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James Dugan
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Journal Articles

Venetoclax (VEN) and azacitidine (AZA) with gilteritinib (GILT) in patients with newly diagnosed (ND) FLT3mut+ Acute Myeloid Leukemia (AML) ineligible for intensive induction chemotherapy (chemo): Interim results from the phase 1/2 VICEROY study

Free
Jessica Altman, Alexander Perl, Eunice Wang, Uma Borate, Elie Traer, James Dugan, Margaret Kasner, Richard Larson, Yehuda Deutsch, Aditi Shastri, Maria Baer, Steven Tsai, Deepa Jeyakumar, Hoda Pourhassan, Alireza Eghtedar, Caroline Chen, Alexandra Heinloth, Rishita Nuthethi, Stanley Gill, Jason Hill, Nahla Hasabou, Mark Levis, Naval Daver
Journal: Blood
Blood (2025) 146 (Supplement 1): 654.
https://doi.org/10.1182/blood-2025-654
Published: 2025
Journal Articles

Asciminib (ASC) in chronic myeloid leukemia in chronic Phase (CML-CP): Efficacy and safety results of the Phase 2 ASC2ESCALATE trial in the cohort of patients (pts) with 1 prior tyrosine kinase inhibitor (TKI)

Free
Jorge Cortes, Ehab Atallah, David Andorsky, Marlise Luskin, Srinivas Tantravahi, Koji Sasaki, James Dugan, CelesteAnn Bremer, Vivian Oehler, Joshua Zeidner, Moshe Levy, Camille Abboud, Paul Koller, Bonnie Kiner-Strachan, Habte Yimer, Islam Mohamad Sadek, Daisy Yang, Dramane Laine, John (randy) Sabo, Bridget Cooper, Ennan Gu, Michael Mauro
Journal: Blood
Blood (2025) 146 (Supplement 1): 906.
https://doi.org/10.1182/blood-2025-906
Published: 2025
Journal Articles

Phase 1b study of bleximenib in combination with venetoclax in Acute Myeloid Leukemia with KMT2A or NPM1 alterations

Free
Jenny O'Nions, Andrew Wei, Jordi Esteve, Ibrahim Aldoss, Ana Alfonso-Pierola, Alicia Allred, Juan Manuel Alonso-Dominguez, Laura Barreyro, Pierre Bories, Nikki Daskalakis, Matteo Della Porta, Hartmut Döhner, Amber D'Souza, James Dugan, Amir Fathi, Pasquale Fedele, Lucille Ferrante, Rachel Kobos, Ana Garrido, Sara Garrido Paniagua, Christina Drenberg Guttke, Emmanuel Gyan, Brett Hiebert, Elias Jabbour, Danielle Trancucci, Naa Sackey, Madlen Jentzsch, Hagop Kantarjian, Marina Konopleva, Jan Krönke, Marie Luise Hütter-Krönke, Christina Loefgren, Oliver Lomas, Valentina Mancini, Daniel Morillo, Kathryn Packman, Cristina Papayannidis, Christian Recher, Christoph Röllig, Olga Salamero, Prathap Nagaraja Shastri, Tim Sauer, Dr. Emma Searle, Natalia Tovar, Nicolas Vallet, Lachlin Vaughan, Paresh Vyas, Uwe Platzbecker, Sylvain Garciaz
Journal: Blood
Blood (2025) 146 (Supplement 1): 5200.
https://doi.org/10.1182/blood-2025-5200
Published: 2025
Journal Articles

Bleximenib in combination with intensive chemotherapy: A phase 1b study in newly diagnosed Acute Myeloid Leukemia with KMT2A or NPM1 alterations

Free
Hartmut Döhner, Andre Schuh, Christian Recher, Jenny O'Nions, Ibrahim Aldoss, Ana Alfonso-Pierola, Alicia Allred, Juan Manuel Alonso-Dominguez, Laura Barreyro, Pierre Bories, Nikki Daskalakis, Matteo Della Porta, Amber D'Souza, James Dugan, Jordi Esteve, Amir Fathi, Lucille Ferrante, Stan Gaj, Sylvain Garciaz, Ana Garrido, Olga Salamero, Christina Drenberg Guttke, Emmanuel Gyan, Brett Hiebert, Elias Jabbour, Madlen Jentzsch, Hagop Kantarjian, Marina Konopleva, Jan Krönke, Marie Luise Hütter-Krönke, Christina Loefgren, Oliver Lomas, Valentina Mancini, Ioannis Mantzaris, Daniel Morillo, Kathryn Packman, Cristina Papayannidis, Ulrike Philippar, Uwe Platzbecker, Sara Garrido Paniagua, Naa Sackey, Tim Sauer, Dr. Emma Searle, Prathap Nagaraja Shastri, Danielle Trancucci, Natalia Tovar, Nicolas Vallet, Lachlin Vaughan, Paresh Vyas, Andrew Wei, Christoph Röllig
Journal: Blood
Blood (2025) 146 (Supplement 1): 5199.
https://doi.org/10.1182/blood-2025-5199
Published: 2025
Journal Articles

Results of the APG2575AU101 Study of lisaftoclax (APG-2575) combined with azacitidine (AZA) in patients with newly diagnosed (ND) or prior venetoclax–exposed myeloid malignancies

Free
Tapan Kadia, Patricia Kropf, Michael Leahy, Chong Chyn Chua, Shaun Fleming, Caspian Oliai, John Kwan, Chun Yew Fong, Joshua Richmond, Paul Cannell, James Dugan, Maria Baer, Stephen Ting, Daniel Egan, Zi Chen, Qian Niu, Mingyu Li, Divya Mekala, Zhiyan Liang, Mohammad Ahmad, Yifan Zhai
Journal: Blood
Blood (2025) 146 (Supplement 1): 1641.
https://doi.org/10.1182/blood-2025-1641
Published: 2025
Journal Articles

Molecular Characterization of Clinical Response in Relapsed/Refractory Acute Myeloid Leukemia and High-Risk Myelodysplastic Syndrome Patients Treated with Single Agent Emavusertib

Free
Klaus H. Metzeler, Eric S. Winer, Uwe Platzbecker, Amit Verma, Daniel J. DeAngelo, Stefano R. Tarantolo, David A. Sallman, James Dugan, Stefanie Gröpper, Katharina S. Goetze, Chia-Cheng Li, Wanying Zhao, Maureen Lane, Reinhard von Roemeling, Samantha Carlisle, Anne Weigert, Matthias Böhme, Anne Sophie Kubasch, Guillermo Garcia-Manero
Journal: Blood
Blood (2022) 140 (Supplement 1): 9048–9049.
https://doi.org/10.1182/blood-2022-167477
Published: 2022
Journal Articles

A Phase 1, Open Label Dose Escalation Trial Evaluating the Safety, Pharmacokinetics, Pharmacodynamics, and Clinical Activity of Orally Administered CA-4948 in Patients with Acute Myelogenous Leukemia or Myelodysplastic Syndrome

Free
Guillermo Garcia-Manero, MD, Uwe Platzbecker, Stefano R. Tarantolo, MD, Stefanie Gropper, Chetasi Talati, MD, Katharina S. Götze, James Dugan, MD, Eric S. Winer, MD, Elizabeth Martinez, PhD DHSC, MSN, Christopher Lieberman, Reinhard von Roemeling, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 16.
https://doi.org/10.1182/blood-2020-140889
Published: 2020
Journal Articles

Relapsed Acute Myeloid Leukemia Is Less Sensitive to Venetoclax + Azacitidine Due to Leukemia Stem Cell Resistance Driven By Fatty Acid Metabolism and Can be Overcome By Pharmacologic Inhibition of CPT1

Free
Daniel A Pollyea, MD, Courtney L Jones, PhD, Brett M Stevens, PhD, Shanshan Pei, PhD, Angelo D'Alessandro, PhD, Rachel Culp-Hill, BS, Diana Abbott, PhD, Andrew Hammes, MS, James Dugan, MD, Jonathan A Gutman, MD, Enkhtsetseg Purev, MD PhD, Clayton Smith, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 432.
https://doi.org/10.1182/blood-2018-99-111507
Published: 2018
Journal Articles

PTPN11 Mutations Confer Unique Metabolic Properties and Increase Resistance to Venetoclax and Azacitidine in Acute Myelogenous Leukemia

Free
Brett M. Stevens, PhDBS, Courtney L Jones, PhD, Amanda Winters, MDPhD, James Dugan, MD, Diana Abbott, PhD, Michael R. Savona, MD, Stephen W. Fesik, PhD, Daniel A Pollyea, MD, Craig T Jordan, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 909.
https://doi.org/10.1182/blood-2018-99-119806
Published: 2018
Journal Articles

Bone Marrow Cellularity and Recovery of Blood Counts after Venetoclax and Azacitidine in Elderly Acute Myeloid Leukemia Patients Unfit for Induction Chemotherapy

Free
James Dugan, MD, Daniel A. Pollyea, MD, Diana Abbott, PhD, Theodore Schultheiss, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 5086.
https://doi.org/10.1182/blood.V130.Suppl_1.5086.5086
Published: 2017
Journal Articles

Epstein-Barr Virus Kinase-Targeted Therapy for Primary Central Nervous System Post-Transplant Lymphoproliferative Disorder

Free
James Dugan, MD MS, Bradley M. Haverkos, MD MPH, Ludmila Katherine Martin, MD, Marisa F. Martin, Mark E Lustberg, MD PhD, John T. Patton, PhD, Gerard Nuovo, MD, Fengting Yan, MD, PhD, Robert Cavaliere, MD, Shannon C. Kenney, MD, Joyce Fingeroth, MD, Gerard Lozanski, MD, Juan Carlos Ramos, MD, Pierluigi Porcu, MD, Michael A. Caligiuri, MD, Robert A. Baiocchi, MD PhD
Journal: Blood
Blood (2014) 124 (21): 1750.
https://doi.org/10.1182/blood.V124.21.1750.1750
Published: 2014