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Rongbao Zhao
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Journal Articles

S100A8/A9 drives T cell exhaustion and compromises the therapeutic efficacy of bispecific antibodies in multiple myeloma.

Free
Adolfo Aleman, Oliver Van Oekelen, Shriya Desai, Sidorela Reci, Leah Grossman, Rudra Prasad Dutta, Mathieu Desaunay, Junia Vieira, Rongbao Zhao, Rahul Sanawar, Mani Mohindru, Tarek Mouhieddine, Alessandro Lagana, Marta Larrayoz, Poulikos Poulikakos, Gurbakhash Kaur, Larysa Sanchez, Cesar Rodriguez Valdes, Santiago Thibaud, Adriana Rossi, Shambavi Richard, Joshua Richter, Hearn Cho, Jose A. Martinez-Climent, Amit Verma, Sundar Jagannath, Samir Parekh
Journal: Blood
Blood (2025) 146 (Supplement 1): 916.
https://doi.org/10.1182/blood-2025-916
Published: 2025
Journal Articles

Ofirnoflast, a novel inflammasome inhibitor, rewires transcriptional programs and shows clinical and preclinical efficacy in myeloid neoplasms

Free
Divij Verma, Rahul Sanawar, Samarpana Chakraborty, Emma Rabinovich, Kith Pradhan, Srabani Sahu, Christopher Selverian, Rongbao Zhao, Surendra Neupane, Colette Prophete, Lidiane Torres, Stephen Anthony, Margit Janat-Amsbury, Alexis Mollard, Shanisha Gordon-Mitchell, Aditi Shastri, Shanye Yin, Eric Padron, Alan List, David Bearss, Amit Verma
Journal: Blood
Blood (2025) 146 (Supplement 1): 323.
https://doi.org/10.1182/blood-2025-323
Published: 2025
Journal Articles

Monoclonal antibodies against pathogenic S100A8/9 alarmins can restore hematopoiesis and result in immunomodulation in myelodysplasia and leukemia models

Free
Rahul Sanawar, Ariel Fromowitz, Srinivas Aluri, Sarah Aminov, Srabani Sahu, Leah Kravets, Shanisha Gordon-Mitchell, Mani Mohindru, Aditi Shastri, Alan List, Eric Padron, Rongbao Zhao, Amit Verma
Journal: Blood
Blood (2025) 146 (Supplement 1): 4959.
https://doi.org/10.1182/blood-2025-4959
Published: 2025
Journal Articles

Degrading SMARCA2/4 Relieves the Differentiation Block in AML Via Chromatin Alterations Affecting S100A8/9

Free
Sarah Aminov, Rongbao Zhao, Kith Pradhan, Srabani Sahu, Rahul Sanawar, Shanisha Gordon Mitchell, Emma Rabinovich, Ariel Fromowitz, Joyeeta Chakraborty, Srinivas Aluri, Nayem Haque, Milagros Carbajal, Aditi Shastri, Ulrich Steidl, Susanta Samajdar, Akhil Kumar, Murali Ramachandra, Kristy Stengel, Robert Coleman, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 2909.
https://doi.org/10.1182/blood-2024-198479
Published: 2024
Journal Articles

TGF-β1-SMAD2 Axis Regulates Hematopoiesis and β-Globin Gene Expression Via Super-Enhancer Associated Chromatin Reorganization

Free
Srinivas Aluri, Kimo Bachiashvili, Anjali Budhathoki, Jong J Jeong, Shanisha Gordon Mitchell, Milagros Carbajal, Samarpana Chakraborty, Sanjay Pandey, Mahinder Paul Wadhwa, Srabani Sahu, Jung-In Yang, Gaurav S Choudhary, Tushar Damodar Bhagat, Nandini Ramachandra, Rongbao Zhao, Bianca Rivera, Ritesh Aggarwal, Kith Pradhan, Shahina Maqbool, Seong jin Kim, Sunjin Hwang, Ulrich Steidl, Aditi Shastri, Marc Raaijmakers, Andrea Pellagatti, Jacqueline Boultwood, Amittha Wickrema, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 878.
https://doi.org/10.1182/blood-2024-201101
Published: 2024
Journal Articles

BCMA CART Therapy Failure in Myeloma Is Associated with Immunosuppressive S100A8/9 Overexpression and Can be Ameliorated with Novel Monoclonal Antibodies

Free
Adolfo Aleman, Rongbao Zhao, Leah Grossman, Rahul Sanawar, Srinivas Aluri, Mani Mohindru, Rudra Prasad Dutta, Sidorela Reci, Junia Vieira, David Melnekoff, Alessandro Lagana, Shriya Desai, Sundar Jagannath, Amit Verma, Samir Parekh
Journal: Blood
Blood (2024) 144 (Supplement 1): 589.
https://doi.org/10.1182/blood-2024-201194
Published: 2024
Journal Articles

Inhibition of Toll-like Receptor 4 (TLR4) Promotes Erythroid and Myeloid Differentiation in Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Free
Ariel Fromowitz, Srinivas Aluri, Jesus D Gonzalez Lugo, Emma Rabinovich, Nandini Ramachandra, Sarah Aminov, Srabani Sahu, Shanisha Gordon Mitchell, Ritesh Aggarwal, Opeyemi Ajibade, Milagros Carbajal, Kith Pradhan, Andrea Pellagatti, Jacqueline Boultwood, Aditi Shastri, Rongbao Zhao, Amit K. Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 5615.
https://doi.org/10.1182/blood-2023-182059
Published: 2023
Journal Articles

Preclinical Activity of Novel TGF Beta Receptor I Kinase Inhibitors IOA-359 and IOA-360 for Treatment of Anemia in MDS/AML

Free
Nandini Ramachandra, Charan Thej Reddy Vegivinti, Srabani Sahu, Bianca Rivera, Sarah Aminov, Ariel Fromowitz, Jinghang Zhang, Fnu Aodengtuya, Kith Pradhan, Rongbao Zhao, Leya Schwartz, Victor Thiruthuvanathan, Rahul Sanawar, Emma Rabinovich, Opeyemi Ajibade, Aditi Shastri, Michael Lahn, Amit K. Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 4589.
https://doi.org/10.1182/blood-2023-179921
Published: 2023
Journal Articles

The Dual Inflammasome/Myddosome Inhibitor HT-6184 Restores Erythropoiesis in MDS/AML

Free
Emma Rabinovich, Ariel Fromowitz, Opeyemi Ajibade, Srabani Sahu, Divij Verma, Sarah Aminov, Nandini Ramachandra, Christopher Selverian, Nailya Khalizova, Srinivas Aluri, Rahul Sanawar, Shanisha Gordon Mitchell, Milagros Carbajal, Jacqueline Boultwood, Andrea Pellagatti, Ulrich Steidl, Aditi Shastri, Rongbao Zhao, Alexis Mollard, Margit Janat-Amsbury, David J. Bearss, Alan F. List, Amit Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 1417.
https://doi.org/10.1182/blood-2023-182289
Published: 2023
Journal Articles

GDF11/SMAD Regulated Splicing of GATA1 Is Associated with Response to Luspatercept in Lower-Risk Myelodysplastic Syndromes (LR-MDS)

Free
Srinivas Aluri, Ellen Fraint, Samarpana Chakraborty, Aarif Ahsan, Gowri Poigailwar, Rongbao Zhao, Kith Pradhan, Kimo Bachiashvili, Anjali Budhathoki, Beamon Agarwal, Shanisha Gordon Mitchell, Milagros Carbajal, Srabani Sahu, Jacqueline Boultwood, Andrea Pellagatti, Ulrich Steidl, Amittha Wickrema, Satish Nandakumar, Aditi Shastri, Teresa Bowman, Sadanand Vodala, Amit K. Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 318.
https://doi.org/10.1182/blood-2023-179131
Published: 2023
Journal Articles

Novel Clinically Useful Inhibitor of Mediator Complex, RVU120, Relives Differentiation Block in MDS/AML

Free
Opeyemi Ajibade, Urszula Pakulska, Emma Rabinovich, Ariel Fromowitz, Srabani Sahu, Sarah Aminov, Nandini Ramachandra, Srinivas Aluri, Shanisha Gordon Mitchell, Milagros Carbajal, Kinga Keska-Izworska, Michał Combik, Marta Obacz, Elżbieta Adamczyk, Jan M. Zaucha, Ewa Zarzycka, Przemyslaw Juszczynski, Jacqueline Boultwood, Andrea Pellagatti, Kith Pradhan, Ulrich Steidl, Aditi Shastri, Rongbao Zhao, Milena Mazan, Tomasz Rzymski, Amit Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 3225.
https://doi.org/10.1182/blood-2023-186227
Published: 2023
Journal Articles

Pyrimethamine, a STAT3 Inhibitor, Synergizes with Venetoclax and Shows Efficacy in Hypomethylating Agent Resistant MDS and AML

Free
Bianca L Rivera, Samarpana Chakraborty, Yang Shi, Hui Zhang, Gaurav S Choudhary, Shanisha Gordon, Kith Pradhan, Bowen Fu, Isidora Tosic, Rongbao Zhao, Mendel Goldfinger, Ioannis Mantzaris, Milagros Carbajal, Nandini Ramachandra, Marina Konopleva, David Frank, Yogenthiran Saunthararajah, Amit Verma, Aditi Shastri
Journal: Blood
Blood (2022) 140 (Supplement 1): 6892–6893.
https://doi.org/10.1182/blood-2022-163255
Published: 2022
Journal Articles

Functional roles of aspartate residues of the proton-coupled folate transporter (PCFT-SLC46A1); a D156Y mutation causing hereditary folate malabsorption

Free
Daniel Sanghoon Shin, Sang Hee Min, Laura Russell, Rongbao Zhao, Andras Fiser, I. David Goldman
Journal: Blood
Blood (2010) 116 (24): 5162–5169.
https://doi.org/10.1182/blood-2010-06-291237
Published: 2010
Journal Articles

The spectrum of mutations in the PCFT gene, coding for an intestinal folate transporter, that are the basis for hereditary folate malabsorption

Free
Rongbao Zhao, Sang Hee Min, Andong Qiu, Antoinette Sakaris, Gary L. Goldberg, Claudio Sandoval, J. Jeffrey Malatack, David S. Rosenblatt, I. David Goldman
Journal: Blood
Blood (2007) 110 (4): 1147–1152.
https://doi.org/10.1182/blood-2007-02-077099
Published: 2007