James C. Mulloy, Chun-Wei David Chen, Ling Li, Lin Xu, Bin Zhang, Guido Marcucci, Steven T. Rosen, Nora Heisterkamp, Marcin Kortylewski, Jianjun Chen, Rui Su
Journal: Blood
Blood (2024) 144 (Supplement 1): 625.
https://doi.org/10.1182/blood-2024-201916
Published: 2024
Journal Articles

TET2-Mediated mRNA and DNA Oxidation in Leukemia Homing and Immune Evasion

Yangchan Li, Xiaolan Deng, Lei Dong, Li Han, Le Xuan Truong Nguyen, Jianhuang Xue, Zhicong Zhao, Wei Li, Ying Qing, Chao Shen, Brandon Tan, Zhenhua Chen, Meilin Xue, Keith Leung, Kitty Wang, Srividya Swaminathan, Ling Li, Mark Wunderlich, James C Mulloy, Bin Zhang, David A Horne, Steve T Rosen, Guido Marcucci, Mingjiang Xu, Zejuan Li, Minjie Wei, Rui Su, Jianjun Chen
Journal: Blood
Blood (2022) 140 (Supplement 1): 2975–2977.
https://doi.org/10.1182/blood-2022-162619
Published: 2022
Journal Articles

Epigenetic regulator genes direct lineage switching in  MLL/AF4 leukemia

Ricky Tirtakusuma, Katarzyna Szoltysek, Paul Milne, Vasily V. Grinev, Anetta Ptasinska, Paulynn S. Chin, Claus Meyer, Sirintra Nakjang, Jayne Y. Hehir-Kwa, Daniel Williamson, Pierre Cauchy, Peter Keane, Salam A. Assi, Minoo Ashtiani, Sophie G. Kellaway, Maria R. Imperato, Fotini Vogiatzi, Elizabeth K. Schweighart, Shan Lin, Mark Wunderlich, Janine Stutterheim, Alexander Komkov, Elena Zerkalenkova, Paul Evans, Hesta McNeill, Alex Elder, Natalia Martinez-Soria, Sarah E. Fordham, Yuzhe Shi, Lisa J. Russell, Deepali Pal, Alex Smith, Zoya Kingsbury, Jennifer Becq, Cornelia Eckert, Oskar A. Haas, Peter Carey, Simon Bailey, Roderick Skinner, Natalia Miakova, Matthew Collin, Venetia Bigley, Muzlifah Haniffa, Rolf Marschalek, Christine J. Harrison, Catherine A. Cargo, Denis Schewe, Yulia Olshanskaya, Michael J. Thirman, Peter N. Cockerill, James C. Mulloy, Helen J. Blair, Josef Vormoor, James M. Allan, Constanze Bonifer, Olaf Heidenreich, Simon Bomken
Journal: Blood
Blood (2022) 140 (17): 1875–1890.
https://doi.org/10.1182/blood.2021015036
Published: 2022
Includes: Supplemental data
Journal Articles

ETV6-NCOA2 fusion induces T/myeloid mixed-phenotype leukemia through transformation of nonthymic hematopoietic progenitor cells

Hila Fishman, Shreyas Madiwale, Ifat Geron, Vase Bari, Wouter Van Loocke, Yael Kirschenbaum, Itamar Ganmore, Eitan Kugler, Avigail Rein-Gil, Gilgi Friedlander, Ginette Schiby, Yehudit Birger, Sabine Strehl, Jean Soulier, Birgit Knoechel, Adolfo Ferrando, Sharon Noy-Lotan, Arnon Nagler, James C. Mulloy, Pieter Van Vlierberghe, Shai Izraeli
Journal: Blood
Blood (2022) 139 (3): 399–412.
https://doi.org/10.1182/blood.2020010405
Published: 2022
Includes: Supplemental data
Journal Articles

Effective Novel Fto Inhibitors Show Potent Anti-Cancer Efficacy and Suppress Drug Resistance

Rui Su, PhD, Lei Dong, PhD, Yangchan Li, Li Han, Min Gao, Mark Wunderlich, MS, Xiaolan Deng, Hongzhi Li, PhD, Lei Gao, Chenying Li, MD, Sean Robison, Brandon Tan, Ying Qing, Xi Qin, Emily Prince, Jun Xie, Hanjun Qin, Yue Huang, Wei Li, Chao Shen, PhD, Jie Sun, PhD, Kulkarni Prakash, Hengyou Weng, PhD, Huilin Huang, PhD, Zhenhua Chen, PhD, Bin Zhang, PhD, Xiwei Wu, PhD, Mark J Olsen, Markus Müschen, MD PhD, Guido Marcucci, MD, Salgia Ravi, Ling Li, PhD, Caiguang Yang, Zejuan Li, MD, James C Mulloy, Minjie Wei, David A Horne, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 233.
https://doi.org/10.1182/blood-2019-124535
Published: 2019
Journal Articles

Global Gene Expression and Mutation Signatures Are Preserved in PDX Models of Pediatric AML and Aid Discovery of Targeted Therapy for Cases with CBFA2T3/GLIS2 Rearrangement

Mark Wunderlich, MS, Jing Chen, Eric O'Brien, BSc, Nicole Manning, Christina Sexton, Luke Byerly, John P Perentesis, Benjamin Mizukawa, James C Mulloy
Journal: Blood
Blood (2019) 134 (Supplement_1): 3766.
https://doi.org/10.1182/blood-2019-129225
Published: 2019
Journal Articles

Overcoming Adaptive Therapy Resistance in AML By Targeting Immune Response Pathways

Katelyn M. Melgar, PhD, LaQuita M Jones, DO, Mackenzie Walker, Lyndsey C Bolanos, BSc, Kathleen Hueneman, Mark Wunderlich, MS, Jiang-Kang Jiang, Kelli Wilson, Xiaohu Zhang, Patrick Sutter, Xin Xu, Kwangmin Choi, PhD, Gregory Tawa, Donald Lorimer, Jan Abendroth, Eric O'Brien, BSc, Scott Hoyt, Ellin Berman, MD, Christopher Famulare, MS, James C Mulloy, Ross L. Levine, MD, Jan S Rosenbaum, John P Perentesis, Craig J Thomas, PhD, Daniel T. Starczynowski, PhD
Journal: Blood
Blood (2019) 134 (Supplement_1): 3934.
https://doi.org/10.1182/blood-2019-124178
Published: 2019
Journal Articles

The Role of LAMP5 in Innate Immune Signaling Is Critical for the Survival of MLL Leukemias

Gabriel Gracia-Maldonado, BS, Jason Clark, MS, Philippe Pierre, PhD, James C. Mulloy, PhD, Ashish R Kumar, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 3900.
https://doi.org/10.1182/blood-2018-99-120190
Published: 2018
Journal Articles

Proton Sensor GPR68 Is Essential to Maintain Myeloid Malignancies

Xiaofei He, B.S., Mark Wunderlich, MS, Benjamin Mizukawa, MD, James C. Mulloy, PhD, Saran Feng, MD, PhD, Lauren Lawley, B.S., Caleb Hawkins, B.S., Wenxin Fan, B.S., Guokun Zhou, PhD, Xiang-ming Zha, PhD, Jiajia Zhang, PhD, Johnie Hodge, MD,PhD, Daping Fan, PhD, Stephanie Halene, MD, Jing Fang, MD PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 1353.
https://doi.org/10.1182/blood-2018-99-110399
Published: 2018
Journal Articles

PD-1 Inhibition Enhances Blinatumomab Response in a UCB/PDX Model of B-Cell Acute Lymphoblastic Leukemia

Mark Wunderlich, MS, Nicole Manning, Christina Sexton, Perentesis P John, MD, Benjamin Mizukawa, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1318.
https://doi.org/10.1182/blood.V130.Suppl_1.1318.1318
Published: 2017
Journal Articles

Targeted Inhibition of STAT/TET1 Axis As a Potent Therapeutic Strategy for Acute Myeloid Leukemia

Xi Jiang, PhD, Chao Hu, Kyle Ferchen, Ji Nie, Xiaolong Cui, Chih-Hong Chen, PhD, Liting Cheng, Zhixiang Zuo, PhD, William Seibel, PhD, Chunjiang He, PhD, Yixuan Tang, Jennifer R Skibbe, Mark Wunderlich, MS, William C Reinhold, Lei Dong, PhD, Chao Shen, PhD, Stephen Arnovitz, Bryan Ulrich, Jiuwei Lu, PhD, Hengyou Weng, PhD, Rui Su, PhD, Huilin Huang, PhD, Yungui Wang, PhD, Chenying Li, MD, Xi Qin, James C. Mulloy, PhD, Yi Zheng, PhD, Jiajie Diao, PhD, Jie Jin, Chong Li, PhD, Paul P Liu, MD, Chuan He, PhD, Yuan Chen, PhD, Jianjun Chen, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 857.
https://doi.org/10.1182/blood.V130.Suppl_1.857.857
Published: 2017
Journal Articles

The cell polarity determinant CDC42 controls division symmetry to block leukemia cell differentiation

Benjamin Mizukawa, Eric O’Brien, Daniel C. Moreira, Mark Wunderlich, Cindy L. Hochstetler, Xin Duan, Wei Liu, Emily Orr, H. Leighton Grimes, James C. Mulloy, Yi Zheng
Journal: Blood
Blood (2017) 130 (11): 1336–1346.
https://doi.org/10.1182/blood-2016-12-758458
Published: 2017
Includes: Supplemental data
Journal Articles

A FOXO1-induced oncogenic network defines the AML1-ETO preleukemic program

Shan Lin, Anetta Ptasinska, Xiaoting Chen, Mahesh Shrestha, Salam A. Assi, Paulynn S. Chin, Maria R. Imperato, B. J. Aronow, Jingsong Zhang, Matthew T. Weirauch, Constanze Bonifer, James C. Mulloy
Journal: Blood
Blood (2017) 130 (10): 1213–1222.
https://doi.org/10.1182/blood-2016-11-750976
Published: 2017
Includes: Supplemental data
Journal Articles

The full transforming capacity of MLL-Af4 is interlinked with lymphoid lineage commitment

Brief Report
Shan Lin, Roger T. Luo, Mahesh Shrestha, Michael J. Thirman, James C. Mulloy
Journal: Blood
Blood (2017) 130 (7): 903–907.
https://doi.org/10.1182/blood-2017-04-777185
Published: 2017
Includes: Supplemental data
Journal Articles

Protease-Activated Receptor 1 (PAR-1) Inhibits Proliferation but Enhances Leukemia Stem Cell Activity in Acute Myeloid Leukemia

Susumu Goyama, MD PhD, Mahesh Shrestha, Janet Schibler, Leah Rosenfeldt, Whitney Miller, Eric O'Brien, Benjamin Mizukawa, MD, Toshio Kitamura, MD PhD, Joseph S. Palumbo, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2016) 128 (22): 2730.
https://doi.org/10.1182/blood.V128.22.2730.2730
Published: 2016
Journal Articles

LAMP5 - a Novel Target of MLL-Fusion Proteins Is Required for the Propagation of Leukemia

Gabriel Gracia-Maldonado, Jason Clark, James C. Mulloy, PhD, Ashish R Kumar, MBBS, PhD
Journal: Blood
Blood (2016) 128 (22): 1512.
https://doi.org/10.1182/blood.V128.22.1512.1512
Published: 2016
Journal Articles

The Transcriptome Heterogeneity of MLL-Fusion ALL Is Driven By Fusion Partners Via Distinct Chromatin Binding

Shan Lin, Anetta Ptasinska, PhD, Salam Adli Assi, Jon Kerry, Ruhikanta A. Meetei, PhD, Roger T. Luo, PhD, Michael J. Thirman, MD, Thomas Milne, PhD, Constanze Bonifer, PhD, James C. Mulloy, PhD
Journal: Blood
Blood (2016) 128 (22): 576.
https://doi.org/10.1182/blood.V128.22.576.576
Published: 2016
Journal Articles

Molecular Analysis and In Vivo Efficacy Studies on a Novel Chemical-Series of FLT3 Inhibitors in Human FLT3-ITD AML

Katelyn Melgar, MacKenzie Walker, Jiang-kang Jiang, Kelli Wison, Kwangmin Choi, PhD, James C. Mulloy, PhD, Craig J Thomas, PhD, Daniel T Starczynowski, PhD
Journal: Blood
Blood (2016) 128 (22): 36.
https://doi.org/10.1182/blood.V128.22.36.36
Published: 2016
Journal Articles

A Xenograft Model of Lymphocyte-Independent, Effector-Driven Macrophage Activation SyndRome Amenable to Anti-CD33 and Anti-IL-6R Treatment

Mark Wunderlich, MS, Courtney Stockman, Mahima Devarajan, Navin Ravishankar, Christina Sexton, Ashish R Kumar, MBBS, PhD, Benjamin Mizukawa, MD, James C. Mulloy, PhD
Journal: Blood
Blood (2016) 128 (22): 3684.
https://doi.org/10.1182/blood.V128.22.3684.3684
Published: 2016
Journal Articles

Loss of Function RUNX1 Mutations Restrict Protein Biosynthesis during Pre-Leukemia and MDS Transition but Not after Leukemic Transformation

Xiongwei Cai, PhD, Yoshihiro Hayashi, MD PhD, Mark Wunderlich, MS, Nancy A. Speck, PhD, James C. Mulloy, PhD, Gang Huang, PhD, Yi Zheng, PhD
Journal: Blood
Blood (2016) 128 (22): 3860.
https://doi.org/10.1182/blood.V128.22.3860.3860
Published: 2016