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Rahul Sanawar
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Journal Articles

S100A8/A9 drives T cell exhaustion and compromises the therapeutic efficacy of bispecific antibodies in multiple myeloma.

Free
Adolfo Aleman, Oliver Van Oekelen, Shriya Desai, Sidorela Reci, Leah Grossman, Rudra Prasad Dutta, Mathieu Desaunay, Junia Vieira, Rongbao Zhao, Rahul Sanawar, Mani Mohindru, Tarek Mouhieddine, Alessandro Lagana, Marta Larrayoz, Poulikos Poulikakos, Gurbakhash Kaur, Larysa Sanchez, Cesar Rodriguez Valdes, Santiago Thibaud, Adriana Rossi, Shambavi Richard, Joshua Richter, Hearn Cho, Jose A. Martinez-Climent, Amit Verma, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2025) 146 (Supplement 1): 916.
https://doi.org/10.1182/blood-2025-916
Published: 2025
Journal Articles

Ofirnoflast, a novel inflammasome inhibitor, rewires transcriptional programs and shows clinical and preclinical efficacy in myeloid neoplasms

Free
Divij Verma, Rahul Sanawar, Samarpana Chakraborty, Emma Rabinovich, Kith Pradhan, Srabani Sahu, Christopher Selverian, Rongbao Zhao, Surendra Neupane, Colette Prophete, Lidiane Torres, Stephen Anthony, Margit Janat-Amsbury, Alexis Mollard, Shanisha Gordon-Mitchell, Aditi Shastri, Shanye Yin, Eric Padron, Alan List, David Bearss, Amit Verma
Journal: Blood
Blood (2025) 146 (Supplement 1): 323.
https://doi.org/10.1182/blood-2025-323
Published: 2025
Journal Articles

Monoclonal antibodies against pathogenic S100A8/9 alarmins can restore hematopoiesis and result in immunomodulation in myelodysplasia and leukemia models

Free
Rahul Sanawar, Ariel Fromowitz, Srinivas Aluri, Sarah Aminov, Srabani Sahu, Leah Kravets, Shanisha Gordon-Mitchell, Mani Mohindru, Aditi Shastri, Alan List, Eric Padron, Rongbao Zhao, Amit Verma
Journal: Blood
Blood (2025) 146 (Supplement 1): 4959.
https://doi.org/10.1182/blood-2025-4959
Published: 2025
Journal Articles

Degrading SMARCA2/4 Relieves the Differentiation Block in AML Via Chromatin Alterations Affecting S100A8/9

Free
Sarah Aminov, Rongbao Zhao, Kith Pradhan, Srabani Sahu, Rahul Sanawar, Shanisha Gordon Mitchell, Emma Rabinovich, Ariel Fromowitz, Joyeeta Chakraborty, Srinivas Aluri, Nayem Haque, Milagros Carbajal, Aditi Shastri, Ulrich Steidl, Susanta Samajdar, Akhil Kumar, Murali Ramachandra, Kristy Stengel, Robert Coleman, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 2909.
https://doi.org/10.1182/blood-2024-198479
Published: 2024
Journal Articles

BCMA CART Therapy Failure in Myeloma Is Associated with Immunosuppressive S100A8/9 Overexpression and Can be Ameliorated with Novel Monoclonal Antibodies

Free
Adolfo Aleman, Rongbao Zhao, Leah Grossman, Rahul Sanawar, Srinivas Aluri, Mani Mohindru, Rudra Prasad Dutta, Sidorela Reci, Junia Vieira, David Melnekoff, Alessandro Lagana, Shriya Desai, Sundar Jagannath, Amit Verma, Samir Parekh
Journal: Blood
Blood (2024) 144 (Supplement 1): 589.
https://doi.org/10.1182/blood-2024-201194
Published: 2024
Journal Articles

Preclinical Activity of Novel TGF Beta Receptor I Kinase Inhibitors IOA-359 and IOA-360 for Treatment of Anemia in MDS/AML

Free
Nandini Ramachandra, Charan Thej Reddy Vegivinti, Srabani Sahu, Bianca Rivera, Sarah Aminov, Ariel Fromowitz, Jinghang Zhang, Fnu Aodengtuya, Kith Pradhan, Rongbao Zhao, Leya Schwartz, Victor Thiruthuvanathan, Rahul Sanawar, Emma Rabinovich, Opeyemi Ajibade, Aditi Shastri, Michael Lahn, Amit K. Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 4589.
https://doi.org/10.1182/blood-2023-179921
Published: 2023
Journal Articles

The Dual Inflammasome/Myddosome Inhibitor HT-6184 Restores Erythropoiesis in MDS/AML

Free
Emma Rabinovich, Ariel Fromowitz, Opeyemi Ajibade, Srabani Sahu, Divij Verma, Sarah Aminov, Nandini Ramachandra, Christopher Selverian, Nailya Khalizova, Srinivas Aluri, Rahul Sanawar, Shanisha Gordon Mitchell, Milagros Carbajal, Jacqueline Boultwood, Andrea Pellagatti, Ulrich Steidl, Aditi Shastri, Rongbao Zhao, Alexis Mollard, Margit Janat-Amsbury, David J. Bearss, Alan F. List, Amit Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 1417.
https://doi.org/10.1182/blood-2023-182289
Published: 2023