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Carine Bossard
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Journal Articles

Trial in progress: A phase I study evaluating the safety of cirtuvivint (CIRT) as monotherapy and in combination with ASTX727 in patients with myelodysplastic syndromes (MDS) and Acute Myeloid Leukemia (AML)

Free
Evan Chen, Yiwen Liu, Eytan Stein, Brian Ball, Ivana Gojo, Olatoyosi Odenike, Neil Palmisiano, Vu Duong, Zimu Gong, Michael Hochman, Carine Bossard, John Hill, Mirta Grifman, Daniel Deangelo, Richard Stone, Ilene Galinsky, Rebecca Leonard, Richard Little, Steven Gore, Jan Philipp Bewersdorf, Lourdes Mendez, Nikolai Podoltsev, Amer Zeidan, Omar Abdel-Wahab, Maximilian Stahl
Journal: Blood
Blood (2025) 146 (Supplement 1): 3431.
https://doi.org/10.1182/blood-2025-3431
Published: 2025
Journal Articles

DYRK1A controls CD47 endocytic degradation and leukemia immune surveillance

Free
Won Jun Kim, Alexander Arnuk, Jeetayu Biswas, Cuijuan Han, Nina Fox, Jacob Winick, Alexander Lewis, Kayla Koenig, Cynthia Castro, Abimbola Lawal, Robert Stanley, Joshua Weinreb, Zachary Zaroogian, Hui Liu, Zhuoning Li, Ileana Miranda, Anurag Sharma, Hilda Amalia Pasolli, Brian Eastman, Gopi Kumar Mittapalli, Chi-Ching Mak, Matthew Jarvis, Mara Monetti, Juan Osorio, Carine Bossard, Omar Abdel-Wahab, Eric Wang
Journal: Blood
Blood (2025) 146 (Supplement 1): 751.
https://doi.org/10.1182/blood-2025-751
Published: 2025
Journal Articles

The Pan-Clk/Dyrk Inhibitor Cirtuvivint (SM08502) Exposes Mechanistic Underpinnings of Alternative Splicing As a Therapeutic Vulnerability in Heme Malignancies

Free
Carine Bossard, Elizabeth A. McMillan, Emily Creger, Brian Eastman, Chi-Ching Mak, Darrin M. Beaupre, Michael A. White
Journal: Blood
Blood (2021) 138 (Supplement 1): 2950.
https://doi.org/10.1182/blood-2021-151305
Published: 2021
Journal Articles

Modulation of RNA Splicing Enhances Response to BCL2 Inhibition in Acute Myeloid Leukemia

Free
Eric Wang, Jose Mario Bello Pineda, Jessie Bourcier, Maximilian Stahl, Alexander V Penson, Isaac Wakiro, Michael E Singer, Daniel Cui, Caroline Erickson, Katherine Knorr, Robert Stanley, Xufeng Chen, Elizabeth A. McMillan, Carine Bossard, Iannis Aifantis, Robert K. Bradley, Omar Abdel-Wahab
Journal: Blood
Blood (2021) 138 (Supplement 1): 507.
https://doi.org/10.1182/blood-2021-146373
Published: 2021