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Journal Articles

Degrading SMARCA2/4 Relieves the Differentiation Block in AML Via Chromatin Alterations Affecting S100A8/9

Sarah Aminov, Rongbao Zhao, Kith Pradhan, Srabani Sahu, Rahul Sanawar, Shanisha Gordon Mitchell, Emma Rabinovich, Ariel Fromowitz, Joyeeta Chakraborty, Srinivas Aluri, Nayem Haque, Milagros Carbajal, Aditi Shastri, Ulrich Steidl, Susanta Samajdar, Akhil Kumar, Murali Ramachandra, Kristy Stengel, Robert Coleman, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 2909.
https://doi.org/10.1182/blood-2024-198479
Published: 2024
Journal Articles

Elevated Clonal Hematopoiesis in Environmentally Exposed Responders Has Distinct Age-Related Patterns and Relies on IL1RAP for Clonal Expansion

Divij Verma, Rachel Zeig Owens, David G Goldfarb, Kith Pradhan, Srabani Sahu, Susheian Kelly, Orsi Giricz, Sakshi Jasra, Yiyu Zou, Colette Prophete, Lidiane Torres, Srinivas Aluri, Samarpana Chakraborty, Shanisha Gordon Mitchell, Rajni Kumari, Jingli Wang, Alexander J Silver, Charles Hall, Ryan Bender, Ola Landgren, Lee Greenberger, Advaitha Madireddy, Aditi Shastri, Lindsay Lafave, Anna Nolan, Michael R. Savona, Ulrich Steidl, David Prezant, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 943.
https://doi.org/10.1182/blood-2024-194127
Published: 2024
Journal Articles

KRAS G12D Specific Inhibitors Relieve Erythroid Differentiation Block and Modulate Inflammatory Pathways at the Single Cell Level in Myeloid Malignancies

Leah Kravets, Mirca S. Saurty-Seerunghen, Divij Verma, Ariel Fromowitz, Srabani Sahu, Bradley Rockwell, Olivia Sakaguchi, Swathi Narayanagari, Shanisha Gordon Mitchell, Milagros Carbajal, Srinivas Aluri, Jingli Wang, Lindsay Lafave, Marina Konopleva, Anna S. Nam, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 326.
https://doi.org/10.1182/blood-2024-208924
Published: 2024
Journal Articles

TGF-β1-SMAD2 Axis Regulates Hematopoiesis and β-Globin Gene Expression Via Super-Enhancer Associated Chromatin Reorganization

Srinivas Aluri, Kimo Bachiashvili, Anjali Budhathoki, Jong J Jeong, Shanisha Gordon Mitchell, Milagros Carbajal, Samarpana Chakraborty, Sanjay Pandey, Mahinder Paul Wadhwa, Srabani Sahu, Jung-In Yang, Gaurav S Choudhary, Tushar Damodar Bhagat, Nandini Ramachandra, Rongbao Zhao, Bianca Rivera, Ritesh Aggarwal, Kith Pradhan, Shahina Maqbool, Seong jin Kim, Sunjin Hwang, Ulrich Steidl, Aditi Shastri, Marc Raaijmakers, Andrea Pellagatti, Jacqueline Boultwood, Amittha Wickrema, Amit Verma
Journal: Blood
Blood (2024) 144 (Supplement 1): 878.
https://doi.org/10.1182/blood-2024-201101
Published: 2024
Journal Articles

GDF11/SMAD Regulated Splicing of GATA1 Is Associated with Response to Luspatercept in Lower-Risk Myelodysplastic Syndromes (LR-MDS)

Srinivas Aluri, Ellen Fraint, Samarpana Chakraborty, Aarif Ahsan, Gowri Poigailwar, Rongbao Zhao, Kith Pradhan, Kimo Bachiashvili, Anjali Budhathoki, Beamon Agarwal, Shanisha Gordon Mitchell, Milagros Carbajal, Srabani Sahu, Jacqueline Boultwood, Andrea Pellagatti, Ulrich Steidl, Amittha Wickrema, Satish Nandakumar, Aditi Shastri, Teresa Bowman, Sadanand Vodala, Amit K. Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 318.
https://doi.org/10.1182/blood-2023-179131
Published: 2023
Journal Articles

Novel Clinically Useful Inhibitor of Mediator Complex, RVU120, Relives Differentiation Block in MDS/AML

Opeyemi Ajibade, Urszula Pakulska, Emma Rabinovich, Ariel Fromowitz, Srabani Sahu, Sarah Aminov, Nandini Ramachandra, Srinivas Aluri, Shanisha Gordon Mitchell, Milagros Carbajal, Kinga Keska-Izworska, Michał Combik, Marta Obacz, Elżbieta Adamczyk, Jan M. Zaucha, Ewa Zarzycka, Przemyslaw Juszczynski, Jacqueline Boultwood, Andrea Pellagatti, Kith Pradhan, Ulrich Steidl, Aditi Shastri, Rongbao Zhao, Milena Mazan, Tomasz Rzymski, Amit Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 3225.
https://doi.org/10.1182/blood-2023-186227
Published: 2023
Journal Articles

Inhibition of Toll-like Receptor 4 (TLR4) Promotes Erythroid and Myeloid Differentiation in Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Ariel Fromowitz, Srinivas Aluri, Jesus D Gonzalez Lugo, Emma Rabinovich, Nandini Ramachandra, Sarah Aminov, Srabani Sahu, Shanisha Gordon Mitchell, Ritesh Aggarwal, Opeyemi Ajibade, Milagros Carbajal, Kith Pradhan, Andrea Pellagatti, Jacqueline Boultwood, Aditi Shastri, Rongbao Zhao, Amit K. Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 5615.
https://doi.org/10.1182/blood-2023-182059
Published: 2023
Journal Articles

The Dual Inflammasome/Myddosome Inhibitor HT-6184 Restores Erythropoiesis in MDS/AML

Emma Rabinovich, Ariel Fromowitz, Opeyemi Ajibade, Srabani Sahu, Divij Verma, Sarah Aminov, Nandini Ramachandra, Christopher Selverian, Nailya Khalizova, Srinivas Aluri, Rahul Sanawar, Shanisha Gordon Mitchell, Milagros Carbajal, Jacqueline Boultwood, Andrea Pellagatti, Ulrich Steidl, Aditi Shastri, Rongbao Zhao, Alexis Mollard, Margit Janat-Amsbury, David J. Bearss, Alan F. List, Amit Verma
Journal: Blood
Blood (2023) 142 (Supplement 1): 1417.
https://doi.org/10.1182/blood-2023-182289
Published: 2023
Journal Articles

Pyrimethamine, a STAT3 Inhibitor, Synergizes with Venetoclax and Shows Efficacy in Hypomethylating Agent Resistant MDS and AML

Bianca L Rivera, Samarpana Chakraborty, Yang Shi, Hui Zhang, Gaurav S Choudhary, Shanisha Gordon, Kith Pradhan, Bowen Fu, Isidora Tosic, Rongbao Zhao, Mendel Goldfinger, Ioannis Mantzaris, Milagros Carbajal, Nandini Ramachandra, Marina Konopleva, David Frank, Yogenthiran Saunthararajah, Amit Verma, Aditi Shastri
Journal: Blood
Blood (2022) 140 (Supplement 1): 6892–6893.
https://doi.org/10.1182/blood-2022-163255
Published: 2022
Journal Articles

Resistance to CD19 Immunotherapy in B-Cell ALL Is Associated with Loss of CD19 and CD22 and an Enhanced Vulnerability to B Cell Receptor Signaling Inhibition

Sarah Aminov, Orsi Giricz, R. Alejandro Sica, Veronika Polishchuk, Bonnie Yates, Hao-Wei Wang, Yanhua Wang, Srabani Sahu, Shanisha Gordon, Carolina Schinke, Kith Pradhan, Srinivas Aluri, Murali Janakiram, Stefan K. Barta, Beamon Agarwal, Mendel Goldfinger, Aditi Shastri, William Matsui, Ulrich Steidl, Joshua Brody, Nirali N. Shah, Samir Parekh, Amit Verma
Journal: Blood
Blood (2022) 140 (Supplement 1): 3480–3482.
https://doi.org/10.1182/blood-2022-169102
Published: 2022
Journal Articles

Preclinical Activity of the Clinical Stage Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor PRT543 in Splicing Mutant Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Leya Y Schwartz, Gaurav S Choudhary, Nandini Ramachandra, Srabani Sahu, Shanisha Gordon, Bruce Ruggeri, Diane Heiser, Peggy Scherle, Daniel Starczynowski, Amit Verma
Journal: Blood
Blood (2021) 138 (Supplement 1): 2597.
https://doi.org/10.1182/blood-2021-148494
Published: 2021
Journal Articles

A Transgenic Murine Model Expressing Hyperactive STAT3 Recapitulates the Features of MDS/AML

Bianca L Rivera, Shanisha Gordon, Srinivas Aluri, Yang Shi, Samarpana Chakraborty, Gaurav S Choudhary, Lauren C Shapiro, Kith Pradhan, David A. Frank, Sergei B. Koralov, Amit Verma, Aditi Shastri
Journal: Blood
Blood (2021) 138 (Supplement 1): 3308.
https://doi.org/10.1182/blood-2021-151691
Published: 2021
Journal Articles

ASXL1 Mutations Are Associated with Widespread and Distinct DNA Methylation Alterations

Nora E Rahmani, MD, Nandini Ramachandra, Tushar D Bhagat, PhD, Shanisha Gordon, Kith Pradhan, PhD, Bianca Rivera Pena, Mohammad Kazemi, Orsi Giricz, PhD, Shahina Maqbool, Raul Olea, Hamid Dolatshad, Vickram Tittrea, Dharamveer Tatwavedi, Shalini Singh, Andrea Pellagatti, Jacqueline Boultwood, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2989.
https://doi.org/10.1182/blood-2019-126850
Published: 2019
Journal Articles

Clinical ALK5 Inhibitor, Vactosertib, Reverses TGFβ-1 Stimulated Smad-2 Driven Ineffective Hematopoiesis in MDS

Srinivas Aluri, Kimo Bachiashvili, MD, Anjali Budhathoki, MD, Tushar D Bhagat, PhD, Gaurav S Choudhary, PhD, Shanisha Gordon, Nandini Ramachandra, Kith Pradhan, PhD, Shahina Maqbool, Aditi Shastri, MD, Jung Im Huh, Sunjin Hwang, Kim Seong-Jin, PhD, Hui Zhang, Britta Will, PhD, Amittha Wickrema, PhD, Ulrich G. Steidl, MD PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 2990.
https://doi.org/10.1182/blood-2019-127561
Published: 2019
Journal Articles

High Burden of Clonal Hematopoiesis in First Responders Exposed to the World Trade Center Disaster

Sakshi Jasra, MD, Orsi Giricz, PhD, Rachel Zeig-Owens, M.P.H, David Goldfarb, M.P.H, Angelica Barreto-Galvez, Kith Pradhan, PhD, Jiahao Chen, PhD, Gaurav S Choudhary, PhD, Srinivas Aluri, Tushar D Bhagat, PhD, Aditi Shastri, MD, Victor Thiruthuvanathan, M.S, Hiroki Goto, MD PhD, Jeannine Gerhardt, PhD, Shanisha Gordon, Arul Veerappan, PhD, Syed Hissam Haider, MD, Matthias Bartenstein, MD, George Nwankwo, Ola Landgren, MD PhD, Michael Weiden, MD, Frederick Fletcher, Lee Greenberger, PhD, Benjamin L. Ebert, MD PhD, Ulrich G. Steidl, MD PhD, Britta Will, PhD, Anna Nolan, MD MS, David Prezant, MD, Advaitha Madireddy, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 3720.
https://doi.org/10.1182/blood-2019-129276
Published: 2019
Journal Articles

SF3B1 Mutations Induce Oncogenic IRAK4 Isoforms and Activate Targetable Innate Immune Pathways in MDS and AML

Gaurav S Choudhary, PhD, Molly A Smith, PhD, Andrea Pellagatti, Tushar D Bhagat, PhD, Shanisha Gordon, Sanjay Pandey, PhD, Nishi Shah, MBBS, MPH, Srinivas Aluri, Robert N Booher, PhD, Murali Ramachandra, PhD, Maria Elena Samson, Kith Pradhan, PhD, Teresa V. Bowman, PhD, Manoj M Pillai, MD, Chandan Guha, MBBS, Amittha Wickrema, PhD, Britta Will, PhD, Aditi Shastri, MD, Ulrich G. Steidl, MD PhD, Jacqueline Boultwood, Daniel T. Starczynowski, PhD, Amit Verma, MBBS
Journal: Blood
Blood (2019) 134 (Supplement_1): 4224.
https://doi.org/10.1182/blood-2019-124458
Published: 2019
Journal Articles

Reduced Expression of DOCK4 Leads to Increased Protein Phosphorylation and Migration of Hematopoietic Stem/Progenitor Cells

Sriram Sundaravel, MS, Wen Liang-Kuo, PhD, Hui Liu, MS, Jong Jeong, PhD, Gaurav Choudhary, PhD, Tushar Damodar Bhagat, PhD, Shanisha Gordon, Amit Verma, MD, Amittha Wickrema, PhD
Journal: Blood
Blood (2018) 132 (Supplement 1): 2563.
https://doi.org/10.1182/blood-2018-99-114320
Published: 2018
Journal Articles

North American ATLL has a distinct mutational and transcriptional profile and responds to epigenetic therapies

Urvi A. Shah, Elaine Y. Chung, Orsi Giricz, Kith Pradhan, Keisuke Kataoka, Shanisha Gordon-Mitchell, Tushar D. Bhagat, Yun Mai, Yongqiang Wei, Elise Ishida, Gaurav S. Choudhary, Ancy Joseph, Ronald Rice, Nadege Gitego, Crystall Parrish, Matthias Bartenstein, Swati Goel, Ioannis Mantzaris, Aditi Shastri, Olga Derman, Adam Binder, Kira Gritsman, Noah Kornblum, Ira Braunschweig, Chirag Bhagat, Jeff Hall, Armin Graber, Lee Ratner, Yanhua Wang, Seishi Ogawa, Amit Verma, B. Hilda Ye, Murali Janakiram
Journal: Blood
Blood (2018) 132 (14): 1507–1518.
https://doi.org/10.1182/blood-2018-01-824607
Published: 2018
Includes: Supplemental data
Journal Articles

Splicesome Mutant MDS and AML Cells Activate Innate Immune Signaling By Regulating the Expression of Therapeutically Targetable IRAK4 Isoforms

Molly A Smith, Gaurav Choudhary, PhD, Andrea Pellagatti, PhD, Kwangmin Choi, PhD, Tushar Damodar Bhagat, PhD, Nathan Salomonis, PhD, Matthew J. Walter, MD, Kakajan Komurov, Maria Elena S Sampson, Shanisha Gordon, Dagny Von Ahrens, Kith Pradhan, PhD, Ulrich G. Steidl, MDPhD, Robert Booher, PhD, Jacqueline Boultwood, PhD, Amit Verma, MD, Daniel Starczynowski, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 785.
https://doi.org/10.1182/blood.V130.Suppl_1.785.785
Published: 2017
Journal Articles

North American Adult T Cell Leukemia Lymphoma (ATLL) Is Characterized By Distinct, Therapeutically Targetable Mutations in Epigenetic Modifiers

Urvi A Shah, MD, Yanhua Wang, MD PhD, Orsolya Giricz, PhD, Shanisha Gordon, Tushar Damodar Bhagat, PhD, Yun Mai, PhD, Yongqiang Wei, MD, Nadege Gitego, Gaurav Choudhary, PhD, Kith Pradhan, PhD, Matthias Bartenstein, MD, Ronald Rice, DHSC, MD PhD, Swati Goel, MD, Ioannis Mantzaris, MD, Aditi Shastri, MD, Olga Derman, Adam F. Binder, MD, Kira Gritsman, MD PhD, Noah Kornblum, MD, Ira Braunschweig, MD, Amit Verma, MD, B. Hilda Ye, PhD, Murali Janakiram, MD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1455.
https://doi.org/10.1182/blood.V130.Suppl_1.1455.1455
Published: 2017