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Journal Articles

Low dose weekly HMA-venetoclax dosing is associated with greater cost-effective efficacy than standard dosing in AML/MDS: Real-world evidence

Free
Wing Fai Li, Bradley Rockwell, Xinhe Shan, Ioannis Mantzaris, Aditi Shastri, Kira Gritsman, R. Alejandro Sica, Noah Kornblum, David Levitz, Lauren Shapiro, Ridhi Gupta, Stephen Peeke, Anne Munoz, Aradhika Dhawan, Karen Fehn, Monica Comas, Jhannine Verceles, Dennis Cooper, Marina Konopleva, Eric Feldman, Amit Verma, Mendel Goldfinger
Journal: Blood
Blood (2025) 146 (Supplement 1): 4429.
https://doi.org/10.1182/blood-2025-4429
Published: 2025
Journal Articles

Ofirnoflast, a novel inflammasome inhibitor, rewires transcriptional programs and shows clinical and preclinical efficacy in myeloid neoplasms

Free
Divij Verma, Rahul Sanawar, Samarpana Chakraborty, Emma Rabinovich, Kith Pradhan, Srabani Sahu, Christopher Selverian, Rongbao Zhao, Surendra Neupane, Colette Prophete, Lidiane Torres, Stephen Anthony, Margit Janat-Amsbury, Alexis Mollard, Shanisha Gordon-Mitchell, Aditi Shastri, Shanye Yin, Eric Padron, Alan List, David Bearss, Amit Verma
Journal: Blood
Blood (2025) 146 (Supplement 1): 323.
https://doi.org/10.1182/blood-2025-323
Published: 2025
Journal Articles

BCL-2 inhibition in North American adult T-cell leukemia/lymphoma: Preclinical insights and early clinical outcomes

Free
Ankit Tanwar, Emma Cordover, Salman Sadullah Usmani, Zixuan Tong, Kith Pradhan, Ella Wesson, Latoya S Townsend, Ioannis Mantzaris, Mendel Goldfinger, Nishi Shah, Aditi Shastri, Noah Kornblum, Dennis Cooper, Ridhi Gupta, Nechama Dreyfus, Julie Nguyen, Lauren Shapiro, Eric Feldman, Beth McLellan, Alyssa de Castro, Buse Eglenen Polat, Xingxing Zang, Ali Bazarbachi, Murali Janakiram, Gregoire Lauvau, Kira Gritsman, B. Hilda Ye, Amit Verma, Marina Konopleva, R. Alejandro Sica
Journal: Blood
Blood (2025) 146 (Supplement 1): 3304.
https://doi.org/10.1182/blood-2025-3304
Published: 2025
Journal Articles

Assessing diagnostic accuracy of DermPathGPT01 for dermatologic diagnosis in post-allogeneic stem cell transplant patients

Free
Ella Wesson, Kimberly Seymour, Emma Cordover, Sidney Hwang, Xiaoyi Zhang, Buse Eglenen Polat, Aditi Shastri, Eric Feldman, Noah Kornblum, Ankit Tanwar, Lauren Shapiro, Mendel Goldfinger, Ioannis Mantzaris, Dennis Cooper, Ridhi Gupta, Kira Gritsman, Marina Konopleva, Amit Verma, Benedict Wu, Beth McLellan, R. Alejandro Sica
Journal: Blood
Blood (2025) 146 (Supplement 1): 7875.
https://doi.org/10.1182/blood-2025-7875
Published: 2025
Journal Articles

Monoclonal antibodies against pathogenic S100A8/9 alarmins can restore hematopoiesis and result in immunomodulation in myelodysplasia and leukemia models

Free
Rahul Sanawar, Ariel Fromowitz, Srinivas Aluri, Sarah Aminov, Srabani Sahu, Leah Kravets, Shanisha Gordon-Mitchell, Mani Mohindru, Aditi Shastri, Alan List, Eric Padron, Rongbao Zhao, Amit Verma
Journal: Blood
Blood (2025) 146 (Supplement 1): 4959.
https://doi.org/10.1182/blood-2025-4959
Published: 2025
Journal Articles

Bi-specific T-cell engagers as a bridge to ciltacabtagene autoleucel in Relapsed/Refractory multiple myeloma: Real-world outcomes in an underserved urban population

Free
Santiago Beltran, Emma Cordover, Xiaoyi Zhang, Kimberly Seymour, Buse Eglenen Polat, Ankit Tanwar, Sidney Hwang, Nicholas Li, Ella Wesson, Aditi Shastri, Noah Kornblum, Lauren Shapiro, Mendel Goldfinger, Ioannis Mantzaris, Dennis Cooper, Kira Gritsman, Marina Konopleva, Amit Verma, Ridhi Gupta, R. Alejandro Sica
Journal: Blood
Blood (2025) 146 (Supplement 1): 4577.
https://doi.org/10.1182/blood-2025-4577
Published: 2025
Journal Articles

Development of a machine learning model to predict overall survival in patients with peripheral T-cell lymphoma in a minority enriched population

Free
Kimberly Seymour, Nicholas Li, Emma Cordover, Sidney Hwang, Ella Wesson, Xiaoyi Zhang, Buse Eglenen Polat, Ankit Tanwar, Lauren Shapiro, Noah Kornblum, Aditi Shastri, David Levitz, Mendel Goldfinger, Kira Gritsman, Ioannis Mantzaris, Ridhi Gupta, Marina Konopleva, Dennis Cooper, Eric Feldman, Amit Verma, R. Alejandro Sica
Journal: Blood
Blood (2025) 146 (Supplement 1): 2568.
https://doi.org/10.1182/blood-2025-2568
Published: 2025
Journal Articles

Venetoclax (VEN) and azacitidine (AZA) with gilteritinib (GILT) in patients with newly diagnosed (ND) FLT3mut+ Acute Myeloid Leukemia (AML) ineligible for intensive induction chemotherapy (chemo): Interim results from the phase 1/2 VICEROY study

Free
Jessica Altman, Alexander Perl, Eunice Wang, Uma Borate, Elie Traer, James Dugan, Margaret Kasner, Richard Larson, Yehuda Deutsch, Aditi Shastri, Maria Baer, Steven Tsai, Deepa Jeyakumar, Hoda Pourhassan, Alireza Eghtedar, Caroline Chen, Alexandra Heinloth, Rishita Nuthethi, Stanley Gill, Jason Hill, Nahla Hasabou, Mark Levis, Naval Daver
Journal: Blood
Blood (2025) 146 (Supplement 1): 654.
https://doi.org/10.1182/blood-2025-654
Published: 2025
Journal Articles

First-in-human study of CTX130, a CD70-directed allogeneic CAR T therapy, in adult T-cell leukemia/lymphoma: Clinical and genomics findings from a long-term follow-up of subgroup analysis from the cobalt-LYM Phase 1 trial

Free
Emma Cordover, Kimberly Seymour, Buse Eglenen Polat, Santiago Beltran, Xiaoyi Zhang, Ankit Tanwar, Sidney Hwang, Nicholas Li, Ella Wesson, Ziliang Li, Joy Mendonez, Alissa Keegan, Aditi Shastri, Noah Kornblum, Lauren Shapiro, Mendel Goldfinger, Ioannis Mantzaris, Dennis Cooper, Kira Gritsman, Marina Konopleva, Ridhi Gupta, Amit Verma, Swami Iyer, Ali Bazarbachi, R. Alejandro Sica
Journal: Blood
Blood (2025) 146 (Supplement 1): 4143.
https://doi.org/10.1182/blood-2025-4143
Published: 2025
Journal Articles

Thrombotic and hemorrhagic events and their impact on mortality among adults with newly diagnosed acute myeloid leukemia

Free
Diego Adrianzen Herrera, Andrew Sparks, Radhika Gangaraju, Karlyn Martin, Mansour Gergi, Katherine Wilkinson, Chris Holmes, Pamela Lutsey, Aditi Shastri, Neil Zakai
Journal: Blood
Blood (2025) 146 (Supplement 1): 2682.
https://doi.org/10.1182/blood-2025-2682
Published: 2025
Journal Articles

Immunotherapy resistant ALL cells exhibit selective dependence on glutamine and specific transporters for growth and survival

Free
Jessica Briggs, Sarah Aminov, Divij Verma, Srabani Sahu, Shanisha Gordon-Mitchell, Samarpana Chakraborty, Ellie Savoy, Aditi Shastri, Marina Konopleva, Stefano Tiziani, Srinivas Aluri, Amit Verma
Journal: Blood
Blood (2025) 146 (Supplement 1): 1535.
https://doi.org/10.1182/blood-2025-1535
Published: 2025
Journal Articles

Distinct patterns of clonal hematopoiesis exist in a longevity enriched cohort

Free
Salman Sadullah Usmani, Kith Pradhan, Tina Gao, Moeen Riaz, Ben Lerman, Kenny Ye, Varun Gupta, Mariapia Riso, Marina Konopleva, Amit Verma, Alan Shuldiner, Nir Barzilai, Sofiya Milman, Aditi Shastri
Journal: Blood
Blood (2025) 146 (Supplement 1): 1393.
https://doi.org/10.1182/blood-2025-1393
Published: 2025
Journal Articles

Venetoclax plus daunorubicin and cytarabine for newly diagnosed acute myeloid leukemia: results of a phase 1b study

Open Access
Clinical Trials & Observations Brief Report
Ioannis Mantzaris, Mendel Goldfinger, Matan Uriel, Aditi Shastri, Nishi Shah, Kira Gritsman, Noah S. Kornblum, Lauren Shapiro, Roberto Alejandro Sica, Anne Munoz, Nicole Chambers, Aradhika Dhawan, Jhannine Alyssa Verceles, Karen Fehn, Balda Tirone, Lamisha Shah, Shaunmonique Clark, Chenxin Zhang, Mimi Kim, Dennis L. Cooper, Amit Verma, Marina Konopleva, Eric J. Feldman
Journal: Blood
Blood (2025) 145 (17): 1870–1875.
https://doi.org/10.1182/blood.2024026700
Published: 2025
Includes: Supplemental data
Journal Articles

A weekly low-dose regimen of decitabine and venetoclax is efficacious and less myelotoxic in a racially diverse cohort

Free
Clinical Trials & Observations
Mendel Goldfinger, Ioannis Mantzaris, Aditi Shastri, Yogen Saunthararajah, Kira Gritsman, R. Alejandro Sica, Noah Kornblum, Nishi Shah, David Levitz, Bradley Rockwell, Lauren C. Shapiro, Ridhi Gupta, Kith Pradhan, Xiaonan Xue, Anne Munoz, Aradhika Dhawan, Karen Fehn, Monica Comas, Jhannine Alyssa Verceles, Brian A. Jonas, Suman Kambhampati, Yang Shi, Ira Braunschweig, Dennis L. Cooper, Marina Konopleva, Eric J. Feldman, Amit Verma
Journal: Blood
Blood (2024) 144 (22): 2360–2363.
https://doi.org/10.1182/blood.2024025834
Published: 2024
Includes: Supplemental data
Journal Articles

Impact of Age and Race on Survival in Adult T-Cell Leukemia/Lymphoma in the United States

Free
Madeline G D'Agostino, B. Hilda Ye, Murali Janakiram, Dennis L Cooper, Ioannis Mantzaris, Aditi Shastri, Mendel Goldfinger, Noah Kornblum, Nishi Shah, Amit Verma, Lauren Shapiro, Ridhi Gupta, Yang Shi, Yanhua Wang, Alyssa De Castro, John X Wei, R. Alejandro Sica
Journal: Blood
Blood (2024) 144 (Supplement 1): 7732.
https://doi.org/10.1182/blood-2024-208561
Published: 2024
Journal Articles

Post-Transplantation Cyclophosphamide and Abatacept Graft-Versus-Host-Disease Prophylaxis Shows Improved Outcomes in North American Adult T-Cell Leukemia/Lymphoma

Free
Julie Nguyen, Abdul-Hamid Bazarbachi, Kith Pradhan, John Yan, Emma Cordover, Daniel K Reef, Riya Patel, Rama Al Hamed, Astha Thakkar, Shafia Rahman, Diego Adrianzen Herrera, Ryann Quinn, Alyssa de Castro, Kailyn Gillick, Jennat Mustafa, Fariha Khatun, Amanda Lombardo, Latoya S Townsend, Michelly Abreu, Nicole Chambers, Richard Elkind, Yang Shi, Yanhua Wang, Olga Derman, Kira Gritsman, Ulrich Steidl, Mendel Goldfinger, Noah Kornblum, Aditi Shastri, Ioannis Mantzaris, Lizamarie Bachier Rodriguez, Brittany Moavero, Jhannine Verceles, Angela Czavar, Lauren Shapiro, Trent Wang, Juan Carlos Ramos, Nishi Shah, Ridhi Gupta, Marina Konopleva, Ira Braunschweig, Amit Verma, B. Hilda Ye, Murali Janakiram, Dennis L Cooper, R. Alejandro Sica
Journal: Blood
Blood (2024) 144 (Supplement 1): 7367.
https://doi.org/10.1182/blood-2024-207521
Published: 2024
Journal Articles

Mogamulizumab Shows Significant Activity with Tolerable Toxicity in a Real-World North American Adult T-Cell Leukemia/Lymphoma (ATLL) Cohort

Free
Emma Cordover, Kith Pradhan, Latoya S. Townsend, Mendel Goldfinger, Ioannis Mantzaris, Nishi Shah, Aditi Shastri, Noah Kornblum, Dennis L Cooper, Ridhi Gupta, Lauren Shapiro, Kira Gritsman, Marina Konopleva, Alyssa de Castro, Roy Browne, Salvatore Lia, Amit Verma, Ali Bazarbachi, B. Hilda Ye, Murali Janakiram, R. Alejandro Sica
Journal: Blood
Blood (2024) 144 (Supplement 1): 6418.
https://doi.org/10.1182/blood-2024-210619
Published: 2024
Journal Articles

Metronomic Low-Dose Regimen of Decitabine and Venetoclax Is Safe and Efficacious for Chronic Myelomonocytic Leukemia

Free
Bradley Rockwell, Ioannis Mantzaris, Aditi Shastri, Kira Gritsman, R. Alejandro Sica, Noah Kornblum, Nishi Shah, David Levitz, Lauren Shapiro, Ridhi Gupta, Annemarie Munoz, Aradhika Dhawan, Karen Fehn, Monica Comas, Jhannine Verceles, Dennis L Cooper, Marina Konopleva, Eric J. Feldman, Amit Verma, Mendel Goldfinger
Journal: Blood
Blood (2024) 144 (Supplement 1): 6723.
https://doi.org/10.1182/blood-2024-211307
Published: 2024
Journal Articles

Environmental Pollution Is Associated with Higher Risk MDS in a Diverse Urban Cohort and Triggers Inflammation in a Murine Models

Free
Megha Verma, Matthew P Davidsohn, Srabani Sahu, Kith Pradhan, Seyedeh Shareh Dehghani, Sakshi Jasra, Ritesh Aggarwal, Hui Zhang, Michael Wysota, Divij Verma, Amit Verma, Dean Hosgood, Yiyu Zou, Aditi Shastri
Journal: Blood
Blood (2024) 144 (Supplement 1): 3200.
https://doi.org/10.1182/blood-2024-206324
Published: 2024
Journal Articles

Promising Safety and Efficacy Data for Peginterferon Alfa-2a (PEG-IFN) and Bictegravir/Emtricitabine/Tenofovir Alafenamide (Biktarvy) in a North American Adult T-Cell Leukemia Lymphoma (NA-ATLL) Cohort of Patients

Free
Nechama Dreyfus, Emma Cordover, Kith Pradhan, Latoya S Townsend, Mendel Goldfinger, Ioannis Mantzaris, Nishi Shah, Aditi Shastri, Noah Kornblum, Dennis L Cooper, Ridhi Gupta, Lauren Shapiro, Kira Gritsman, Marina Konopleva, Beth McLellan, Simon Zhen, Alyssa de Castro, Salvatore Lia, Virleny Garcia, Roy Browne, Eric Meyerowitz, Yoram Puius, Margaret McCort, Yang Shi, Yanhua Wang, Amit Verma, B. Hilda Ye, Murali Janakiram, Abdul-Hamid Bazarbachi, R. Alejandro Sica
Journal: Blood
Blood (2024) 144 (Supplement 1): 3067.
https://doi.org/10.1182/blood-2024-208199
Published: 2024