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Journal Articles

FLT3L-based conjugate targets chemoresistant leukemia stem cells via cell cycle re-entry in Acute Myeloid Leukemia

Dengyang Zhang, Yao Guo, Zhiyong Peng, Yan Xiao, Zhiguang Chang, Liuting Yu, Yuming Zhao, Qi Zhang, Lingling Ma, Shuping Li, Chi Kong Li, Kam Tong Leung, Zhizhuang Zhao, Chun Chen, Yun Chen

Blood (2025) 146 (Supplement 1): 319.

https://doi.org/10.1182/blood-2025-319

Published: 2025

Journal Articles

PTPN11 copy number gain drives leukemogenesis via mutant SHP2 in juvenile myelomonocytic leukemia

Zhiguang Chang, Zhiyong Peng, Lingling Ma, Yan Xiao, Yao Guo, Dengyang Zhang, Yuming Zhao, Liuting Yu, Junbin Huang, Hongman Xue, Chi Kong Li, Chun Chen, Zhizhuang Zhao, Yun Chen

Blood (2025) 146 (Supplement 1): 3234.

https://doi.org/10.1182/blood-2025-3234

Published: 2025

Journal Articles

Discovery of first-in-class calr-targeted precision ADCs delivering a CDK9degrader payload for the treatment of calr-mutated MPNs

Norman Fultang, Ashley Schwab, Sharayu Chandratre, Jake Karwoski, Grace Davis, Ian Johnson, Neha Bhagwat, Yue Zou, Arpita Mondal, Max Foroutan, Ryan Holmes, Chun Chen, Corey Basch, Andrew Buesking, Sang Hyun Lee, Diane Heiser, Andrew Combs, Peggy Scherle

Blood (2025) 146 (Supplement 1): 72.

https://doi.org/10.1182/blood-2025-72

Published: 2025

Journal Articles

Long-acting GM-CSF-based drug conjugate effectively targets leukemia stem cells in Acute Myeloid Leukemia with limited toxicity

Yan Xiao, Yao Guo, Dengyang Zhang, Zhiyong Peng, Yuming Zhao, Zhiguang Chang, Liuting Yu, Lingling Ma, Chi Kong Li, Zhizhuang Zhao, Chun Chen, Yun Chen

Blood (2025) 146 (Supplement 1): 752.

https://doi.org/10.1182/blood-2025-752

Published: 2025

Journal Articles

CFP1 controls H3K4me3-mediated chromatin architecture to promote v(D)j recombination in early B cell development

Wanyu Bai, Yalin Yang, Yanan Zhao, Junchao Dong, Chi Kong Li, Chun Chen

Blood (2025) 146 (Supplement 1): 629.

https://doi.org/10.1182/blood-2025-629

Published: 2025

Journal Articles

PI3Kδ inhibition enhances trametinib efficacy by suppressing feedback-activated PI3K/AKT signaling in PTPN11-mutant JMML

Yuming Zhao, Yao Guo, Zhiyong Peng, Tianqi Liang, Zhiguang Chang, Yan Xiao, Dengyang Zhang, Liuting Yu, Lingling Ma, Chi Kong Li, Zhizhuang Zhao, Chun Chen, Yun Chen

Blood (2025) 146 (Supplement 1): 5010.

https://doi.org/10.1182/blood-2025-5010

Published: 2025

Journal Articles

Identification of factors associated with a high success rate of treatment-free remission in chronic myeloid leukemia: A multicenter study in Taiwan

Ning-Chun Chen, Ming-Chung Kuo, Tung-Huei Lin, Ming-Chun Ma, Ching-Yuan Kuo, Hung Chang, Hsuan-Jen Shih, Tung-Liang Lin, Hsiao-Wen Kao, Chang-Liang Lai, Tsai-Yun Chen, Chih-Cheng Chen, Ming-Chung Wang, Lee-Yung Shih

Blood (2025) 146 (Supplement 1): 3781.

https://doi.org/10.1182/blood-2025-3781

Published: 2025

Journal Articles

5-HT prompt TPO mRNA transcription via H3Q5 serotonylation

Liang Li, Mo Yang, En-yu Liang, ouyang cheng, Chun Chen

Blood (2025) 146 (Supplement 1): 6751.

https://doi.org/10.1182/blood-2025-6751

Published: 2025

Journal Articles

Targeting SP1 condensates suppresses HNRNPUL1 via super-enhancers to attenuate Acute Myeloid Leukemia progression

Yuchen Wen, Chun Chen, Chi Kong Li, Yun Chen

Blood (2025) 146 (Supplement 1): 3267.

https://doi.org/10.1182/blood-2025-3267

Published: 2025

Journal Articles

FBXO7 通过靶向 TMED10 进行泛素介导的降解和激活 wnt 信号传导来促进 T-ALL 的化疗耐药性

zefan du, ouyang cheng, Chi Kong Li, Yun Chen, Chun Chen

Blood (2025) 146 (Supplement 1): 3263.

https://doi.org/10.1182/blood-2025-3263

Published: 2025

Journal Articles

The Kinetics of FLT3L during Induction Chemotherapy for Pediatric Acute Lymphoblastic Leukemia Suggests a Novel Clinical Diagnostic and Treatment Strategy

Wenqing Wang, Yan-lai Tang, Zhen Li, Hao Jiang, Chi-Kong Li, Chun Chen, Yun Chen, Hongman Xue

Blood (2023) 142 (Supplement 1): 5823.

https://doi.org/10.1182/blood-2023-187653

Published: 2023

Journal Articles

Comparing Phenotyping, Gene Expression, and Function of T Lymphocytes before Mobilization Chemotherapy Versus after Stem Cell Harvesting in Patients with B Cell Lymphoma and Multiple Myeloma

Sheng-Hsuan Chien, Xiuli Wang, Wen-Chun Chen, Chun-Yu Liu

Blood (2023) 142 (Supplement 1): 2147.

https://doi.org/10.1182/blood-2023-173443

Published: 2023

Journal Articles

Aurora Kinase B/C Inhibitor GSK1070916 Specifically Targets Juvenile Myelomonocytic Leukemia Cells with SHP2(PTPN11) Mutation

Chunxiao He, Dengyang Zhang, Yao Guo, Yuming Zhao, Junbin Huang, Hongman Xue, Chun Chen, Yun Chen, Zhizhuang Joe Zhao

Blood (2022) 140 (Supplement 1): 3092.

https://doi.org/10.1182/blood-2022-168468

Published: 2022

Journal Articles

Niclosamide Inhibits the Growth of Acute Lymphoblastic Leukemia Cells By Increasing Intracellular ROS and Activation of p53-PUMA/NOXA

Junbin Huang, Jing Yang, Yun Chen, Zhizhuang Joe Zhao, Chun Chen

Blood (2022) 140 (Supplement 1): 5917.

https://doi.org/10.1182/blood-2022-168825

Published: 2022

Journal Articles

Screening of Differential DNA Methylation Sites and Signal Pathway Analysis of Juvenile Myelomonocytic Leukemia in Children before and after Decitabine Treatment

Junbin Huang, Zhiyong Peng, Chunfu Li, Chun Chen

Blood (2022) 140 (Supplement 1): 11736–11737.

https://doi.org/10.1182/blood-2022-168428

Published: 2022

Journal Articles

Insufficient Phosphorylation of STAT5 in Tregs Inhibits the Expression of BLIMP-1, Leading to a Lack of Tregs in Pediatric Aplastic Anemia

Lifen Huang, Junbin Huang, Chengming Zhu, Hongman Xue, Chi Kong Li, Chun Chen

Blood (2021) 138 (Supplement 1): 2183.

https://doi.org/10.1182/blood-2021-152339

Published: 2021

Journal Articles

Small Molecule Kinase Inhibitor Sunitinib Specifically Targets Juvenile Myelomonocytic Leukemia Cells with SHP2(PTPN11) Mutation

Chunxiao He, Yuming Zhao, Junbin Huang, Yao Guo, Hongman Xue, Chun Chen, Yun Chen, Zhizhuang Joe Zhao

Blood (2021) 138 (Supplement 1): 3353.

https://doi.org/10.1182/blood-2021-149324

Published: 2021

Journal Articles

Establishment of Stable Cell Lines Representing Juvenile Myelomonocytic Leukemia with SHP2 Mutations

Yuming Zhao, Yao Guo, Chunxiao He, Dengyang Zhang, Han Zhong Pei, Ming Yang, Zhiguang Chang, Liuting Yu, Junbin Huang, Hongman Xue, Chun Chen, Zhizhuang Joe Zhao, Yun Chen

Blood (2021) 138 (Supplement 1): 4353.

https://doi.org/10.1182/blood-2021-150007

Published: 2021

Journal Articles

Tumor Associated Macrophages Express High-Levels of FLT3 Ligand, Which Induces Activation of FLT3 Signaling That Promotes Survival of Neoplastic Cells in B-Cell Acute Lymphoblastic Leukemia

Yao Guo, PhD, Junbin Huang, MDPhD, Dengyang Zhang, PhD, Liqin Zhang, Yuming Zhao, Liuting Yu, Zhiguang Chang, PhD, Han Zhong Pei, Chun Chen, MDPhD, Hongman Xue, MDPhD, Xiaojun Xu, MDPhD, Zhizhuang Joe Zhao, PhD, Yun Chen, PhD

Blood (2020) 136 (Supplement 1): 36–37.

https://doi.org/10.1182/blood-2020-142093

Published: 2020

Journal Articles

FLT3 Ligand-DM1 Conjugate Selectively Targets Acute Myeloid Leukemia Cells with FLT3 Expression

Dengyang Zhang, PhD, Yao Guo, PhD, Yuming Zhao, MD, Liuting Yu, Zhiguang Chang, PhD, Han Zhong Pei, Junbin Huang, MDPhD, Chun Chen, MDPhD, Hongman Xue, MDPhD, Yihang Pan, MD, Ningning Li, PhD, Chengming Zhu, PhD, Zhizhuang Joe Zhao, PhD, Jian Yu, PhD, Yun Chen, PhD

Blood (2020) 136 (Supplement 1): 30–31.

https://doi.org/10.1182/blood-2020-140200

Published: 2020

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FLT3L-based conjugate targets chemoresistant leukemia stem cells via cell cycle re-entry in Acute Myeloid Leukemia

PTPN11 copy number gain drives leukemogenesis via mutant SHP2 in juvenile myelomonocytic leukemia

Discovery of first-in-class calr-targeted precision ADCs delivering a CDK9degrader payload for the treatment of calr-mutated MPNs

Long-acting GM-CSF-based drug conjugate effectively targets leukemia stem cells in Acute Myeloid Leukemia with limited toxicity

CFP1 controls H3K4me3-mediated chromatin architecture to promote v(D)j recombination in early B cell development

PI3Kδ inhibition enhances trametinib efficacy by suppressing feedback-activated PI3K/AKT signaling in PTPN11-mutant JMML

Identification of factors associated with a high success rate of treatment-free remission in chronic myeloid leukemia: A multicenter study in Taiwan

5-HT prompt TPO mRNA transcription via H3Q5 serotonylation

Targeting SP1 condensates suppresses HNRNPUL1 via super-enhancers to attenuate Acute Myeloid Leukemia progression

FBXO7 通过靶向 TMED10 进行泛素介导的降解和激活 wnt 信号传导来促进 T-ALL 的化疗耐药性

The Kinetics of FLT3L during Induction Chemotherapy for Pediatric Acute Lymphoblastic Leukemia Suggests a Novel Clinical Diagnostic and Treatment Strategy

Comparing Phenotyping, Gene Expression, and Function of T Lymphocytes before Mobilization Chemotherapy Versus after Stem Cell Harvesting in Patients with B Cell Lymphoma and Multiple Myeloma

Aurora Kinase B/C Inhibitor GSK1070916 Specifically Targets Juvenile Myelomonocytic Leukemia Cells with SHP2(PTPN11) Mutation

Niclosamide Inhibits the Growth of Acute Lymphoblastic Leukemia Cells By Increasing Intracellular ROS and Activation of p53-PUMA/NOXA

Screening of Differential DNA Methylation Sites and Signal Pathway Analysis of Juvenile Myelomonocytic Leukemia in Children before and after Decitabine Treatment

Insufficient Phosphorylation of STAT5 in Tregs Inhibits the Expression of BLIMP-1, Leading to a Lack of Tregs in Pediatric Aplastic Anemia

Small Molecule Kinase Inhibitor Sunitinib Specifically Targets Juvenile Myelomonocytic Leukemia Cells with SHP2(PTPN11) Mutation

Establishment of Stable Cell Lines Representing Juvenile Myelomonocytic Leukemia with SHP2 Mutations

Tumor Associated Macrophages Express High-Levels of FLT3 Ligand, Which Induces Activation of FLT3 Signaling That Promotes Survival of Neoplastic Cells in B-Cell Acute Lymphoblastic Leukemia

FLT3 Ligand-DM1 Conjugate Selectively Targets Acute Myeloid Leukemia Cells with FLT3 Expression

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