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Christoph Gaul
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Journal Articles

Novel inhibitors of the histone methyltransferase DOT1L show potent antileukemic activity in patient-derived xenografts

Florian Perner, Jayant Y. Gadrey, Yijun Xiong, Charles Hatton, Benjamin K. Eschle, Andreas Weiss, Frédéric Stauffer, Christoph Gaul, Ralph Tiedt, Jennifer A. Perry, Scott A. Armstrong, Andrei V. Krivtsov
Journal: Blood
Blood (2020) 136 (17): 1983–1988.
https://doi.org/10.1182/blood.2020006113
Published: 2020
Includes: Supplemental data
Journal Articles

Type II JAK2 Inhibitor NVP-CHZ868 Is Active in Vivo Against JAK2-Dependent B-Cell Acute Lymphoblastic Leukemias (B-ALLs)

Loretta S. Li, MD, Shuo-Chieh Wu, Nadja Kopp, MA, Joan Montero, PhD, Jeremy Ryan, SM, Bjoern Chapuy, MD PhD, Jordy C. Van der Zwet, Jacob Layer, Oliver Weigert, MD, Amanda L Christie, Alexandra N. Christodoulou, Huiyun Liu, Akinori Yoda, PhD, Francesco Hofmann, PhD, Fabienne Baffert, Eric Vangrevelinghe, Christoph Gaul, PhD, Thomas Radimerski, PhD, Anthony G. Letai, MD PhD, David M. Weinstock, MD
Journal: Blood
Blood (2014) 124 (21): 3713.
https://doi.org/10.1182/blood.V124.21.3713.3713
Published: 2014
Journal Articles

Type II Inhibition of JAK2 with NVP-CHZ868 Reverses Type I JAK Inhibitor Persistence and Demonstrates Increased Efficacy in MPN Models

Sara C Meyer, MD PhD, Matthew D Keller, BS, Priya Koppikar, PhD, Olga A Guryanova, MD PhD, Maria Kleppe, PhD, Anna Sophia McKenney, MPH, William R Sellers, MD, Francesco Hofmann, PhD, Fabienne Baffert, Christoph Gaul, PhD, Thomas Radimerski, PhD, Ross L Levine, MD
Journal: Blood
Blood (2014) 124 (21): 160.
https://doi.org/10.1182/blood.V124.21.160.160
Published: 2014
Journal Articles

Genetic Resistance to JAK2 Enzymatic Inhibitors Is Overcome by HSP90 Inhibition

Oliver Weigert, MD, Andrew A. Lane, MD, PhD, Liat Bird, Nadja Kopp, Angela V Toms, Ph.D., Christoph Gaul, Eric Vangrevelinghe, Alain De Pover, Catherine H. Regnier, PhD, Dirk Erdmann, Francesco Hofmann, PhD, Michael Eck, Andrew L. Kung, MD, PhD, Thomas Radimerski, PhD, David M Weinstock, MD
Journal: Blood
Blood (2011) 118 (21): 62.
https://doi.org/10.1182/blood.V118.21.62.62
Published: 2011