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Diane Heiser
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Journal Articles

Selective SMARCA2 Degradation Promotes Leukemic Differentiation and Synergizes with CDK9 Inhibition to Potently Induce Death in Pre-Clinical Models of Acute Myeloid Leukemia

Norman Fultang, Ashley M Schwab, Ian Johnson, Alexander Grego, Emma Filler, Carly Bachner, Jake Karwoski, Andrew Moore, Ashley Bartilomo, Anjana Agarwal, Olusola Peace Osinubi, Koichi Ito, Sarah Aminov, Srabani Sahu, Amit Verma, Peggy A Scherle, Neha Bhagwat, Diane Heiser
Journal: Blood
Blood (2024) 144 (Supplement 1): 2774.
https://doi.org/10.1182/blood-2024-208196
Published: 2024
Journal Articles

Phase Ib Study of PRT543, an Oral Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor, in Patients with Relapsed or Refractory, Splicing Factor-Mutant Myeloid Malignancies

Jan Philipp Bewersdorf, Xiaoli Mi, Bin Lu, Andrew T. Kuykendall, David Sallman, Manish Patel, Don A. Stevens, Alexander Philipovskiy, Grerk Sutamtewagul, Lucia Masarova, Gina Keiffer, Amit Verma, Neha Bhagwat, Diane Heiser, Sunhee Ro, Wan-Jen Hong, Omar Abdel-Wahab, Eytan M. Stein
Journal: Blood
Blood (2024) 144 (Supplement 1): 3215.
https://doi.org/10.1182/blood-2024-198495
Published: 2024
Journal Articles

PRT2527, a Novel Highly Selective Cyclin-Dependent Kinase 9 (CDK9) Inhibitor, Has Potent Antitumor Activity in Combination with BTK and BCL2 Inhibition in Various Lymphoid Malignancies

Norman Fultang, Ashley M Schwab, Sophia McAneny-Droz, Diane Heiser, Peggy A Scherle, Neha Bhagwat
Journal: Blood
Blood (2023) 142 (Supplement 1): 5783.
https://doi.org/10.1182/blood-2023-190093
Published: 2023
Journal Articles

Preclinical Activity of the Clinical Stage Protein Arginine Methyltransferase 5 (PRMT5) Inhibitor PRT543 in Splicing Mutant Myelodysplastic Syndrome (MDS) and Acute Myeloid Leukemia (AML)

Leya Y Schwartz, Gaurav S Choudhary, Nandini Ramachandra, Srabani Sahu, Shanisha Gordon, Bruce Ruggeri, Diane Heiser, Peggy Scherle, Daniel Starczynowski, Amit Verma
Journal: Blood
Blood (2021) 138 (Supplement 1): 2597.
https://doi.org/10.1182/blood-2021-148494
Published: 2021
Journal Articles

A Feasibility Study of Biologically Focused Therapy for Myelodysplastic Syndrome Patients Refractory to Hypomethylating Agents

Michael A Spinner, Alexey Aleshin, MD MBA, Marianne A Santaguida, PhD, Steven A Schaffert, PhD, Taher Abbasi, MS, MBA, Jeffrey N Sanders, A Scott Patterson, MA, Diane Heiser, PhD, James L Zehnder, Peter L Greenberg, MD
Journal: Blood
Blood (2019) 134 (Supplement_1): 4239.
https://doi.org/10.1182/blood-2019-129473
Published: 2019
Journal Articles

PTC299 Is a Novel DHODH Inhibitor That Modulates VEGFA mRNA Translation and Inhibits Proliferation of a Broad Range of Leukemia Cells

Liangxian Cao, MD, Arthur Branstrom, PhD, John Baird, PhD, Christopher Trotta, PhD, Joseph Colacino, PhD, Marianne T. Santaguida, BSc, PhD, Diane Heiser, PhD BA, Mark Ma, PhD, Kensuke Kojima, MD PhD, Stuart Peltz, PhD, Edward O'Mara, MD, Robert Spiegel, MD, Marla Weetall, PhD
Journal: Blood
Blood (2017) 130 (Supplement 1): 1371.
https://doi.org/10.1182/blood.V130.Suppl_1.1371.1371
Published: 2017
Journal Articles

Ex Vivo High-Throughput Flow Cytometry Screening Identifies Subsets of Responders to Differentiation Agents in Individual AML Patient Samples

Sacha L. Prashad, PhD, Leylah Drusbosky, PhD, Hassan Sibai, MD, Mark D. Minden, MD PhD, Stephen J. Western, Chris Biondi, MS, Reecha Shah, MS, Debra Liu, MS, Transon Nguyen, MS, Connor Warnock, BS, Pete Quinzio, BA, Matthew De Silva, BS, Elie Traer, MD, Christopher R. Cogle, MD, Aaron D. Schimmer, MD PhD, Diane Heiser, PhD
Journal: Blood
Blood (2016) 128 (22): 5206.
https://doi.org/10.1182/blood.V128.22.5206.5206
Published: 2016
Journal Articles

Dnmt3a Deletion Cooperates with the Flt3-ITD Mutation to Drive Leukemogenesis in a Murine Model

Jennifer L Poitras, BS, Diane Heiser, PhD, Li Li, PhD, Bao Nguyen, M.S., Amy S. Duffield, MD PhD, Christopher Gamper, MD PhD, Donald Small, MD PhD
Journal: Blood
Blood (2014) 124 (21): 3568.
https://doi.org/10.1182/blood.V124.21.3568.3568
Published: 2014
Journal Articles

FLT3-ITD Knock-in Impairs Hematopoietic Stem Cell Quiescence/Homeostasis, Leading to a Myeloproliferative Neoplasm

S. Haihua Chu, Diane Heiser, Li Li, PhD, Ian M Kaplan, PhD, David Huso, D.V.M., Ph.D., Curt I. Civin, MD, Donald Small, MD, PhD
Journal: Blood
Blood (2011) 118 (21): 46.
https://doi.org/10.1182/blood.V118.21.46.46
Published: 2011
Journal Articles

MicroRNA Maestros of Hematopoiesis

Kara A. Scheibner, PhD, Diane Heiser, Ian M Kaplan, Wen-Chih Cheng, PhD, MinJung Kim, PhD, Shubhada Shashikant Bharne, PhD, Sebastien Morisot, PhD, Curt I. Civin, MD
Journal: Blood
Blood (2010) 116 (21): SCI-32.
https://doi.org/10.1182/blood.V116.21.SCI-32.SCI-32
Published: 2010
Journal Articles

Sorafenib Treatment Reverses Depletion of Primitive Hematopoietic Stem Cells and Resolves FLT3-ITD Driven Myeloproliferative Disease In a Mouse Model.

Diane Heiser, S. Haihua Chu, Li Li, PhD, Ian M Kaplan, Curt I. Civin, MD, Donald Small, MD, PhD
Journal: Blood
Blood (2010) 116 (21): 1586.
https://doi.org/10.1182/blood.V116.21.1586.1586
Published: 2010
Journal Articles

The Hematopoietic Stem Cell (HSC) Compartment in Tristetraprolin (TTP) Knock-out Mice Is Abnormal Phenotypically but Normal Functionally.

Ian M Kaplan, BS, Sebastien Morisot, PhD, Diane Heiser, BA, Wen-Chih Cheng, PhD, Christina LaDana, Curt I. Civin, MD
Journal: Blood
Blood (2009) 114 (22): 2541.
https://doi.org/10.1182/blood.V114.22.2541.2541
Published: 2009
Journal Articles

FLT3 Internal Tandem Duplication (ITD) Mutations Disrupt Homeostasis in Hematopoietic Stem Cells.

S. Haihua Chu, BSE, Diane Heiser, BA, Li Li, MD, PhD, Ian M Kaplan, BS, Curt I. Civin, MD, Donald Small, MD, PhD
Journal: Blood
Blood (2009) 114 (22): 1420.
https://doi.org/10.1182/blood.V114.22.1420.1420
Published: 2009