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Daniel Starczynowski
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Journal Articles

Characterization of E1 Ligase Dependencies in a Mutant- UBA1 Human Cell Model Reveals UBA6 As a Novel Therapeutic Target in Vexas Syndrome

Courtnee A. Clough, Claire Cunningham, Sophia Philbrook, Daniel Starczynowski
Journal: Blood
Blood (2024) 144 (Supplement 1): 4049.
https://doi.org/10.1182/blood-2024-207451
Published: 2024
Journal Articles

Single-Cell Multi-Omic Analysis of KMT2A -Rearranged Pediatric Acute Leukemia Clonal Evolution

Morgan Drucker, Dalia Dhingra, Mark Wunderlich, John Perentesis, Daniel Starczynowski, Robert L. Bowman, Linde A. Miles
Journal: Blood
Blood (2024) 144 (Supplement 1): 66.
https://doi.org/10.1182/blood-2024-202590
Published: 2024
Journal Articles

MYD88 Is Mutated in Clonal Hematopoiesis and Drives Altered Immune Cell Populations

Jennifer Yeung, Sophia Philbrook, Kwangmin Choi, Kathleen Hueneman, Erin K. Hertlein, John C. Byrd, Daniel Starczynowski
Journal: Blood
Blood (2024) 144 (Supplement 1): 2663.
https://doi.org/10.1182/blood-2024-208279
Published: 2024
Journal Articles

Codon-Specific Differences in RAS Mutations in AML and Differential Response to Therapeutic Agents

Annabelle J Anandappa, Vidushi Trivedi, Tiffany Merlinsky, Nicole Delgaudio, Emily Guzzardi, Ashley Wooten, Daniel Starczynowski, Robert L. Bowman, Ross Levine, Linde A. Miles
Journal: Blood
Blood (2024) 144 (Supplement 1): 2713.
https://doi.org/10.1182/blood-2024-205218
Published: 2024
Journal Articles

The Zymogen Form of Caspase-1 Is Required to Finetune Excessive Cell-Intrinsic Inflammation in Myelodysplastic Syndromes

Emma E. Uible, Kathleen Hueneman, Lyndsey C. Bolanos, Kwangmin Choi, William Seibel, Daniel Starczynowski
Journal: Blood
Blood (2024) 144 (Supplement 1): 4572.
https://doi.org/10.1182/blood-2024-207548
Published: 2024
Journal Articles

Momelotinib Is a Highly Potent Inhibitor of FLT3-Mutant AML

Mohammad Azhar, Zachary Kincaid, Meenu Kesarwani, Mark Wunderlich, Tahir Latif, Daniel Starczynowski, Mohammad Azam
Journal: Blood
Blood (2021) 138 (Supplement 1): 206.
https://doi.org/10.1182/blood-2021-148822
Published: 2021
Journal Articles

Preclinical Activity of the Clinical Stage Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor PRT543 in Splicing Mutant Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Leya Y Schwartz, Gaurav S Choudhary, Nandini Ramachandra, Srabani Sahu, Shanisha Gordon, Bruce Ruggeri, Diane Heiser, Peggy Scherle, Daniel Starczynowski, Amit Verma
Journal: Blood
Blood (2021) 138 (Supplement 1): 2597.
https://doi.org/10.1182/blood-2021-148494
Published: 2021
Journal Articles

Heterozygous Mutations in DDX41 Cause Erythroid Progenitor Cell Defects

Timothy M Chlon, Emily Stepanchick, Analise Sulentic, Kathleen Hueneman, Daniel Starczynowski
Journal: Blood
Blood (2021) 138 (Supplement 1): 148.
https://doi.org/10.1182/blood-2021-153544
Published: 2021
Journal Articles

Targeted Sequencing of 7 Genes Can Help Reduce Pathologic Misclassification of MDS

Johannes B Goll, MSc, Travis L Jensen, BS, R. Coleman Lindsley, MD PhD, Rafael Bejar, MD PhD, Jason Walker, Robert Fulton, MS, Gregory A. Abel, MD MPH, Tareq Al Baghdadi, MD, H. Joachim Deeg, MD, Amy E. DeZern, MD, Benjamin L. Ebert, MDPhD, James M. Foran, MD, Edward J. Gorak, DO,MBA,MS, Steven D. Gore, MD, Rami Komrokji, MD, Jane Jijun Liu, MD, Jaroslaw P. Maciejewski, MD PhD, Eric Padron, MD, Wael Saber, MD MS, Daniel Starczynowski, PhD, Myron Waclawiw, PhD, Steffanie H. Wilson, PhD, Donnie Hebert, PhD, Harrison Reed, MSc, Nancy L. DiFronzo, PhD, Mikkael A. Sekeres, MD MS, Alexandra M. Harrington, MDMT(ASCP), Steven H. Kroft, MD, Ling Zhang, MD, Matthew J. Walter, MD
Journal: Blood
Blood (2020) 136 (Supplement 1): 32–33.
https://doi.org/10.1182/blood-2020-140317
Published: 2020
Journal Articles

The Inherited MDS Gene DDX41 Is Essential for Ribosomal RNA Processing through Regulation of Snorna Biogenesis

Timothy M Chlon, PhD, Emily Stepanchick, Daniel Starczynowski, PhD, Kathleen Hueneman
Journal: Blood
Blood (2020) 136 (Supplement 1): 40.
https://doi.org/10.1182/blood-2020-143222
Published: 2020
Journal Articles

Splicesome Mutant MDS and AML Cells Activate Innate Immune Signaling By Regulating the Expression of Therapeutically Targetable IRAK4 Isoforms

Molly A Smith, Gaurav Choudhary, PhD, Andrea Pellagatti, PhD, Kwangmin Choi, PhD, Tushar Damodar Bhagat, PhD, Nathan Salomonis, PhD, Matthew J. Walter, MD, Kakajan Komurov, Maria Elena S Sampson, Shanisha Gordon, Dagny Von Ahrens, Kith Pradhan, PhD, Ulrich G. Steidl, MDPhD, Robert Booher, PhD, Jacqueline Boultwood, PhD, Amit Verma, MD, Daniel Starczynowski, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 785.
https://doi.org/10.1182/blood.V130.Suppl_1.785.785
Published: 2017
Journal Articles

Tifab Deficiency Protects Against Stress-Induced Bone Marrow Failure at the Expense of Pre-Leukemic Selection

Madeline Niederkorn, BS, Melinda Varney, PhD, Ken Greis, PhD, Ruhikanta A. Meetei, PhD, Kwangmin Choi, PhD, Daniel Starczynowski, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 2960.
https://doi.org/10.1182/blood.V130.Suppl_1.2960.2960
Published: 2017
Journal Articles

Innate Immune Signal Pathway Activation Induced By Combined Loss of Del(5q) MDS Genes, Tifab and Mir-146a, Accelerates Hematopoietic Stem Cell Exhaustion Driven By Chronic Exposure to a TLR Ligands

Tomoya Muto, MD PhD, Melinda Varney, PhD, Callum Walker, MSc, Lyndsey Bolanos, BSc, Kathleen Hueneman, BSc, Daniel Starczynowski, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1674.
https://doi.org/10.1182/blood.V130.Suppl_1.1674.1674
Published: 2017
Journal Articles

Ubiquitin Editing of a Spliceosome Auxiliary Factor By TRAF6 Links Chronic TLR Signaling with Hematopoietic Defects and Myelodysplasia

Jing Fang, MD, PhD, Lyndsey Bolanos, BSc, Kwang-Min Choi, PhD, Xiaona Liu, Ms, Susanne Christie, Shailaja Akunuru, PhD, Rupali Kumar, PhD, Ken Greis, PhD, Peter Stoilov, PhD, Marie-Dominique Filippi, PhD, Jaroslaw P. Maciejewski, MD PhD, Guillermo Garcia-Manero, MD, Matthew Weirauch, PhD, Nathan Salomonis, PhD, Hartmut Geiger, PhD, Yi Zheng, PhD, Daniel Starczynowski, PhD
Journal: Blood
Blood (2015) 126 (23): 143.
https://doi.org/10.1182/blood.V126.23.143.143
Published: 2015